133 results about "Neuronal protection" patented technology

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative as well as a pharmaceutical composition, application and a preparation method thereof. The piperidine derivative has the following general formula. The piperidine derivative can be effectively used for treating or preventing multiple sclerosis, and shows an unexpected synergistic effect in an animal model: the piperidine derivative not only can significantly improve neurological function impairment and promote recovery, but also can deeply reduce the levels of key proinflammatory cytokines IFN-gamma and IL-17 at the same time. The invention provides a novel small molecule candidate drug with central permeability, neuroprotection and comprehensive immune regulation functions for treatment of multiple sclerosis.

The invention discloses novel application of notoginsenoside Rg1, namely application of the notoginsenoside Rg1 in preparation of a cathepsin D (CTSD) inhibitor, the notoginsenoside Rg1 can inhibit CTSD enzyme activity so as to recover lysosome structure and function, relieve endoplasmic reticulum stress reaction and relieve alpha-syn aggregation and dopaminergic neuron apoptosis, has a remarkable protection effect on a Parkinson's disease model, and can be used for preparing a novel anti-inflammatory drug. The invention provides a new thought and a potential drug basis for targeted intervention of Parkinson's disease. The invention discloses a new mechanism that Rg1 plays a role in neuroprotection through a CTSD-lysosome-endoplasmic reticulum stress pathway.

The invention discloses a curcumin-loaded brain-targeted drug delivery system as well as a preparation method and application thereof. The delivery system comprises a carrier macrophage and a curcumin drug, the curcumin nano-drug is prepared by encapsulating curcumin with a lipoic acid modified cyclodextrin conjugate, then macrophages and the curcumin nano-drug are mixed, and co-incubation is carried out, so that the curcumin nano-drug is constructed. The brain-targeted macrophage drug delivery system loaded with curcumin is a multifunctional composite drug with brain targeting property for treatment of cerebral arterial thrombosis. A brain-targeted macrophage drug delivery system loaded with the curcumin nano-drug gathers in cerebral apoplexy tissues, phenotypic transformation of inflammatory microglial cells is promoted, and a pro-inflammatory microenvironment is improved; the oxidative stress pressure of the stroke part is improved; the two effects promote each other, the stroke microenvironment is improved, the functions of neuronal cells are saved, the synergistic nerve protection effect can be achieved in the aspect of treating ischemic cerebral apoplexy, and potential safety hazards are reduced.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

The invention discloses a bipeptide modified bionic nano-vesicle as well as a preparation method and application thereof, and belongs to the field of biological medicines. The dipeptide modified bionic nano-vesicle comprises nano-particles formed by PLGA (poly (lactic-co-glycolic acid)), and the nano-particles are loaded with a medicine with a nerve protection or nerve repair effect; the surface of the nanoparticle is coated with a macrophage membrane for expressing RVG peptide and T7 peptide. The bipeptide modified bionic nano-vesicle simultaneously presents T7 peptide and RVG peptide through an engineered macrophage membrane, the T7 peptide is combined with a blood-brain barrier transferrin receptor through high affinity to realize efficient brain entry, astrocytes in the brain are specifically recognized by virtue of the RVG peptide, accurate recognition and delivery of target cells in a focus area are realized, and the bipeptide modified bionic nano-vesicle has a good application prospect. Meanwhile, the natural inflammation tropism and immune escape ability of a macrophage membrane are reserved, and the problems that a traditional drug delivery system is low in targeting precision, and cross-barrier distribution and intracerebral distribution are difficult to cooperate are solved.

The invention discloses application of ginsenoside Rg5 in preparation of a medicine for treating Alzheimer's disease and an evaluation method, and relates to application of ginsenoside Rg5 in preparation of a medicine for treating Alzheimer's disease. The medicine improves A beta deposition, tau protein phosphorylation and neuron damage by adjusting the intestinal flora structure and metabolite level, and is used for relieving the pathological process of the Alzheimer's disease. The invention has the characteristics of multi-target effect, nerve protection, inflammation resistance and oxidation resistance.

A handheld ultrasound guiding system for the transcutaneous delivery of a needle into blood vessel that can be used to then deliver a guidewire, the battery powered light-weight device consisting of a phased array ultrasound generator, a transducer probe, a screen, computer processor that is mechanically coupled to a needle holder mounted at an angle to the ultrasound probe, the needle is mounted such that it can be advanced into a target blood vessel that is being visualized real-time by the ultrasound probe.

