Citicoline sodium tablets and preparation method thereof

A technology of citicoline sodium and sodium starch glycolate, applied in the field of citicoline sodium tablets and preparation thereof, can solve the problems of inconvenience in carrying and use, unstable physicochemical properties of medicines, and high production costs, and achieves improved performance. Stability and applicability, improved appearance quality, long shelf life effect

Active Publication Date: 2011-04-27
四川梓橦宫药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an injection, its production cost is high, it is not very convenient to carry and use, and the physical and chemical properties of the drug are not very stable.

Method used

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  • Citicoline sodium tablets and preparation method thereof
  • Citicoline sodium tablets and preparation method thereof
  • Citicoline sodium tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of citicoline sodium tablet, every 1000 tablets comprises the following components:

[0032] Citicoline Sodium 200.0g

[0033] Starch 50.0g

[0034] Microcrystalline Cellulose 100.0g

[0035] Hydroxypropyl methylcellulose 0.125g

[0036] Magnesium Stearate 3.5g.

[0037] The preparation method of above-mentioned citicoline sodium tablet, comprises the steps:

[0038] 1) Raw material preparation: Citicoline sodium is pulverized through a 100-mesh sieve, starch, microcrystalline cellulose and magnesium stearate are passed through a 100-mesh sieve, and hydroxypropyl methylcellulose is prepared into a 2.5% aqueous solution as a binder agent;

[0039] 2) Accurately weigh each raw and auxiliary material;

[0040] 3) Mix starch, microcrystalline cellulose and citicoline sodium evenly, add binder, stir evenly, make soft material, pass through 20 mesh nylon sieve to make granules;

[0041] 4) Place the granules in a drying oven, and heat and dry at 50°C;

[0042] ...

Embodiment 2

[0046] A kind of citicoline sodium tablet, every 1000 tablets comprises the following components:

[0047] Citicoline Sodium 300.0g

[0048] Starch 60.0g

[0049] Microcrystalline Cellulose 110.0g

[0050] Hydroxypropyl methylcellulose 1.8g

[0051] Pregelatinized starch 5.0g

[0052] Magnesium Stearate 5g

[0053] Carboxymethyl starch sodium 8g

[0054] The preparation method of above-mentioned citicoline sodium tablet, comprises the steps:

[0055] 1) Raw material preparation: Citicoline sodium is pulverized through a 100-mesh sieve, starch, microcrystalline cellulose, carboxymethyl starch sodium and magnesium stearate are passed through a 100-mesh sieve, and hydroxypropyl methylcellulose is prepared into 2.5% aqueous solution as a binder;

[0056] 2) Accurately weigh each raw and auxiliary material;

[0057] 3) Mix starch, microcrystalline cellulose, and citicoline sodium evenly, add a binder, stir evenly, make a soft material, pass through a 20-mesh nylon sieve to ...

Embodiment 3

[0063] A kind of citicoline sodium tablet, every 1000 tablets comprises the following components:

[0064] Citicoline Sodium 100.0g

[0065] Starch 40g

[0066] Microcrystalline Cellulose 55.0g

[0067] Hydroxypropyl methylcellulose 0.7g

[0068] Magnesium Stearate 1.5g

[0069] Sodium starch glycolate 2g

[0070] The preparation method of above-mentioned citicoline sodium tablet, comprises the steps:

[0071] 1) Raw material preparation: Citicoline Sodium is crushed through a 100-mesh sieve, starch, microcrystalline cellulose, pregelatinized starch and magnesium stearate are passed through a 100-mesh sieve, and hydroxypropyl methylcellulose is prepared into 2.5% aqueous solution as a binder;

[0072] 2) Accurately weigh each raw and auxiliary material;

[0073] 3) Mix starch, microcrystalline cellulose, pregelatinized starch and citicoline sodium evenly, add binder, stir evenly, make soft material, pass through 20-mesh nylon sieve to make granules;

[0074] 4) Place t...

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PUM

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Abstract

The invention provides citicoline sodium tablets which are medicinal preparations for treating sequela of a nervous system caused by a craniocerebral injury or a cerebrovascular accident, and a preparation method thereof. Every 1,000 tablets comprise 100.0 to 300.0g of citicoline sodium, 20.0 to 70.0g of starch, 50.0 to 160.0g of microcrystalline cellulose, 0.6 to 3g of hydroxypropyl methyl cellulose, 1.7 to 5.5g of magnesium stearate, 0 to 10g of sodium starch glycolate and 0 to 6.0g of pregelatinized starch. The preparation method of the citicoline sodium tablets mainly comprises the steps of sieving, weighing, proportioning, premixing, preparing a soft material, preparing wet granules, drying, granulating, mixing, tabletting, performing aluminum-plastic-aluminum packaging and outer packaging and the like. The tablets prepared by the method have the advantages of high yield, low cost, accurate divided dose, relatively stable medicinal physicochemical property and longer storage period and are convenient to carry and use.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to citicoline sodium tablets and a preparation method thereof. Background technique [0002] Citicoline Sodium (Citicoline Sodium), its molecular formula is C 14 h 25 N 4 NaO 11 P 2 , is the monosodium salt of choline cytidine nucleoside diphosphate, is a nucleoside derivative, and the dry product contains not less than 98% of citicoline sodium. Citicoline sodium can promote brain substance metabolism and improve cerebral circulation by reducing cerebrovascular resistance and increasing cerebral blood flow. It can also enhance the function of the ascending reticular activation system of the brain stem, enhance the function of the vertebral system, and improve motor paralysis, so it has a certain effect on promoting the recovery of brain function and waking up. After injection of citicoline sodium injection, it can quickly enter the blood, and part of it enters the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7068A61K47/38A61P9/10A61P25/28
Inventor 陈健李威唐铣张义发黄学兵
Owner 四川梓橦宫药业股份有限公司
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