27results about How to "Good dissolution effect" patented technology

The invention relates to the technical field of cement clinker preparation, and particularly discloses a calcium sulphosilicate mineral clinker with high carbonization activity, a raw material and a preparation method and a hardening method of the calcium sulphosilicate mineral clinker. The clinker is prepared from the following mineral phases: 87.2 to 95.1 percent of calcium sulphosilicate, 2.6 to 9.5 percent of dicalcium silicate and the balance of unreacted raw materials, inevitable impurities and the like. Part of calcium elements in crystal lattices of the calcium sulphosilicate are replaced by at least one of lithium elements, sodium elements, potassium elements and strontium elements. The hardening method comprises the following steps: mixing the calcium sulphosilicate mineral clinker with water, and curing in a carbon dioxide environment to obtain the calcium sulphosilicate mineral hardened body. The mineral clinker disclosed by the invention has excellent carbonization activity, so that the mineral clinker can react with carbon dioxide to obtain high strength, high carbon sequestration is realized, carbon emission is reduced, and the mineral clinker has excellent mechanical properties.

The invention relates to the technical field of medicine preparation processes, discloses a preparation process of inositol nicotinate tablets, and aims to improve uniform distribution and particle stability of medicine components. The process comprises the following steps: premixing a filling agent and a disintegrating agent to form a first auxiliary material mixture; mixing inositol nicotinate with a first auxiliary material, and screening to obtain a second raw material mixture; dry inositol nicotinate particles are obtained through wet granulation and staged drying; optimizing a particle screening process by adopting an airflow screening model to obtain target particles; and finally, mixing with a lubricant and pressing into tablets. Through application of the airflow screening model and segmented temperature control drying based on the dissolution rate, the uniformity, the dissolution performance and the production efficiency of the product are remarkably improved.

The invention relates to the technical field of oral solid preparations, in particular to a high-bioavailability coenzyme Q10 tablet and a preparation method thereof. The coenzyme Q10 tablet comprises an active component coenzyme Q10, a filler, an adhesive, a disintegrating agent, a lubricant and a high polymer material, compared with the prior art, hydroxyethyl methylcellulose and hydroxypropyl methylcellulose succinate are mixed according to a certain mass ratio to serve as a high polymer carrier material, the prepared coenzyme Q10 tablet can be rapidly dissolved out in vitro, and the coenzyme Q10 tablet has the advantages that the preparation process is simple, and the cost is low. Moreover, the stability of the medicine can be improved, the medicine can be rapidly absorbed in vivo after being orally taken, the oral bioavailability of the coenzyme Q10 is greatly improved, and a preparation process of the preparation is simple to operate, good in reproducibility and suitable for industrial production.

The invention relates to the technical field of medicine preparation, and particularly discloses a preparation method and application of a xantinol nicotinate pharmaceutical composition, and the preparation method comprises the following steps: step S1, preparing the following raw materials in parts by weight: 6.2-7.6 parts of xantinol nicotinate, 86-98 parts of purified water, 16-22 parts of a filler, 64-76 parts of a coating solution, 14-20 parts of a flavoring agent, 42-54 parts of a modified disintegrating solution and 2-4 parts of a lubricant; step S2, preparing the xantinol nicotinate pharmaceutical composition; the coating liquid and the modified disintegrating liquid are added, active functional groups contained in the coating liquid can form hydrogen-bond interaction with the active ingredients of the medicine, flexible long-chain alkane on the coating liquid can be entangled with alkyl chains on the modified disintegrating agent, the modified disintegrating agent not only contains a cellulose nanocrystal structure, but also contains a carboxymethyl structure, so that the cellulose nanocrystal-modified disintegrating agent has the advantages that the cellulose nanocrystal-modified disintegrating agent can be applied to the preparation of the medicine; through the combined action of the structures, the coating property, the disintegration property and the slow release property of the xantinol nicotinate pharmaceutical composition are improved.

The invention discloses skin antibacterial powder and a preparation method thereof, and relates to the technical field of skin antibacterial products. Comprising the following components in parts by weight: 1-3 parts of chlorhexidine acetate nanocrystals, 5-8 parts of radix sophorae flavescentis powder, 6-10 parts of cortex phellodendri powder, 3-6 parts of cortex dictamni powder, 2-4 parts of sail powder, 1-3 parts of tea polyphenol / chitosan nanoparticles, 15-25 parts of other Chinese herbal medicine extracts, 0.8-1.5 parts of borneol powder and 0.6-1 part of plant polysaccharide. The skin antibacterial powder is good in antibacterial activity, good in antibacterial durability, low in toxic and side effects and remarkable in wound repairing effect.