The invention provides an antioxidant peptide as well as a preparation method and application thereof, and belongs to the technical field of biology. The invention provides an antioxidant peptide with an amino acid sequence as shown in SEQ ID NO. 2 and / or an antioxidant peptide with an amino acid sequence as shown in SEQ ID NO. 4. Two antioxidative peptides are identified from the gastrodia elata protein hydrolysate through enzymolysis, ultrafiltration, gel chromatography purification and mass spectrometry technologies in combination with ABTS and DPPH free radical scavenging activity, the molecular weights of the two antioxidative peptides are 937.08 Da and 1153.50 Da respectively, and the two antioxidative peptides have high antioxidative activity, heat stability and in-vitro safety and can be used for preparing antioxidative peptides for the gastrodia elata protein hydrolysate. The cell viability decline and ROS level rise caused by oxidative stress injury of cells can be effectively relieved, and the neuroprotective effect can be achieved by activating an Nrf2 pathway. The antioxidant peptide is suitable for daily chemical products, skin care and beauty cosmetics, health foods and medicines with antioxidant efficacy requirements.

The application discloses a cardiovascular maintenance functional wine based on a composite fermentation process and a preparation method thereof. Through synergistic fermentation of rosewood flavones, five-grain nutrients and rhizoma notopterygii blood-activating components, a cardiovascular maintenance wine with multiple effects of blood pressure regulation, microcirculation improvement, nerve protection and anti-inflammation is developed. Process parameters are optimized and designed to ensure efficient reservation and release of active components, and the cardiovascular maintenance wine is suitable for daily auxiliary conditioning of sub-healthy people and cardiovascular risk groups.

The application discloses a preparation method and application of a conjugate targeting pelvic autonomic nerves, wherein the conjugate is NE-RH formed by coupling of rhein and norepinephrine, the conjugate can realize precise targeting of norepinephrine neurons, improve the accumulation effect of RH in the norepinephrine neurons, and further enhance the nerve protection effect of RH. The conjugate has a molecular weight of less than 1000 Da, can help to penetrate the blood-brain barrier, and can avoid the defects of being easily removed by a mononuclear phagocyte system and having a short half-life. The production process of the conjugate is simple, the chemical coupling reaction is clear, the yield can reach 38%, and the purity of the product is greater than 99%, so that the conjugate is convenient to popularize and use. The conjugate and the preparation method have important significance for the damage repair of pelvic autonomic nerves.

The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.

The invention discloses a system for predicting the risk of nerve injury caused by radiotherapy based on deep learning, and belongs to the technical field of medical artificial intelligence and radiotherapy, and the system comprises a neural structure automatic segmentation module, a dose-neural response modeling module, an individualized risk assessment module, a radiotherapy plan optimization module and a closed-loop feedback regulation unit. The system adopts an encoder-decoder deep network to perform high-precision segmentation on nervous tissues, establishes a dose-nerve response quantitative model by fusing dosiomics and radiomics characteristics, and realizes individualized risk assessment based on a multi-factor risk quantitative network. An optimization scheme for balancing tumor control and neuroprotection is generated through Pareto optimal search, collaborative optimization of all the modules is achieved through closed-loop feedback, and decision support is provided for precise radiotherapy.

This invention belongs to the field of biomedical technology, specifically relating to an engineered exosome and its applications. This invention is the first to discover that PCDH12 is specifically highly expressed in the trabecular meshwork tissue of glaucoma patients. Based on this target, engineered exosomes loaded with PCDH12 antibodies were successfully developed. These engineered exosomes can achieve non-invasive and precise targeted delivery to the trabecular meshwork tissue. In glaucoma model mouse experiments, they not only significantly reduced intraocular pressure but also effectively protected the optic nerve. The non-invasive and precise delivery strategy proposed in this invention combines potent intraocular pressure reduction with direct neuroprotection, providing a candidate solution with direct clinical translational potential for integrated "pressure reduction-neuroprotection" treatment of glaucoma.

The invention discloses a colla corii asini in-vivo bioactive component cyclic dipeptide and a discovery method thereof, and belongs to the technical field of bioactive component analysis and application. The method comprises the following steps: establishing a rat donkey-hide gelatin administration model and collecting a sample, performing solid-phase extraction on the sample, performing LC-MS / MS peptidomics analysis and PEAKS database search, screening exogenous oligopeptides based on a feature-based molecular network (FBMN), performing cyclic dipeptide targeted metabonomics identification, and verifying cell viability. According to the method, 29 cyclic dipeptides are produced by metabolism in donkey-hide gelatin, and the cyclic dipeptides containing hydroxyproline (Hyp) can significantly improve the survival rate of HT-22 cells damaged by glutamic acid or hydrogen peroxide induction and have neuroprotective activity.

