Immunotherapy Regimes Dependent On APOE Status

a technology of immunotherapy and apoe status, applied in the direction of antibody medical ingredients, instruments, drug compositions, etc., can solve the problems of neuronal cell death and unroutinely performed genetic screening for e4 , to improve the safety of bapineuzumab
US20090155256A1Inactive Publication Date: 2009-06-18WYETH LLC +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
WYETH LLC
Publication Date
2009-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] Provisional U.S. Application Nos. 60 / 999,423 and 61 / 083,827, filed Oct. 17, 2007 and Jul. 25, 2008, respectively, are incorporated by reference in their entirety for all purposes.REFERENCE TO A SEQUENCE LISTING

[0002] The Substitute Sequence Listing written in file Sequence_Listing_for—15270C-000420US.txt is 164,721 bytes and was created on Oct. 14, 2008 for the instant application. The information contained in this file is hereby incorporated by reference.BACKGROUND OF THE INVENTIONI. General

[0003] Alzheimer's disease (AD) is a progressive disease resulting in senile dementia. See generally Selkoe, TINS 16:403 (1993); Hardy et al., WO 92 / 13069; Selkoe, J. Neuropathol. Exp. Neurol. 53:438 (1994); Duff et al., Nature 373:476 (1995); Games et al., Nature 373:523 (1995). Broadly speaking, the disease falls into two categories: late onset, which occurs in old age (65+ years) and early onset, which develops well before the senile period, i.e., bet...

Claims

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