123 results about "Cerebral circulation" patented technology

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

The invention provides a system and a method for removal of contrast from blood. In one aspect, the invention provides a catheter for removal of contrast from the veins that drain the cerebral circulation. In a second aspect, the invention provides a method for removing contrast from blood by contacting the blood with a sorbent.

A simple always-portable stethoscope for enabling accurate diagnosis. A radiation / light-receiving fiber (11) serving as a probe part for noninvasively irradiating a diseased part with near-infrared light is applied to the diseased part so as to measure, e.g., a change of the cerebral circulation blood flow. The change is hard as sound pulse modulation to examine the change of the cerebral function. For example, a light beam of three wavelengths λ=760, 800, 830 nm from a semiconductor laser light source (22) is applied to the diseased part, the reflection data from the diseased part is processed by a control device (21), and the doctor can make a diagnosis with the doctor's ears by hearing with a receiver (32) the change as the change of the frequency of the sound the pitch and volume of which are constant.

The invention discloses a halogen substituted 2-(a-hydroxyl amyl) benzoate compound, a preparation method and medicinal application thereof, which belong to the technical field of organic chemical synthesis. The structural formula of the compound which is showed as above has an antimer structure, wherein <R1> represents a halogen atom; n is equal to 1 to 3; and M represents a univalent metallic ion or a bivalent metallic ion or a trivalent metallic ion or an organic base. The compound has the advantages of better activity on preventing and treating cardio-cerebral ischemia diseases, improving cardio-cerebral circulation disturbance and resisting thrombus, and the like.

The invention relates to a brain vascular blood circulation dynamic analysis method and the apparatus thereof. According to the cerebral circulation vascular bed anatomical model, an equivalent network model which comprises 12 pipeline units simulating the brain circulation blood dynamics is built, and the relevant parameter calculation formulas are confirmed, by utilizing the formulas, the flow rate waveform and the value inside the cartid artery, the pressure waveform, the blood pressure of the body, the diameter of the blood vessel, the flow rate waveform and the valve of the vertebral artery and the front, the middle and the rear parts on two sides inside the skull, and the characteristic and the parameter of the cartid artery and each blood vessel section inside the skull can be determined, the apparatus designed by the invention can be performed, the detecting system comprises the vessel diameter detecting of the cartid artery outside the skull, the blood pressure detecting, theblood flow rate detecting of the cartid artery outside the skull, the pressure waveform detecting of the cartid artery outside the skull, and the blood flow rate detecting on the artery inside the skull; the control system comprises a control module and a power supply module; the calculation and analysis system comprises a host computer, a peripheral equipment, and an analog-digital converter, the invention can fully analyze the brain circulation dynamic characteristic, thereby having notable effect on the early stage and the ultra early stage diagnosis and therapy of the brain vascular illness.

A system, apparatus and methods are provided for extra-corporeal blood treatment, and in particular for establishing and maintaining a neck down differential body temperature, while maintaining near normal brain temperatures, to protect the brain from extended or extreme hypothermia or hyperthermia. A blood treatment apparatus and system is provided for differential control of brain temperature and body temperature below the neck. For example, a first bypass circuit with heat exchanger for brain blood circulation maintains a near normal blood temperature, while a second bypass circuit for below the neck blood circulation provides for thermal treatment to induce a temperature differential, e.g. hyperthermia or hypothermia, relative to brain circulation. Such systems and apparatus have application, for example, for diagnostic and therapeutic treatments using hyperthermia, particularly for treatments of extended duration or at elevated temperatures above 42° C., for example, hyperthermia for treatment of cancer, infectious bacterial or viral diseases.

Single filter and multi-filter endolumenal methods and systems for filtering fluids within the body. In some embodiments a blood filtering system captures and removes particulates dislodged or generated during a surgical procedure and circulating in a patient's vasculature. In some embodiments a filter system protects the cerebral vasculature during a cardiac valve repair or replacement procedure.

A means for the treatment of insult based on hydrogenated pyrido(4,3-b)indoles (variants) of formula (1) or formula (2) a pharmacological means based thereon and a method for the use thereof relate to the use of chemical compounds in the field of medicine and may be used for the treatment of ischemic and hemorrhagic insults and their consequences.