The invention belongs to the technical field of medicines, and relates to a berberine tannate oral preparation and a preparation method thereof. The oral preparation comprises berberine tannate, a filling agent, a disintegrating agent, an adhesive and a wetting agent, the filling agent is pregelatinized starch, microcrystalline cellulose and colloidal silicon dioxide; the disintegrating agent is one or more of sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone. The auxiliary materials of the berberine tannate oral preparation cooperate with one another, so that the flowability and compressibility of the powder are effectively improved, and the obtained final preparation product is excellent in stability and dissolution property and high in bioavailability; in addition, the oral preparation is simple in preparation process and suitable for large-scale production.

The present application belongs to the technical field of white carbon black preparation, and particularly relates to an industrialized preparation method for preparing high-purity low-fluorine white carbon black by taking fluorine-containing silicon slag as raw material, and through mechanical activation, composite alkali leaching, fractional impurity removal, low-temperature crystallization and surface modification. The present application can realize harmless disposal of the fluorine-containing silicon slag and high-value regeneration and utilization of fluorine and silicon resources, has good environmental protection value and economic benefits, and has wide industrialized application prospect.

The invention discloses a tabletting condiment and a preparation method thereof, and belongs to the technical field of condiments. The tableting seasoning is prepared from the following raw materials in parts by weight: 15-40 parts of cumin, 10-30 parts of star anise, 5-20 parts of cinnamon, 5-20 parts of Chinese prickly ash, 1-5 parts of cinnamon, 1-5 parts of horseradish, 1-5 parts of liquorice, 1-5 parts of sago, 0.5-1 part of eggplant powder and 0-1 part of nanocrystalline cellulose. The seasoning is in a sheet shape, the problem that the adding amount is inconvenient to control during use can be solved, and meanwhile, the tableting seasoning is easy to form during tableting, the quality guarantee period of a finished product is long, the dissolution speed is high, and the dissolution effect is good.

The invention relates to the technical field of pharmaceutical preparations, discloses a preparation method of pediatric paracetamol and amantadine hydrochloride granules, and aims to improve the stability and uniformity of medicines. The method comprises the following steps: preparing an adhesive, preparing a pre-mixture, carrying out wet granulation, drying wet granules, and finally finishing the granules. Through a multi-stage premixing and optimized wet granulation process, the uniform distribution of medicine components is ensured; segmental temperature control based on dissolution rate is adopted in the drying process, so that the drying time is effectively shortened, and particle surface hardening is prevented; according to the method, the dissolution performance and bioavailability of the medicine are improved, and the production efficiency and the stability of the product quality are remarkably improved.

The invention relates to the technical field of medicine preparation, in particular to a baltefibrate oral-soluble film agent and a preparation method thereof, and the baltefibrate oral-soluble film agent can achieve ideal dissolution speed and bioavailability equivalent to tablets in an oral cavity by controlling particle size distribution of raw material medicines in the baltefibrate oral-soluble film agent and dissolving baltefibrate through polyvinylpyrrolidone aqueous dispersion. According to the invention, the characteristic of good dissolution effect can be realized without additionally adding a pH regulator, and rapid disintegration and dissolution can be realized without additionally adding water in the oral cavity. The preparation method of the Pengfibrate oral soluble film is simple and easy to operate, and is suitable for modern industrial mass production, required production equipment is conventional equipment, the cost is saved, and the production possibility is improved.

The present invention relates to the technical field of cement clinker preparation, and specifically discloses a calcium sulfosilicate mineral clinker with high carbonization activity, raw material, and a preparation method and hardening method thereof. The clinker includes the following mineral phases: 87.2-95.1% of calcium sulfosilicate, 2.6-9.5% of dicalcium silicate, and the remainder includes unreacted raw materials, inevitable impurities, etc. Part of the calcium element in the crystal lattice of the calcium sulfosilicate is replaced by at least one of lithium, sodium, potassium, and strontium. The hardening method includes: mixing the calcium sulfosilicate mineral clinker with water and placing it in a carbon dioxide environment for curing, and after completion, a calcium sulfosilicate mineral hardened body is obtained. The above-mentioned mineral clinker of the present invention has excellent carbonization activity, so that it can react with carbon dioxide to obtain high strength, which not only achieves high carbon fixation and reduces carbon emissions, but also has excellent mechanical properties.

