365 results about "Alcohol derivative" patented technology

A method of producing a diol derivative efficiently and to high purity is provided. Specifically, the present invention relates to a method of producing a diol derivative having, as a fundamental step, a step of obtaining an alpha-hydroxycarboxylic acid ester by reacting (i) one or more 1,2-diols or (ii) a 1,2-diol and a primary alcohol as starting material(s) with oxygen in the presence of a catalyst comprising metal loaded on a carrier.

A photoresist stripper composition is made up of a mixture of an acetic acid ester, gamma-butyrolactone (GBL), and a non-acetate ester or a poly alkyl alcohol derivative. The acetic acid ester may be at least one of n-butyl acetate, amyl acetate, ethyl aceto-acetate, and isopropyl acetate. The non-acetate ester may be at least one of ethyl lactate (EL), ethyl-3-ethoxy propionate (EEP) and methyl-3-methoxy (MMP). The poly alkyl alcohol derivative may be at least one of propylene glycol monomethyl ester (PGME) and propylene glycol monomethyl ester acetate (PGMEA).

The present invention is triptolide alcohol derivative, its pharmaceutically acceptable salt and optical isomer, their synthesis process and the application as antiphlogistic, immunological regulator and relevant disease treating agent.

There is provided a process for obtaining a cordierite honeycomb structural body with thin cell walls and no molding defects such as cell breakage or the like. Cell breakage is prevented by limiting the maximum particle size of the cordierite starting material powder to no greater than 85% of the slit width of the extrusion molding die so that the starting material particles will not clog inside the slits or the introduction port of the slits. As one cordierite starting material, talc with a mean particle size of 5 mum or greater is used to give a honeycomb structural body with a void volume of greater than 30%, for production of a honeycomb structural body, with good moldability, having a small thickness and a low heat capacity. It is preferred to add to the starting material at least a lubricant / humectant, a binder and / or a mixture of a water-soluble polyhydric alcohol derivative and a polyhydric alcohol.

An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:

The invention discloses a method for preparing graphene through photo-catalysis, belongs to the technical field of materials, and relates to a method for synthesizing graphene through the photo-catalytic reduction of an organic hydride donor, an ascorbic acid derivative, an amine derivative, an alcohol derivative or an inorganic hydride donor in a solution with an organic dye or a metal complex dye as a photo-catalyst. The method comprises the following steps: preprocessing graphite; oxidizing the graphite; peeling the obtained graphite oxide to form a graphene oxide; and carrying out photo-catalytic reduction of the graphene oxide under a light irradiation condition especially a visible light irradiation condition. The photo-catalytic system constructed in the invention allows a large amount of single-layer graphene having a high reduction degree to be obtained after the light irradiation especially the visible light irradiation for a short reaction time without any stabilizing agents.

The invention provides a clean production process of glycine. An organic mixed solvent is used for producing glycine and a by-product ammonium chloride by combined production. The organic mixed solvent comprises methanol, ethanol, and dihydric alcohol solvents or dihydric alcohol derivative solvents. The mixed solvent is added into a glycine synthesis reactor, urotropine and chloroacetic acid are added, ammonia is added, and a mixed crystal solid of glycine and ammonium chloride is obtained. The mixed crystal solid is added into a mixed solvent for separation, the mixed solvent for separation is heated to 60-80 DEG C, after glycine crystal is filtered, the mixed solvent for separation is cooled to 0-20 DEG C, and an ammonium chloride solid is separated by centrifugation.

A stable silicone oil composition is provided which comprises:a) at least one silicone gel;b) at least one boron nitride powder (a);c) a static charge-dissipating amount of at least one silicone oil; and,d) optionally, at least one component selected from the group consisting of other silicone, surfactant, emulsifier, solvent, emollient, moisturizer, humectant, pigment, colorant, fragrance, preservative, antioxidant, biocide, biostat, antiperspirant, exfoliant, hormone, enzyme, medicinal, vitamin substance, hydroxy acid, retinol, retinol derivative, niacinamide, skin lightening agent, salt, electrolyte, alcohol, polyol, ester, ultraviolet radiation scattering and / or absorbing agent, botanical extract, peptide, protein, organic oil, gum, saccharide, oligosaccharide, polysaccharide, derivative, wax, film former, thickening agent, particulate filler, plasticizer, humectant, occlusive, sensory enhancer, resin and optically active particle.

