28 results about "Methylguanidine" patented technology

The invention discloses a method for preparing substituted imidazole by taking acyl chloride as a raw material, belongs to the technical field of synthesis of fine chemicals, and aims to solve the problems that the raw material structure is complicated, the source is limited, the raw material needs to be prepared in advance and the cost is low in the existing method for synthesizing substituted imidazole. The reaction conditions are harsh, the reaction time is long, and a transition metal catalyst needs to be used. The method comprises the following steps: synthesizing 2-substituted-4-dimethylamino-5-cyano imidazole from acyl chloride, tetramethylguanidine and a cyaniding reagent at a certain temperature and under an alkaline condition; according to the method disclosed by the invention, the 2-substituted-4-dimethylamino-5-cyano imidazole is synthesized in one step by taking the acyl chloride as the substrate, the reaction rate is greatly accelerated by selecting various acyl chlorides and alkali and synergistically and reasonably controlling the ratio of various substances, efficient synthesis of the 2-substituted-4-dimethylamino-5-cyano imidazole is realized, and the substrate is good in adaptability and high in yield. The method has wide application prospects in the fields of chemistry, biology, medicine and the like.

The invention discloses a bio-based nylon composite material and a preparation method thereof, and relates to the technical field of polymer materials. When preparing the bio-based nylon composite material, the present invention first modifies shell powder with a silane coupling agent to obtain silicon-hydrogen modified shell powder; reacts N-hydroxyethyl maleimide with allyl phosphine dichloride to obtain bismaleimide monomer; reacts bismaleimide monomer with silicon-hydrogen modified shell powder to obtain modified shell powder; reacts dibutyl oxalate with methylguanamine to obtain multi-hydrogen bond monomer; reacts furfurylamine with methyl acrylate to obtain side furanyl dimethyl ester; solid-phase polymerization of side furanyl dimethyl ester, 1,10-decanediamine, and multi-hydrogen bond monomers to obtain modified bio-based nylon; and melt-extrudes and granulates the modified bio-based nylon and the modified shell powder to obtain a bio-based nylon composite material. The bio-based nylon composite material prepared by the present invention has the advantages of high mechanical strength, flame retardancy, self-repairing, and good heat resistance.

The present invention provides a method for preparing a high-purity and high-yield abiraterone acetate intermediate. The preparation method of the present invention comprises the steps of: (1) detecting the water content of raw material iodine: reacting zinc powder with iodine in solvent A, filtering and removing solids, and using Karl Fischer method to determine the water content N1 in the filtrate; performing a blank control experiment without iodine addition at the same time, using Karl Fischer method to determine the water content N2 in the filtrate in the blank control experiment, and calculating the water content of raw material iodine; (2) adding solvent B, iodine, and acetic anhydride to a container, stirring the reaction, adding tetramethylguanidine, adding dehydroepiandrosterone-17-hydrazone I, performing iodination reaction, and obtaining abiraterone acetate intermediate 17-iodo-androsta-5,16-diene-3β-alcohol II; the abiraterone acetate intermediate obtained by the method of the present invention has high yield and high purity.

The invention belongs to the technical field of atmospheric pollutant control, and relates to a polyacid functionalized guanidine salt ionic liquid system for removing hydrogen sulfide and dimethyl sulfide. The harm of hydrogen sulfide and dimethyl sulfide to a human body and the environment is elaborated, and the limitations of secondary pollution, high energy consumption and the like of the existing removal method are indicated. According to the system, 1, 1, 3, 3-tetramethylguanidine salt and amino acid ionic liquid are dissolved in water according to the ratio of 1: 1 to prepare tetramethylguanidine amino acid ionic liquid, and then Keggin type polyacid is dissolved in the tetramethylguanidine amino acid ionic liquid. The method comprises the following steps: respectively carrying out removal experiments on hydrogen sulfide with the concentration of 500-1000mg / m < 3 > and sulfur-containing VOC (Volatile Organic Compounds) with the concentration of 120-13000mg / ml by using the system at the temperature of 25-45 DEG C by taking N2 as carrier gas, and monitoring tail gas by using a specific instrument. Embodiments show that the system has a good removal effect on both hydrogen sulfide and sulfur-containing VOC, and has application potential in related fields.