The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic as well as a preparation method and application thereof, and belongs to the technical field of pesticide preparation. The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic which is formed by combining 3, 5-dihydroxy-4'-pentylbiphenyl and betaine through an intermolecular hydrogen bond, and a preparation method of the 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic. According to the 3, 5-dihydroxyl-4 '-pentylbiphenyl-betaine eutectic and the preparation method thereof, the eutectic is formed by BP and BET, the solubility and the dissolution rate of BP are improved, the application amount of pesticide molecules is reduced, and the 3, 5-dihydroxyl-4'-pentylbiphenyl-betaine eutectic is applied to various plant pathogenic fungi. Results of the embodiment show that the co-crystals formed by BP and BET are combined through hydrogen bonds in a molar ratio of 1: 1, the dissolution effect of the co-crystals is superior to that of the medicine, and the dissolution effect is not affected by the pH environment. Compared with drugs with the same concentration and the drug eutecticum, the drug eutecticum shows the antibacterial activity advantage superior to that of original drug molecules.

The invention discloses a pharmaceutical composition containing a heterocyclic compound. The pharmaceutical composition comprises the following components: (a) a compound of formula (I); and (b) hydroxypropyl methylcellulose acetate succinate or copovidone; wherein the component (a) and the component (b) are mixed and subjected to hot melt extrusion, and the weight ratio of the component (b) to the component (a) is 0.4-0.8. The pharmaceutical composition disclosed by the invention can be stably stored for a long time under the conditions of room temperature and relatively high relative humidity, and has a remarkable and better dissolution effect. # imgabs0 #

The invention belongs to the technical field of medicines, and relates to a riociguat solid dispersion composition, a riociguat sustained-release composition and a preparation method and application thereof. The riociguat solid dispersion composition is prepared from riociguat and a carrier material, the carrier material is selected from one or more of copovidone, a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol grafted copolymer, hydroxypropyl methylcellulose acetate succinate, polyethylene glycol and hydroxy propyl cellulose. The riociguat is prepared into a solid dispersion form, the solubility of the raw material medicine can be remarkably improved, the dissolution end point is improved, meanwhile, the absorption of the raw material medicine in a body is improved, and the riociguat solid dispersion has a very good slow-release effect and is more suitable for treating pulmonary arterial hypertension.

The application provides a preparation method of lipoic acid enteric-soluble capsules and relates to the technical field of medicines.The raw materials of the capsule include lipoic acid, and the preparation steps are as follows: lipoic acid is mixed with a disintegrating agent and stirred, a wetting agent is added for granulation, the granulation is discharged to obtain wet granules; the obtained wet granules are dried, sieved and coated to obtain coated granules, the coating liquid includes a binder, an opacifier and a plasticizer; the coated granules are filled with a lubricant into capsules to prepare lipoic acid capsules.The bulk density of the prepared lipoic acid coated granules can reach 0.5-0.7g / mL, which can meet the filling requirements of large-size capsules (such as 600mg capsules), and the lipoic acid coated granules have excellent dissolution performance and high stability.

The invention relates to the technical field of sludge floc treatment, and discloses an urban domestic sludge floc structure high-pressure shearing treatment method which comprises the following steps: communicating a treatment box body provided with a mechanical device for generating high pressure with a sludge conveying pipeline; the sludge conveying pipeline is used for conveying sludge into the treatment box body; a mechanical device is started, so that alternating pressure of 0-16 MPa is generated in the treatment box body, and mechanical treatment of repeatedly applying high pressure to the sludge and instantly releasing the pressure is performed; a plurality of groups of slit structures are mounted in the sludge conveying pipeline, and the sludge is conveyed into the plurality of groups of slit structures by alternating pressure to be subjected to multi-stage reciprocating extrusion, cutting and friction; and the sludge conveying pipeline is used for conveying the treated sludge into the filter pressing dehydrator for dehydration treatment. After the steps are adopted, the method has the following advantages that separation of most of cell water and urban domestic sludge flocs is improved, preparation is made for subsequent deep dehydration of the urban domestic sludge, and the purpose of improving the dehydration efficiency of the urban domestic sludge is achieved.

The invention relates to the technical field of metformin hydrochloride tablet preparation, and discloses a metformin hydrochloride tablet and a preparation method thereof.The preparation method of the metformin hydrochloride tablet comprises the following specific steps of raw material preparation, auxiliary material selection, preparation, granulation, tabletting and quality detection. According to the metformin hydrochloride tablet and the preparation method thereof, the metformin hydrochloride raw material and the auxiliary materials are mixed in three times, and the results of the second time mixing and the third time mixing are evaluated, so that the mixing effect is effectively improved; according to the metformin hydrochloride tablet and the preparation method thereof, the metformin hydrochloride raw material and the auxiliary material are sieved to ensure that the particle size of the metformin hydrochloride raw material is close to that of the auxiliary material, so that the metformin hydrochloride raw material and the auxiliary material can be mixed more uniformly; therefore, the dissolution rate is improved in an auxiliary manner.

