44 results about "Cefazolin" patented technology

The invention relates to a mouse monoclonal antibody cell strain for resisting both amoxicillin and ampicillin, belonging to the technical field of B cell hybridoma. The mouse monoclonal antibody cell strain for resisting the amoxicillin and the ampicillin has the preservation number of CGMCC NO.2674. The monoclonal antibody aiming at the amoxicillin has 100 percent of cross reaction with the ampicillin which also belongs to the penicillin antibiotics, and has no cross reaction with cefazolin of cephalosporin antibiotics. The invention can be used for rapidly detecting the residual condition of the amoxicillin and the ampicillin in animal-sourced food, and can be further used for developing an immunity detection product rapidly and accurately detecting the amoxicillin and the ampicillin in the animal-sourced food.

The invention discloses a process for preparing cefuzonam. The process includes steps of (1), weighing 7-aminocephalosporanic acid (7-ACA, a chemical compound I) and AE-mica ester (AEMA, a chemical compound II), mixing the 7-aminocephalosporanic acid and the AE-mica ester with each other to obtain a mixture, then uniformly grinding the mixture, adding a chemical compound III and triethylamine into the mixture, stirring the chemical compound III, the triethylamine and the mixture so allow solid phases and liquid phases to be in sufficient contact with one another, adding polyethylene glycol 400 into the solid phases and the liquid phases and stirring the polyethylene glycol 400, the solid phases and the liquid phases for 2-5 minutes; (2), carrying out 450W microwave reaction for 2-3 minutes, carrying out 800W microwave reaction for 2-3 minutes and carrying out 1000W microwave reaction for 3-5 minutes; (2), washing reaction residues by the aid of cold water at the temperature of 0-5 DEG C after reaction is completed, dissolving remaining solid in ethyl acetate, adding petroleum ester at the temperature of 0-5 DEG C into the remaining solid, dissolving out white solid and drying the white solid to obtain a chemical compound IV. The process has the advantages that the microwave one-pot reaction is carried out, so that various reactants are in sufficient contact with one another by the aid of the polyethylene glycol 400 which is a surfactant under the alkaline actions of the triethylamine, the process is easy and convenient to implement and short in reaction time, and the high-purity cefuzonam can be obtained in a high-yield manner.

The invention discloses a cefazolin derivative and a preparation method thereof as well as an oral antibiotic preparation. The molecular structural formula of the cefazolin derivative is (I) shown in description. The preparation method comprises the following steps: preparing a low-temperature reactant mixed solution of a cefazolin mother nucleus and cefazolin acid and carrying out condensation reaction on the low-temperature reactant mixed solution through heating. The oral antibiotic preparation contains the cefazolin derivative with the structural formula (I). The cefazolin derivative disclosed by the invention has the activity of a cefazolin medicine, has a suitable lipid-water partition coefficient and is suitable for gastro-intestinal tract dosing. The preparation method has easily-controlled reaction conditions, a simple process and a high product yield. The oral antibiotic preparation has a good efficacy, is convenient and safe to use, and can effectively reduce the occurrence rate of abusing antibiotics; meanwhile, the range of selecting the oral antibiotic preparation in China is expanded.

The invention relates to a synthetic method of cefazolin acid. According to the synthetic method, 7-aminocephalosporanic acid is taken as a raw material, and is reacted with 1H-tetrazole-1-acetic acid in a solvent so as to obtain an intermediate; the intermediate is reacted with 5-mercapto-1-methyltetrazole under base catalysis at solution states without crystallization, washing, and drying so as to obtain cefazolin acid. One-pot method is adopted; the synthetic method is simple; solvent application amount is low; environmental pollution is low; product yield is high; cost is low; and the synthetic method is suitable for industrialized production.