This invention belongs to the field of cycloazinone preparation technology, and provides a high-yield cycloazinone synthesis process, including the following steps: Step 1: N-ethoxycarbonyl-N,N,N-trimethylguanidine and a solid-phase catalyst are added to toluene and stirred evenly. Under nitrogen protection, the temperature is raised to 40-60°C, and a cyclohexyl isocyanate toluene solution is added dropwise. Stirring is continued for 2-4 hours. The solid-phase catalyst is recovered by filtration, and the mixture is concentrated under reduced pressure to obtain N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine; Step 2: Under nitrogen protection, the temperature is raised to 50-60°C, and the N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine toluene solution is added dropwise to a sodium methoxide toluene solution and stirred for 1-2 hours. The temperature is lowered to room temperature, and glacial acetic acid is added for neutralization. After washing, the mixture is concentrated under reduced pressure, and a crystallizing agent is added. The temperature is lowered to 0-5°C, and the mixture is stirred for crystallization for 2-4 hours. After filtration and washing, the mixture is dried under vacuum to obtain the finished cycloazinone.

The invention discloses a method for determining clothianidin and metabolite residues of clothianidin in soil. The method comprises the following steps: step 1, preparing a clothianidin standard stock solution and a standard stock solution of metabolites (Z)-1-methylene-2-nitroguanidine and (2-chlorothiazol-5-y1) metyl)-3-metyl guanidine, and preparing the clothianidin standard stock solution and the standard stock solution of the metabolites (Z)-1-methylene-2-nitroguanidine and (2-chlorothiazol-5-y1) metyl-3-metyl guanidine; 2, preparing a solvent mixed standard working solution according to the standard stock solution in the step 1; 3, the solvent mixed standard working solution is added into the soil blank extracting solution, and a matrix mixed standard working solution is prepared; and 4, weighing a soil sample to be detected, carrying out pretreatment, and detecting by adopting a liquid chromatography-tandem mass spectrometry method. According to the technical scheme provided by the invention, the residual quantity of the clothianidin and the metabolites (Z)-1-methyl-2-nitroguanine and the residual quantity of the 1-((2-chlorothiazol-5-y1)-3-methylguanine of the clothianidin in the soil can be rapidly, simply, conveniently and accurately measured.

The invention discloses a compound desulfurizer as well as a preparation method and a use method thereof, and relates to the technical field of gas separation. A preparation method of a composite desulfurizer comprises the following steps: taking 1, 1, 3, 3-tetramethylguanidine, 1-methylimidazole or tetraethylammonium hydroxide in a container, carrying out ice-water bath, adding lactic acid into the container while stirring, heating after the lactic acid is added, continuously stirring, and carrying out rotary evaporation to obtain a lactic acid ionic liquid; and uniformly mixing the lactic acid ionic liquid with the H2S removal agent to obtain the composite desulfurizer. The composite desulfurizer can realize simultaneous removal of H2S and SO2 with low energy consumption.

The present invention discloses an antibacterial compound of Formula 1 or pharmaceutically acceptable salt thereof:wherein X is CH, S, CH—NH2;R1 is C1-C8 alkyl, substituted alkyl, alkyl amine, substituted amine; preferably R1 is methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, methyl amine, ethylamine, propylamine, isopropyl amine, isobutylamine, N-ethylprop-2-yn-1-amine, N-isopropyl propane-1,3-diamine, N1-isopropyl ethane-1,3-diamine, 1-butyl-2-methylguanidine, N1-ethyl-N1-propylethane-1,2-diamine, cyclobutyamine, phosphate, sulphate;R2 is hydrogen, alkyl, substituted alkyl; preferably R2 is methyl, propyl, isopropyl;R3 is hydrogen, alkyl, substituted alkyl; and preferably R3 is methyl, propyl, isopropyl.The Formula 1 or pharmaceutically acceptable salt thereof is an imidazole glycerol phosphate dehydratase (IGPD) inhibitor and treats or prevents or ameliorates tuberculosis.