The invention relates to a traditional Chinese medicine for treating cardiac, cerebral and vascular diseases; the drug is composed of forty kinds of crude drugs by weight parts: milk veteh, salvia miltiorrhiza, root of common peony, ligusticum wallichii, lumbricus, sanguisuga, rhizoma acori graminei, polygala root, red ocher, oyster, angelica, the root of kudzu vine, arisaema cum bile and the like; the preparation method is that: (1) the crude drugs are prepared into water extract liquid; (2) the water extract liquid is prepared into oral liquid; (3)the water extract liquid obtained by the step (1) is dried, crushed, sieved, undersize material is extracted powder; (4) the extracted powder prepared by the step (3) is prepared into various dosage forms. The preparation method of crude powder is that: lime earth of the crude drugs is sieved, and then the crude drugs are crushed and sieved, the undersize material is taken out and is sterilized to be crude powder, and the crude powder is prepared into various dosage forms. The traditional Chinese medicine has the major functions of treating miocardial infarction and angina caused by coronary heart disease, high blood pressure and cerebral thrombosis, hemiplegia, cerebral infarction, cerebrovascular accident, sequel of apoplexy and other symptoms, and the medicine has obvious effect on headache, dizziness and heart cerebrovascular diseases caused by high blood pressure and cerebral circulation insufficiency.

Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and / or solubilizing agent thereby to enhance the dispersibility and / or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.

A medical device for providing retrograde venous perfusion to the cerebral vasculature for treatment of global or focal cerebral ischemia is disclosed. The device includes a catheter having an infusion port at its distal end, venous drainage port(s), and an expandable occluder disposed between the infusion port and drainage port(s). The catheter can be inserted into the superior vena cava or the internal jugular vein. The catheter is attached proximally to a pump and an oxygenator with or without a cooling system. Alternatively, the device includes two catheters, each having a lumen communicating with a distal infusion port and an occluder mounted proximal to the port. The catheters can be inserted into the internal jugular veins distal to jugular venous valves. Methods of using the devices to provide retrograde venous perfusion and isolated cerebral hypothermia are disclosed.

A pharmaceutical composition comprising at least one of components (a) and at least one of components (b) shown in below: (a) a compound represented by the general formula (I) (wherein R1 represents a hydrogen atom or a hydroxyl group) or an acid addition salt or hydrate thereof; and (b) an ameliorant of cerebral circulation, a vasodilator, a cerebral protecting drug, an brain metabolic stimulants, an anticoagulant, an antiplatelet drug, a thrombolytic drug, an amelirant of psychiatric symptom, a antihypertensive drug, an antianginal drug, a diuretic, a cardiotonic, an antiarrhythmic drug, an antihyperlipidemic drug, an immunosuppressant, or a pharmaceutically acceptable salt (except the components shown in (a)). It is useful as a preventive or remedy for cerebrovascular disorders and cardiac diseases.

This document provides systems and methods for testing and assessing cognitive performance of a user over a period of time in order to test environmental effects and other factors on the performance of the user. For example, cognitive performance over a period of time can be assessed for users experiencing stress conditions including hypoxia (oxygen deprivation), hypothermia, sleep deprivation, fatigue or other factors that may cause degradation in cognitive performance. Furthermore, the systems and methods described herein can be used to identify when hypoxia has manifested in the cerebral circulation of an individual rather than merely in the extremities of an individual.

A method for modifying a property of a brain of a patient includes presenting an odorant to an air passage of the patient, the odorant having been selected for presentation to the air passage because it is such as to increase conductance of molecules from a systemic blood circulation of the patient through a blood brain barrier (BBB) of the brain into brain tissue of the patient. The molecules are selected from the group consisting of: a pharmacological agent, a therapeutic agent, an endogenous agent, and an agent for facilitating a diagnostic procedure.

A cerebrovascular regulation function monitor system and a method for detection of cerebrovascular circulation critical closing pressure, wherein the cerebrovascular regulation function monitor system includes a signal collection system for in-phase sampling analog signal of transcranial doppler (TCD) signal and continuous artery pressure signal and further converting the analog signals into correspondent digital signals and a signal processing / displaying system connected with the signal collection system via interfaces for processing the digital signals to obtain the cerebrovascular critical closing signal and displaying them. The method and system realize a non-invasion detection and monitor of cerebrovascular autoregulation function in clinical practice.

A medical device having a catheter and one or more expandable constricting / occluding members. The catheter is adapted for use with therapeutic or diagnostic devices, including an angioplasty / stent catheter and an atherectomy catheter. A first constrictor / occluder mounted at the distal end of the catheter is adapted for placement in a brachiocephalic or subclavian artery. A second constrictor mounted proximal to the first constrictor / occluder is adapted for placement in the descending aorta. Pressure measuring devices may be included, and filters may be used to capture embolic debris. Methods of using the devices for preventing distal embolization during extracranial or intracranial carotid procedures or vertebral artery procedures by augmenting collateral cerebral circulation by coarctation of the aorta to enhance reversal of blood flow in an internal carotid artery, an external carotid artery, and / or a common carotid artery toward the subclavian artery are disclosed.

