28results about How to "Good content uniformity" patented technology

The invention relates to the technical field of TMBP preparation, in particular to a TMBP reaction device and a TMBP synthesis method. The reaction device comprises a closed tank body, a heating mechanism is arranged in the tank body, the tank body is divided into a gas phase area and a liquid phase area from top to bottom, a hollow rotating shaft is arranged in the center of the tank body, the top of the hollow rotating shaft is connected with a motor, a gas inlet mechanism is arranged in the hollow rotating shaft, gas inlet holes communicated with the gas phase area are formed in the upper portion of the side wall, and a gas distribution mechanism is arranged below the side wall. The gas distribution mechanism comprises a plurality of hollow and horizontally-arranged spiral blades which are communicated with the hollow rotating shaft in a sealed mode, the outer side wall is provided with a gas outlet pipe perpendicular to the normal of the outer side wall, and the gas outlet pipe is provided with a one-way nozzle. The device is compact in overall structure, small in occupied area and good in stirring effect, oxygen in a gas phase region can be dispersed into a liquid phase region, the gas distribution mechanism has gas distribution and stirring effects at the same time, the oxygen content and dispersion uniformity in a liquid phase are greatly improved, the reaction efficiency is improved, and the reaction time is shortened.

The invention belongs to the technical field of perampanel medicines, and particularly relates to a perampanel medicine composition and a preparation thereof. The perampanel pharmaceutical composition provided by the invention comprises perampanel, Tween 80, a flavoring agent, a plasticizer and a film forming material, the pharmaceutical preparation of the perampanel pharmaceutical composition is a perampanel oral soluble film, and the preparation method of the perampanel oral soluble film comprises the following steps: mixing perampanel, first Tween 80 and an ethanol aqueous solution, performing vacuum freeze drying, and crushing to obtain freeze-dried powder; heating the freeze-dried powder to 20-30 DEG C, performing vacuum freeze-drying, and crushing to obtain secondary freeze-dried powder; mixing second Tween 80 with water, adding the secondary freeze-dried powder, a flavoring agent, a plasticizer and a film-forming material, and stirring to obtain slurry; and carrying out vacuum defoaming on the slurry, then coating a base material with the slurry, and drying to obtain the perampanel oral soluble film. The oral soluble film provided by the invention has the advantages of excellent content uniformity and stability, high dissolution rate and good flexibility.

The invention relates to the technical field of medicine preparation, and discloses a rebamipide tablet and a preparation method and application thereof, the rebamipide tablet comprises 40-60 parts of rebamipide, 3-6 parts of polyethylene glycol, 20-30 parts of beta-cyclodextrin, 5-8 parts of an adhesive, 10-20 parts of a filler, 2-5 parts of a disintegrating agent, 0.1-1 part of a flow aid, and 1-3 parts of a lubricant. According to the rebamipide tablet, beta-cyclodextrin and PEG are combined for use, so that the electrostatic adsorption phenomenon of rebamipide is weakened, agglomeration among rebamipide molecules is prevented, the flowability of rebamipide particles is improved, and the prepared rebamipide tablet is higher in particle uniformity and faster and higher in dissolution rate. In the preparation method, the beta-cyclodextrin is firstly added, stirred and sheared, the PEG solution is sprayed, then the adhesive, the filler, the disintegrating agent and the glidant are added, and the lubricant is added, so that the preparation process is relatively smooth, the yield is increased, the content uniformity of the rebamipide tablet is improved, the tablet weight difference is reduced, the dissolution rate is accelerated, and the bitter taste of the rebamipide is covered.

The invention belongs to the field of medicines, and particularly discloses a dapagliflozin pharmaceutical composition, the pharmaceutical composition contains dapagliflozin, a stabilizer and at least one pharmaceutically acceptable excipient, and the weight ratio of dapagliflozin to the stabilizer is not less than 20000: 1. The invention also comprises preparation and application of the pharmaceutical composition. According to the dapagliflozin pharmaceutical composition disclosed by the invention, the dapagliflozin pharmaceutical composition has excellent stability.

