A kind of dequinium chloride buccal tablet and preparation method thereof

A dequinium chloride and prescription technology, applied in the field of medicine, can solve the problems of short containing time, astringent taste, poor taste of users and the like

Active Publication Date: 2020-01-21
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the dequalinium chloride buccal tablets in the prior art have a relatively short melting time, so patients need to take the medicine very frequently and take it again. Also bring inconvenience to the patient; In addition, after the dequalinium chloride buccal tablet of current sale is taken entrance for a period of time, a kind of bad mouthfeel that is not greasy, astringent usually can be produced, gives poor mouthfeel to the user, easily causes taking Resisting emotions, so it is difficult to be accepted by patients, which is not conducive to promotion

Method used

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  • A kind of dequinium chloride buccal tablet and preparation method thereof
  • A kind of dequinium chloride buccal tablet and preparation method thereof
  • A kind of dequinium chloride buccal tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036]

[0037] The preparation method comprises the following steps:

[0038] (1) Take by weighing the sucrose, mannitol, stearic acid, pigment pulverization of prescription portion, fully mix;

[0039] (2) Take by weighing gelatin and methyl p-hydroxybenzoate of the prescription amount, add water to disperse, heat and keep warm until fully dissolved, then add licorice liquid extract, stir evenly, and set aside;

[0040] (3) take by weighing the principal agent dequalinium chloride of prescription quantity, add ethanol solution heating and stirring and dissolving, for subsequent use;

[0041] (4) Mix the solution obtained in step (2) and step (3) uniformly, then add it to the uniformly mixed medicinal powder in step (1), stir, make soft material and granulate;

[0042] (5) After the granulation is completed, dry, sieve and granulate;

[0043] (6) Mix the granules prepared in step (5) with menthol, essence, magnesium stearate, and sodium carboxymethylcellulose evenly, and...

Embodiment 2

[0045]

[0046] The preparation method refers to Example 1.

Embodiment 3

[0048]

[0049] The preparation method refers to Example 1.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a dequalinium chloride buccal tablet and a preparation method thereof. The dequalinium chloride buccal tablet is prepared from the following components in parts by weight: 80 to 95 parts of cane sugar, 1.5 to 2.5 parts of mannitol, 0.15 to 0.4 part of stearic acid, 0.005 to 0.01 part of pigment, 0.01 to 0.025 part of dequalinium chloride, 0.3 to 0.5 part of liquorice root fluid extract, 0.002 to 0.004 part of p-hydroxybenzoic acid methyl ester, 1 to 3 parts of gelatin, 0.1 to 0.3 part of menthol, 0.1 to 0.3 part of essence, 0.1 to 0.35 part of magnesium stearate and 0.5 to 1.5 parts of sodium carboxymethylcellulose. The dequalinium chloride buccal tablet has long buccal time, good mouthfeel and lasting efficacy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a dequalinium chloride buccal tablet and a preparation method thereof. Background technique [0002] Dequalinium chloride, also known as dequalinium chloride, is off-white or milky white powder, odorless, bitter in taste, easily soluble in boiling water, and easily deteriorated when exposed to light. Dequalinium chloride is a broad-spectrum antibacterial drug, used for dosage forms of pharyngitis, oral disinfection, etc. [0003] Dequalinium chloride buccal tablet is a compressed tablet that can be contained in the oral cavity and dissolves slowly. It can produce a relatively long-lasting drug effect on the oral cavity and pharynx, and is used for local anti-inflammatory and disinfection. Dequalinium chloride buccal tablets are welcomed by patients because of their convenience and good taste. Due to the slow absorption, the drug can stay in the pharynx for a long t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/4709A61K47/26A61K47/40A61P31/02A61P1/02A61P11/04
CPCA61K9/0056A61K9/2018A61K9/205A61K31/4709
Inventor 黄毅陈敏魏光琍刘辉陈丽
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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