175results about How to "Improve clinical treatment effect" patented technology

The invention discloses a diagnosis marker combination suitable for early screening and diagnosis of lung cancer. The diagnosis marker combination comprises one of 14 serum (or plasma) metabolites ormore: Acylcarnitine C8, decenoyl-carnitine (Acylcarnitine C10: 1), decanoyl-carnitine (Acylcarnitine C10), lauryl-carnitine (Acylcarnitine C12), dimyristoyl-carnitine (Acylcarnitine C14: 2); lysophosphatidyl-ethanolamine (16: 0) (LPE(16: 0)), lysophosphatidyl-ethanolamine (20: 4) (LPE (20: 4)), lysophosphatidyl-ethanolamine (20: 3) (LPE (20:3)), lysophosphatidyl-choline (20: 3/0: 0) (LPC (20: 3/0:0)), lysophosphatidyl-choline (0: 0/22: 5) (LPC (0: 0/22: 5)); 3-hydroxyl lauroleic acid (FA(12: 1(OH))), 3-hydroxy myristic dienoic acid (FA(14: 2(OH))), 3-hydroxyl linoleic acid (FA (18: (OH))), 3-hydroxy oleic acid (FA (18: 1(OH))). The diagnosis marker can be used for constructing a diagnosis model, and the model is high in sensitivity and good in specificity, can be used for early screeningand diagnosis of lung cancer, and has good clinical use and popularization values.

The present invention relates to a protein A immunoadsorption material for purifying blood and its preparation method. Said protein A immunoadsorption material is a high-molecular material which is obtained by using agarose gel as carrier matrix, making said agarose gel be reacted with diglycidyl ether coupling reagent to obtain active carrier, then making said active carrier and protein A implement coupling reaction. Said invention can be used for making clinical immunoadsorption therapy.

The invention relates to a staphylococcal protein A (SPA) immunoadsorption material used for blood purification and a preparation method thereof. The invention discloses a macromolecule material which is coupled by agarose gel and SPA. The material is prepared by taking the agarose gel as carrier substrate which is reacted with epoxy bromopropane to obtain the epoxy-based active carrier; after that, polyamines reagent is taken as a space arm which is then reacted with carbonyl diimidazole and is then coupled with the SPA. The material has the advantages of short synthesis time, safe preparation, strong specificity of product, high adsorption efficiency and good regeneration performance to immunoglobulin and the compound thereof, and being able to be applied to clinic immunoadsorption cure.

The invention relates to a compound liquorice tablet and a preparation process thereof. The compound liquorice tablet comprises the following raw materials: liquorice root extracts, opium powder, camphor, star anise oil, sodium benzoate, an adsorbent and a corrective. The preparation process comprises the following steps: adding the adsorbent in the raw material composition, and hiding special foul smell of the camphor and the star anise oil by adopting an adsorption method to eliminate the foul smell; adding the corrective in the raw material composition to enable the compound liquorice tablet to have satisfactory mouthfeel. Therefore, the compound liquorice tablet prepared by the invention is suitable for being taken orally, excellent in mouthfeel, good in clinical effects, and high in bioavailability. Meanwhile, through the improvement on the process, especially, a manner of performing direct tabletting on powder is adopted, so that the compound liquorice tablet is remarkably improved in process level, stable in quality and stable in effect; the production cost of the product is further reduced, and the tablet can serve patients better.

The invention discloses a pancreatic ductal adenocarcinoma marker and a screening method thereof, which belongs to the field of clinical test and diagnosis. In view of the problem that the detection sensitivity and the detection specificity of the existing pancreatic ductal adenocarcinoma diagnosis marker are poor, serum of an early patient of early stage pancreatic duct adenocarcinoma is subjected to a trace metabolomics analysis by the high-performance liquid chromatography-tandem mass spectrometry technology, and different metabolites between normal human and the early stage pancreatic ductal adenocarcinoma patients are found. The different metabolites between normal human and pancreatic ductal adenocarcinoma patients are further analyzed by this technique to find the specific differentmetabolites C10:1 acyl carnitine and lysophosphatidyl choline LysoPC (14:0) of pancreatic ductal adenocarcinoma patients caused by cancer, i.e., the diagnostic molecules of the pancreatic ductal adenocarcinoma. According to the pancreatic ductal adenocarcinoma marker and the screening method thereof, the method can assist CA19-9 in diagnosing pancreatic duct adenocarcinoma patients, and can improve the diagnosis rate for the CA19-9 negative patients by 85%. The method is suitable for the screening of tumor markers.