The invention belongs to the technical field of pharmaceutical preparations, and relates to an oral solid pharmaceutical composition containing irbesartan and a preparation method thereof. Irbesartan particles are prepared by adopting a wet granulation process, levamlodipine besylate particles are prepared by adopting a dry granulation process, the irbesartan particles and the levamlodipine besylate particles are mixed, a filling agent adopted in the dry granulation process is microcrystalline cellulose, and the mass ratio of irbesartan to levamlodipine besylate is (150-300): (2-4). The content uniformity of the levamlodipine besylate can meet the standard, and the stability of the composition can be improved.

The invention belongs to the technical field of medicines, and particularly relates to high-stability vitamin D3 granules and a preparation method thereof. The preparation method of the vitamin D3 granules provided by the invention comprises the following steps: (1) mixing vitamin D3 and an oil-phase solvent to obtain an oil phase; (2) mixing an emulsifier, a film-forming agent, a thickening agent and water to obtain a water phase; (3) mixing, shearing and homogenizing the oil phase and the water phase to obtain a vitamin D3 emulsion, and (4) performing spray drying to obtain vitamin D3 particles; the viscosity of the vitamin D3 emulsion ranges from 350 mPa.s to 400.9 mPa.s; in the spray drying, the feeding speed of the vitamin D3 emulsion is 160 to 180 mL / h; the preparation method is simple and convenient, low in cost and easy for industrial production; the prepared vitamin D3 particles are uniform in particle size, good in content uniformity and controllable in specification.

The invention relates to the technical field of veterinary drug preparation production, and discloses a melatonin implant, the melatonin implant comprises an embedded core and a coating, the coating is sprayed on the surface layer of the embedded core, the embedded core comprises the following components by mass: 65-75% of melatonin, 8-12% of a carrier, 10-15% of a lubricant, and 7-9% of a first plasticizer; the coating comprises the following components: a film-forming agent, a second plasticizer and a solvent, the mass ratio of the film-forming agent to the second plasticizer is (1.5-2.5): 1, and the ratio of the mass of the film-forming agent to the volume of the solvent is (2.5-3.5): 100 (g / mL). The implant has large drug loading capacity and can be slowly released for a long time, and only 13% of the implant can be released in vitro for 28 days. The melatonin implant can be prepared by adopting a hot melt extrusion and coating method, and the preparation method has the advantages of simple process, continuous production, short and stable production period, less material loss, better drug content uniformity and high technical yield, and is beneficial to expanded production.

The invention relates to a preparation containing a heterocyclic compound or a compound formed by the heterocyclic compound and pharmaceutically acceptable salt as well as a preparation method and application of the preparation. The preparation comprises an active component and a pharmaceutically acceptable carrier, the content of the active component is 1 wt%-50 wt%; the active component is a compound as shown in a formula I-3B or a compound thereof; the compound of the compound as shown in the formula I-3B is a compound formed by the compound as shown in the formula I-3B and pharmaceutically acceptable acid. The application comprises the following steps: preparing a 15-PGDH inhibitor, and / or preparing a medicine, a pharmaceutical composition or a preparation for preventing and / or treating 15-PGDH related diseases. .

The invention belongs to the technical field of medicine preparation, and particularly relates to a huperzine A capsule and a preparation method thereof. The huperzine A capsule is prepared from the following components in parts by weight: 0.01 to 0.5 part of huperzine A, 40.0 to 99.0 parts of a filling agent, 0.4 to 4.5 parts of a flow aid and a wetting agent, the filling agent is prepared from an internally added filling agent and an externally added filling agent, the weight part of the flow aid is 10 to 14 percent of the weight part of the internally added filling agent, and the weight part of the wetting agent is 10 to 14 percent of the weight part of the externally added filling agent. Wherein the mesh number of the internally added filler is smaller than that of the externally added filler, and the wetting agent is an ethanol solution. According to the method disclosed by the invention, the filler is used for internal addition and external addition according to the mass ratio of 1: 3, so that the particles have good uniformity and flowability, and the stability of the huperzine-A capsule can be ensured to be better. The huperzine-A capsule prepared by the invention can be quickly dissolved out and released, and is uniform in quality and content.