The invention belongs to the technical field of medicine detection and analysis, and particularly relates to a method for determining tetramethylguanidine residues in cefcapene pivoxil hydrochloride through high performance liquid chromatography. The determination method comprises the following steps: dissolving to-be-determined cefcapene pivoxil hydrochloride with a methanol aqueous solution to obtain a test solution; and carrying out high performance liquid chromatography detection on the test solution, and obtaining the residual quantity of tetramethylguanidine in cefcapene pivoxil hydrochloride to be detected according to the obtained peak area and a predetermined standard curve. The method disclosed by the invention can be used for detecting trace tetramethylguanidine residues in the cefcapene pivoxil hydrochloride, is high in sensitivity (the quantitation limit is 0.07 mu g / mL, and the detection limit is 0.05 mu g / mL), good in separation degree, simple, rapid and high in specificity, and can be used for detecting the tetramethylguanidine residues in the cefcapene pivoxil hydrochloride, so that the quality of a cefcapene pivoxil hydrochloride raw material medicine is effectively controlled.

The utility model relates to the technical field of chemical equipment, in particular to a production device of N-methylguanidinoacetic acid. According to the technical scheme, the device comprises a dissolving kettle, a mother liquor kettle, a tubular reactor, a pH adjusting kettle, a concentration kettle, a crystallization kettle and a rotary furnace, a dissolving constant-temperature heat exchanger is arranged on the outer wall of the dissolving kettle, and a dissolving liquid outlet is formed in the bottom of the dissolving kettle and connected with reaction inlets of the mother liquor kettle and the tubular reactor; a mother liquid outlet is formed in the bottom of the mother liquid kettle, a mother liquid constant-temperature heat exchanger is arranged on the outer wall, and a top mother liquid inlet is communicated with a concentrated liquid outlet in the bottom of the concentration kettle; a reaction constant-temperature heat exchanger is sleeved on the outer wall of the tubular reactor, and a reaction outlet is formed to be communicated with a top pH adjusting feeding hole of the pH adjusting kettle. The high-purity N-methylguanidinoacetic acid monohydrate is continuously produced in a continuous feeding and intermittent discharging mode, and the equipment utilization rate and the production efficiency are improved.

The invention relates to the technical field of oilfield exploitation, in particular to a liquid gel breaker for guanidine gum and polymer fracturing fluid as well as a preparation method and application of the liquid gel breaker. The cleaning agent is prepared from, by mass, 10%-12% of ammonium persulfate, 6%-7.5% of sodium hypochlorite, 0.5%-1% of aminoethanol phosphoric acid, 0.5%-1% of hydroxyethylidene diphosphonic acid, 0.4%-0.8% of ethylene diamine tetraacetic acid disodium salt, 10%-12% of benzoyl peroxide, 0.5%-1% of tetramethylguanidine, 0.5%-1% of triethylamine, 3%-4% of isopropanol and the balance deionized water, and the total amount is 100%. The oxidant stabilizer is added into the liquid gel breaker, so that the oxidant is prevented from being decomposed and damaged under the storage condition, and the liquid gel breaker has the characteristics of high flash point and low volatility and is safe to store; the added oxidant activator can be suitable for gel breaking under a low-temperature condition, and the applicable range of the gel breaking temperature reaches 20-180 DEG C; and the fracturing fluid is thorough in gel breaking and does not cause damage to artificial fractures and reservoirs.

The invention relates to a preparation method and application of 2, 2-disubstituted-4-dimethylamino imidazolinone. The invention belongs to the technical field of fine chemical synthesis. The invention aims to solve the problems of tedious steps, narrow substrate application range and high production cost of the existing method for synthesizing imidazolinone. According to the method disclosed by the invention, ketone is taken as a substrate and reacts with tetramethylguanidine and a cyaniding reagent to prepare the 2, 2-disubstituted-4-dimethylamino imidazolinone. According to the method disclosed by the invention, the 2, 2-disubstituted-4-dimethylamino imidazolinone is synthesized in one step under a mild condition, the reaction rate is greatly accelerated by selecting various ketone substrates and synergistically and reasonably controlling the ratio of various substances, the efficient synthesis of the 2, 2-disubstituted-4-dimethylamino imidazolinone is realized, the substrate adaptability is good, and the yield is high. The method has wide application prospects in the fields of chemistry, biology, medicine and the like.

