13 results about "Methylguanidine" patented technology

The invention discloses a method for preparing substituted imidazole by taking acyl chloride as a raw material, belongs to the technical field of synthesis of fine chemicals, and aims to solve the problems that the raw material structure is complicated, the source is limited, the raw material needs to be prepared in advance and the cost is low in the existing method for synthesizing substituted imidazole. The reaction conditions are harsh, the reaction time is long, and a transition metal catalyst needs to be used. The method comprises the following steps: synthesizing 2-substituted-4-dimethylamino-5-cyano imidazole from acyl chloride, tetramethylguanidine and a cyaniding reagent at a certain temperature and under an alkaline condition; according to the method disclosed by the invention, the 2-substituted-4-dimethylamino-5-cyano imidazole is synthesized in one step by taking the acyl chloride as the substrate, the reaction rate is greatly accelerated by selecting various acyl chlorides and alkali and synergistically and reasonably controlling the ratio of various substances, efficient synthesis of the 2-substituted-4-dimethylamino-5-cyano imidazole is realized, and the substrate is good in adaptability and high in yield. The method has wide application prospects in the fields of chemistry, biology, medicine and the like.

This invention belongs to the field of cycloazinone preparation technology, and provides a high-yield cycloazinone synthesis process, including the following steps: Step 1: N-ethoxycarbonyl-N,N,N-trimethylguanidine and a solid-phase catalyst are added to toluene and stirred evenly. Under nitrogen protection, the temperature is raised to 40-60°C, and a cyclohexyl isocyanate toluene solution is added dropwise. Stirring is continued for 2-4 hours. The solid-phase catalyst is recovered by filtration, and the mixture is concentrated under reduced pressure to obtain N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine; Step 2: Under nitrogen protection, the temperature is raised to 50-60°C, and the N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine toluene solution is added dropwise to a sodium methoxide toluene solution and stirred for 1-2 hours. The temperature is lowered to room temperature, and glacial acetic acid is added for neutralization. After washing, the mixture is concentrated under reduced pressure, and a crystallizing agent is added. The temperature is lowered to 0-5°C, and the mixture is stirred for crystallization for 2-4 hours. After filtration and washing, the mixture is dried under vacuum to obtain the finished cycloazinone.

The invention discloses a compound desulfurizer as well as a preparation method and a use method thereof, and relates to the technical field of gas separation. A preparation method of a composite desulfurizer comprises the following steps: taking 1, 1, 3, 3-tetramethylguanidine, 1-methylimidazole or tetraethylammonium hydroxide in a container, carrying out ice-water bath, adding lactic acid into the container while stirring, heating after the lactic acid is added, continuously stirring, and carrying out rotary evaporation to obtain a lactic acid ionic liquid; and uniformly mixing the lactic acid ionic liquid with the H2S removal agent to obtain the composite desulfurizer. The composite desulfurizer can realize simultaneous removal of H2S and SO2 with low energy consumption.

The present invention discloses an antibacterial compound of Formula 1 or pharmaceutically acceptable salt thereof:wherein X is CH, S, CH—NH2;R1 is C1-C8 alkyl, substituted alkyl, alkyl amine, substituted amine; preferably R1 is methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, methyl amine, ethylamine, propylamine, isopropyl amine, isobutylamine, N-ethylprop-2-yn-1-amine, N-isopropyl propane-1,3-diamine, N1-isopropyl ethane-1,3-diamine, 1-butyl-2-methylguanidine, N1-ethyl-N1-propylethane-1,2-diamine, cyclobutyamine, phosphate, sulphate;R2 is hydrogen, alkyl, substituted alkyl; preferably R2 is methyl, propyl, isopropyl;R3 is hydrogen, alkyl, substituted alkyl; and preferably R3 is methyl, propyl, isopropyl.The Formula 1 or pharmaceutically acceptable salt thereof is an imidazole glycerol phosphate dehydratase (IGPD) inhibitor and treats or prevents or ameliorates tuberculosis.

The invention belongs to the technical field of medicine detection and analysis, and particularly relates to a method for determining tetramethylguanidine residues in cefcapene pivoxil hydrochloride through high performance liquid chromatography. The determination method comprises the following steps: dissolving to-be-determined cefcapene pivoxil hydrochloride with a methanol aqueous solution to obtain a test solution; and carrying out high performance liquid chromatography detection on the test solution, and obtaining the residual quantity of tetramethylguanidine in cefcapene pivoxil hydrochloride to be detected according to the obtained peak area and a predetermined standard curve. The method disclosed by the invention can be used for detecting trace tetramethylguanidine residues in the cefcapene pivoxil hydrochloride, is high in sensitivity (the quantitation limit is 0.07 mu g / mL, and the detection limit is 0.05 mu g / mL), good in separation degree, simple, rapid and high in specificity, and can be used for detecting the tetramethylguanidine residues in the cefcapene pivoxil hydrochloride, so that the quality of a cefcapene pivoxil hydrochloride raw material medicine is effectively controlled.