The invention discloses a didrogesterone tablet as well as a preparation method and application thereof. The preparation method of the didrogesterone tablet comprises the following steps: S1, spraying an ethanol solution of didrogesterone into a diluent, and drying to obtain a powdery mixture A; s2, spraying an aqueous solution of an adhesive into the mixture A in the step S1, and granulating to obtain particles B; s3, the mixture C is tableted, and the mixture C comprises the particles B in the step S2. The didrogesterone tablet disclosed by the invention has excellent dissolution rate and content uniformity.

This invention relates to the field of oxygen humidification technology, specifically to a medical oxygen cylinder nebulizer humidification device, comprising a water tank with a removable sealing cap at the top and a removable mixing hood at the top of the sealing cap. The operation of a driving component drives a cleaning component, which in turn drives a linkage component, causing the linkage component to rotate. The linkage component's internal components drive a mixing component, which in turn drives the mixing component's internal components, causing them to rotate around the arc-shaped structure of the mixing hood and rotate on their own axis. This agitates the nebulized medication and oxygen inside the mixing hood, ensuring thorough mixing of the oxygen and medication. This improves the uniformity of the nebulized medication content in the oxygen, resulting in uniform oxygen humidity and reducing the possibility of uneven mixing when the nebulized medication is mixed with oxygen. This ensures consistent oxygen humidification delivered to the patient's respiratory tract, improving the therapeutic effect on the patient.

The invention provides a carbamazepine pharmaceutical composition as well as a preparation method and application thereof, and belongs to the field of medicine preparation. The carbamazepine pharmaceutical composition provided by the invention comprises carbamazepine, a filler, an adhesive, a disintegrating agent and a lubricant, wherein the filling agent comprises microcrystalline cellulose, the disintegrating agent comprises low-substituted hydroxy propyl cellulose and carbamazepine, and the mass ratio of the microcrystalline cellulose to the low-substituted hydroxy propyl cellulose is 1: (2.795-2.895): (0.18-0.28). According to the carbamazepine pharmaceutical composition, the content uniformity of the medicine can be improved, the dissolution rate of a self-developed preparation is consistent with that of a reference preparation under the condition that the same specification is guaranteed, it is guaranteed that tabletting is smooth in the production process, and the carbamazepine pharmaceutical composition has actual clinical application value.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a bepiridic acid quick-release preparation and a preparation method thereof. Compared with the prior art, the preparation method strictly controls the particle size of the bepiridic acid, greatly reduces the types of used auxiliary materials, does not need to add an organic solvent in the preparation process, and is safe and pollution-free; the preparation process belongs to a continuous process and has fewer process steps, so that the production time is shortened, continuous operation is realized, and the production cost is reduced; according to the present invention, with the preparation method, the particles can be uniformly dispersed, the extrudate content uniformity is good, the good in vitro dissolution uniformity is provided, the compressibility of the effective component is not required, the medication safety of the patient is substantially improved, the dissolution rate is improved, and the high bioavailability is provided.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a compound pharmaceutical preparation based on spray lactose and a preparation method thereof. The compound pharmaceutical preparation comprises the following components in parts by weight: active drug 10-15 parts, spray lactose 27-33 parts, mannitol 30-35 parts, modified microcrystalline cellulose 13-16 parts, disintegrating agent 3-5 parts, lubricant 1-2 parts, and flavoring agent 1-3 parts. The compound pharmaceutical preparation has the characteristics of high hardness, low friability, rapid disintegration, good content uniformity, excellent taste masking effect and good taste.