The invention provides a duodenum ablation system and method combined with three-dimensional reconstruction. The duodenum ablation system combined with three-dimensional reconstruction comprises a main control unit, a three-dimensional reconstruction module, an intelligent ablation planning module, a neurological function surveying and mapping module, an ablation execution device and a real-time monitoring and feedback control module, through an integrated intracavity electrical stimulation surveying and mapping technology, functional evaluation and mapping can be performed on nerve excitability of a target area before ablation, and a'nerve high-risk area 'is visually marked on a three-dimensional mucous membrane model. When the system performs automatic path planning, the areas can be actively avoided, or verified safe energy parameters are adopted in the areas, so that important intestinal nerve functions are protected to the greatest extent, and the risk of nerve injury related complications is reduced from the source. Therefore, the purposes of intelligent navigation, automatic planning, individualized self-adaptive control and functional nerve protection are achieved.

The invention discloses a triterpenoid component cyclatraine A in stems and leaves of astragalus membranaceus and application of the triterpenoid component cyclatraine A in neuroprotection, and belongs to the field of medicines. According to the method, separation methods such as normal-phase silica gel column chromatography, reversed-phase ODS column chromatography and high-performance liquid chromatography are adopted, chemical components in the ethanol extract of the stems and leaves of astragalus membranaceus are separated and purified, and a new triterpenoid component is successfully found and identified. Meanwhile, through an A beta 25-35 induced damaged PC12 cell model, the protection effect of the new triterpenoid component on nerve cells is researched. Experimental results show that the new triterpenoid components in the stems and leaves of the astragalus membranaceus can remarkably protect PC12 cells from being damaged through an anti-inflammatory and apoptosis inhibiting mechanism. The discovery provides an important scientific basis for further development and utilization of the stems and leaves of astragalus membranaceus, and also provides a new research direction for research and development of neuroprotective drugs.

The present invention relates to a composition for protecting nerve cells, comprising a supercritical extract of Cannabis sativa and, more specifically, to a composition for protecting nerve cells, comprising a supercritical extract of Cannabis sativa, thereby exhibiting an antioxidant effect and a nerve cell death inhibitory effect.

The invention particularly discloses application of an outer vesicle to treatment of neuron injury, and relates to the technical field of biological medicines. The extracellular vesicle is secreted after exercise, a mouse SCI model is used for proving that the plasma extracellular vesicle of an athlete can remarkably inhibit neuronal ferroptosis, so that the recovery of the exercise function after injury is promoted, and further mechanism research shows that the extracellular vesicle can be used for inhibiting neuronal ferroptosis of the athlete. The plasma extracellular vesicles of athletes play a key role in ferroptosis inhibition and functional recovery after SCI through RNF216. Generally speaking, the invention discloses an important role of the plasma extracellular vesicles of athletes in neuronal protection and motor function recovery after SCI, provides a theoretical basis and an experimental basis for developing a new treatment strategy, and has good clinical transformation and clinical application prospects.

Interleukin-34 is a cytokine that is involved in the differentiation and survival of macrophages, monocytes, and dendritic cells in response to inflammation. The involvement of IL-34 has been shown in areas as diverse as neuronal protection, autoimmune diseases, infection, cancer, and transplantation. Recent work has also demonstrated a new and possible therapeutic role for IL-34 as a Foxp3+ Treg-secreted cytokine mediator of transplant tolerance. New mutated IL-34 polypeptides have been generated, which can be used as agonists or antagonists.

The invention relates to application of NADH (nicotinamide adenine dinucleotide) in preparation of drugs for preventing or treating autism, and further provides a liposome nanoparticle oral preparation for preventing or treating autism, the NADH can reduce central nervous system inflammation, and tests prove that the NADH can remarkably reduce neural immune inflammation of autism model rats, and can be used for preventing or treating autism. The method has the advantages that the method is simple and convenient to operate and has neuroprotection and progeny rat behavioral correction capacity, social experiment defects of progeny rats are overcome, the engraving behaviors of the progeny rats are reduced, the influence of autism-related behaviors of the progeny rats is reversed, and a new scheme is provided for prevention or treatment of autism.

