355results about How to "Good dissolution effect" patented technology

The invention discloses a sparingly soluble active component particle, a particle preparation and a preparation method thereof. The preparation method of the sparingly soluble active component particle comprises the following steps: dissolving sparingly soluble active component and ionic polymer into an alkaline solution or an acidic solution, and then mixing the alkaline solution and acidic solution to change the pH value of solutions so as to precipitate the sparingly soluble active component and ionic polymer from the mixed solution to form particles; and the performance of the sparingly soluble active component particle is improved. According to the preparation method, sparingly soluble active component and ionic polymer are co-precipitated, at the same time, a preparation technology is adopted, and two technologies are tightly combined to prepare the sparingly soluble active component particle preparation. The prepared preparation has the advantages of excellent dissolving-out characteristic, high bioavailability, small individual difference, good stability, and good content uniformity.

A dripping pill of breviscapine is prepared from breviscapine and polyethylene glycol (PEG 4000) 5-8 times through conventional process. Its advantages are high curative effect and high biological utilization rate.

The invention relates to a gefinitib medicinal composite, which consists of the following components in proportion by weight: 20%-65% gefinitib, 20%-75% diluent, 0.1%-3% solubilizer, 1%-5% adhesive, 2%-10% disintegrant and 0.4%-2% lubricant. The gefinitib in the composite provided in the invention also can exist in an amorphous state, and accordingly, the dissolution efficiency is further improved. The gefinitib medicinal composite provided in the invention adopts conventional adjuvant, has a simple and easy preparing technology, and dissolution experiments prove that a better dissolution effect can be achieved, and the quality of the gefinitib medicinal composite is obviously better than products on the market.

The invention discloses a cefetamet pivoxil hydrochloride tablet and a preparation method thereof. On the premise of specific active ingredients of the cefetamet pivoxil hydrochloride, the invention takes into account the varieties and dosages of disintegrating agents and joint usage thereof, suitable components and ratios of bonding agents and other filling agents, and the micronization treatment of the raw and auxiliary materials and selection of corresponding optimized process conditions. Experiment results indicate that compared with the prior art, the product of the invention has quick disintegration and dissolution and stable quality.

The invention discloses an olaparib pharmaceutical composition and a preparation method thereof, belongs to the field of pharmaceutical preparation, and particularly relates to the olaparib composition and the preparation method thereof. The composition comprises olaparib and a carrier. The olaparib composition provided by the invention has the advantages of safety, stability and excellent in-vitro dissolution effect.

The invention belongs to the technical field of medicines, and in particular relates to a medical composition which is high in stability, digestion and absorption and a preparation method thereof. The medical composition contains vilazodone or officinal salt of vilazodone and a solid matrix.

The invention discloses a cefuroxime axetil composition which comprises the following components in parts by weight: 1 part of cefuroxime axetil, 1-15 parts of a low-melting-point wax material, 5-8 parts of filler, 0-0.6 part of a disintegrating agent, 0-0.15 part of a binder and 0-0.08 part of a corrigent. The invention further discloses a preparation method of the cefuroxime axetil composition. The cefuroxime axetil composition obtained can better cover bitter taste of the medicine and is good in dissolution rate, so that the medication compliance of patients is further improved.

The invention discloses a sugar-increasing high-yield green planting method for beta vulgaris. The method comprises the following steps: step 1, selecting seeds and performing pretreatment; step 2, preparing a traditional Chinese medicine sterilizing liquid; step 3, sterilizing the seeds through immersing; step 4, preparing a seed coating agent specially used for the beta vulgaris; step 5, treating the seeds of the beta vulgaris with the seed coating agent; step 6, accelerating germination; step 7, raising seedlings; step 8, pretreating planting land; step 9, transplanting the seedlings; step10, performing management in a seedling stage; step 11, performing leaf surface management in the seedling stage; and step 12, performing harvesting. The method provided by the invention significantlyimproves the virus resistant and mildew resistant ability of the seeds, so that the germination energy and the seed vitality are significantly improved, the seeds have a high seedling emergence rateand a quick germination speed, microenvironments for germination and seedling growth are excellent, the yield and the sugar content of the beta vulgaris can be significantly increased, the costs are reduced, the benefits are improved, and the method provides powerful guarantee for large-scale planting, and has higher practical value and good application prospects.

This invention relates to a method for preparing superfine prednisolone powder, and belongs to the field of micronization. Open question at present: particle diameter of prednisolone is small but can not obtain dry powder, or the dry powder has wide size distribution, bad redispersibility, and instability in water. The invention is to realize the preparation of prednisolone granule with controllable particle diameter, narrow particle size distribution, and superfine or nano-graded quadrilate and hexagon through inverse solvent recrystallization.the prednisolone of the invention has the advantages of controllable particle diameter, narrow particle size distribution, good redispersibility, stable micropowder, and good dissolving effect; and has prodigious dominance in the development of drug effect and new medicament form.

The invention discloses an enalapril maleate tablet and a preparation method thereof, belonging to the technical field of chemical pharmaceutical industry. The enalapril maleate tablet mainly contains 3 to 9 parts of enalapril maleate, 40 to 60 parts of filling agent, 0 to 35 parts of disintegrating agent, 0 to 2 parts of caking agent, 0.1 to 4 parts of lubricating agent and 0.1 to 3 parts of flow aid. Compared with the conventional merchant enalapril maleate tablet, the enalapril maleate table provided by the invention adopts auxiliary materials which have poorer compatibility with the enalapril maleate technical on the traditional conception and ensures that the enalapril maleate tablet produced by using common auxiliary materials has excellent stability by utilizing the specified proportions among raw and auxiliary materials and the specific preparation process; and after being detected, the material qualities of batches of products are all not more than 3.0 percent, the quality stability thereof is superior to the same product from other enterprises, and the cost is saved to the largest extent at the same time of improving the stability.