The invention discloses an ionic liquid-based high-voltage fast-charging electrolyte and a preparation method thereof, and the preparation method of the electrolyte comprises the following steps: mixing 1-ethyl-3-methylimidazolium trifluoromethanesulfonate, zinc trifluoromethanesulfonate and a trace amount of deionized water to obtain a mixed solution A; and adding tetramethylguanidine hydrochloride, stirring and reacting at 60-80 DEG C, cooling, and continuously stirring and aging to obtain the electrolyte. Wherein based on each milliliter of the ionic liquid, the addition amount of the deionized water is 60-100 microliters, and the concentration of the addition amount of the tetramethylguanidine hydrochloride in the mixed solution is 30-80 mM. Through the synergistic effect of the ionic liquid matrix and the guanidine salt additive, the zinc ion solvation structure is regulated and controlled, and while a wide electrochemical stable window is achieved, the ionic conductivity is remarkably improved, and the interface impedance and zinc deposition overpotential are reduced. The zinc ion battery assembled by the electrolyte has high energy density and excellent rapid charge-discharge capacity and cycling stability, and the preparation process is simple and suitable for large-scale application.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a preparation method of tetramethylguanidine, which comprises the following steps: step 1, reacting cyanogen chloride with dimethylamine at low temperature in a tubular reactor to generate dimethylamino cyanogen and dimethylamine hydrochloride, step 2, heating intermediates of the dimethylamino cyanogen and the dimethylamine hydrochloride, and reacting to obtain the tetramethylguanidine. The method comprises the following steps: 1, adding a sodium hydroxide aqueous solution into a reaction solution, carrying out heat preservation on the reaction solution after adding a catalyst, and carrying out high-temperature condensation to generate tetramethylguanidine hydrochloride, 3, cooling the product, filtering to obtain tetramethylguanidine hydrochloride, and washing the tetramethylguanidine hydrochloride with a detergent, and 4, carrying out a neutralization reaction on the sodium hydroxide aqueous solution and tetramethylguanidine hydrochloride to obtain the tetramethylguanidine hydrochloride. And extracting the reaction solution by using an organic solvent, and fractionating to obtain free tetramethylguanidine. The catalyst is added in the reaction process, so that the temperature required by the reaction is reduced, the time required by the reaction is shortened, a continuous flow process is realized, and the productivity is remarkably improved.

The invention discloses a method for detecting novel disinfection by-products in aquatic products, and relates to the technical field of disinfection by-product detection. The specific preparation method comprises the following steps: firstly, carrying out pretreatment; mincing and uniformly mixing the aquatic products; adding a solvent, carrying out vortex oscillation, and carrying out centrifugal separation after oscillation to obtain a supernatant, namely a crude sample extract; passing the crude extract of the matrix sample through an extraction column, collecting effluent, drying and dissolving, and filtering to obtain a purified sample solution; and then detecting the target disinfection by-product N-cyano-N ', N'-dimethylguanidine in the matrix sample purification liquid by adopting a high performance liquid chromatography-tandem mass spectrometry method. The detection method provided by the invention can effectively detect N-cyano-N ', N'-dimethylguanidine in aquatic products, has the advantages of low detection limit and quantitation limit, high sensitivity, high recovery rate and high precision, meets the standard requirements, and provides reference for the field of aquatic product safety.

