The invention belongs to the field of medicines and in particular relates to a refining method of high-purity cefepime dihydrochloride monohydrate. The refining method comprises the following steps: dissolving cefepime inner salt, concentrated hydrochloric acid, sodium hydrogen sulfite and EDTA-Na2 (ethylene diamine tetraacetic acid-sodium 2) in methanol, adding active carbon, mixing, and filtering; adding acetone into filter liquor, crystallizing, filtering again, and washing a filter cake to obtain cefepime dihydrochloride monohydrate. According to the refining method, the conditions are mild, cefepime is less influenced, and the process is easy to operate; the cefepime loss is low in the reaction process, cefepime dihydrochloride monohydrate is obtained by the method, cefepime dihydrochloride dihydrate is prevented from being generated, the purity of cefepime is improved, and the quality of cefepime is greatly improved.