117 results about "Alcohol derivative" patented technology

The invention relates to the field of ecological restoration, in particular to a degradable material for mine ecological restoration and a mine ecological restoration method. The material is prepared from the following raw materials in parts by weight: 30 to 50 parts of polycaprolactone, 10 to 20 parts of gamma-polyglutamate, 5 to 10 parts of a microbial agent, 20 to 30 parts of bentonite and 10 to 20 parts of pure wood fiber. The repairing method is realized based on the material. The degradable material is prepared from alcohol derivatives and gamma-polyglutamic acid through esterification cross-linking modification, the hydrophilicity of the material is reduced by introducing ester bonds, and the hydrophobicity of the material is improved; hydroxyl in the geniposide cross-linking agent reacts with active sites on gamma-polyglutamic acid and alcohol derivatives to form a complex three-dimensional network structure, so that the physical properties, such as hydrophobicity, mechanical properties and degradability, of the material are remarkably improved. The method can restore the ecology of a mine, degrade organic pollutants of soil and adsorb and solidify heavy metal ions, and has a wide application prospect.

The invention relates to the technical field of medicines, and provides a lanosterol derivative as well as a preparation method and application thereof. The lanosterol derivative provided by the invention has a structural formula as shown in a formula I or a formula II. The lanosterol derivative provided by the invention has both fat solubility and water solubility, and can effectively permeate into a diseased region in a body, so that the medicinal availability is improved; results of the embodiment show that the solubility of the lanosterol derivative provided by the invention in water is obviously higher than that of lanosterol or 25-hydroxylanosterol, and the lanosterol derivative shows an obvious cataract treatment effect in animal in-vivo experiments and has a wide prospect in preparation of drugs for treating eye diseases or symptoms. # imgabs0 #

The invention provides a fluorenyl alcohol derivative which can be used as an antibiotic adjuvant with a broad-spectrum synergistic effect. According to the compound, bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are taken as targets, and a series of fluorenyl alcohol derivatives targeting the bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are obtained through screening. The preferable compound WTU-15 can improve the antibacterial activity of antibiotics such as polymyxin, cefepime, tetracycline and the like on negative bacteria such as sensitive and drug-resistant escherichia coli, salmonella, klebsiella pneumoniae, acinetobacter baumannii and the like, and can also improve the in-vivo treatment effect of cefepime on mice infected by the drug-resistant acinetobacter baumannii. And the visceral organs of the mice survived after administration have fewer bacteria, and the mice are better after being healed. Normal physiological and visceral organ functions of the mouse are not affected by single and continuous administration of the WTU-15.

The utility model belongs to the technical field of detection, particularly relates to an ethanol derivative detection device, and aims to solve the problems that a test tube is oscillated by shaking a wrist to accelerate mixing of solutions, the next step cannot be prepared in the process, and the wrist of a tester is damaged by long-time shaking, and the ethanol derivative detection device comprises a base, the alcohol lamp is arranged at the top of the base, the reagent bottle is arranged at the top of the base, the supporting frame is fixedly connected to the top of the base, and the test tube rack is fixedly connected to the top of the base. Meanwhile, an oscillating assembly capable of automatically swinging left and right in a reciprocating manner is arranged, so that wrist injury of a tester caused by long-time swinging is avoided, reagent solution mixing is accelerated, two hands are liberated, the tester can prepare for the next operation step, and the testing speed is increased.

The invention belongs to the technical field of medicines, and particularly relates to a nitroimidazole brucea javanica bitter alcohol derivative with a low-oxygen activation prodrug property in dry fruits of a medicinal plant brucea javanica, and a preparation method and an application of the nitroimidazole brucea javanica bitter alcohol derivative. According to the invention, a series of novel brucea javanica bitter alcohol derivatives or pharmaceutically acceptable salts thereof are designed and synthesized by carrying out necessary structural modification on brucea javanica bitter alcohol. Anti-tumor drug screening on digestive system cancer cell proliferation through pharmacological experiments shows that the brucea javanica bitter alcohol derivative or the pharmaceutically acceptable salt thereof has good colon cancer cell inhibition activity, so that the brucea javanica bitter alcohol derivative or the pharmaceutically acceptable salt thereof can be developed into a new anti-colon cancer drug; and the method has very high potential research value and clinical application prospect.