The invention discloses a preparation method of a trialkylphosphine oxide hydrophobic deep-eutectic solvent, which comprises the following steps: by taking trialkylphosphine oxide as a hydrogen bond acceptor and guanidine, tetramethylguanidine, piracetam, catechol, organic acid and an imidazole compound as hydrogen bond donors, mixing the trialkylphosphine oxide with one or more hydrogen bond donors, and stirring to react, thereby obtaining the trialkylphosphine oxide hydrophobic deep-eutectic solvent. The eutectic solvent is prepared by adjusting the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor. The preparation method disclosed by the invention is simple in process, green, environment-friendly and easy to popularize, and the synthesized eutectic solvent is high in purity, can be repeatedly utilized and has an application prospect in the fields of carbon dioxide capture, medicines, pollutant absorption and the like.

The present invention discloses an arylpiperidine compound containing guanidinourea, its preparation and application. The structural formula of this kind of compound is shown as Formula I. In the present invention, a piperidine structure with good liposolubility is used to splice methylguanidinourea with some hydrophobic aromatic hydrocarbons having a planar structure, and a series of small molecule chitinase inhibitors with novel structures and easy to synthesize are successfully designed. The results of insecticidal activity research show that these compounds have high insecticidal activity against Lepidoptera pests such as Asian corn borer, Spodoptera litura, Helicoverpa armigera, Plutella xylostella, etc. The present invention has very important significance in the prevention and control of agricultural pests and the protection of crops.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a method for synthesizing 1, 1, 3, 3-tetramethylguanidine, which comprises the following steps: step 1, adding dimethylamine into a reaction flask, starting stirring, then controlling the temperature at 20-50 DEG C, introducing chlorine gas into the reaction liquid while adding hydrocyanic acid for 1-4 hours, reacting to generate dimethylamino nitrile and dimethylamine hydrochloride, and then adding the dimethylamine hydrochloride into the reaction flask to obtain dimethylamine hydrochloride; the method comprises the following steps: 1, preparing a reaction solution, 2, heating the reaction solution to carry out a condensation reaction so as to generate tetramethylguanidine hydrochloride, and 3, adding liquid caustic soda into the reaction solution to carry out alkalization so as to generate tetramethylguanidine, and sequentially carrying out dimethylamine recovery, solvent extraction, solvent concentration and rectification on the reaction solution so as to finally obtain tetramethylguanidine. The method is simple in technological process, mild in reaction condition, free of high-temperature and high-pressure operation, low in production risk and beneficial to large-scale production.

The present invention relates to a ready-to-use liquid pest control composition comprising: at least one trisiloxane surfactant of formula (I), at least 40 wt% water, and at least one hydrolysis-preventing compound selected from at least one bulky base with steric hindrance, tocopherol, and combinations thereof, wherein the bulky base with steric hindrance is selected from the group consisting of alkali metal bicarbonates, trialkylamines, trialkanolamines, 2-tert-Butyl-1,1,3,3- tetramethylguanidine, lithium diisopropylamine, alkali metal tert-butoxide, and combinations thereof; wherein the composition has a pH of at least 7, measured at 20°C. Formula (I) wherein: R is –(CH2)3-(OCH2CH2)nR1; R1 is -CH3, -OH, or -O(O)CCH3, and n is 2 to 25. The invention also relates to a method of immobilising and / or killing insects and to a pest control product.

The invention belongs to the technical field of organic synthesis, and particularly relates to beta-alkoxy ketone with lasting fragrance retention as well as a preparation method and application of the beta-alkoxy ketone. The invention provides a preparation method of beta-alkoxy ketone with lasting fragrance, which comprises the following steps: mixing alpha, beta-unsaturated ketone and an alcohol compound, and carrying out Michael addition reaction in the presence of an acid catalyst to obtain the beta-alkoxy ketone, the acid catalyst comprises one or more of bis (trifluoromethanesulfonimide), sodium p-toluenesulfinate, tricyclohexylphosphine and tetramethylguanidine. The beta-alkoxy ketone is synthesized by starting from an alcohol raw material which is cheaper and easier to obtain, the method which is simple to operate and mild in condition is provided, and since the leaving ability of alkoxy is smaller than that of sulfydryl, the beta-alkoxy ketone can release alpha, beta-unsaturated ketone more slowly, so that the purpose of lasting fragrance is achieved.