The invention provides everolimus micro-tablets as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The everolimus micro-tablet provided by the invention is prepared from the following components in percentage by mass: 0.1%-10% of everolimus, 0.02%-0.2% of an antioxidant, 9%-25% of a carrier, 10%-30% of a disintegrating agent, 0.1%-3% of a lubricating agent and the balance of a filling agent, the specification of the everolimus micro-tablets is that each tablet contains 0.005 to 2mg of everolimus; wherein the disintegrating agent is at least one of cross-linked povidone, cross-linked sodium carboxymethyl cellulose, corn starch, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, sodium alginate, bentonite and colloidal magnesium aluminum silicate; the carrier is selected from at least one of hydroxypropyl methylcellulose, povidone, hydroxypropyl cellulose and polyethylene glycol. The everolimus micro-tablet is good in dissolution performance and content uniformity, and fills the blank of related products and preparation methods.

This invention belongs to the field of pharmaceutical technology, specifically relating to a highly stable vitamin D3 granule and its preparation method. The preparation method of vitamin D3 granules provided by this invention includes: (1) mixing vitamin D3 and an oil phase solvent to obtain an oil phase; (2) mixing an emulsifier, a film-forming agent, a thickener, and water to obtain an aqueous phase; (3) mixing the oil phase and the aqueous phase, shearing, and homogenizing to obtain a vitamin D3 emulsion; and (4) spray drying to obtain vitamin D3 granules. The viscosity of the vitamin D3 emulsion is 350-400.9 mPa·s. In the spray drying, the feed rate of the vitamin D3 emulsion is 160-180 mL / h. This preparation method is simple, low in cost, and easy to industrialize. The obtained vitamin D3 granules have uniform particle size, good content uniformity, and controllable specifications.

Cobamamide capsule powder uniform mixing equipment based on electrostatic field driving is composed of a cylindrical shell and comprises an air inlet area, a feeding area, an airflow mixing area, a material collecting area and a vibration excitation assembly. The air inlet area is located at the bottom and provided with an air inlet pipe. The feeding area is positioned above the air inlet area and is provided with a plurality of feeding units; the airflow mixing area is located above the feeding area, the material collecting area is located above the airflow mixing area, and a spray pipe and a material collecting bottom plate are arranged at the bottom; the shock excitation assembly is located in the equipment and comprises a shock excitation net and a mixing frame, and the shock excitation net and the mixing frame are connected through a floating ring and a shock excitation connecting rod; the material collecting assembly is located in the material collecting area and comprises a material collecting frame and a scraper mechanism. The electric field driver is connected with the excitation frame and the collection frame and is respectively connected with a cathode and an anode; according to the scheme, double drive that large particles are greatly driven by airflow and small particles are greatly driven by an electric field is utilized, synchronous movement of the large particles and the small particles is guaranteed, uniform mixing of the large particles and the small particles is guaranteed, the content uniformity is improved, and RSD can be controlled to be 0.5% or below.

The high-temperature-resistant brake pad material is prepared from the following raw materials in parts by weight: 18 to 22 parts of boron modified phenolic resin, 10 to 15 parts of modified carbon fiber, 4 to 7 parts of aramid fiber, 9 to 13 parts of ferrotitanium powder, 10 to 15 parts of potassium magnesium titanate lamellar crystal, 3 to 5 parts of nitrile rubber powder, 4 to 6 parts of natural graphite, 3 to 5 parts of petroleum coke, 5 to 8 parts of barite and 3 to 5 parts of aluminum oxide. According to the high-temperature-resistant brake pad material, boron-modified phenolic resin serves as a base body, functional components such as modified carbon fibers, aramid fibers, ferrotitanium powder and potassium magnesium titanate lamellar crystals are matched, and through the reasonable formula design and the forming technology, on the basis that it is guaranteed that a brake pad has the excellent friction and wear performance, the high-temperature-resistant brake pad material is obtained; the thermal stability and the interface bonding strength of the material under the high-temperature working condition are remarkably improved, and the problems that a traditional brake pad material is prone to heat fading and interface stripping under the high-temperature braking condition are solved.