To provide a copper particulate dispersion allowed to obtain a joined body improved in joint strength even after stored over a constant period of time, owing to the improvements in stability of dispersion and storage and in low-temperature sinter-ability and joint-ability.SOLUTION: A copper particulate dispersion contains a copper nanoparticle A dispersed with polymer B and a dispersion medium C, in which the polymer B includes a monomer-derivative constituent unit having a carboxy group and a monomer-derivative constituent unit having a poly-alkylene glycol segment, the alkylene glycol segment in the polymer B has a content of 55 mass% or more and 97 mass% or less, the polymer B has an acid value of 20 mgKOH / g or greater and 250 mgKOH / g or smaller, and the dispersion medium C contains at least one selected from a group consisting of (poly-)alkylene glycol, (poly-)alkylene glycol derivative, terpene alcohol, glycerin, and glycerin derivative. There is also provided a method of making a joined body.SELECTED DRAWING: None

Provided is a novel polycarbonate polyol derivative having a terminal amino group. The polycarbonate polyol derivative of the present disclosure is represented by Formula (1) below. In Formula (1), A denotes a group having a polycarbonate skeleton, and n and m are average values and are numbers satisfying n≥2 and n−m>0. The group A in Formula (1) is a group in which all hydroxyl groups are removed from the structural formula of a polycarbonate polyol having a number average molecular weight from 300 to 10000, and preferably includes a group having a repeating unit represented by Formula (a) below.

This invention provides a novel phosphine oxide compound that inhibits SHP2, a composition thereof, a method for preparing the compound, and a method for treating SHP2-related diseases (such as cancer).

A process for making L-glufosinate, the process comprising the following steps: a) reacting a compound according to formula (I), (I), wherein R1 is hydrogen, (C1-C12)-alkyl, (C1-C12)-haloalkyl, (C6-C10)-aryl, (C6-C10)-haloaryl, (C7-C10)-aralkyl, (C7-C10)-haloaralkyl, (C4-C10)-cycloalkyl, or (C4-C10)-halocycloalkyl, with a compound according to formula (II), (II), wherein R2 and R3 are independently from each other (C1-C8)-acyloxy, (C1-C8)-alkoxy or hydroxy, or R2 and R3 form together an epoxide group or an ethylene carbonate group, and optional subsequent acidic treatment to form a diol according to formula (III), (III), b) Oxidizing the diol according to formula (III) to form 2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid (PPO); and c) aminating the PPO to L-glufosinate.

The application belongs to the technical field of chemical synthesis, and particularly relates to a trifluoromethyl-containing benzothiazole tertiary alcohol derivative, a preparation method and application thereof. 1 , R 2 are independently selected from hydrogen, C1-C3 alkyl, C1-C3 alkoxy or halogen; or R 1 , R 2 independently form a naphthalene ring with the substituted benzene ring together. The trifluoromethyl-containing benzothiazole tertiary alcohol derivative provided by the application has good bacteriostatic effect on one or more of Rhizoctonia solani, Fusarium moniliforme, Fusarium graminearum, Fusarium oxysporum and Phytophthora nicotianae.

The invention discloses a cobalt catalyst and a preparation method and application thereof. The structural formula of the cobalt catalyst is Co-Co3O4 (S)-coated NC-X, in the structural formula, S is the particle size of a cobalt active site, X is the pyrolysis temperature during preparation of the catalyst, and the microstructure of the cobalt catalyst is in a sphere-like shape sequentially comprising a cobalt core, cobaltosic oxide and a nitrogen-doped carbon shell from inside to outside. According to the invention, the catalyst is designed and prepared by using the cheap precursor, and the cobalt active sites are confined in the nitrogen-doped carbon shell, so that the agglomeration and loss of the cobalt active sites are effectively prevented, and the stability of the catalyst is improved. The cobalt catalyst can be used for synthesizing products of carbonyl compounds through selective catalytic oxidation with alcohol derivatives as substrates and air as an oxygen source, and has the advantages of being high in yield and efficient and green in reaction process.