The application discloses a method for continuously synthesizing N-methyl guanidino acetic acid and belongs to the technical field of organic synthesis. A mixed aqueous solution of cyanamide and N-methyl glycine sodium is prepared; an aqueous solution of N-methyl guanidino acetic acid is added into a reaction kettle as a reaction base material, stirring is carried out, and temperature is raised to 65-80 DEG C; the mixed aqueous solution of cyanamide and N-methyl glycine sodium is continuously added dropwise, the pH value of a reaction system is controlled to be greater than 8.0; when the volume of liquid in the reaction kettle reaches the highest liquid level set by the reaction kettle, the reaction liquid overflows into a next-stage cooling kettle; when the reaction liquid in the cooling kettle is cooled to be lower than 25 DEG C, the pH value is adjusted to be 7-8 through acidification; after being left to stand at room temperature for 2-3 h, filtration is carried out; the filter cake is recrystallized with water, dried, and then monohydrate N-methyl guanidino acetic acid is obtained. The application effectively avoids the generation of by-products such as dicyandiamide and dihydrotriazine, reduces production cost, and continuously feeds and discharges materials to replace the intermittent production mode, further reduces production cost, and is beneficial to improving market competitiveness.

The application discloses a nirmatrelvir intermediate and a preparation method and application thereof, and belongs to the technical field of drug synthesis. The nirmatrelvir intermediate and the preparation method thereof are characterized in that 3-methyl-2-butenal is used as a starting material, and a first reactant is obtained through reductive amination reaction of the 3-methyl-2-butenal and benzylamine; acylation reaction of the first reactant and bromoacetyl bromide is performed to obtain a second reactant; under the condition that tetramethylguanidine is used as an alkali, diazotization reaction of the second reactant and N,N'-bis(p-tolylsulfonyl)hydrazine is performed to obtain a diazo compound; and the diazo compound is catalyzed by a metal catalyst to obtain a chiral pure cyclopropane compound, namely the nirmatrelvir intermediate. The method for preparing the nirmatrelvir intermediate has the advantages that a metal catalyst is used for catalysis, the reaction condition is mild, and the ee value of the obtained target product can reach 92.6%.

The invention discloses a methylguanidine dipeptide compound and a synthesis method and application thereof, and belongs to the technical field of chemical synthesis, the chemical structural formula of the compound is as follows: the synthesis method of the methylguanidine dipeptide compound comprises the following steps: heating L-ornithine hydrochloride and 1, 2-dimethyl-2-isothiourea hydriodate in an alkaline solution to react overnight; adjusting the pH value of the solution to be neutral, purifying, adding water for dissolving, adjusting to be acidic, and passing through ion exchange resin to obtain an intermediate 1; adding pure water and isopropanol into the intermediate 1 and adjusting the intermediate 1 to be alkaline; adding isovaleryl chloride into the solution, adjusting the solution to be alkaline, and stirring at room temperature for reaction; keeping the solution to be alkaline, heating to 45-55 DEG C, adjusting to be weakly acidic, cooling to 5-15 DEG C, and collecting precipitate to obtain a crude product; adding the crude product into a methanol-water mixed solution for dissolving, carrying out gradient elution through liquid chromatography, and drying to obtain the compound. The methylguanidine dipeptide compound synthesized by the method is high in purity, simple in synthesis process and convenient to operate.

The present invention relates to the technical field of insecticides, and specifically discloses a synthesis process of clothianidin. The specific process includes the following steps: Synthesis: Add water into a reaction kettle, then put nitroguanidine and monomethylamine solution, and slowly raise the temperature of the reaction kettle to 40-43 °C and keep it warm for 1.5-2 h. After the heat preservation is completed, when the reaction solution is sampled and analyzed without nitroguanidine, continue the heat preservation reaction for 0.5 h, and then make the clothianidin filter cake through neutralization, filtration, recrystallization, centrifugation, drying, substitution, filtration, desolvation, crystallization, centrifugation and drying and packaging of the materials. The present invention obtains methylguanidine by the processes of synthesis, neutralization, filtration, recrystallization, centrifugation and drying of water, synthesis mother liquor, nitroguanidine and monomethylamine solution, and then uses carbon tetrachloride, methylguanidine, potassium carbonate, tetrabutylammonium bromide and dichloromethylthiophene as solvents for substitution reaction. After the reaction, clothianidin is prepared through filtration, desolvation, crystallization, centrifugation and drying processes, thus opening up a new synthesis method.

