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Method for preparing cefepime dihydrochloride monohydrate crystal

A technology of cefepime dihydrochloride and monohydrate, which is applied in the field of preparation of cefepime hydrochloride to control the formation of specific hydrate crystals, and can solve problems such as reducing water content, failing to meet Chinese quality standards, and unable to guarantee crystallization.

Inactive Publication Date: 2010-06-30
SHENZHEN SALUBRIS PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] There is certain shortcoming in the above-mentioned method that adds organic solvent (acetone or ethanol) to separate out cefepime hydrochloride in aqueous solution
It cannot guarantee that every batch of crystals is cefepime dihydrochloride monohydrate
In individual cases, especially in the case of Example 7 of US Pat.
The product at this time does not meet the Chinese quality standards for the variety

Method used

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  • Method for preparing cefepime dihydrochloride monohydrate crystal

Examples

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Embodiment 1

[0030] Embodiment 1, the refining of cefepime dihydrochloride monohydrate

[0031]Add 150 g of cefepime dihydrochloride monohydrate (HPLC purity 98%, prepared according to the method in US4910301) to 750 mL of methanol under stirring at room temperature, add an appropriate amount of activated carbon after 10 minutes, and stir for 20 minutes. Filter and wash the carbon residue with an appropriate amount of acetone-methanol 1:1 (v / v) mixed solution. Combine the filtrates and cool to 10-20°C. Add 6500 mL of acetone to the filtrate under stirring, and complete the addition within about 1 hour. Stirring was continued for 1 hour. Suction. The filter cake was washed with acetone and dried under vacuum at 40° C. to obtain about 140 g of white crystals of cefepime dihydrochloride monohydrate. HPLC purity 99.5%, water content 3.3% (K-F method), residual methanol 0.20%, residual acetone 0.35%.

Embodiment 2

[0032] Embodiment 2, prepare cefepime dihydrochloride monohydrate by cefepime monohydrochloride

[0033] 136 g of cefepime monohydrochloride (HPLC purity 97%, prepared according to the method in US4910301) was added to 750 mL of methanol under stirring at room temperature, and 50 mL of 20% HCl was added after 10 minutes. Stir for 10 minutes, if there is any insoluble matter, filter it off. Then add 6500 mL of acetone to the solution, and add it within about 1 hour. Stirring was continued for 1 hour. Suction. The filter cake was washed with acetone and dried under vacuum at 40° C. to obtain about 130 g of white crystals of cefepime dihydrochloride monohydrate with an HPLC purity of 99%.

Embodiment 3

[0034] Embodiment 3, prepare cefepime dihydrochloride monohydrate by cefepime dihydrochloride dihydrate

[0035] Add 150g of cefepime dihydrochloride dihydrate (HPLC purity 98%, prepared according to the method in US5391729) to the mixed solution of 150mL water and 900mL methanol under stirring at room temperature, add an appropriate amount of activated carbon after 10 minutes, and stir for 30 minutes . Filter and wash the carbon residue with an appropriate amount of acetone-methanol 1:1 (v / v) mixed solution. Combine the filtrates and cool to 10-20°C. Add 8500 mL of acetone to the filtrate under stirring, and complete the addition within about 1 hour. Stirring was continued for 1 hour. Suction. The filter cake was washed with acetone and dried under vacuum at 40° C. to obtain about 130 g of white crystals of cefepime dihydrochloride monohydrate with an HPLC purity of 99.5%.

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Abstract

The invention relates to a preparation or purification method of cefepime dihydrochloride monohydrate. The invention is characterized in that acetone, ethanol or the mixed solution of acetone and ethanol at the random portion is added into the methanol solution containing cefepime dihydrochloride and then cefepime dihydrochloride monohydrate crystal is precipitated. The method can effectively avoid the formation of cefepime dihydrochloride dihydrate.

Description

technical field [0001] The invention relates to a preparation method of cephalosporin, in particular to a preparation process for controlling cefepime hydrochloride to generate specific hydrate crystals. Background technique [0002] Cefepime (I, cefepime) is a fourth-generation cephalosporin antibiotic for injection. It is a broad-spectrum antibacterial substance developed in 1982 (US4,406,899) by the American Boomer-Bristol-Myers Squibb (BMS). [0003] Cefepime is a neutral inner salt with high water solubility, its structure is: [0004] [0005] The cefepime hydrochloride (also known as "cefepime hydrochloride" or "cefepime hydrochloride") that has been found includes cefepime monohydrochloride (Example IV of US4910301), amorphous Anhydrous cefepime dihydrochloride (Example 1 of US5095011), anhydrous cefepime dihydrochloride (Example V of US4910301), cefepime dihydrochloride monohydrate (Example XI and XII of US4910301), There are 6 kinds of unstable cefepime dihyd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/46
Inventor 叶澄海谭端明
Owner SHENZHEN SALUBRIS PHARMA CO LTD
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