Provided is a composition capable of suppressing generation of a trimer even when an aliphatic aldehyde at a high concentration of 90 mass% or more is stored at a low temperature. The composition contains 90 mass% or more of an aliphatic aldehyde having 8-16 carbon atoms and 100 ppm or more and 1 mass% or less of an additive with respect to the mass of the aliphatic aldehyde, wherein the additive is one or more selected from the group consisting of polyalkylene glycol derivatives represented by formula (I), sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitol fatty acid esters, amino acids represented by formula (II), anthranilic acid esters represented by formula (III), and pyrazine derivatives represented by formula (IV).

The application discloses a W / O / W composition and a preparation method thereof, and belongs to the technical field of cosmetics. The W / O / W composition comprises the following components in percentage by weight: 0.5-2% of lipophilic surfactant, 1-5% of hydrophilic surfactant, 5-20% of oil phase, 0.5-2% of cholesterols and / or sterol derivatives, 5-20% of polyhydric alcohol and 0.1-2% of thickening agent. Based on the long-term stability of multiple emulsions, the application adds cholesterols and / or sterol derivatives to obtain a W / O / W composition which is long-term stable and has excellent skin feeling. In addition, the preparation method of the W / O / W composition is less than 40 DEG C, which can reduce the production energy consumption and the risk of inactivation of temperature-sensitive active ingredients.

The present application relates to the technical field of medicine, and provides a lanosterol derivative, a preparation method and application thereof.The structural formula of the lanosterol derivative provided by the present application is shown as formula I or formula II.The lanosterol derivative provided by the present application has both fat solubility and water solubility, can effectively penetrate into the pathological site in the body, and improves the drug utilization degree;the results of examples show that the solubility of the lanosterol derivative provided by the present application in water is obviously higher than that of lanosterol or 25-hydroxy lanosterol, and the lanosterol derivative shows obvious cataract treatment effect in animal body experiments, and has a broad prospect in the preparation of drugs for treating eye diseases or conditions.

The invention belongs to the technical field of lubricants, and discloses a lubricant containing Guerbet alcohol derivatives and a preparation method and application thereof. The lubricant is prepared from the following components in parts by weight: 2 to 6 parts of Guerbet alcohol derivative, 0.2 to 1 part of sulfurized isobutylene, 0.05 to 0.3 part of tungsten disulfide nanosheet, 0.01 to 0.1 part of surface modified fullerene, 0.5 to 1.5 parts of triisopropanolamine borate, 80 to 95 parts of 2-octyl-dodecyl cyclopentane, 0.3 to 0.8 part of antioxidant and 0.1 to 0.5 part of antirust agent. The Guerbet alcohol derivative is an ester derivative of Guerbet alcohol; the surface modified fullerene is obtained by modifying fullerene by using dodecyl mercaptan and azodiisobutyronitrile. When ester synthesized from isostearyl alcohol is used as an ester derivative of Guerbet alcohol, the lubricant still has good lubricating performance. Furthermore, the high-temperature-resistant and high-pressure-resistant oxidation performance is good.

A preparation method of amino alcohol derivatives, the present application relates to the field of preparing amino alcohol derivatives by double functionalization of styrene derivatives, and aims to solve the technical problems of complicated steps and low utilization rate of raw materials in the existing synthesis of amino alcohol derivatives.Method: I. under the condition of nitrogen atmosphere and room temperature, the styrene derivative and N-benzamide-2,4,6-triphenylpyridine tetrafluoroborate derivative are dissolved in a mixed solvent containing alkyl alcohol, then a photocatalyst and a Lewis base are added, mixed uniformly, placed under blue LED light for photoreaction, after the reaction is completed, extracted with water and ethyl acetate, the organic phase is collected, the solvent is removed by rotary evaporation, and then separated and purified by silica gel column chromatography.The method can react at normal temperature and pressure, the reaction condition is mild, green and environmental protection, and has the advantages of simple and effective operation, safety, environmental protection, low cost and the like.The present application is used for synthesizing amino alcohol derivatives.