The invention relates to the technical field of oilfield exploitation, in particular to a liquid gel breaker for guanidine gum and polymer fracturing fluid as well as a preparation method and application of the liquid gel breaker. The cleaning agent is prepared from, by mass, 10%-12% of ammonium persulfate, 6%-7.5% of sodium hypochlorite, 0.5%-1% of aminoethanol phosphoric acid, 0.5%-1% of hydroxyethylidene diphosphonic acid, 0.4%-0.8% of ethylene diamine tetraacetic acid disodium salt, 10%-12% of benzoyl peroxide, 0.5%-1% of tetramethylguanidine, 0.5%-1% of triethylamine, 3%-4% of isopropanol and the balance deionized water, and the total amount is 100%. The oxidant stabilizer is added into the liquid gel breaker, so that the oxidant is prevented from being decomposed and damaged under the storage condition, and the liquid gel breaker has the characteristics of high flash point and low volatility and is safe to store; the added oxidant activator can be suitable for gel breaking under a low-temperature condition, and the applicable range of the gel breaking temperature reaches 20-180 DEG C; and the fracturing fluid is thorough in gel breaking and does not cause damage to artificial fractures and reservoirs.

The invention discloses an ionic liquid-based high-voltage fast-charging electrolyte and a preparation method thereof, and the preparation method of the electrolyte comprises the following steps: mixing 1-ethyl-3-methylimidazolium trifluoromethanesulfonate, zinc trifluoromethanesulfonate and a trace amount of deionized water to obtain a mixed solution A; and adding tetramethylguanidine hydrochloride, stirring and reacting at 60-80 DEG C, cooling, and continuously stirring and aging to obtain the electrolyte. Wherein based on each milliliter of the ionic liquid, the addition amount of the deionized water is 60-100 microliters, and the concentration of the addition amount of the tetramethylguanidine hydrochloride in the mixed solution is 30-80 mM. Through the synergistic effect of the ionic liquid matrix and the guanidine salt additive, the zinc ion solvation structure is regulated and controlled, and while a wide electrochemical stable window is achieved, the ionic conductivity is remarkably improved, and the interface impedance and zinc deposition overpotential are reduced. The zinc ion battery assembled by the electrolyte has high energy density and excellent rapid charge-discharge capacity and cycling stability, and the preparation process is simple and suitable for large-scale application.

The application discloses a method for continuously synthesizing N-methyl guanidino acetic acid and belongs to the technical field of organic synthesis. A mixed aqueous solution of cyanamide and N-methyl glycine sodium is prepared; an aqueous solution of N-methyl guanidino acetic acid is added into a reaction kettle as a reaction base material, stirring is carried out, and temperature is raised to 65-80 DEG C; the mixed aqueous solution of cyanamide and N-methyl glycine sodium is continuously added dropwise, the pH value of a reaction system is controlled to be greater than 8.0; when the volume of liquid in the reaction kettle reaches the highest liquid level set by the reaction kettle, the reaction liquid overflows into a next-stage cooling kettle; when the reaction liquid in the cooling kettle is cooled to be lower than 25 DEG C, the pH value is adjusted to be 7-8 through acidification; after being left to stand at room temperature for 2-3 h, filtration is carried out; the filter cake is recrystallized with water, dried, and then monohydrate N-methyl guanidino acetic acid is obtained. The application effectively avoids the generation of by-products such as dicyandiamide and dihydrotriazine, reduces production cost, and continuously feeds and discharges materials to replace the intermittent production mode, further reduces production cost, and is beneficial to improving market competitiveness.

The application discloses a nirmatrelvir intermediate and a preparation method and application thereof, and belongs to the technical field of drug synthesis. The nirmatrelvir intermediate and the preparation method thereof are characterized in that 3-methyl-2-butenal is used as a starting material, and a first reactant is obtained through reductive amination reaction of the 3-methyl-2-butenal and benzylamine; acylation reaction of the first reactant and bromoacetyl bromide is performed to obtain a second reactant; under the condition that tetramethylguanidine is used as an alkali, diazotization reaction of the second reactant and N,N'-bis(p-tolylsulfonyl)hydrazine is performed to obtain a diazo compound; and the diazo compound is catalyzed by a metal catalyst to obtain a chiral pure cyclopropane compound, namely the nirmatrelvir intermediate. The method for preparing the nirmatrelvir intermediate has the advantages that a metal catalyst is used for catalysis, the reaction condition is mild, and the ee value of the obtained target product can reach 92.6%.

