Pancreatic cancer diagnostic marker combination as well as application and determination method thereof

A diagnostic marker and pancreatic cancer technology, applied in the biological field, can solve the problems of low sensitivity and low detection accuracy in early disease, achieve high sensitivity and specificity, improve clinical treatment effect, and improve clinical treatment effect

Active Publication Date: 2016-05-11
麦特绘谱生物科技(上海)有限公司
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  • Abstract
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  • Claims
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  • Pancreatic cancer diagnostic marker combination as well as application and determination method thereof
  • Pancreatic cancer diagnostic marker combination as well as application and determination method thereof
  • Pancreatic cancer diagnostic marker combination as well as application and determination method thereof

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Embodiment Construction

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0036] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0037] Embodiments of the present invention will be specifically explained below in conjunction with the accompanying drawings.

[0038] Embodiments of the present invention apply chromatography-mass spectrometry technology to detect metabolites in serum or plasma samples to find diagnostic ...

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Abstract

The invention discloses a pancreatic cancer diagnostic marker combination as well as application and a determination method thereof. The pancreatic cancer diagnostic marker combination comprises 15 differentiated metabolites (2,5-dihydroxybenzoic acid, talopyranose, proline, glutamate, choline, 1,5-anhydro-D-glucitol, tryptophan, glutamine, betaine, 2-oxoglutaric acid, methylguanidine, adenine, glycocholic acid, valine and 2-aminobutyric acid). The invention further provides a combination of the 15 differentiated metabolites to serve as a marker for early discovery and diagnosis of pancreatic cancer, application and a diagnostic marker determination method, and the method is a liquid-phase/gas-phase chromatography-mass spectrometry combined metabonomics analysis method based on plasma/serum of patients with pancreatic cancer. The pancreatic cancer diagnostic marker combination provided by the technical scheme of the invention has the characteristics of being high in sensitiveness and specificity, has relatively high sensitiveness and specificity on early pancreatic cancer diagnosis, can be used for early discovery of pancreatic cancer, gains time for the patients to receive treatment as soon as possible, and improves the clinical treatment effect.

Description

technical field [0001] The invention relates to the field of biotechnology, and relates to a pancreatic cancer diagnostic marker combination, application and determination method thereof. Background technique [0002] Pancreatic cancer is a malignant tumor of the digestive tract with a high incidence and a high degree of malignancy. Its morbidity and mortality have increased significantly in recent years. It is one of the malignant tumors with the worst prognosis, and its five-year survival rate is less than 5%. A major obstacle to improving this situation is the lack of biomarkers for early-stage diagnosis of pancreatic cancer disease. [0003] So far, the fundamental treatment of pancreatic cancer is still based on surgical resection, but data show that only 20-25% of patients in the early stage undergo appropriate surgical resection. Due to the occult nature of pancreatic cancer, the early diagnosis rate of pancreatic cancer is not high. Once diagnosed, most patients' tu...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06
Inventor 贾伟谢国祥刘佳健赵爱华
Owner 麦特绘谱生物科技(上海)有限公司
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