The invention provides a vinpocetin containing high-capacity sodium chloride injection and a preparation method thereof, aiming at solving the problems that vinpocetin is mainly applied to middle aged and elderly patients, high-capacity glucose injection contains massive glucose and is not beneficial to treating patients suffering from diabetes at the same time. The invention has the key point that the injection is mainly composed of vinpocetin, osmotic pressure regulator, cosolvent and pH value regulator. The vinpocetin high-capacity sodium chloride injection of the invention has high bioavailability and stable quality, is convenient to use and is applicable to treatment of patients suffering from neurologic disease caused by cerebral circulation restriction, especially the patients suffering from diabetes at the same time.

The invention discloses application of a Tibetan medicinal composition to the preparation of a medicament for treating cerebral circulation insufficiency. The Tibetan medicinal composition consists of the following raw material medicaments in part by weight: 5 to 15 parts of lamiophlomis, 2 to 10 parts of whin, 15 to 60 parts of turmeric, 7 to 20 parts of pepper, 5 to 15 parts of buffalo horn, 15 to 40 parts of myricariagermanica, 0.1 to 2.5 parts of safflower, 0.1 to 5 parts of borneol and 0.1 to 5 parts of camphor. Further research on the pharmacology of the conventional Tibetan medicinal composition indicates that the Tibetan medicinal composition has good curative effect on cerebral circulation insufficiency. Moreover, natural wild medicinal materials from the Tibet Plateau are adopted and no chemically-synthesized stabilizing agent is added, so that the Tibetan medicinal composition has no toxic or side effect on a human body, is safe and effective and is suitable for all kinds of people and for treating various types of cerebral circulation insufficiency.

The present invention discloses the puerarin derivatives, and their preparation process, medicine compositions and application in preparing medicine for treating cardiac and cerebral vascular diseases, obstruction of retinal artery and vein, sudden hearing loss and other diseases, improving memory and lowering blood sugar.

The invention relates to a Chinese medicinal preparation for treating chronic cerebral circulation insufficiency. The Chinese medicinal preparation is prepared from the following traditional Chinese medicines: 30 grams of astragalus, 15 grams of kudzuvine root, 15 grams of Chinese taxillus twig, 30 grams of root of red-rooted salvia, 9 grams of raw fructus crataegi, 9 grams of szechuan lovage rhizome, 10 grams of cassia twig, 12 grams of dwarf lilyturf root, 6 grams of Chinese magnoliavine fruit and 15 grams of fried date kernel. A preparation method of the Chinese medicinal preparation comprises the following steps of: adding 1,000 ml of water into the Chinese medicinal herbs subjected to processing for decocting; concentrating the decoction to 200 ml; and extracting residues and filtering to obtain a decoction. The Chinese medicinal preparation is taken once every day, and each treatment course lasts for two weeks. The Chinese medicinal preparation has the effects of replenishing qi, enriching the blood, relaxing muscles and joints, activating the channels, remarkably improving heart and brain circulation, enhancing mechanism immunity, resisting inflammation, delaying senility, treating both principal and secondary aspects of a disease, and the like, has reasonable compatibility, and can be used for effectively relieving symptoms such as dizziness, head heaviness, headache, dysphoria, tinnitus, irritability, insomnia, dreaminess, hypomnesia, inattention, fatigue, and the like of a patient suffering from chronic cerebral circulation insufficiency.

The invention relates to a Chinese medicinal preparation for treating chronic cerebral circulation insufficiency. The Chinese medicinal preparation is prepared from the following traditional Chinese medicines: 30 grams of astragalus, 15 grams of kudzuvine root, 15 grams of Chinese taxillus twig, 30 grams of root of red-rooted salvia, 9 grams of raw fructus crataegi, 9 grams of szechuan lovage rhizome, 10 grams of cassia twig, 12 grams of dwarf lilyturf root, 6 grams of Chinese magnoliavine fruit and 15 grams of fried date kernel. A preparation method of the Chinese medicinal preparation comprises the following steps of: adding 1,000 ml of water into the Chinese medicinal herbs subjected to processing for decocting; concentrating the decoction to 200 ml; and extracting residues and filtering to obtain a decoction. The Chinese medicinal preparation is taken once every day, and each treatment course lasts for two weeks. The Chinese medicinal preparation has the effects of replenishing qi, enriching the blood, relaxing muscles and joints, activating the channels, remarkably improving heart and brain circulation, enhancing mechanism immunity, resisting inflammation, delaying senility, treating both principal and secondary aspects of a disease, and the like, has reasonable compatibility, and can be used for effectively relieving symptoms such as dizziness, head heaviness, headache, dysphoria, tinnitus, irritability, insomnia, dreaminess, hypomnesia, inattention, fatigue, and the like of a patient suffering from chronic cerebral circulation insufficiency.