The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable adjuvant, wherein, the diameter of the micro tablet is 1 ~ 3mm, the ratio of diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor palatability of cholic acid drugs, improve medication compliance;It can realize the effect of consistent dissolution characteristics of different doses, ensure the stability of treatment effect under different doses;It can reduce the use of adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High bioavailability, can more effectively realize in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.

This invention discloses a perampanel oral suspension and its preparation method. The preparation method of this invention includes the following steps: S1, adding microcrystalline cellulose sodium carboxymethyl cellulose co-treatment material to water for homogenization to obtain a first dispersion; S2, adding sorbitol, an antibacterial agent, and a pH adjuster to the first dispersion to obtain a second dispersion; S3, pulverizing perampanel and sieving it to control the particle size D. 90 The sample size is 10–15 μm; S4, the perampanel obtained in step S3 is subjected to antistatic treatment; S5, the perampanel treated in step S4, defoamer, and polyoxyethylene hydrogenated castor oil are added to the second dispersion to obtain the third dispersion; S6, water is added to the third dispersion to bring it to a final volume, and homogenization is performed to obtain the perampanel oral suspension. This method can significantly improve the dissolution rate, long-term stability, and control level of drug-related substances at day 0, and improve the uniformity of content.

The invention relates to a dexmedetomidine hydrochloride oral soluble film, which is prepared from the following components in percentage by weight: 0.1 to 10 percent of dexmedetomidine hydrochloride and 90 to 99.9 percent of film forming material, the film forming material is selected from any one or a combination of copovidone, a polyvinyl caprolactam polyvinyl acetate polyethylene glycol grafted copolymer, hydroxypropyl methyl cellulose, hydroxy propyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol, polyoxyethylene, povidone and poloxamer. The dexmedetomidine hydrochloride oral soluble film has the advantages of fast disintegration time in the oral cavity, good mechanical extrusion performance, good film forming performance and high content uniformity, meets the requirements of cutting, packaging, transportation, clinical use and the like, significantly improves the dissolution rate, dissolution rate, stability and bioavailability, does not need to be taken with water, significantly improves the compliance of child patients, and has a good application prospect. The medication safety and effectiveness are ensured.

The invention discloses a preparation method and application of a polyester fiber fabric, the preparation method is combined with a polyester fiber padding process, an olefine acid-methyl acrylate prepolymer and a polyurethane coating adhesive are mixed to prepare an anti-condensation finishing liquid, the anti-condensation finishing liquid is impregnated with polyester fibers, and then the polyester fibers penetrate through the interior and the exterior of the polyester fibers to generate acrylic acid water-absorbent resin; the bonding strength of the acrylic water-absorbent resin and the polyester fiber is improved, and the content and distribution uniformity of the acrylic water-absorbent resin in the polyester fiber are improved; the acrylic acid water-absorbent resin can absorb moisture in the environment to form hydrogel, and the hydrogel saturated after water absorption has certain hydrostatic pressure resistance and does not continuously absorb water, so that the effect of preventing water through water (gel) is achieved, the problem that a traditional outdoor tent fabric is prone to moisture condensation in the low-temperature and high-humidity environment is effectively solved, the comfort of a user is improved, and the outdoor tent fabric is worthy of popularization and application. When the weather is clear, the hydrogel releases water, the pores are opened again, and the dynamic balance of waterproofness and ventilation is realized.

The invention relates to the technical field of photolithography auxiliary chemicals, and discloses a dual-color photolithography bottom anti-reflection coating, which is prepared from the following organic coating solution, wherein the organic coating solution includes at least one film-forming substance containing a dual-color ultraviolet absorbing dye structure, an auxiliary agent and an organic solvent; the dual-color ultraviolet absorbing dye structure is as shown in formula (I); the dual-color photolithography bottom anti-reflection coating has strong absorption of electromagnetic waves with wavelengths of 193nm and 248nm. The invention uses a film-forming substance containing the dual-color ultraviolet absorbing dye structure in a molecular structure, an auxiliary agent and a solvent to form an organic coating solution, and solidifies it through a spin coating process and a hot plate baking process, so that it has strong absorption of electromagnetic waves with wavelengths of 193nm and 248nm, which is manifested as the imaginary part k of the complex refractive index at the two wavelengths reaching more than 0.2, and is suitable for ArF and KrF excimer laser lithography.