The invention discloses a linalool derivative with a lasting disinfection function as well as preparation and application of the linalool derivative. The structure of the linalool derivative is shown as a formula (I), and the preparation method of the linalool derivative comprises the following steps: adding linalool and sorbic acid into an organic solvent, uniformly mixing, reacting for 2-6 hours under stirring and heating conditions to obtain a mixed product, removing the organic solvent in the mixed product to obtain a crude product, and purifying the crude product to obtain the linalool derivative. The linalool derivative is prepared through the esterification reaction modification of the linalool and the sorbic acid, so that the volatility of the linalool derivative is effectively reduced, and the effectiveness period of the linalool derivative is prolonged. Compared with linalool, the bacteriostatic durability of the cinnamomum camphora sorbic ester is remarkably improved, the bacteriostatic rate can still be higher than 85% within 8 h, and the cinnamomum camphora sorbic ester can be applied to preparation of a long-acting disinfectant. # imgabs0 #

The invention discloses cycloastragenol derivatives with activity of resisting methicillin-resistant staphylococcus aureus and a preparation method of the cycloastragenol derivatives. According to the invention, cycloastragenol is used as a matrix, and is optimized by a chemical synthesis means to obtain a series of novel cycloastragenol derivatives. Experiments for resisting methicillin-resistant staphylococcus aureus prove that the series of compounds have good activity for resisting methicillin-resistant staphylococcus aureus, can be used as active ingredients of antibacterial drugs, and have relatively wide application in development of novel antibiotics.

The present invention belongs to the technical field of medicinal chemistry, and specifically relates to an azole alcohol derivative containing a difluorophenyl structure and the use thereof in the preparation of a drug for treating various diseases caused by fungal infection. The derivative is a compound represented by formula I, or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof. Further provided are a preparation method therefor and the use thereof in the preparation of a drug for preventing or treating various diseases caused by fungal infection.

The invention relates to pyrazolo oleanolic acid reduced alcohol derivatives as well as a preparation method and application thereof. The pyrazolo oleanolic acid reducing alcohol compound has a structure as shown in a formula I which is described in the specification. The compound disclosed by the invention has exact anti-inflammatory activity and osteoclast differentiation inhibition activity, so that the compound has a prospect of being developed into drugs for treating inflammation and osteoclast activity abnormity related diseases. # imgabs0 #

The invention belongs to the technical field of medicine, and discloses a bicyclol derivative shown as a formula (I) or pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition thereof and application thereof, especially application of the bicyclol derivative in medicines for treating liver diseases.

The invention belongs to the technical field of medicines, and particularly relates to a triphenylphosphine brucea javanica bitter alcohol derivative with anti-tumor activity in dry fruits of a medicinal plant brucea javanica, and a preparation method and application of the triphenylphosphine brucea javanica bitter alcohol derivative. According to the invention, a series of brucea javanica triphenylphosphine derivatives or pharmaceutically acceptable salts thereof are designed and synthesized by carrying out necessary structural modification on brucea javanica. Anti-tumor drug screening on digestive system cancer cell proliferation through pharmacological experiments shows that the brucea javanica bitter alcohol derivative or the pharmaceutically acceptable salt thereof has good gastric cancer cell inhibition activity, so that the brucea javanica bitter alcohol derivative or the pharmaceutically acceptable salt thereof can be developed into new anti-gastric cancer drugs and has very high potential research value and clinical application prospect.

This invention discloses a polyurea component A and its preparation method, as well as a polyurea containing component A and its preparation method, belonging to the field of polyurea technology. The technical solution is as follows: S1: Using polycaprolactone diol, polyether polyol, and halogen-substituted phenol or phenolic alcohol derivatives as mixed initiators, a bimetallic catalyst is used to catalyze the ring-opening polymerization of epoxides to synthesize a polyether polyol / polyester ether polyol containing flame-retardant elements; S2: The polyether polyol / polyester ether polyol prepared in step S1 is reacted with isocyanate and polytetrahydrofuran ether diol to prepare component A. This invention utilizes the synthesized polyether polyol / polyester ether polyol to impart excellent flame-retardant and mechanical properties to polyurea materials.

