43 results about "Cefetamet Pivoxil Hydrochloride" patented technology

The invention is applicable to the technical field of pharmaceuticals, and provides a cefetamet pivoxil hydrochloride capsule and a preparation method thereof. The cefetamet pivoxil hydrochloride capsule comprises cefetamet pivoxil hydrochloride, a diluting agent, an antitack agent, a surface active agent, a lubricant and a disintegrating agent. In the cefetamet pivoxil hydrochloride capsule disclosed by the invention, the antitack agent, namely, colloidal silicon dioxide (N2O), is adopted to prevent the cefetamet pivoxil hydrochloride medicament from being agglomerated and caked so as to promote dissolution and release of the medicament; and by the use of the diluting agent, the further dispersion of the cefetamet pivoxil hydrochloride is realized, and the agglomeration phenomenon is reduced. The preparation method of the cefetamet pivoxil hydrochloride capsule is simple to operate, saves the processing step of material granulating, avoids the essential components from decomposing due to high temperature and high moisture, has low cost, and is beneficial to reducing the input of equipment funds; the preparation method is suitable for industrial production; and the product prepared by the method disclosed by the invention has the advantages of low water content, few impurities, desirable dissolution performance, and stable quality.

The invention relates to a cefetamet pivoxil hydrochloride capsule which contains the raw materials by the weight percent: 59% of effective and active ingredient, 10-15% of disintegrant, 1-3% of solubilizer, 20-28% of bulking agent and 2-3% of lubricating agent; wherein the effective and active ingredient is cefetamet pivoxil hydrochloride; the disintegrant comprises sodium carboxymethyl starch and cross-linked sodium carboxyl cellulose; the solubilizer is lauryl sodium sulfate; the bulking agent is one or two of lactose and mannitol; and the lubricating agent includes superfine silica powder and magnesium stearate. The invention also discloses a preparation method of the cefetamet pivoxil hydrochloride capsule, which adopts dry pressing pelletization technique; therefore, the invention has the advantages of simple equipment and less investment; the prepared capsule is stable in quality, excellent in solubility property, rapid in absorption, convenient in taking and good in mouthfeel.

The invention provides a cefetamet pivoxil hydrochloride hydrate, wherein an X-ray powder diffraction spectrogram obtained by measurement by using Cu-Kalpha rays is represented by the figure 1. Cefetamet pivoxil hydrochloride hydrate crystals disclosed by the invention are good in stability, difficult to absorb moisture and good in mobility and can be uniformly mixed with other accessories; and a prepared cefetamet pivoxil hydrochloride dispersible table is rapid in absorption speed and high in bioavailability.

A dispersing tablet of cefetamet hydrochloride is prepared from the active component, filler, disintegrant, flavouring, lubricant and adhesive through proportionally mixing, granulating, adding auxiliaries, stirring and tabletting.

The invention relates to a cefetamet pivoxil hydrochloride preparation method, which comprises: generating an intermediate I by using 7-ADCA and ethyl methylaminothiazolyloximate as starting raw materials under the catalysis of AlMe3; and carrying out an esterification reaction on the intermediate I and iodomethyl pivalate under the actions of a phase transfer catalyst and an acid adsorbent, carrying out salt formation on the esterified product, and crystallizing to obtain the target product cefetamet pivoxil hydrochloride. According to the present invention, the method has characteristics ofmild reaction conditions, high product purity, high yield and stable process, and is suitable for industrial production.

The invention belongs to the field of chemistry, which in particular relates to a method for preparing cefetamet which is an intermediate of cefetamet pivoxil hydrochloride. By optimizing the process, especially improving the synthesis ratio of raw materials and a crystal growing process, the invention enhances the yield and the purity of a product. The method for preparing the cefetamet, which is provided by the invention, has the advantages of mild reaction conditions and little discharge of three wastes, also has stable process and is suitable for industrial large-scale production.

The invention discloses a cefetamet pivoxil hydrochloride tablet and a preparation method thereof. On the premise of specific active ingredients of the cefetamet pivoxil hydrochloride, the invention takes into account the varieties and dosages of disintegrating agents and joint usage thereof, suitable components and ratios of bonding agents and other filling agents, and the micronization treatment of the raw and auxiliary materials and selection of corresponding optimized process conditions. Experiment results indicate that compared with the prior art, the product of the invention has quick disintegration and dissolution and stable quality.

The invention relates to the field of a medicine, in particular to a cefetamet pivoxil hydrochloride dispersible tablet and a preparation method of the cefetamet pivoxil hydrochloride dispersible tablet. The cefetamet pivoxil hydrochloride dispersible tablet is prepared by the following components in parts by weight: 40 to 60% of cefetamet pivoxil hydrochloride, 10 to 20% of microcrystalline cellulose, 5 to 15% of polyvinylpolypyrrolidone, 5 to 12% of calcium hydrophosphate and 5 to 15% of carboxymethyl starch sodium. Compared with the ordinary tablet, the cefetamet pivoxil hydrochloride dispersible tablet provided by the invention has the advantages of being good in disperse state, short in disintegration time, high in bioavailability, little in untoward effect, rapid to dissolve the medicines, fast to absorb and convenient to take and the like.