The present invention provides a bromhexine hydrochloride direct-take granules and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The bromhexine hydrochloride direct-take granules include the following components by weight percentage: the following components by weight percentage: bromhexine hydrochloride 1.3-2.0%; filler 90-95%; disintegrant 2-3%; binder 0.3-0.7%; coating agent 3-4.5%; bulk drug particle size D90 <50 μm; the mass ratio of the disintegrant and the binder is 4-10:1. The present invention provides a bromhexine hydrochloride direct-take granules through a specific raw material ratio and process, which is convenient for patients with difficulty in taking medicine. At the same time, the bromhexine hydrochloride direct-take granules provided by the present invention also have the advantages of high powder quality, good dissolution performance, high content of active ingredients and content uniformity, and good particle stability.

The present invention relates to the technical field of TMBP preparation, and in particular to a TMBP reaction device and a synthesis method thereof. The reaction device comprises a sealed tank body, a heating mechanism is arranged inside the tank body, and the tank body is divided into a gas phase area and a liquid phase area from top to bottom. A hollow rotating shaft is arranged at the center of the tank body, a motor is connected to the top of the hollow rotating shaft, an air intake mechanism is arranged inside, an air intake hole connected to the gas phase area is arranged above the side wall, a gas distribution mechanism is arranged below the side wall, and the gas distribution mechanism comprises a plurality of hollow and horizontally arranged spiral blades, the spiral blades are sealed and connected to the hollow rotating shaft, an outer side wall is provided with an outlet pipe perpendicular to its normal, and a one-way nozzle is arranged on the outlet pipe. The overall structure of the present invention is compact, the footprint is small, the stirring effect is good, the oxygen in the gas phase area can be dispersed into the liquid phase area, the gas distribution mechanism has both gas distribution and stirring effects, greatly improves the oxygen content and dispersion uniformity in the liquid phase, improves the reaction efficiency, and shortens the reaction time.

The invention provides a tablet containing lutrombopag and a preparation method thereof, lutrombopag and magnesium oxide are dispersed in hydroxypropyl cellulose and lauryl sodium sulfate, high-pressure homogeneous dispersion is carried out, a uniformly dispersed lutrombopag suspension can be prepared, then the high-pressure homogeneous suspension is used as an adhesive, and the tablet containing lutrombopag and magnesium oxide is prepared. The preparation method comprises the following steps: mixing the raw materials, adding the mixture into a one-step granulator containing a diluent and a disintegrating agent in a top spray granulation manner, adding a lubricant into the prepared granules, uniformly mixing, tabletting, and coating to obtain the tablet containing the lutrombopag. The whole preparation method disclosed by the invention is simple to operate, the production efficiency is improved, the content uniformity of the product is improved, and the problem of slow dissolution of the lutrombopag is solved.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a desloratadine orally dissolving film and a preparation method thereof. The desloratadine orally dissolving film comprises the following components: desloratadine, a film-forming material being polyvinyl alcohol, and a flavoring agent being stevioside. The desloratadine orally dissolving film prepared by using the prescription composition and the preparation process has higher stability of the preparation, better taste, good film-forming property, smaller size, can be quickly disintegrated and dissolved, has good content uniformity, and has good appearance and other advantages.

The present application relates to the field of drug crystal forms, in particular to a new crystal form of a compound of formula 1 and a preparation method thereof. The new crystal form of the compound of formula 1 of the present application has excellent physical stability and chemical stability, high solubility and bioavailability, good flowability and low hygroscopicity. In addition, the new crystal form of the compound of formula 1 of the present application has mild preparation conditions, simple operation, good process reproducibility, high purity and is suitable for industrial production.