Citicoline sodium tablets and preparation method thereof
A technology of citicoline sodium and sodium starch glycolate, applied in the field of citicoline sodium tablets and preparation thereof, can solve the problems of inconvenience in carrying and use, unstable physicochemical properties of medicines, and high production costs, and achieves improved performance. Stability and applicability, improved appearance quality, long shelf life effect
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Embodiment 1
[0031] A kind of citicoline sodium tablet, every 1000 tablets comprises the following components:
[0032] Citicoline Sodium 200.0g
[0033] Starch 50.0g
[0034] Microcrystalline Cellulose 100.0g
[0035] Hydroxypropyl methylcellulose 0.125g
[0036] Magnesium Stearate 3.5g.
[0037] The preparation method of above-mentioned citicoline sodium tablet, comprises the steps:
[0038] 1) Raw material preparation: Citicoline sodium is pulverized through a 100-mesh sieve, starch, microcrystalline cellulose and magnesium stearate are passed through a 100-mesh sieve, and hydroxypropyl methylcellulose is prepared into a 2.5% aqueous solution as a binder agent;
[0039] 2) Accurately weigh each raw and auxiliary material;
[0040] 3) Mix starch, microcrystalline cellulose and citicoline sodium evenly, add binder, stir evenly, make soft material, pass through 20 mesh nylon sieve to make granules;
[0041] 4) Place the granules in a drying oven, and heat and dry at 50°C;
[0042] ...
Embodiment 2
[0046] A kind of citicoline sodium tablet, every 1000 tablets comprises the following components:
[0047] Citicoline Sodium 300.0g
[0048] Starch 60.0g
[0049] Microcrystalline Cellulose 110.0g
[0050] Hydroxypropyl methylcellulose 1.8g
[0051] Pregelatinized starch 5.0g
[0053] Carboxymethyl starch sodium 8g
[0054] The preparation method of above-mentioned citicoline sodium tablet, comprises the steps:
[0055] 1) Raw material preparation: Citicoline sodium is pulverized through a 100-mesh sieve, starch, microcrystalline cellulose, carboxymethyl starch sodium and magnesium stearate are passed through a 100-mesh sieve, and hydroxypropyl methylcellulose is prepared into 2.5% aqueous solution as a binder;
[0056] 2) Accurately weigh each raw and auxiliary material;
[0057] 3) Mix starch, microcrystalline cellulose, and citicoline sodium evenly, add a binder, stir evenly, make a soft material, pass through a 20-mesh nylon sieve to ...
Embodiment 3
[0063] A kind of citicoline sodium tablet, every 1000 tablets comprises the following components:
[0064] Citicoline Sodium 100.0g
[0065] Starch 40g
[0066] Microcrystalline Cellulose 55.0g
[0067] Hydroxypropyl methylcellulose 0.7g
[0068] Magnesium Stearate 1.5g
[0069] Sodium starch glycolate 2g
[0070] The preparation method of above-mentioned citicoline sodium tablet, comprises the steps:
[0071] 1) Raw material preparation: Citicoline Sodium is crushed through a 100-mesh sieve, starch, microcrystalline cellulose, pregelatinized starch and magnesium stearate are passed through a 100-mesh sieve, and hydroxypropyl methylcellulose is prepared into 2.5% aqueous solution as a binder;
[0072] 2) Accurately weigh each raw and auxiliary material;
[0073] 3) Mix starch, microcrystalline cellulose, pregelatinized starch and citicoline sodium evenly, add binder, stir evenly, make soft material, pass through 20-mesh nylon sieve to make granules;
[0074] 4) Place t...
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