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

The present invention pertains to certain alkane diol derivatives (including, e.g., mono- and di-esters) of the formula R1—O-A-O—R2, wherein: A is a C2-10 alkylene group; R1 is independently a first hydroxy protecting group (e.g., an ester group); and, R2 is independently —H or a second hydroxy protecting group (e.g., an ester group); and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrug thereof, which, inter alia, inhibit osteoclast survival, formation, and / or activity; and / or inhibit bone resorption. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit osteoclast survival, formation, and / or activity, and to inhibit conditions mediated by osteoclasts and / or characterised by bone resorption, such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, and the like; and / or conditions associated with inflammation or activation of the immune system.

The invention discloses an epoxy resin bonding agent cured at the normal temperature for roads and bridges. The epoxy resin bonding agent comprises a component A and a component B, wherein the component A comprises the following ingredients in parts by mass: 100 parts of epoxy resin, 30-40 parts of flexible epoxy resin, and 5-15 parts of a diluent; the component B comprises the following ingredients in parts by mass: 60-70 parts of a curing agent, 3-5 parts of a flexibilizer, 1-3 parts of an accelerant, and 0.2-0.5 part of a defoaming agent; the ratio of the component A to the component B is (100:80)-(100:100). According to the invention, the flexible epoxy resin is added into the commonly-used epoxy resin, and after the flexible epoxy resin reacts with the curing agent, a thermoset three-dimensional crosslinking structure is formed, so that the good flexibility, better bonding capacity and water resistance are achieved; cashew nut shell oil modified amine is used as the curing agent, so that the water resistance and low temperature resistance of the bonding agent are improved effectively; in addition, since novel multiple-alcohol derivative is used as the flexibilizer of the epoxy resin, the toughness of the epoxy resin is effectively improved, so as to adapt to deformation of steel bridge decks or cement concrete bridge decks during vibration, and realize the purpose of high durability of the epoxy resin bonding agent solidified at the normal temperature for roads and bridges. The epoxy resin bonding agent solidified at the normal temperature for roads and bridges is suitable for bonding and water resistance of steel bridge decks, urban viaducts, cement concrete bridge decks, tunnels and pavements of expressways and the like. The invention further discloses a preparation method of the epoxy resin bonding agent.

Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: wherein R1 and R2 are a hydrogen atom, an amino protecting group; R3 is a hydrogen atom, a hydroxy protecting group; R4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C1-C10 alkylene group, a C1-C10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R5 is an aryl group; R6 and R7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R5 is a hydrogen atom, Y is not a single bond or a straight chain C1-C10 alkylene group.

Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols according to formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.

An addition-reaction-curable silicone rubber composition comprising: 0.001 to 5 mass % of a metal deactivator and 0.001 to 5 mass % of a curing-retarder selected from an alcohol derivative having carbon-carbon triple bonds, an enzyne compound, an alkenyl-containing low-molecular-weight organosiloxane compound, or an alkyne-containing silane; and a molded body produced by curing the aforementioned addition-reaction-curable silicone rubber composition. The addition-reaction-curable silicone rubber composition is capable of producing a molded silicone rubber body, which is obtained with low compression set without resorting to secondary thermal treatment.

The invention relates to an additive for bright nickel plating technology for a permanent magnetic material. The additive comprises a primary brightening agent, a secondary brightening agent and an auxiliary additive, wherein the primary brightening agent is a compound containing an acetylenic bond or sulfonyl; sulphur in the sulfonyl is positive quadrivalent or positive hexavalent; and the secondary brightening agent is a pyridine derivative. By a combination of the pyridine derivative, a ynamine compound and a propiolic alcohol derivative and a combination of a softening agent (impurity removing agent) and a low-foam wetting agent, the novel additive for the bright nickel plating technology is prepared, and has high bright dipping speed, high dispersibility, high color and luster uniformity, fewer decomposition products, long processing cycle, high level, good ductility, high impurity tolerance, low stress and excellent electrochemical performance.

The invention provides a polymer with a structure shown in a formula (I) which can be seen in the specification, wherein n is polymerization degree and is an integer between 25 and 500, x, y and z are relative mole numbers; x / (x+y+z) is less than 1 and greater than or equal to 0.5; z / (y+z) is less than or equal to 1 and greater than or equal to 0.1. The polymer comprises a hyaluronic acid hydrophilic main chain and a hydrophobic nitrobenzyl alcohol derivative-grafted chain segment, wherein the polymer can form the micelle (containing a hydrophobic chain segment at the inside and a hydrophilic chain segment at the outside) in a water solution, and the drug can be wrapped inside the hydrophobic chain segment to achieve slow release of the drug when the polymer is used as a drug carrier. In the polymer, the hyaluronic acid has an active targeting effect and the nitrobenzyl alcohol derivative chain segment has photosensitivity; therefore, the polymer can make response to external photic stimulation to realize slow release of the drug when being used as a drug carrier. The invention also provides preparation methods of the polymer, the light response micelle and the light response drug-loading micelle thereof. The methods have broad application prospects in clinic.