The shape memory alloy microwound intervertebral fusion device for fixing vertebral column of human body in the course of surgical operation. Said fusion device is a hollow cylinder, between upper portion and lower portion of external side of said hollow cylinder a ring of vertical ribs is set, on the vertical rib the ring barbed teeth rings are set from top to bottom, the vertical rib and the ring barbed teeth ring are crossed to form small hle, and two vertical ribs and parallelly arranged and formed into motion combination surface, the upper end of said fusion device is equipped with ring arranged teeth, and the lower end of said fusion device is equipped with sealing cap on which the cap fastener is set, and the external side of lower bottom edge of said fusion device is equipped with fastener seam, and said cap fastener is fastened on the fastener seam.

The invention belongs to the biotechnical field and relates to a plasma miRNA marker for diagnosis of lung cancer and application. The invention provides the plasma miRNA marker for diagnosis of lung cancer. The marker comprises miRNA-486, miRNA-150, miRNA-205 and miRNA-210. The invention further provides primer probes shown in sequences SEQ ID NO. 1, SEQ ID NO.2, SEQ ID NO.3 and SEQ ID NO.4 as well as application of the primer probes in preparation of kits for diagnosis of lung cancer. The marker provided by the invention has the beneficial effects that a biomarker which has a relatively high diagnostic value on lung cancer is found, and the biomarker has a relatively high diagnostic value (AUC is 0.975, and the sensitivity and specificity are respectively 90.9% and 100%).

The invention discloses an upper jaw Le Fort I type osteotomy operation guide plate and a design method thereof; the operation guide plate is used for fixing 4 titanium plates on the front wall of the upper jaw so as to rectify cranio-jaw-facial deformity; the guide plate comprises a guide plate body and guide holes; the guide plate body comprises a left structure and a right structure mutually separated; the left and right structures are respectively used for operation of the left upper jaw and right upper jaw; the outer surface of each structure is provided with an osteotomy line and a plurality of guide holes; the osteotomy line is provided with a plurality of osteotomy line mark holes penetrating the structure; a positioning hole is arranged on each guide hole and the structure; one ends, close to the nose cavity, of the two structures are respectively provided with a piriform aperture edge limit composition; a spina nasalis anterior limit composition is arranged below the piriform aperture edge limit composition; the inner surface of the structure is provided with a water guide slot. The invention also provides a method designing the upper jaw Le Fort I type osteotomy operation guide plate.

The invention discloses a gene group evaluating breast cancer molecule typing and a detection kit thereof. The gene group evaluating breast cancer molecule typing is a gene group composed of 216 genes. The invention also discloses the detection kit for the gene group evaluating breast cancer molecule typing. The detection kit comprises a primer capable of detecting the genes in the gene group for evaluating breast cancer molecule typing and cancer recurrence risk. An Illumina second-generation sequencing technology DASL-Seq is employed for detecting expression spectrum of cancer tissue, and on the above basis, breast cancer cases of Chinese women are divided into five molecule typing: 1) luminal type A, 2) luminal type B, 3) HER2 enrichment type, 4) basal cell type and 5) normal-cell like type, and propagation and immunization index are combined for calculating recurrence risk and pridicting recurrence possibility in 10 years, and thus individual treatment on breast cancer is guided.

