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Composite medicine comprising cefazolin

A technology of cefazolin and medicine, which is applied in the field of cefazolin combination medicine and its preparation, can solve the problems of increasing product storage cost and transportation cost, inconvenient storage and transportation, unstable storage, etc., and achieve the protection of liver tissue and cells , Eliminate drug allergic reactions and oxidation, and stabilize the curative effect

Inactive Publication Date: 2014-04-30
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, cefazolin for injection is not stable when stored in the greenhouse, and it is easily damaged when exposed to external forces such as light, heat, water, oxidation, etc., which brings great inconvenience to storage and transportation, and also increases the cost of product storage. and shipping costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Invent a kind of combination medicine of cefazolin, be made by the effective medicinal ingredient of following parts by weight:

[0025] Cefazolin 63-130

[0026] Vitamin C 6-12

[0027] Propylene glycol 12-40

[0028] Lidocaine 15-36

[0029] The method of described cefazolin combination medicine, its preparation method and steps are as follows:

[0030] (1). Take water for injection whose weight is 5-15 times that of the cefazolin, and under stirring, dissolve the cefazolin, vitamin C, propylene glycol, and lidocaine completely respectively to obtain a combination of cefazolin drug solution;

[0031] (2).Use the medicinal solution obtained in step (1) with an ultrafiltration membrane with a molecular weight cut-off of 8000D. The filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D. The filtrate is adjusted to a pH value of 6.5-7.4 with 8% sodium hydroxide solution;

[0032] (3). The liquid medicine obtained in step (2) was steam ...

Embodiment 2

[0038] Invent a kind of combination medicine of cefazolin, be made by the effective medicinal ingredient of following parts by weight:

[0039] Cefazolin 63-130

[0040] Vitamin C 6-12

[0041] Propylene glycol 12-40

[0042] Lidocaine 15-36

[0043] The method of described cefazolin combination medicine, its preparation method and steps are as follows:

[0044] (1). Take water for injection whose weight is 5-15 times that of the cefazolin, and under stirring, dissolve the cefazolin, vitamin C, propylene glycol, and lidocaine completely respectively to obtain a combination of cefazolin drug solution;

[0045] (2).Use the medicinal solution obtained in step (1) with an ultrafiltration membrane with a molecular weight cut-off of 8000D. The filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D. The filtrate is adjusted to a pH value of 6.5-7.4 with 8% sodium hydroxide solution;

[0046] (3). The liquid medicine obtained in step (2) was steam ...

Embodiment 3

[0052] Invent a kind of combination medicine of cefazolin, be made by the effective medicinal ingredient of following parts by weight:

[0053] Cefazolin 63-130

[0054] Vitamin C 6-12

[0055] Propylene glycol 12-40

[0056] Lidocaine 15-36

[0057] The method of described cefazolin combination medicine, its preparation method and steps are as follows:

[0058] (1). Take water for injection whose weight is 5-15 times that of the cefazolin, and under stirring, dissolve the cefazolin, vitamin C, propylene glycol, and lidocaine completely respectively to obtain a combination of cefazolin drug solution;

[0059] (2).Use the medicinal solution obtained in step (1) with an ultrafiltration membrane with a molecular weight cut-off of 8000D. The filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D. The filtrate is adjusted to a pH value of 6.5-7.4 with 8% sodium hydroxide solution;

[0060] (3). The liquid medicine obtained in step (2) was steam ...

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Abstract

The invention provides a composite medicine comprising cefazolin, which is prepared from the following active ingredients: cefazolin, vitamin C, propylene glycol and lidocaine at a fraction ratio of (63-130):(6-12):(12-40):(15-36). The invention also provides a preparation method of the composite medicine. The composite medicine provided by the invention is superior to the prior art in safety, stability and therapeutic effect, and the preparation method is energy-saving and environment-friendly.

Description

technical field [0001] The invention relates to a combination medicine of cefazolin and a preparation method thereof. Background technique [0002] Cefazolin injection. It is indicated for the treatment of moderate infections caused by sensitive aerobic bacteria. It can be widely used for penicillin-resistant, cefazolin-sensitive Staphylococcus aureus infection and infections caused by Pseudomonas aeruginosa, sensitive-negative bacilli, respiratory tract, urogenital tract, biliary tract, skin and soft tissue, and postoperative infection , Trauma infection, eye, ear, nose and throat infection and surgical perioperative prophylaxis. This product is unstable to β-lactamase produced by negative bacilli, and is ineffective against infections caused by anaerobic bacteria such as drug-resistant Enterobacter, Pseudomonas aeruginosa and Bacteroides fragilis. At present, cefazolin for injection is not stable when stored in the greenhouse, and it is easily damaged when exposed to ex...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K9/08A61K9/12A61K31/546A61K47/22A61K47/18A61K47/10A61P31/04A61K31/375A61K31/167
Inventor 邓学峰
Owner 邓学峰
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