The invention discloses a medicinal cefetamet pivoxil hydrochloride dry suspension for treating sensitive bacterial infection diseases and belongs to the technical field of medicine. The dry suspension is prepared from cefetamet pivoxil hydrochloride, dextrin, sucrose, HPMC, xanthan gum and absolute ethyl alcohol. The cefetamet pivoxil hydrochloride is a novel crystal-form compound. As shown in Figure 1 of X-ray powder diffraction diagram obtained by means of Cu-K alpha ray measurement, the cefetamet pivoxil hydrochloride is different from cefetamet pivoxil hydrochloride reported in the prior art. Tests find that the dry suspension prepared from the novel crystal-form compound of the cefetamet pivoxil hydrochloride is low in high-molecular polymer content and good in stability, and the content of high-molecular polymers gradually decreases along with prolonging of storage time; meanwhile, the composition has more remarkable antibacterial activity with respect to pneumococcocci and hemophilus influenza and also has strong antibacterial activity with respect to enterococcocci and staphylococcocci.

The invention relates to a cefetamet pivoxil hydrochloride capsule which contains the raw materials by the weight percent: 59% of effective and active ingredient, 10-15% of disintegrant, 1-3% of solubilizer, 20-28% of bulking agent and 2-3% of lubricating agent; wherein the effective and active ingredient is cefetamet pivoxil hydrochloride; the disintegrant comprises sodium carboxymethyl starch and cross-linked sodium carboxyl cellulose; the solubilizer is lauryl sodium sulfate; the bulking agent is one or two of lactose and mannitol; and the lubricating agent includes superfine silica powderand magnesium stearate. The invention also discloses a preparation method of the cefetamet pivoxil hydrochloride capsule, which adopts dry pressing pelletization technique; therefore, the invention has the advantages of simple equipment and less investment; the prepared capsule is stable in quality, excellent in solubility property, rapid in absorption, convenient in taking and good in mouthfeel.

The invention provides granules of cefetamet pivoxil hydrochloride and a preparation method thereof, which belong to the technical field of medicine. The granularity of the granules is 200-1600mu m, and the granules are prepared from fine cefetamet pivoxil hydrochloride coating granules and pharmaceutically acceptable auxiliary materials. The fine cefetamet pivoxil hydrochloride coating granules are obtained by coating after cefetamet pivoxil hydrochloride and auxiliary materials are prepared into fine granules by a spray method of a fluidized bed, wherein the fine cefetamet pivoxil hydrochloride coating granules account for 30-75% of the total weight of the entire granules. A coating material used for coating contains a film-forming material, a plasticizer and an antiblocking agent; the invention has the advantages of completely covering up the special bitter taste of the cefetamet pivoxil hydrochloride and enhancing the application conformability of the aged, children and patients with difficulties in deglutition.

The invention belongs to the field of chemistry, which in particular relates to a method for preparing cefetamet which is an intermediate of cefetamet pivoxil hydrochloride. By optimizing the process, especially improving the synthesis ratio of raw materials and a crystal growing process, the invention enhances the yield and the purity of a product. The method for preparing the cefetamet, which is provided by the invention, has the advantages of mild reaction conditions and little discharge of three wastes, also has stable process and is suitable for industrial large-scale production.

The invention discloses a pharmaceutical composition containing cefetamet pivoxil hydrochloride. According to the pharmaceutical composition, sodium cyclamate is added into the composition and is usedas a gel inhibitor, and a phenomenon that a solid preparation forms gel in a water-soluble solution is effectively inhibited; the dissolution performance of the solid preparation is effectively improved and the bioavailability is improved. The sodium cyclamate has a sweet taste so that the problem that a granular preparation has a bitter taste is solved. A dry-process granulation technology is adopted so that introduction of bad factors including moisture, high temperature and the like is avoided; a preparation prescription is matched so that the problem of hydrolysis or oxidative degradationof an ester bond, an amide bond, a lactam bond and a primary amine bond in crude drug molecules is solved. A test proves that the effect is good.

The invention provides a cefetamet pivoxil hydrochloride liposome solid preparation and a preparation method thereof. The cefetamet pivoxil hydrochloride liposome solid preparation comprises 125 parts of cefetamet pivoxil hydrochloride, 20 to 250 parts of aluminum dicetyl phosphate, 50 to 200 parts of cholesterol, 10 to 150 parts of tween 80 and 100 to 250 parts of other medicinal auxiliary materials. The cefetamet pivoxil hydrochloride liposome solid preparation can be processed into tablets and particles. The cefetamet pivoxil hydrochloride liposome solid preparation has a high entrapment rate, even particle sizes and long retention time of drugs in blood circulation. The preparation method of the cefetamet pivoxil hydrochloride liposome solid preparation improves preparation quality, reduces toxic and side effects, needs simple equipment, is easy for operation and is suitable for industrialized large-scale production.

The invention discloses a cefetamet pivoxil hydrochloride tablet composition, and belongs to the technical field of medicine. The cefetamet pivoxil hydrochloride tablet composition is prepared from cefetamet pivoxil hydrochloride, compressible starch, microcrystalline cellulose 102, sodium starch glycolate, hydroxypropyl cellulose, glyceryl behenate and magnesium stearate. Tests show that tablets prepared from the cefetamet pivoxil hydrochloride tablet composition, compared with the prior art, have the advantages that the macromolecular polymer content is relatively lower and increases a little along with prolonging of storage time, and the stability is high; in addition, the composition has more remarkable antibacterial activity to pneumococcus and hemophilus influenzae, and also has relatively higher antibacterial activity to enterococcus and staphylococcus.