Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hydrochloric acid cefetamet pivoxil dispersible tablet and method for preparing the same

A technology of ceftazidime hydrochloride and dispersible tablets, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. particles, etc.

Active Publication Date: 2008-07-16
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD +1
View PDF3 Cites 19 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But, because the viscosity of ceftazidime pivoxil hydrochloride raw material is too strong, and chemical performance is unstable under high temperature and high humidity conditions
Based on this point, the prior art generally believes that the wet granulation process is not only difficult to make granules, but also the active ingredients contained are easily degraded during the granulation and drying process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] prescription:

[0070] Ceftazidime Pixil Hydrochloride 125g

[0071] Starch 25g

[0072] Microcrystalline Cellulose 50g

[0073] Hypromellose 50g

[0074] Acesulfame honey amount

[0075] Proper amount of ethanol

[0076] Carboxymethyl Starch Sodium 25g

[0077] Magnesium Stearate Appropriate amount

[0078]

[0079] Makes 1000 pieces

[0080] Preparation Process:

[0081] 1) Prepare materials

[0082] Ceftazidime hydrochloride was pulverized, passed through a 100-mesh sieve, starch, microcrystalline cellulose, hydroxypropyl cellulose, acesulfame potassium and carboxymethyl starch sodium were respectively pulverized, and passed through a 120-mesh sieve to obtain spare raw materials and auxiliary materials;

[0083] 2) Humidification granules

[0084] Weigh the above-mentioned spare ceftazidime hydrochloride, starch, microcrystalline cellulose, acesulfame potassium and hyprolose in the prescribed amount, put them into a high-s...

Embodiment 2

[0090] prescription:

[0091] Ceftazidime Pixil Hydrochloride 125g

[0092] Starch 40g

[0093] Hypromellose 10g

[0094] Microcrystalline Cellulose 100g

[0095] Acesulfame honey amount

[0096] 95% ethanol appropriate amount

[0097] Carboxymethyl Starch Sodium 5g

[0098] Magnesium Stearate Appropriate amount

[0099]

[0100] Makes 1000 pieces

[0101] Preparation Process:

[0102] 1) Prepare materials

[0103] Ceftazidime hydrochloride was pulverized, passed through a 100-mesh sieve, starch, microcrystalline cellulose, hydroxypropyl cellulose, acesulfame potassium and carboxymethyl starch sodium were respectively pulverized, and passed through a 120-mesh sieve to obtain spare raw materials and auxiliary materials;

[0104] 2) Humidification granules

[0105] Weigh the above-mentioned spare ceftazidime hydrochloride, starch, microcrystalline cellulose, acesulfame potassium and hyprolose in the prescribed amount, put them i...

Embodiment 3

[0111] prescription:

[0112] Ceftazidime Pixil Hydrochloride 125g

[0113] Starch 25g

[0114] Microcrystalline Cellulose 50g

[0115] Hypromellose 50g

[0116] Acesulfame honey amount

[0117] Proper amount of ethanol

[0118] Carboxymethyl Starch Sodium 15g

[0119] Magnesium Stearate Appropriate amount

[0120]

[0121] Makes 1000 pieces

[0122] Preparation Process:

[0123] 1) Prepare materials

[0124] Ceftazidime hydrochloride was pulverized, passed through a 100-mesh sieve, starch, microcrystalline cellulose, hydroxypropyl cellulose, acesulfame potassium and carboxymethyl starch sodium were respectively pulverized, and passed through a 120-mesh sieve to obtain spare raw materials and auxiliary materials;

[0125] 2) Humidification granules

[0126] Weigh the above-mentioned standby ceftazidime hydrochloride, starch, microcrystalline cellulose, acesulfame potassium and hyprolose in the prescribed amount, put them into a high-spee...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a cefetamet pivoxil hydrochloride tablet and a preparation method thereof. On the premise of specific active ingredients of the cefetamet pivoxil hydrochloride, the invention takes into account the varieties and dosages of disintegrating agents and joint usage thereof, suitable components and ratios of bonding agents and other filling agents, and the micronization treatment of the raw and auxiliary materials and selection of corresponding optimized process conditions. Experiment results indicate that compared with the prior art, the product of the invention has quick disintegration and dissolution and stable quality.

Description

technical field [0001] The invention relates to a ceftazidime hydrochloride dispersible tablet and a preparation method of the dispersible tablet. Background technique [0002] In the prior art, β-lactam antibiotics are the most clinically used antibiotics, the most widely used, the most varieties, the best curative effect and the highest evaluation. Among them, cephalosporin series products account for about 70%. Among cephalosporins, ceftazidime pivoxil hydrochloride is an oral third-generation broad-spectrum cephalosporin antibiotic, which has the characteristics of broad-spectrum, high efficiency, enzyme resistance, and low toxicity. Compared with similar varieties of cephalexin and cephradine, it has antibacterial With the advantages of stronger activity and smaller dose, it overcomes the shortcomings of Pioneer series products that are unstable to β-lactamase, and is an ideal substitute for cephalexin and cephradine. [0003] On the market, ceftazidime pivoxil prepara...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/546A61K47/38A61P31/04
Inventor 刘保起李明华冯长运
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com