The invention discloses a method and an instrument for analyzing the energy indexes of the cerebral blood vessel. The method comprises the steps of: detecting out the blood flow velocity wave form, the numerical value, the blood vessel diameter and the pressure waveform of carotid artery; detecting out the diastolic pressure and the systolic pressure of a human body to obtain the pressure waveform and the numerical value of the carotid artery; then calculating out the total potential energy, the stable potential energy, the oscillation potential energy, the total kinetic energy, the stable kinetic energy, the oscillation kinetic energy, the total energy, the stable total energy and the oscillation total energy of the cerebral blood vessel, and finally calculating out the ration of the oscillation total energy to the total energy, the ratio of the total kinetic energy to the total energy, the ratio of the oscillation potential energy to the total potential energy and the ratio of the oscillation kinetic energy to the total kinetic energy of the cerebral blood vessel. The detection analysis instrument comprises a detection system, a control system and a computation analysis system, wherein the control system can send an operation command to each detection module and can also transmit the acquired data information to a master industrial personal computer. A series of indexes of the cerebral circulation blood flow energy can be comprehensively analyzed with an invasive method, therefore, the invention has great importance for the basic research and clinical application of the cerebral circulation.

The invention relates to an application of acteoside in preparing a medicine for treating alzheimer disease. The acteoside is used for preventing the alzheimer disease by multi-target-point action. The acteoside is synthesized artificially or is obtained from plants. Verified by in vivo and vitro experiments, the acteoside has the advantages that the central cholinergic nervous system can be improved, the level of glutamic acid can be adjusted, the formation and deposition of beta amyloid protein (Abeta) can be inhibited, the action of neuroprotection is achieved, the hyperphosphorylation of tau protein is inhibited, the antioxidant action is achieved, the cerebral circulation is improved, and cholesterol can be reduced, so that the multi-target-point prevention and treatment of the alzheimer disease is realized.

The invention discloses application of a Tibetan medicinal composition to the preparation of a medicament for treating cerebral circulation insufficiency. The Tibetan medicinal composition consists of the following raw material medicaments in part by weight: 5 to 15 parts of lamiophlomis, 2 to 10 parts of whin, 15 to 60 parts of turmeric, 7 to 20 parts of pepper, 5 to 15 parts of buffalo horn, 15to 40 parts of myricariagermanica, 0.1 to 2.5 parts of safflower, 0.1 to 5 parts of borneol and 0.1 to 5 parts of camphor. Further research on the pharmacology of the conventional Tibetan medicinal composition indicates that the Tibetan medicinal composition has good curative effect on cerebral circulation insufficiency. Moreover, natural wild medicinal materials from the Tibet Plateau are adopted and no chemically-synthesized stabilizing agent is added, so that the Tibetan medicinal composition has no toxic or side effect on a human body, is safe and effective and is suitable for all kinds of people and for treating various types of cerebral circulation insufficiency.

The invention discloses a portable multifunctional monitoring and analyzing instrument for cerebral circulation dynamics. The portable multifunctional monitoring and analyzing instrument for the cerebral circulation dynamics comprises a detection unit, a data conversion unit and an analysis unit in sequence, wherein the detection unit comprises a blood flow velocity detection module, a blood pulsating pressure detection module and an electrocardiograph detection module which are arranged in parallel, signals of the three modules are output to the data conversion module and are converted into data through the data conversion unit, and the analysis unit is used for calculating cerebral circulation dynamic indexes and a total score of cerebral vascular functions according to the data output by the data conversion unit. According to the scheme, the portable multifunctional monitoring and analyzing instrument for the cerebral circulation dynamics can rapidly and comprehensively evaluate cerebral vascular function state and damage degree, has great significance in pre-warning of stroke, objective evaluation of therapeutic measures, screening of prevention and cure drugs and the like, solves the key technical problem of a data acquisition system and an analysis system, breaks monopoly of overseas technologies and clears away obstacles in large-scale application of a novel cerebrovascular disease detecting instrument.