The invention relates to the technical field of polysaccharide extraction, and discloses a composite ionic liquid and its application, wherein the composite ionic liquid is a mixture of trimethylamine hydrochloride and 1-ethyl-3-methylimidazolium acetate; the mass ratio of the trimethylamine hydrochloride and the 1-ethyl-3-methylimidazolium acetate is 1-1.5:2-3.5. The composite ionic liquid is used to extract polyporus polysaccharide. The invention uses the composite ionic liquid trimethylamine hydrochloride and 1-ethyl-3-methylimidazolium acetate to extract polyporus polysaccharide for the first time, and the extraction rate is 11.94%±0.36%, reaching 11.6-12.3mg / 100mg, which is 3-4 times the extraction rate of polyporus polysaccharide by the traditional water extraction method.

The present invention relates to the field of biopharmaceutical technology, and specifically discloses a Grifola frondosa polysaccharide-protein complex with anti-tumor activity. The present invention also discloses a method for preparing the Grifola frondosa polysaccharide-protein complex with anti-tumor activity, including: extracting Grifola frondosa fruiting bodies by wet grinding, combining extracts, ultraviolet treatment for 1-2 minutes under stirring, the ultraviolet power is 13-17w, concentrating, and vacuum drying to obtain a crude product; purifying the crude product to obtain a purified material; adding dopamine hydrochloride and 2,2,6,6-tetramethylpiperidinoxide to an ethanol aqueous solution and stirring, adding 1,3,5-trimethylbenzene and continuing to stir, centrifuging, drying, washing, drying, and then mixing with the purified material and polyethylene glycol 400 and adding to chloroform, ultrasonication at room temperature, adding hydrogenated soybean lecithin, lecithin, and cholesterol to mix, rotary evaporation, adding phosphate buffer to hydrate, ultrasonication, and whole grains.

This application discloses a telmisartan-amlodipine bilayer tablet. The telmisartan layer comprises telmisartan, an alkaline reagent, a binder, a filler, and a lubricant; the amlodipine layer comprises amlodipine besylate, a diluent, a disintegrant, a flow aid, a colorant, and a lubricant. The binder for the telmisartan layer is povidone, with a weight-average molecular weight of 3000–6000 kDa. The diluent for the amlodipine layer is microcrystalline cellulose, specifically a blend of two types. The weight ratio of microcrystalline cellulose PH-102 to PH-302 is 1–4:1–4. The povidone is one or both of povidone K-25 and K-29 / 32. The telmisartan-amlodipine bilayer tablet provided in this application exhibits high stability and dissolution performance similar to the reference tablet.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an oral rapidly disintegrating tablet composition containing a sustained-release pellet core, a preparation method and a method for effectively improving the hardness of tablets. The invention provides a method for improving the hardness of tablets, which comprises the following steps of: granulating and tabletting raw materials containing maltose and / or maltitol in an environment with the humidity of 40-70%, and placing in an environment with the relative humidity of below 10% for 12-96 hours. According to the method, the hardness of the tablet containing one or more functional coating layers can be improved under the condition of low-pressure tabletting through a simple environment control means, and the functional coating layers are not damaged. The method can be achieved only by controlling the environment humidity in the production process, redundant operation steps are reduced, and the production efficiency is improved. The invention further provides a tamsulosin hydrochloride orally disintegrating sustained-release tablet and a preparation method thereof. The tamsulosin hydrochloride orally disintegrating sustained-release tablet is simple to prepare, the process is stable and controllable, and the hardness can be well improved.

The invention discloses lacosamide granules and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The lacosamide particles comprise 8 to 12 weight percent of lacosamide, the bulk density of the lacosamide particles is 0.45 to 0.55 g / ml, and the tap density of the lacosamide particles is 0.55 to 0.65 g / ml. The lacosamide particles can maintain good hardness and compressibility, prevent the particles from being broken to generate more powder, and solve the problems that in the prior art, due to poor fluidity of lacosamide, when the lacosamide is used for preparing granules with other auxiliary materials, the particles are poor in compressibility, low in hardness and easy to break, and more powder is generated. In addition, within the control range of the bulk density and the tap density, the lacosamide particles have better dissolution property.