The invention belongs to the field of biological separation engineering and relates to a protein A immune adsorption material used for purifying blood and a preparation method thereof. The invention discloses a biopolymer separating material coupled with agarose gel microspheres and recombinant protein A. An immune adsorption material with high protein A absorption performance is prepared according to the following steps: taking agarose gel as a carrier, activating with allyl glycidyl ether, coupling with sulfydryl on recombinant protein A amino terminal (C terminal) cysteine, and finally, blocking the terminal, thereby fixing the C terminal of the protein A on the agarose gel microspheres at a fixed point. The material has the advantages that the recombinant protein A on the agarose gel microspheres is uniform in structure and fixed in sequence, so that the adsorption capacity of the adsorption material for an antibody is promoted, and the adsorption material can be used for clinical immune adsorption treatment.

The invention discloses enrofloxacin sustained-release tablets for pets and a preparation process for the same. The enrofloxacin sustained-release tablets disclosed by the invention are stable in medicine release and safe in medication, as well as is composed of enrofloxacin, a sustained-release or controlled-release material, a filler, an adhesive, a lubricant and a flavouring agent. The enrofloxacin sustained-release tablets prepared by the preparation process disclosed by the invention have the characteristics of being convenient to administrate, lasting in action and stable in curative effect.

The invention discloses a cyclovirobuxinum D crystal with a molecular formula of C27H50N2O2 belonging to monoclinic crystal system and space group P2(1). The process for preparing crystalline consists of dissolving the market available cyclovirobuxinum D into organic solvent, carrying out solution growth by the mode of recrystallization, wherein the solvent include at least 80 wt% of methanol. The invention also discloses two typeso of cyclovirobuxinum D crystal.

The invention discloses a compound florfenicol preparation for treating swine respiratory tract infection diseases and a preparation method thereof. The compound florfenicol preparation comprises florfenicol, flunixin meglumine, a composite organic solvent and an antioxidant agent, and the florfenicol and the flunixin meglumine are used as main drugs. The compound florfenicol preparation has anti-infection, anti-inflammation, antipyresis and analgesia effects, is dosed through subcutaneous injection and has remarkable effects for preventing and treating the swine respiratory tract diseases. The compound florfenicol preparation is exquisite in preparing process, controllable in quality, safe, reliable, convenient to use, low in cost, and suitable for being popularized and applied to cultivation industry.

The invention provides a bionic immune adsorbent using PAMAM (polyamidoamine) as a spacer arm. The bionic immune adsorbent has the following chemical structure of Gel-PAMAM-AA as shown in the specification, wherein Gel represents a hydroxy-containing hydrophilic carrier; AA represents amino acid; n is 0, 1, 2 or 3; and PAMAM is polyamidoamine dendrimer, the hydrophilic carrier is agarose, cellulose or polyvinyl alcohol, and the amino acid is L-histidine, phenylalanine or tryptophan. The invention also provides a preparation method of the bionic immune adsorbent. By using the dendric macromolecular PAMAM as a spacer arm, the outer surface of the carrier has more active sites for coupling more ligands; by adjusting the position and direction of a triazole ring, the triazole ring is farther from the dendric PAMAM, so that adsorption of target substances is facilitated, and the adsorbent has specific adsorption; and the cost is low, the process is simple, and the reaction condition is mild.

The invention discloses a berberine hydrochloride and malic acid eutectic compound as well as a preparation method, a composition and application thereof. Specifically, the invention discloses a novelberberine hydrochloride and malic acid eutectic substance which takes berberine hydrochloride as a medicinal active component and malic acid as a eutectic precursor, a preparation method of the berberine hydrochloride and malic acid eutectic substance, and application of the berberine hydrochloride and malic acid eutectic substance as a medicinal active ingredient in preparation of medicines forpreventing and treating cardiovascular diseases, resisting viruses and cancers, reducing blood fat, reducing blood sugar, resisting inflammation, resisting bacteria and resisting infection.

