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Sophocarpidine pH/ magnetic dual-sensitive hydrogel globule and preparation method thereof

A dual-sensitivity, matrine-based technology, applied in pharmaceutical formulations, organic active ingredients, medical preparations of non-active ingredients, etc., can solve toxic side effects and complications, large fluctuations in blood drug concentration, and patients are prone to Drug resistance and other problems, to achieve non-allergic, enhance clinical treatment effect, reduce adverse drug reactions and side effects

Inactive Publication Date: 2012-10-17
LANZHOU UNIV SECOND HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As far as the current common oral preparations of matrine are concerned, due to the short duration of drug efficacy in most of their own dosage forms, frequent administration is required, and the blood drug concentration fluctuates greatly, with many side effects and complications, and patients are prone to drug resistance. And adverse drug reactions, low patient compliance, low drug bioavailability, poor clinical efficacy, etc.

Method used

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  • Sophocarpidine pH/ magnetic dual-sensitive hydrogel globule and preparation method thereof
  • Sophocarpidine pH/ magnetic dual-sensitive hydrogel globule and preparation method thereof
  • Sophocarpidine pH/ magnetic dual-sensitive hydrogel globule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] 1) Weigh 0.04g of chitosan, sprinkle it evenly into 20ml of 1% acetic acid solution, leave it overnight, stir until it dissolves completely, and obtain a chitosan solution with a concentration of 0.2%, which is set aside.

[0023] 2) Weigh CaCl 2 0.5g, add to 20ml of above-mentioned 0.2% chitosan solution, stir to dissolve, obtain chitosan and CaCl 2 The mixed solution is set aside. CaCl 2 The concentration in chitosan solution is 2.5%.

[0024] 3) Weigh 0.25g of sodium alginate, sprinkle it evenly into 10ml of purified water, let it stand overnight, stir until completely dissolved, and obtain a sodium alginate solution with a concentration of 2.5%, which is set aside.

[0025] 4) Weigh 1.25g of matrine, Fe 3 o 4 Add 0.05g of nanoparticles to 10ml of the above-mentioned 2.5% sodium alginate solution, ultrasonicate for 30 minutes, and stir evenly to obtain 3 o 4 The suspension of nanoparticles and sodium alginate, set aside.

[0026] 5) Measure the above-mentione...

Embodiment 2

[0028] 1) Weigh 0.04g of chitosan, sprinkle it evenly into 20ml of 1% acetic acid solution, let it stand overnight, stir until it dissolves completely, and obtain a chitosan solution with a concentration of 0.2%, which is set aside.

[0029] 2) Weigh CaCl 2 0.5g, add to 20ml of above-mentioned 0.2% chitosan solution, stir to dissolve, obtain chitosan and CaCl 2 The mixed solution is set aside. CaCl 2 The concentration in chitosan solution is 2.5%.

[0030] 3) Weigh 0.15g of sodium alginate, sprinkle it evenly into 10ml of purified water, let it stand overnight, and stir until it is completely dissolved to obtain a sodium alginate solution with a concentration of 1.5%, which is set aside.

[0031] 4) Weigh 1.25g of matrine, Fe 3 o 4 Add 0.05g of nanoparticles to 10ml of the above-mentioned 1.5% sodium alginate solution, ultrasonically treat for 30 minutes, and stir evenly to obtain 3 o 4 The suspension of nanoparticles and sodium alginate, set aside.

[0032] 5) Measure...

Embodiment 3

[0034] 1) Weigh 0.04g of chitosan, sprinkle it evenly into 20ml of 1% acetic acid solution, leave it overnight, stir until it dissolves completely, and obtain a chitosan solution with a concentration of 0.2%, which is set aside.

[0035] 2) Weigh CaCl 2 0.5g, add to 20ml of above-mentioned 0.2% chitosan solution, stir to dissolve, obtain chitosan and CaCl 2 The mixed solution is set aside. CaCl 2 The concentration in chitosan solution is 2.5%.

[0036] 3) Weigh 0.20 g of sodium alginate, sprinkle it evenly into 10 ml of purified water, let it stand overnight, stir until it is completely dissolved, and obtain a sodium alginate solution with a concentration of 2.0%, which is set aside.

[0037] 4) Weigh 1.25g of matrine, Fe 3 o 4 Add 0.05g of nanoparticles to 10ml of the above-mentioned 2.0% sodium alginate solution, ultrasonicate for 30 minutes, and stir evenly to obtain matrine, Fe 3 o 4 The suspension of nanoparticles and sodium alginate, set aside.

[0038] 5) Measur...

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Abstract

The invention relates to a sophocarpidine pH / magnetic dual-sensitive hydrogel globule which is orally administrated and is used for treating digestive cancers and the preparation method of the sophocarpidine pH / magnetic dual-sensitive hydrogel globule. The preparation method comprises the steps of: adding 0.3 to 0.7 g of CaCl to chitosan acetum; agitating to dissolve CaCl; preparing a 1.5 to 2.5% sodium alginate solution based on the mass to the volume concentration; weighing a proper amount of sophocarpidine and a proper amount of Fe3O4 nanoparticle respectively, and adding to the sodium alginate solution to obtain a suspension containing the sophocarpidine, the Fe3O4 nanoparticle and the sodium alginate; and weighing the suspension containing the sophocarpidine, the Fe3O4 nanoparticle and the sodium alginate, and dropping to the mixed solution of the chitosan and CaCl2 for crosslinking, and then filtering, washing, and then placing and naturally drying at room temperature so as to obtain the sophocarpidine pH / magnetic dual sensitive hydrogel globule.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a matrine pH / magnetic double sensitive hydrogel pellet for treating digestive tract tumors through oral administration and a preparation method thereof. Background technique [0002] Matrine is derived from the leguminous plant Sophora flavescens ( Sophora flavescens Ait. ), leguminous plant broad bean root ( Sophora subprosstratae ) or bitter beans ( Sophora alopecuroides L. ) is an alkaloid extracted and isolated from tetracyclic quinolizidines, which has significant antitumor activity [1] . Studies have shown that the mechanism of its anti-tumor activity includes inhibiting tumor proliferation, inducing tumor differentiation and apoptosis, inhibiting tumor invasion and distant metastasis, alleviating tumor-induced cachexia and inhibiting tumor drug resistance, and inhibiting telomerase activity. [0003] In addition, matrine also has various pharmacological effects such as...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/4375A61K47/36A61K47/02A61P35/00
Inventor 李平李玉民张玲玲李晓强焦海胜刘涛
Owner LANZHOU UNIV SECOND HOSPITAL
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