9results about How to "Good content uniformity" patented technology

The invention relates to a preparation containing a heterocyclic compound or a compound formed by the heterocyclic compound and pharmaceutically acceptable salt as well as a preparation method and application of the preparation. The preparation comprises an active component and a pharmaceutically acceptable carrier, the content of the active component is 1 wt%-50 wt%; the active component is a compound as shown in a formula I-3B or a compound thereof; the compound of the compound as shown in the formula I-3B is a compound formed by the compound as shown in the formula I-3B and pharmaceutically acceptable acid. The application comprises the following steps: preparing a 15-PGDH inhibitor, and / or preparing a medicine, a pharmaceutical composition or a preparation for preventing and / or treating 15-PGDH related diseases. .

This invention relates to the field of oxygen humidification technology, specifically to a medical oxygen cylinder nebulizer humidification device, comprising a water tank with a removable sealing cap at the top and a removable mixing hood at the top of the sealing cap. The operation of a driving component drives a cleaning component, which in turn drives a linkage component, causing the linkage component to rotate. The linkage component's internal components drive a mixing component, which in turn drives the mixing component's internal components, causing them to rotate around the arc-shaped structure of the mixing hood and rotate on their own axis. This agitates the nebulized medication and oxygen inside the mixing hood, ensuring thorough mixing of the oxygen and medication. This improves the uniformity of the nebulized medication content in the oxygen, resulting in uniform oxygen humidity and reducing the possibility of uneven mixing when the nebulized medication is mixed with oxygen. This ensures consistent oxygen humidification delivered to the patient's respiratory tract, improving the therapeutic effect on the patient.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a compound pharmaceutical preparation based on spray lactose and a preparation method thereof. The compound pharmaceutical preparation comprises the following components in parts by weight: active drug 10-15 parts, spray lactose 27-33 parts, mannitol 30-35 parts, modified microcrystalline cellulose 13-16 parts, disintegrating agent 3-5 parts, lubricant 1-2 parts, and flavoring agent 1-3 parts. The compound pharmaceutical preparation has the characteristics of high hardness, low friability, rapid disintegration, good content uniformity, excellent taste masking effect and good taste.

This invention belongs to the field of pharmaceutical technology, specifically relating to a highly stable vitamin D3 granule and its preparation method. The preparation method of vitamin D3 granules provided by this invention includes: (1) mixing vitamin D3 and an oil phase solvent to obtain an oil phase; (2) mixing an emulsifier, a film-forming agent, a thickener, and water to obtain an aqueous phase; (3) mixing the oil phase and the aqueous phase, shearing, and homogenizing to obtain a vitamin D3 emulsion; and (4) spray drying to obtain vitamin D3 granules. The viscosity of the vitamin D3 emulsion is 350-400.9 mPa·s. In the spray drying, the feed rate of the vitamin D3 emulsion is 160-180 mL / h. This preparation method is simple, low in cost, and easy to industrialize. The obtained vitamin D3 granules have uniform particle size, good content uniformity, and controllable specifications.

The high-temperature-resistant brake pad material is prepared from the following raw materials in parts by weight: 18 to 22 parts of boron modified phenolic resin, 10 to 15 parts of modified carbon fiber, 4 to 7 parts of aramid fiber, 9 to 13 parts of ferrotitanium powder, 10 to 15 parts of potassium magnesium titanate lamellar crystal, 3 to 5 parts of nitrile rubber powder, 4 to 6 parts of natural graphite, 3 to 5 parts of petroleum coke, 5 to 8 parts of barite and 3 to 5 parts of aluminum oxide. According to the high-temperature-resistant brake pad material, boron-modified phenolic resin serves as a base body, functional components such as modified carbon fibers, aramid fibers, ferrotitanium powder and potassium magnesium titanate lamellar crystals are matched, and through the reasonable formula design and the forming technology, on the basis that it is guaranteed that a brake pad has the excellent friction and wear performance, the high-temperature-resistant brake pad material is obtained; the thermal stability and the interface bonding strength of the material under the high-temperature working condition are remarkably improved, and the problems that a traditional brake pad material is prone to heat fading and interface stripping under the high-temperature braking condition are solved.

The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable adjuvant, wherein, the diameter of the micro tablet is 1 ~ 3mm, the ratio of diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor palatability of cholic acid drugs, improve medication compliance;It can realize the effect of consistent dissolution characteristics of different doses, ensure the stability of treatment effect under different doses;It can reduce the use of adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High bioavailability, can more effectively realize in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.

This invention discloses a perampanel oral suspension and its preparation method. The preparation method of this invention includes the following steps: S1, adding microcrystalline cellulose sodium carboxymethyl cellulose co-treatment material to water for homogenization to obtain a first dispersion; S2, adding sorbitol, an antibacterial agent, and a pH adjuster to the first dispersion to obtain a second dispersion; S3, pulverizing perampanel and sieving it to control the particle size D. 90 The sample size is 10–15 μm; S4, the perampanel obtained in step S3 is subjected to antistatic treatment; S5, the perampanel treated in step S4, defoamer, and polyoxyethylene hydrogenated castor oil are added to the second dispersion to obtain the third dispersion; S6, water is added to the third dispersion to bring it to a final volume, and homogenization is performed to obtain the perampanel oral suspension. This method can significantly improve the dissolution rate, long-term stability, and control level of drug-related substances at day 0, and improve the uniformity of content.

The invention discloses a preparation method and application of a polyester fiber fabric, the preparation method is combined with a polyester fiber padding process, an olefine acid-methyl acrylate prepolymer and a polyurethane coating adhesive are mixed to prepare an anti-condensation finishing liquid, the anti-condensation finishing liquid is impregnated with polyester fibers, and then the polyester fibers penetrate through the interior and the exterior of the polyester fibers to generate acrylic acid water-absorbent resin; the bonding strength of the acrylic water-absorbent resin and the polyester fiber is improved, and the content and distribution uniformity of the acrylic water-absorbent resin in the polyester fiber are improved; the acrylic acid water-absorbent resin can absorb moisture in the environment to form hydrogel, and the hydrogel saturated after water absorption has certain hydrostatic pressure resistance and does not continuously absorb water, so that the effect of preventing water through water (gel) is achieved, the problem that a traditional outdoor tent fabric is prone to moisture condensation in the low-temperature and high-humidity environment is effectively solved, the comfort of a user is improved, and the outdoor tent fabric is worthy of popularization and application. When the weather is clear, the hydrogel releases water, the pores are opened again, and the dynamic balance of waterproofness and ventilation is realized.

The present application relates to the field of drug crystal forms, in particular to a new crystal form of a compound of formula 1 and a preparation method thereof. The new crystal form of the compound of formula 1 of the present application has excellent physical stability and chemical stability, high solubility and bioavailability, good flowability and low hygroscopicity. In addition, the new crystal form of the compound of formula 1 of the present application has mild preparation conditions, simple operation, good process reproducibility, high purity and is suitable for industrial production.