5 results about "Digestive cancers" patented technology

The present application provides a marker combination for early detection of digestive system cancer, tissue localization, diagnosis, prognosis detection and identification of benign and malignant, the marker combination is selected from 1656 chromosome regions in table 1. A multi-cancer early screening and localization technology GutSeer for five high mortality digestive system cancers is also provided, which proves that using a relatively small second-generation sequencing panel can realize accurate cancer detection and organ tissue localization by using multiple dimensional characteristics including methylation, copy number variation and terminal motif.

Described herein are methods and compositions related to inhibiting bile salt hydrolase (BSH) and uses thereof. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), gastrointestinal disease (e.g., a gastrointestinal infection; inflammatory bowel disease (IBD); appendicitis; Crohn's disease (CD); ulcerative colitis (UC); gastritis; enteritis; esophagitis; pancreatitis; diabetes; hepatitis; liver diseases (e.g., Non-alcoholic Fatty Liver Disease (NAFLD); non-alcoholic steatohepatitis (NASH); hepatitis A; hepatitis B; hepatitis C; autoimmune hepatitis; and cirrhosis of the liver) gastroesophageal reflux disease (GERD); celiac disease; diverticulitis; food intolerance; ulcer; infectious colitis; irritable bowel syndrome; leaky gut; and cancer), cancer (e.g., cancer of the digestive system, liver cancer), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVIII).

The application provides a traditional Chinese medicine composition and a preparation method thereof, which is used for treating the symptom of water and rice not entering of upper gastrointestinal cancer, and is mainly made of eaglewood, borax, green malachite, white vine, belamcanda, ginseng, mint, wintergreen, mountain bittercress, Sichuan fritillary and borneol, and is characterized by that: white vine, belamcanda, ginseng, mint, wintergreen, mountain bittercress and Sichuan fritillary medicinal materials are extracted to obtain an extract; the extract is filtered and concentrated after being combined to obtain a clear paste; the eaglewood and the borax and the green malachite are crushed into fine powder; the fine powder, the borneol and the clear paste are uniformly mixed to obtain a medicinal paste. The traditional Chinese medicine composition has the effect of treating the symptom of water and rice not entering of esophageal cancer, is green, low in cost, low in side effect and the like, fills the blank of water and rice not entering of advanced esophageal cancer at home and abroad at present, combines the traditional Chinese medicine concept and the modern pharmaceutical technology, can become a new type of medicine for treating the symptom of water and rice not entering caused by digestive system cancer, has wide market prospect and application value.

Methods of treating cancer of the digestive system, preferably of the gastrointestinal system, in a patient using an anti-GUCY2CxCD3 antibody are disclosed.

Use of a pyrido[1,2-a]pyrimidone analogue. Specifically disclosed is use of a compound I or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating and / or preventing cancers in the digestive tract system. The compound I or the pharmaceutically acceptable salt thereof has good antitumor activity against one or more of head and neck cancer, hepatocellular cancer, colorectal cancer, esophageal cancer, gastric cancer and nasopharyngeal cancer.