87 results about "Sodium Starch Glycolate" patented technology

The invention relates to levamlodipine besylate crystals, a preparation method thereof and a brand-new medicinal composition containing the crystals. Characteristic peaks in an X-ray powder diffraction pattern obtained by measuring the levamlodipine besylate crystals by using Cu-K alpha rays are displayed as 8.0, 12.1, 15.4, 17.0, 19.8, 21.6, 23.0, 24.3, 25.7, 27.4, 30.7 and 33.5 degrees at 2 theta. The medicinal composition comprises the levamlodipine besylate crystals and pharmaceutically acceptable excipients, wherein the pharmaceutically acceptable excipients are microcrystalline cellulose, sodium starch glycolate and magnesium stearate. The crystals improve the dissolubility of levamlodipine besylate; and tablets prepared from the crystals have improved bioavailability.

The invention discloses absorbable composite styptic powder which is prepared from the following raw materials in parts by weight: 10-30 parts of carboxymethyl chitosan, 10-30 parts of sodium alginate, 10-20 parts of sodium carboxymethylcellulose, 15-50 parts of sodium starch glycolate, 30-60 parts of mannitol, 1-5 parts of calcium chloride and 2,000-4,000 parts of distilled water. The absorbable composite styptic powder disclosed by the invention does not contain any toxic chemical agent and has the functions of inhibiting bacteria, promoting wound healing and inhibiting scar formation; after the absorbable composite styptic powder is scattered and applied, moisture in blood can be uniformly and quickly absorbed by the absorbable composite styptic powder, and a 'white core' is not formed, therefore, the absorbable composite styptic powder is styptic powder which is convenient to use, high in efficiency and extremely good in styptic effect and has no side effect.

The invention relates to a collagen calcium tablet, which is a film coated tablet prepared from calcium carbonate, collagen powder, chondroitin sulfuric acid, microcrystalline cellulose, sodium starch glycolate, magnesium stearate and a film coating agent in a certain weight proportion. The collagen calcium tablet product takes the calcium carbonate as a calcium supplement source, the collage powder is added for promoting calcium absorption and bone cell growth, the chondroitin sulfuric acid is matched to promote bone cell growth, resist inflammation and protect bone joints, and the calcium carbonate, the collagen powder and the chondroitin sulfuric acid are compatible with other auxiliary materials; and the product is scientific, reasonable and safe in formula design and suitable for preventing, improving and treating osteoporosis of the old, and has a health care effect of increasing the bone density of middle-aged and aged people.

The invention relates to a letrozole tablet and a preparation method thereof. The letrozole tablet comprises the following main auxiliary materials: microcrystalline cellulose, lactose, sodium starch glycolate, L-HPC (low-substituted hydroxypropyl cellulose), sodium lauryl sulfate, Tween 80, magnesium stearate and starch; the preferable sodium lauryl sulfate:Tween 80 ratio is 2:1, and the sodium starch glycolate:L-HPC ratio is 5:1. The tablet has stable product quality, obviously enhances the letrozole dissolution, and effectively enhances the bioavailability; and the tablet preparation technique is simple, does not need special equipment, and is convenient to operate and suitable for industrial production.

Provided herein are compositions and methods of making compositions of ibuprofen in combination with a narcotic analgesic. Specifically provided is a pharmaceutical tablet composition comprising ibuprofen; a narcotic analgesic; colloidal silicon dioxide; a filler selected from the group consisting of microcrystalline cellulose and powdered cellulose; a disintegrant selected from the group consisting of croscarmellose sodium, crospovidone, and sodium starch glycolate; a binder consisting of an akylhydroxy methylcellulose; a starch; and a lubricant. Also provided herein is a method of preparing a pharmaceutical tablet composition comprising: (a) Granulating ibuprofen, a narcotic analgesic, a first glidant, a first disintegrant, a binder, and starch to form granules wherein said granulating step comprises a wet granulation process; (b) blending the granules with extra-granular material comprised of a second glidant, a second disintegrant, a filler and starch to form a blend of granules and extra-granular material; and (c) compressing the blend into a tablet.

The invention relates to the field of a medicinal preparation, in particular to a lafutidine-containing coated tablet and a preparation method thereof.. The preparation provided by the invention is an oral solid preparation consisting of lafutidine, lactose, microcrystalline cellulose, starch, sodium starch glycolate and magnesium stearate. In order to ensure the main dissolution rate, most of the auxiliaries in the prescription are hydrophilic. In the invention, the technology of the preparation is simple and adopts a few auxiliaries; and the product has stable quality and good dissolution rate, takes an effect quickly and acts for a long time.

The invention relates to a lamivudine tablet composition and a preparation method thereof. The core of the lamivudine tablet composition is prepared from the following ingredients: 80-120 parts of lamivudine, microcrystalline cellulose 90-150 parts, 4-20 parts of sodium starch glycolate, 1-6 parts of silicon dioxide, 0.5-4 parts of magnesium stearate. The preparation method is as follows: sieving; weighing lamivudine, microcrystalline cellulose, sodium carboxymethyl starch, silicon dioxide, and magnesium stearate, mixing evenly, measuring the content of the mixed powder, and calculating the tablet weight after passing the test. It is directly pressed into tablets, coated, dried, fully inspected and packaged to obtain the finished product.