The invention discloses a preparation method of sutacillin, and belongs to the technical field of biological medicines. The preparation method of the sutacillin comprises the following steps: (1) weighing sutacillin tosilate, adding the sutacillin tosilate into an organic solvent for dissolving, cooling and stirring, dropwise adding an alkali solution, stirring until a system is dissolved, separating liquid, taking an organic phase, adding a dehydrating agent for drying, and filtering to obtain filtrate; and (2) adding a seed crystal into the filtrate obtained in the step (1), carrying out primary vacuum concentration, cooling, stirring and crystallizing, carrying out secondary vacuum concentration, adding an organic solvent when the filtrate is concentrated until no obvious fraction exists, and carrying out gradient cooling and crystal growing, filtering, pumping and vacuum drying to obtain the sutacillin. The sultacillin bulk drug prepared by the method is high in yield, high in purity and stable in chemical property. Moreover, according to the preparation method of the sutacillin, generation of related impurities possibly caused in the crushing process is avoided, the production cost is saved, the production efficiency is high, the particle size of the sutacillin raw material medicine can be effectively controlled, and the dissolution effect is good when the sutacillin raw material medicine is prepared into an oral preparation.

The invention provides a flufenidone capsule preparation as well as a preparation method and application thereof. The florfenidone capsule preparation comprises florfenidone serving as an active ingredient and a pharmaceutically acceptable capsule preparation carrier serving as an inactive ingredient, and the florfenidone serving as the active ingredient is prepared by crushing the florfenidone and then sieving the crushed florfenidone through a 60-100-mesh sieve, preferably a 70-90-mesh sieve and most preferably a 80-mesh sieve; the pharmaceutically acceptable capsule preparation carrier comprises a filler, a disintegrating agent, an adhesive and a lubricant. The flufenidone capsule provided by the invention has better in-vitro dissolution rate, can be dissolved out for 30 minutes in vitro to reach 85% or more, and is good in dissolution effect, high in bioavailability, more beneficial to in-vivo absorption and good in stability.

The present application provides a preparation method of temozolomide preparation, comprising the following steps: A) adding sodium carboxymethyl starch, tartaric acid, colloidal silicon dioxide and part of anhydrous lactose into a compulsory mixer, then adding stearic acid and the rest of anhydrous lactose into the mixer in sequence after sieving, and mixing uniformly; B) adding temozolomide into the compulsory mixer, mixing uniformly, and filling capsules. The present application changes the adding time of stearic acid, simultaneously uses compulsory mixing in the preparation process, makes stearic acid uniformly distribute in the excipients, reduces the moisture absorption of the moisture-absorbing material, and then shows the overall moisture absorption reduction in the preparation, so as to achieve the effect of reducing the requirement of the preparation production on the environmental humidity while ensuring the dissolution stability.

The invention discloses an in-vitro dissolution method of a hydrobromic acid vortioxetine tablet, the in-vitro dissolution method adopts a paddle method, a dissolution medium is degassed purified water, and the dissolution medium contains 0.01% of cetyltrimethylammonium bromide (CTAB). The method comprises the following steps: taking samples at fixed time points at intervals, detecting the concentrations of the votioxetine hydrobromide samples at each time point by using a high performance liquid chromatograph to obtain a votioxetine dissolution curve which is good in homogeneity, smooth and free of jump points (that is, the dissolution amount at the latter time point is lower than that at the former time point), and predicting the in-vitro similarity of a tested preparation and a reference preparation. The cetyltrimethyl ammonium bromide (CTAB) is selected as a surfactant, compared with conventionally used lauryl sodium sulfate (SDS) and Tween 80, the cetyltrimethyl ammonium bromide has a better dissolution effect at a lower concentration, the dosage is smaller, the data uniformity is good, the relative standard deviation (RSD) is within 2%, and the accuracy and reliability of dissolution detection are remarkably improved. The dissolution method adopted by the invention can simulate the in-vivo release and absorption process, and the f < 2 > factor is combined to analyze the preparation difference, so that the quality and process difference between the reference preparation and the tested preparation can be effectively distinguished, and the evaluation on the dissolution behavior and quality consistency between the hydrobromic acid vortioxetine tablets is realized.

The invention relates to a solid composition, an agent for improving dissolution of ibuprofen, and a method for improving dissolution of ibuprofen. The present invention addresses the problem of providing a solid composition containing ibuprofen having improved dissolution properties. [Solution] A solid composition which contains (A) ibuprofen and (B) at least one substance selected from the group consisting of noscabine, dextromethorphan, and salts thereof, and which does not contain: (i) a solid composition which does not contain dextromethorphan or a salt thereof and in which ibuprofen and noscabine or a salt thereof are present as different granulated materials; and (ii) a solid composition which does not contain noscabine or a salt thereof and comprises ibuprofen, dextromethorphan or a salt thereof, a hydrogel-forming polymer, and an organic acid or acidic amino acid.