Novel clean fuels comprising selected nonlinear long chain saturated primary monohydric / dihydric alcohol derivatives and mixtures thereof; novel diols and / or diol derivatives; and processes for making clean synthetic jet fuels and / or clean synthetic diesel fuels as well as processes for making clean synthetic jet fuels and / or clean synthetic diesel fuels concurrently with making nonlinear alcohols for use by the detergent industry.

A process for recovering sterols from organic material containing sterols and sterol derivatives. In a first step (a) the organic material is reacted with at least one of polyols, polyamines, alkanolamines or monohydric alcohols to increase the amount of free sterols in the organic material; (b) reacting residual reactants, and their esters or amides with epoxydated components; and (c) separating the free sterols from the mixture by short path distillation, thin film evaporation, or flash evaporation. The recovered sterols can be further purified by a crystallization step.

The invention relates to a triazole alcohol derivative and a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is as shown in the formula I. The invention also provides salt of the compound, a pharmaceutical composition, a preparation method and application. The compound of the invention has strong antifungal activity, has advantages of low toxicity and wide antimicrobial spectrum, and can be used for preparation of antifungal drugs.

An object is to provide a medicament preparation which is excellent in the solubilization stability in relation to a compound represented by the general formula (1) during the storage in a low temperature region and a high temperature region. The present invention resides in a pharmaceutical composition comprising 1) the compound represented by the general formula (1) and / or a salt thereof and 2) a polyhydric alcohol derivative. General formula (1) (In the formula, R1, R2 independently represent hydrogen atom or halogen atom respectively, and at least one of R1, R2 is halogen atom.)

The invention discloses a fly ash concrete carbon adsorption inhibitor comprising the following components by weight: 5-10 parts of aromatic amino micromolecule, 12-26 parts of aromatic sodium sulfonate, 38-50 parts of alcohol derivative, 8-14 parts of neighboring hydroxybenzoic acid salt, 3-8 parts of crylic acid-2-acrylamide-2-methyl propanesulfonic acid copolymer, 3-10 parts of ethanediamine tetramethylene phosphonate and 6-10 parts of organosilan. The fly ash concrete carbon adsorption inhibitor inhibits adsorption of an additive by carbon particles in the fly ash, improves the performance stability and durability of concrete, is favorably adapted to various additives, has favorable inhibitive ability to the fly ash concrete carbon adsorption with various mixing amount and quality, and does not influence the performance of the concrete. The inhibitor is small in the mixing amount so that the strength of concrete is improved and the construction is convenient.

The invention relates to a triazole alcohol derivative, a preparation method and application thereof. The triazole alcohol derivative is a 2-(2, 4-difluorophenyl)-3-(1-substituted-1H-1, 2, 3-triazole-4-yl)-1-(1H-1, 2, 4-triazole-1yl)-2-propanol compound. The invention also provides a salt of the compound, a pharmaceutical composition, a preparation method and application thereof. The compound provided by the invention has strong antifungal activity, and has the advantages of low toxicity, broad antibacterial spectrum and the like, and can be used for preparation of antifungal drugs.

The invention discloses a 3-o-methylphenyl-2-oxo-1-oxaspiro[4,5]-decyl-3-alkene-4-ol derivative with insecticidal, acaricidal and antifungal biological activities and a preparation method thereof, wherein R is a substituent shown as the description.

The present invention relates to the following water-soluble triptolide derivatives with immunosuppression activity. Said invention provides their structure formulas and their synthesis method, and their application for curing acive immunodeficiency disease and immunosuppression associated inflammation.

The present invention discloses 1-(acetyl-AA-OBzl)-3-(ethoxyacetyl-AA-OBzl) indole represented by the following formula (wherein AA is L-Ala residue, Gly residue, L-IIe residue, L-Val residue and L-Leu residue), a preparation method, antitumor activity, anti-tumor-metastasis activity and anti-inflammatory activity thereof, such that the present invention discloses applications of the 1-(acetyl-AA-OBzl)-3-(ethoxyacetyl-AA-OBzl) indole in preparation of antitumor drugs, anti-tumor-metastasis drugs and anti-inflammatory drugs. The formula is defined in the specification.

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3, R4, R5 and R6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R7 and R8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R9 is —C(O)—R10, -A1-C(O)—R10, —O-A2-C(O)—R10 or a tetrazol-5-yl group, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.