The invention discloses a Glimepiride tablet, wherein the Glimepiride tablet comprises the following components: Glimepiride tablet bulk pharmaceutical chemical, lactose, sodium starch glycolate, microcrystalline cellulose, microcrystalline silica gel and magnesium stearate at the weight ratio of (2-6):(60-90):(10-30):(10-60):(2-6):1, wherein the Glimepiride tablet bulk pharmaceutical chemical ispowder with the particle size less than 2 mu m. The invention also discloses a preparation method. With regard to Glimepiride, pharmaceuticals are smashed into particulates with the particle size less than 2mu m by an improved technology, and the hydrophilicity of the pharmaceuticals is improved; and the problem that the dissolution velocity of the pharmaceuticals is influenced is solved. Statistical analysis indicates that the average dissolution degree is above 98.5% by adopting the improved prescription and technology, and the accelerated test result for 6 months is very stable; and the research on primary pharmacokinetic parameters indicate that the preparation has the advantages of better dynamic course in human bodies and better absorption elimination properties through the checkingof statistics.

A pharmaceutical formulation is disclosed which includes at least: (1) elagolix sodium, (2) magnesium oxide, and (3) at least one disintegrating agent, such as crospovidone, croscarmellose sodium, sodium starch glycolate, pregelatinized and mixtures thereof. A tablet is also disclosed which includes a tablet core formed from the pharmaceutical formulation. The elagolix sodium tablets of the present disclosure display improved dissolution rates when tested using for example the Tablet Sink Time test. The tablets also exhibit improved storage stability of the elagolix sodium, with a reduction in degradation products during storage.

The invention relates to a medicine for treating child influenza, which takes acetaminophen, pseudoephedrine hydrochloride and chlorphenamine maleate as main materials, and takes microcrystalline cellulose, starch, aspartame, sodium starch glycolate, magnesium stearate, 60% ethanol and 2% sodium starch glycolate aqueous solution as auxiliary materials. A preparation method is as follows: the acetaminophen, the pseudoephedrine hydrochloride and the chlorphenamine maleate are crushed into fine powder for spare use; the chlorphenamine maleate is uniformly mixed with the acetaminophen and the pseudoephedrine hydrochloride through a equivalent incremental method; parts of the microcrystalline cellulose, the starch, the aspartame and the sodium starch glycolate are weighed to be uniformly mixed, are crushed to sieve, and are mixed again, the 60% ethanol and the 2% sodium starch glycolate aqueous solution are added to the prepared mixture, are completely stirred to make a soft material, and wet particles are produced after the sieving; the produced wet particles are dried at 75 DEG C and granulated; after the granulation, the residual auxiliary materials of the microcrystalline cellulose, the starch, the sodium starch glycolate and the magnesium stearate are added again to mix uniformly; and dispersible tablets are pressed and packaged. The medicine has the advantages of obvious curative effect, good safety, convenience in medicine taking and suitable taste for children.

The invention relates to a glimepiride tablet and a preparation method thereof, belonging to the technical field of medicine. The glimepiride tablet is prepared from the following components in parts by weight: 1-2 parts of glimepiride, 74-128 parts of lactose, 3.2-6.4 parts of microcrystalline cellulose, 4.25-8.5 parts of sodium starch glycolate, 1.7-3.4 parts of povidone K30 and 0.85-1.7 parts of magnesium stearate. The glimepiride tablet provided by the invention enhances the bioavailability, thereby enhancing the curative effect. The glimepiride tablet has the advantages of higher stability, better leaching effect and higher unit-dosage use efficiency, provides a good option for medicine selection and clinical application in hospitals, and has very high economic and social meanings.

A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver. The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, acrylic resin S100, carboxymethyl cellulose sodium, polyoxyethylene polyoxypropylene, menthol, low-substituted hydrocarbon propyl cellulose, pregelatinized starch, Dextrates NF hydrated, citric acid, polyoxyethylene castor oil, colloidal silica, polyethylene glycol monostearate aliphatic ester, sorbic acid, lemon oil, hydroxypropyl cellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, PEG 4000, PEG 2000, and the like, so as to reduce the side effect of the toxicity caused by acetaminophen to the liver.