The invention discloses a methylguanidine dipeptide compound and a synthesis method and application thereof, and belongs to the technical field of chemical synthesis, the chemical structural formula of the compound is as follows: the synthesis method of the methylguanidine dipeptide compound comprises the following steps: heating L-ornithine hydrochloride and 1, 2-dimethyl-2-isothiourea hydriodate in an alkaline solution to react overnight; adjusting the pH value of the solution to be neutral, purifying, adding water for dissolving, adjusting to be acidic, and passing through ion exchange resin to obtain an intermediate 1; adding pure water and isopropanol into the intermediate 1 and adjusting the intermediate 1 to be alkaline; adding isovaleryl chloride into the solution, adjusting the solution to be alkaline, and stirring at room temperature for reaction; keeping the solution to be alkaline, heating to 45-55 DEG C, adjusting to be weakly acidic, cooling to 5-15 DEG C, and collecting precipitate to obtain a crude product; adding the crude product into a methanol-water mixed solution for dissolving, carrying out gradient elution through liquid chromatography, and drying to obtain the compound. The methylguanidine dipeptide compound synthesized by the method is high in purity, simple in synthesis process and convenient to operate.

The present invention relates to a ready-to-use liquid pest control composition comprising: at least one trisiloxane surfactant of formula (I), at least 40 wt% water, and at least one hydrolysis-preventing compound selected from at least one bulky base with steric hindrance, tocopherol, and combinations thereof, wherein the bulky base with steric hindrance is selected from the group consisting of alkali metal bicarbonates, trialkylamines, trialkanolamines, 2-tert-Butyl-1,1,3,3- tetramethylguanidine, lithium diisopropylamine, alkali metal tert-butoxide, and combinations thereof; wherein the composition has a pH of at least 7, measured at 20°C. Formula (I) wherein: R is –(CH2)3-(OCH2CH2)nR1; R1 is -CH3, -OH, or -O(O)CCH3, and n is 2 to 25. The invention also relates to a method of immobilising and / or killing insects and to a pest control product.

The invention discloses an embryo quality marker screening method based on metabonomics, an electrochemical sensor for simultaneously detecting three markers and application, and belongs to the technical field of detection. According to the method, three metabolites, namely 1-methylguanidine acid, L-valine and oleic acid, which are closely related to embryo quality are screened through metabonomics analysis of a conditioned medium for culturing human embryos in vitro in the third celestial body in combination with various statistical methods, and reduced graphene oxide is modified on the surfaces of working electrodes 1, 2 and 3 to serve as a modification material; the reduced graphene oxide has good conductivity, can amplify an electrochemical signal of the electrode, and enhances the recognition of the sensor on three embryo quality markers at the same time. An L-valine molecularly imprinted polymer is synthesized on the surface of a working electrode 1 through electropolymerization, a 1-methylguanidine acid molecularly imprinted polymer is synthesized on the surface of a working electrode 2, an oleic acid molecularly imprinted polymer is synthesized on the surface of a working electrode 3, and the molecularly imprinted polymer has the advantages of high sensitivity and strong specificity. The adsorbability of the sensor to an embryo quality marker is greatly improved, and the specificity of the sensor is improved. According to the invention, quantitative detection of single components of the three embryo quality markers can be realized, simultaneous detection of the three embryo quality markers can also be realized, and a new thought is provided for clinical prediction of embryonic development potential.

The application discloses a preparation method of monohydrate N-methyl guanidino acetic acid and belongs to the technical field of organic synthesis. A sodium N-methyl glycine aqueous solution is heated to 65-80 DEG C, adjusted to a pH value of >8.0, and then an amino cyanide aqueous solution is added dropwise, and the dropwise addition is completed in 1-2 hours. After the dropwise addition is completed, the reaction is preserved for 0-0.5 h. The reaction solution is cooled to <10 DEG C, acid is added to adjust the pH value of the system to 7-8, and then aging, filtration, filter cake purification and drying are carried out to obtain the monohydrate N-methyl guanidino acetic acid. It is found that by controlling the reaction conditions and the reaction time, the generation of dicyandiamide can be avoided, the product is easier to purify, and the unreacted materials can be recycled after simple treatment under the influence of no impurities, so that the purification difficulty of the raw material recycling is reduced, and the raw material utilization is improved.