The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

The invention belongs to the technical field of coatings, and relates to a bi-component bionic super-hydrophobic ice and snow prevention coating and a preparation method thereof.The coating is prepared from a component A and a component B. The mass ratio of the component A to the component B is 1: (1-1.5), and the component A is prepared from 10-15 parts of modified hydroxyl-terminated polyurethane prepolymer, 20-30 parts of fluorosilicone resin, 2-5 parts of simethicone and 15-20 parts of graft modified inorganic particles; the modified hydroxyl-terminated polyurethane prepolymer is prepared by reacting diisocyanate, polymer dihydric alcohol and an alkyne-containing binary chain extender to prepare hydroxyl-terminated alkyne-containing polyurethane and then carrying out phenylacetylene in-situ graft polymerization; the grafted modified inorganic particles are prepared by in-situ grafting a mixture of phenylacetylene and phenylacetylene alcohol derivatives by taking alkynyl of an alkynyl silane coupling agent modified inorganic filler as an active site, and under the action of a component B polyisocyanate curing agent, a hydroxyl-terminated polyurethane prepolymer and active hydroxyl on the surfaces of the modified inorganic particles are subjected to a cross-linking reaction; and dense cross-linked networks are respectively formed, so that the coating has excellent hydrophobicity and durability.

The invention generally refers to pharmaceutical uses of tetracyclic terpene 3-ols, as an example lanosta-8,24-dien-3-ol, bearing polar and / or charged moieties, as anti-inflammatory, anti-cancer and analgesic agents via the inhibition of the disordered activation of serine-threonine protein kinases, particularly PKC.

The invention relates to the technical field of medicine synthesis, in particular to ergosterol amino alcohol derivatives with antibacterial activity and a preparation method and application thereof. The structure is as shown in general formula (I). The ergosterol amino alcohol derivative disclosed by the invention is high in gram-positive bacterium and gram-negative bacterium resisting activity, and the antibacterial activity of the derivative with the optimal activity on staphylococcus aureus and escherichia coli is improved by 64 times and 32 times respectively, so that the ergosterol amino alcohol derivative is obviously superior to that of lead compound ergosterol and compounds reported in literatures. The IC50 values of the human body normal cells HK-2 (near-end renal tubular epithelial cells) and HEK-293 (human embryo renal epithelial cells) are obviously higher, and when MIC < lt > is less than MIC < lt >, MIC < lt > is less than MIC < lt >; the ergosterol amine alcohol derivative has the selectivity index SI of more than or equal to 6.0 when the molecular weight of the ergosterol amine alcohol derivative is 32 [mu] g mL <-1 >, has the characteristics of high efficiency and low toxicity, and has potential application value in the aspect of anti-infection drug development.

To provide compounds, pharmaceutical compositions, and uses thereof for activating Kv7 potassium channels and treating related disorders.SOLUTION: Compounds selected from the group consisting of (R)-N-((R)-2-(difluoromethoxy)-1-(3-(difluoromethoxy)phenyl)ethyl)-3-hydroxy-4,4-dimethylpentanamide; (S)-3-(3,3-difluorocyclobutyl)-N-((R)-2-(difluoromethoxy)-1-(3-(difluoromethoxy)phenyl)ethyl)-3-hydroxypropanamide; (R)-3-(3,3-difluorocyclobutyl)-N-((R)-2-(difluoromethoxy)-1-(3-(trifluoromethoxy)phenyl)ethyl)-3-hydroxypropanamide; and pharmaceutically acceptable salts thereof are provided.SELECTED DRAWING: None

A liquid composition comprising a micronutrient dissolved in a solvent which is selected from the group consisting of polyhydric alcohols, derivatives of polyhydric alcohols, and mixtures thereof. The