The invention relates to a drug for the treatment of dyspepsia, and takes amylase, hawthorn fluid extract, calcium pantothenate, nicotinamide and vitamin B1 as the active ingredients. The preparation method is that: the hawthorn is prepared into the hawthorn fluid extract and then is dissolved in 40 percent ethanol; the amylase, the calcium pantothenate, the nicotinamide, the vitamin B1, calcium hydrophosphate and microcrystalline cellulose are taken, mixed evenly and screened; the 40 percent ethanol solution which is dissolved with the hawthorn fluid extract is used as the binding agent for granulation, drying and stabilization; the sodium starch glycolate and talc powder are added and mixed evenly for granule preparation and tablet pressing; or the prescription dose of sodium benzoate, ethyl hydroxybenzoate, hawthorn fluid extract and caramel colorant are taken to be dissolved in purified water, the steam is used for heating till boiling for 30 minutes, and then the mixture is cooled slightly for standby; the prescription dose of calcium pantothenate, nicotinamide, vitamin B1 and edible flavor are dissolved in the purified water; the solution is merged and cooled; the prescription dose of amylase is taken, dissolved in purified water and screened; the solution is merged, the purified water is added till the full amount, and the oral solution is obtained by evenly stirring and filtration.

The invention discloses an adhesive agent used for environmental and low-cost paper boxes and a preparation method thereof. The adhesive agent comprises following components: acrylic acid emulsion, starch, titanium dioxide, sodium silicate, sodium metasilicate, sodium citrate, ammonium persulfate, vinyltriethoxysilane, phthalic anhydride, sodium pentachlorophenol, zine stearate, sodium starch glycolate, and water. The adhesive agent used for environmental and low-cost paper boxes adopts acrylic acid emulsion and starch as the main materials, through oxidation treatment of starch, the performance of the starch is improved, and the adhesivity of the product is strengthened. Furthermore, the product is environmental and pollution free, preparation method is simple, the cost is low, and the product is suitable for mass production.

The invention relates to the field of medicines, in particular to a compound allopurinol dispersible tablet. The tablet is prepared by the following steps of: respectively sieving 100g of allopurinol, 20g of benzbromarone, 22g of sodium starch glycolate and 4g of superfine silica gel powder by a sieve of 80 meshes; putting 104g of microcrystalline cellulose in an oven at the temperature of 80 DEG C, baking for 2 hours, and sieving by the sieve of 80 meshes for later use; taking the prescription amounts of allopurinol and benzbromarone, and uniformly mixing by an equivalent amount increasing method; taking the prescription amounts of sodium starch glycolate and microcrystalline cellulose and half of the prescription amount of superfine silica gel powder, adding into the mixture of allopurinol and benzbromarone by the equivalent amount increasing method, and uniformly mixing; taking the mixture, using water as an adhesive to make damp mass, sieving by a sieve of 24 meshes to granulate, drying for 3 hours at the temperature of 60-70 DEG C, and arranging particles by a sieve of 22 meshes; uniformly mixing the left half of the prescription amount of superfine silica gel powder with the particles and tabletting, and the weight of each tablet is 0.25g.

There is provided a film coated pharmaceutical composition comprising 5′-deoxy-5-fluoro-N-[(pentyloxy)-carbonyl]-cytidine (capecitabine) and at least one disintegrant selected from the group comprising of crospovidone (particle size <15-400μ), croscarmellose sodium, sodium starch glycolate, low-substituted hydroxypropylcellulose, Ludiflash® or any combination of these, together with other pharmaceutically acceptable excipients to form a rapidly disintegrating tablet.

The invention relates to the medical field, in particular to a cefetamet pivoxil hydrochloride dispersible tablet and a preparation method thereof. The cefetamet pivoxil hydrochloride dispersible tablet is prepared by the following components, by weight: 40-60% of cefetamet pivoxil hydrochloride, 10-20% of microcrystalline cellulose, 5-15% of polyvinylpolypyrrolidone, 5-12% of calcium hydrophosphate, 5-15% of sodium starch glycolate, 0.5-5% of silicon dioxide, 0.5-5% of magnesium stearate, 0.01-0.2% of steviosin and a proper amount of water. Compared with the ordinary tablets and capsules, the cefetamet pivoxil hydrochloride dispersible tablet has the advantages of being good in dispersing state, short in disintegration time, fast in medicine dissolution and absorption, high in bioavailability, few in bar reaction, convenient to take and the like.

The invention discloses four-colored granular Keteling capsules. The four-colored granular Keteling capsules comprises a component A, a component B, a component C and a component D, wherein the component A is a ficus microcarpa dry extract; the component B comprises chlorpheniramine maleate and a proper amount of starch; the component C is starch; the component D is sodium starch glycolate; the component A, the component B, the component C and the component D are separately coated and granulated, and are then mixed to obtain the capsules. The invention further discloses a preparation method ofthe four-colored granular Keteling capsules. Aspects of indexes of correlation and the like such as the character, water, disintegration time, thin-layer identification, the content of the ficus microcarpa dry extract and the content of the chlorpheniramine maleate of the four-colored granular Keteling capsules conform to the rule of the pharmacopoeia criterion, wherein the stability of the content of the ficus microcarpa dry extract and the stability of the content of the chlorpheniramine maleate are remarkably higher than the stability of conventional sold products. Due to stable content, short disintegration time, rapid dissolving and rapid absorption, the efficacy is good.