The present invention relates to a phenanthroline substituted methylguanidine compound and its preparation and application. The phenanthroline substituted methylguanidine compound has a structure as shown in formula (I):, wherein R is selected from any one of the following groups:,,,. Compared with the prior art, the compound provided by the present invention has a significant PKM2 inhibitory effect, has good anti-proliferation activity on A549 and HCC1833 cells, and can significantly inhibit tumor growth in a human NSCLC model. In addition, the phenanthroline substituted methylguanidine compound is a promising new PKM2 inhibitor, which can be used to prevent and / or treat diseases related to PKM2.

The present invention relates to a ready-to-use liquid pest control composition comprising: at least one trisiloxane surfactant of formula (I), at least 40 wt% water, and at least one hydrolysis-preventing compound selected from at least one bulky base with steric hindrance, tocopherol, and combinations thereof, wherein the bulky base with steric hindrance is selected from the group consisting of alkali metal bicarbonates, trialkylamines, trialkanolamines, 2-tert-Butyl-1,1,3,3- tetramethylguanidine, lithium diisopropylamine, alkali metal tert-butoxide, and combinations thereof; wherein the composition has a pH of at least 7, measured at 20°C. Formula (I) wherein: R is –(CH2)3-(OCH2CH2)nR1; R1 is -CH3, -OH, or -O(O)CCH3, and n is 2 to 25. The invention also relates to a method of immobilising and / or killing insects and to a pest control product.

The invention discloses an embryo quality marker screening method based on metabonomics, an electrochemical sensor for simultaneously detecting three markers and application, and belongs to the technical field of detection. According to the method, three metabolites, namely 1-methylguanidine acid, L-valine and oleic acid, which are closely related to embryo quality are screened through metabonomics analysis of a conditioned medium for culturing human embryos in vitro in the third celestial body in combination with various statistical methods, and reduced graphene oxide is modified on the surfaces of working electrodes 1, 2 and 3 to serve as a modification material; the reduced graphene oxide has good conductivity, can amplify an electrochemical signal of the electrode, and enhances the recognition of the sensor on three embryo quality markers at the same time. An L-valine molecularly imprinted polymer is synthesized on the surface of a working electrode 1 through electropolymerization, a 1-methylguanidine acid molecularly imprinted polymer is synthesized on the surface of a working electrode 2, an oleic acid molecularly imprinted polymer is synthesized on the surface of a working electrode 3, and the molecularly imprinted polymer has the advantages of high sensitivity and strong specificity. The adsorbability of the sensor to an embryo quality marker is greatly improved, and the specificity of the sensor is improved. According to the invention, quantitative detection of single components of the three embryo quality markers can be realized, simultaneous detection of the three embryo quality markers can also be realized, and a new thought is provided for clinical prediction of embryonic development potential.

The application discloses a preparation method of monohydrate N-methyl guanidino acetic acid and belongs to the technical field of organic synthesis. A sodium N-methyl glycine aqueous solution is heated to 65-80 DEG C, adjusted to a pH value of >8.0, and then an amino cyanide aqueous solution is added dropwise, and the dropwise addition is completed in 1-2 hours. After the dropwise addition is completed, the reaction is preserved for 0-0.5 h. The reaction solution is cooled to <10 DEG C, acid is added to adjust the pH value of the system to 7-8, and then aging, filtration, filter cake purification and drying are carried out to obtain the monohydrate N-methyl guanidino acetic acid. It is found that by controlling the reaction conditions and the reaction time, the generation of dicyandiamide can be avoided, the product is easier to purify, and the unreacted materials can be recycled after simple treatment under the influence of no impurities, so that the purification difficulty of the raw material recycling is reduced, and the raw material utilization is improved.