The invention relates to a method for recovering metal elements from a waste and old ternary lithium-ion battery, belongs to the technical field of recovery of waste and old batteries, and aims at solving the problem that the conventional method is low in recovery rate of metal elements. The method comprises the following steps: disassembling the waste and old ternary lithium-ion battery, and collecting the powder of positive electrode materials of the battery; preprocessing the powder of the positive electrode materials with a mixed solution containing biogenic organic acid and bioflavonoid;filtering, and collecting the filtrate; selectively depositing the collected filtrate; recovering at least one metal element. According to the method, the adhesive component in the positive electrodematerial can be effectively removed and decomposed, so that the metal elements can be effectively separated and dissolved out, thus the dissolving rate is effectively increased, and the subsequent recovery effect of the metal elements can be ensured.

The invention discloses an L-amlodipine benzene sulfonate tablet which contains fewer auxiliary materials, but can keep higher dissolution performance and higher stability, and a preparation process of the L-amlodipine benzene sulfonate tablet. Per 10000 L-amlodipine benzene sulfonate tablets contain 34.66g of L-amlodipine benzene sulfonte, 280-420g of microcrystalline cellulose, 280-420g of calcium sulfate, 72-108g of hydropropylcellulose and 6.4-9.6g of magnesium stearate. The L-amlodipine benzene sulfonate tablet contains fewer auxiliary materials and is particularly free of lactose in the formula, is simple in preparation process, contains fewer related substances, but can keep higher dissolution performance and higher stability; and microcrystalline cellulose and calcium sulfate are used as filling agents, hydropropylcellulose is used as the adhesive and disintegrant, and magnesium stearate is used as the lubricant, and the formula is free of lactose, so that the tablet is also suitable for the patients suffering from lactose intolerance disease.

The invention discloses a hydroxychloroquine sulphate solid preparation, which contains hydroxychloroquine sulphate or pharmaceutically acceptable salts thereof and an auxiliary material, wherein the auxiliary material comprises a buffer pair; the buffer pair is dissolved in water to form a buffer solution with pH of 4-6.5; and the content of the buffer pair is 0.05-2% in terms of mass percentage. The invention further discloses a preparation method of the hydroxychloroquine sulphate solid preparation. The hydroxychloroquine sulphate solid preparation disclosed by the invention has excellent dissolution property and stability, and particularly, is obviously increased in stability compared with the prior art.

The invention relates to a separation method for macadimia nut fine protein, which mainly comprises the following steps: (1) smashing macadimia nuts, and separating macadimia nut fruit oil via infrared treatment and the hydraulic cold pressing method; (2) mixing the obtained macadimia nut dreg and purified water, and processing the mixture through a colloid mill and a homogenizer, performing hardening and tempering, and then performing dynamic ultrahigh pressure processing; (3) adjusting the pH of fruit pulp to the isoelectric point, separating, repetitively washing precipitate with warm water, and then performing low-temperature spray drying to obtain the macadimia nut fine protein. The technology is continuous and compact, the production yield is high and the quality of the macadimia nut fine protein is good.

The invention relates to a method for reinforcing denitrification in a constructed wetland with strong carbon secretion type modified biological carbon. The constructed wetland is reinforced for denitrification by taking the strong carbon secretion type modified biological carbon as a treating agent, the strong carbon secretion type modified biological carbon and a substrate are mixed and filled in a bed body of the constructed wetland or are directly embedded into the bed body of the constructed wetland as filler columns, and the strong carbon secretion type modified biological carbon is obtained by low temperature carbonization and ferrous loading by taking wetland plants as raw materials; the temperature of denitrification is 0-40 DEG C, the pH value is 6-8, and the total nitrogen content of sewage of the constructed wetland is 5-60 mg/L. According to the method, the denitrification in the constructed wetland is reinforced by utilizing the strong carbon secretion type modified biological carbon, so as to obtain an unexpected effect; when in application, Fe(II) is loaded simple and conveniently, Fe(II) can serve as an electron donor for transferring electrons to high-valence nitrogen (such as NO3<-> and NO2<->), and the high-valence nitrogen is reduced into nitrogen while the high-valence nitrogen is oxidized. Therefore, the chemical denitrification process is realized, and efficient denitrification is achieved.

The invention relates to a Bayer method digesting technology for bauxite that includes the following steps: taking preheating and heating for aluminum ore slurry after taking pre-desilication process and cycling alkaline liquor in the double pipe heat exchanger, heating to digesting temperature and taking heat insulation reaction for digesting in pot autoclave, and taking explosive boiling cooling to gain digesting ore slurry. The invention has the advantages of good digesting effect, light heat exchanger scar over, low constructing cost, low producing cost, etc.

The invention discloses a preparation method of domperidone particles. The method comprises the following steps: dispersing domperidone and dispersion aids into a solvent; adding an acid to dissolve to obtain a solution I; adding an alkali liquor to the solution I under an agitation condition, so as to obtain a mixture containing the domperidone particles; separating the domperidone particles, wherein the mean grain size of the obtained particles is smaller than 20mum, the particles have the specific surface area equivalent to over twice of those of common domperidone particles and are high in dissolution rate. The invention also discloses a preparation method of the preparation containing the domperidone particles. The method for preparing the domperidone particles is simple and convenient to operate, free of harsh process condition and equipment, low in cost and easy for realization of industrial production.