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Hydrochloric acid cefetamet pivoxil dispersible tablet and method for preparing the same

A technology of ceftazidime pivoxil hydrochloride and dispersible tablets, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can solve the problems of strong viscosity, difficulty in making granules, and poor chemical properties. Stability and other issues, to achieve the effect of improving dissolution and dispersion performance

Active Publication Date: 2009-05-06
SHANDONG LUOXIN PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But, because the viscosity of ceftazidime pivoxil hydrochloride raw material is too strong, and chemical performance is unstable under high temperature and high humidity conditions
Based on this point, the prior art generally believes that the wet granulation process is not only difficult to make granules, but also the active ingredients contained are easily degraded during the granulation and drying process

Method used

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  • Hydrochloric acid cefetamet pivoxil dispersible tablet and method for preparing the same
  • Hydrochloric acid cefetamet pivoxil dispersible tablet and method for preparing the same
  • Hydrochloric acid cefetamet pivoxil dispersible tablet and method for preparing the same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] prescription:

[0070]

[0071] Preparation Process:

[0072] 1) Prepare materials

[0073] Ceftazidime hydrochloride was pulverized, passed through a 100-mesh sieve, starch, microcrystalline cellulose, hydroxypropyl cellulose, acesulfame potassium and carboxymethyl starch sodium were respectively pulverized, and passed through a 120-mesh sieve to obtain spare raw materials and auxiliary materials;

[0074] 2) Humidification granules

[0075] Weigh the above-mentioned spare ceftazidime hydrochloride, starch, microcrystalline cellulose, acesulfame potassium and hyprolose in the prescribed amount, put them into a high-speed mixing granulator, seal and dry-mix at high speed for 10 minutes, and then add an appropriate amount of ethanol Wet mixing for 3 minutes, after wet mixing, wet mixing and cutting for 2 minutes, releasing granules to obtain wet granules;

[0076] 3) Make dry granules

[0077] Transfer the wet granules prepared in the previous step into a boiling ...

Embodiment 2

[0081] prescription:

[0082]

[0083] Preparation Process:

[0084] 1) Prepare materials

[0085] Ceftazidime hydrochloride was pulverized, passed through a 100-mesh sieve, starch, microcrystalline cellulose, hydroxypropyl cellulose, acesulfame potassium and carboxymethyl starch sodium were respectively pulverized, and passed through a 120-mesh sieve to obtain spare raw materials and auxiliary materials;

[0086] 2) Humidification granules

[0087] Weigh the above-mentioned spare ceftazidime hydrochloride, starch, microcrystalline cellulose, acesulfame potassium and hyprolose in the prescribed amount, put them into a high-speed mixing granulator, seal and dry-mix at high speed for 5 minutes, and then add an appropriate amount of ethanol Wet mixing for 1 minute, after wet mixing, wet mixing and cutting for 3 minutes, releasing granules to obtain wet granules;

[0088] 3) Make dry granules

[0089] Transfer the wet granules prepared in the previous step to a boiling drye...

Embodiment 3

[0093] prescription:

[0094]

[0095]

[0096] Preparation Process:

[0097] 1) Prepare materials

[0098] Ceftazidime hydrochloride was pulverized, passed through a 100-mesh sieve, starch, microcrystalline cellulose, hydroxypropyl cellulose, acesulfame potassium and carboxymethyl starch sodium were respectively pulverized, and passed through a 120-mesh sieve to obtain spare raw materials and auxiliary materials;

[0099] 2) Humidification granules

[0100] Weigh the above-mentioned standby ceftazidime hydrochloride, starch, microcrystalline cellulose, acesulfame potassium and hyprolose in the prescribed amount, put them into a high-speed mixing granulator, seal and dry-mix at high speed for 15 minutes, and then add an appropriate amount of ethanol Wet mixing for 5 minutes, after wet mixing, wet mixing and cutting for 1 minute, releasing the granules to obtain wet granules;

[0101] 3) Make dry granules

[0102] Transfer the wet granules prepared in the previous ste...

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Abstract

The invention discloses a cefetamet pivoxil hydrochloride tablet and a preparation method thereof. On the premise of specific active ingredients of the cefetamet pivoxil hydrochloride, the invention takes into account the varieties and dosages of disintegrating agents and joint usage thereof, suitable components and ratios of bonding agents and other filling agents, and the micronization treatment of the raw and auxiliary materials and selection of corresponding optimized process conditions. Experiment results indicate that compared with the prior art, the product of the invention has quick disintegration and dissolution and stable quality.

Description

technical field [0001] The invention relates to a ceftazidime hydrochloride dispersible tablet and a preparation method of the dispersible tablet. Background technique [0002] In the prior art, β-lactam antibiotics are the most clinically used antibiotics, the most widely used, the most varieties, the best curative effect and the highest evaluation. Among them, cephalosporin series products account for about 70%. Among cephalosporins, ceftazidime pivoxil hydrochloride is an oral third-generation broad-spectrum cephalosporin antibiotic, which has the characteristics of broad-spectrum, high efficiency, enzyme resistance, and low toxicity. Compared with similar varieties of cephalexin and cephradine, it has antibacterial With the advantages of stronger activity and smaller dose, it overcomes the shortcomings of Pioneer series products that are unstable to β-lactamase, and is an ideal substitute for cephalexin and cephradine. [0003] On the market, ceftazidime pivoxil prepara...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K31/546A61K9/20A61P31/04
Inventor 刘保起李明华冯长运
Owner SHANDONG LUOXIN PHARMA GRP CO LTD
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