The invention relates to a sarafloxacin hydrochloride sustain-released injection and a preparation method thereof, belongs to a medicinal preparation field. The sarafloxacin hydrochloride sustain-released injection is composed of sarafloxacin hydrochloride, an emulsifier, a suspending agent, a stabilizing agent, an antioxidant, plant oil for injection, and injection water. The preparation method comprises the following steps of: heating sieved sarafloxacin hydrochloride raw material drug, the plant oil for injection, the emulsifier and the antioxidant in a constant temperature magnetic stirrer, to obtain a mixture A; heating the suspending agent, a water-soluble emulsifier, the stabilizing agent and the injection water in the constant temperature magnetic stirrer, to obtain a mixture B; continuously adding the mixture A into the mixture B, mixing and shearing to obtain colostrums; complementing margin of the colostrum with injection water, then homogenizing, loading, and disinfecting with cobalt 60 ray, to obtain the product. The sarafloxacin hydrochloride injection with obvious sustain-released effect on intramuscular injection of livestock and poultry, can reduce stress reaction, mitigates culture labor intensity, and raises economic benefits and social benefits for livestock and poultry culture.

The invention relates to a sophocarpidine pH/ magnetic dual-sensitive hydrogel globule which is orally administrated and is used for treating digestive cancers and the preparation method of the sophocarpidine pH/ magnetic dual-sensitive hydrogel globule. The preparation method comprises the steps of: adding 0.3 to 0.7 g of CaCl to chitosan acetum; agitating to dissolve CaCl; preparing a 1.5 to 2.5% sodium alginate solution based on the mass to the volume concentration; weighing a proper amount of sophocarpidine and a proper amount of Fe3O4 nanoparticle respectively, and adding to the sodium alginate solution to obtain a suspension containing the sophocarpidine, the Fe3O4 nanoparticle and the sodium alginate; and weighing the suspension containing the sophocarpidine, the Fe3O4 nanoparticle and the sodium alginate, and dropping to the mixed solution of the chitosan and CaCl2 for crosslinking, and then filtering, washing, and then placing and naturally drying at room temperature so as to obtain the sophocarpidine pH/ magnetic dual sensitive hydrogel globule.

The invention discloses a preparation method for a rhizoma bletillae polysaccharide gastric-floating tablet and an application of the rhizoma bletillae polysaccharide gastric-floating tablet and belongs to the technical field of new uses of drugs. The invention relates to a new formulation of rhizoma bletillae polysaccharide, and the new formulation of the rhizoma bletillae polysaccharide is used for treating a gastric ulcer. The gastric-floating tablet is prepared through matching the rhizoma bletillae polysaccharide, xanthan gum and glyceryl behenate by the preparation method disclosed by the invention. The rhizoma bletillae polysaccharide gastric-floating tablet has the characteristics that the preparation method is simple, and a treatment effect on a peptic ulcer is good.

The invention provides application of fangji root extract and fangchinoline in pharmacy. Fangji root extract and fangchinoline are used as components of an acetylcholinesterase inhibitor, and the acetylcholinesterase inhibitor is used for preparing a medicine for preventing and treating Alzheimer disease. The invention provides the application of fangji root extract and fangchinoline in pharmacy,provides a new drug candidate source for preventing and treating Alzheimer disease, and has important significance in the aspects of improving the clinical treatment effect of the Alzheimer disease and reducing the toxic and side effects of drugs.

The invention belongs to the technical field of biology and relates to a miRNA landmark for lung cancer tissue typing and an application thereof. The miRNA landmark for lung cancer tissue typing provided by the invention comprises a miRNA-205, a miRNA-21 and a miRNA-26b. The invention also discloses primer probes with the sequences shown in SEQ ID NO.1, SEQ ID NO.2 and SEQ ID NO.3, and an application thereof in preparation of a lung cancer tissue typing kit. The miRNA landmark has the beneficial effects that a biomarker with very high diagnostic value (AUC is 1.000, sensitivity is 100% and specificity is 100%) for the lung cancer tissue typing is discovered for the first time and a kit capable of detecting the content of the biomarker in the tissue is provided.