The invention belongs to the technical field of pharmaceutical co-crystals, and particularly relates to a synthetic method and application of an amantadine-butylphthalide co-crystal. Butylphthalide reacts to obtain butylphthalide salt or butylphenyltitanic acid, the butylphthalide salt or butylphenyltitanic acid reacts with different substituted amantadine or hydrochloride thereof to synthesize the pharmaceutical co-crystal, and the co-crystal structure can adjust the crystal lattice energy of the pharmaceutical, improve the solubility of the pharmaceutical in water or physiological media, promote the rapid dissolution and absorption of the pharmaceutical in vivo, improve the bioavailability and improve the bioavailability of the pharmaceutical. According to the eutecticum, the problem of solubility of butylphthalide is solved, the formed eutecticum shows certain neuroprotective activity, the biological activity of the eutecticum is remarkably superior to that of a monomer drug, the clinical medication dosage can be reduced while the same treatment effect is achieved, and the eutecticum has certain scientific research value and industrial popularization significance.

The invention discloses an euphausia superba oil composition for promoting growth of retinal cells and improving oxidative damage of the retinal cells and application of the euphausia superba oil composition, and belongs to the technical field of functional foods.The euphausia superba oil composition is prepared from, by weight, 0.1-500 parts of euphausia superba oil, 0.1-25 parts of lutein ester and 0.1-5 parts of zeaxanthin; the content of phospholipid in the euphausia superba oil is greater than or equal to 38 wt%, and the content of omega-3 polyunsaturated fatty acid is greater than or equal to 9 wt%. The raw materials of the composition are easy to obtain, the safety is high, retinal cell proliferation can be promoted, the inhibition effect of H2O2 on retinal cells is improved, H2O2-induced high inflammation and high oxidative stress states are relieved, damage of H2O2 to retinal cells is relieved, and the composition has wide application prospects in the aspect of preparing products for optic nerve protection.

The invention provides a method for preparing a composition capsule containing a sea squirt extract, DHA and NMN, and relates to the technical field of health-care food. The composition capsule is composed of the sea squirt extract, free docosahexaenoic acid, nicotinamide mononucleotide and vitamin E. The composition comprises the following components in parts by weight: 14-20 parts of the sea squirt extract, 20-40 parts of the free docosahexaenoic acid, 40-53 parts of the nicotinamide mononucleotide and 0.2-2 parts of the vitamin E. The plasmalogen in the sea squirt extract can improve the function of a cell membrane in brain cells and improve the immunity of the brain cells. DHA has the effect of promoting formation and development of brain cells, NMN is utilized for promoting synthesis and release of neurotransmitters to improve the function stability of a nervous system, vitamin E serves as an antioxidant and an anti-inflammatory agent to enhance nerve protection, and the composition capsule has the synergistic effect, so that the brain function is remarkably enhanced, brain aging is delayed, and the effect of improving the brain function is achieved. The senile dementia is effectively prevented and improved.

Microorganisms for lowering blood ammonia level and composition for protecting neuronal cells containing the same, particularly relates to microbes or a symbiotic pair that has a neuroprotective function by lowering blood ammonia levels or reducing ammonia levels in the body and composition for protecting neuronal cells comprising the microbes. The microorganisms having a neuroprotective function by lowering the blood ammonia level can be selected from the group that include, but not limited to, a Lactobacillus sp. strain and a Streptococcus sp. strain. The ammonia removal strains and the composition have a neuroprotective effect by their excellent ability to remove neurotoxic ammonia, and thus can be widely used as a preventive or therapeutic agent for hyperammonemia and neurological diseases caused thereby.

The present disclosure relates to highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate and biomedical uses thereof. In particular highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate, is provided for enhancing bodily function and treating various disease states. The methods described herein provide for production of a highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate via processes external to the human body and administering effective amounts of highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate to human subjects to achieve a range of therapeutic benefits, including but not limited to, one or more of: inhibiting inflammasome activation, reducing pro-inflammatory cytokines, improving insulin sensitivity, enhancing mitochondrial biogenesis, and promoting muscle protein synthesis. Additionally, highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate is administered in an amount and frequency conducive to one or more of: improving cognitive function, reducing oxidative stress, enhancing cardiovascular health, and supporting neuroprotection. Methods for manufacturing and purifying (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate compositions to ensure high specificity and efficacy in therapeutic applications are also provided.

The invention discloses a spinal stenosis minimally invasive nerve protection decompression device, and relates to the related field of spinal stenosis minimally invasive, the spinal stenosis minimally invasive nerve protection decompression device comprises a fixing cylinder, the outer side of the upper end of the fixing cylinder is fixedly provided with a connecting block, and the lower end of the circle center of the fixing cylinder is movably provided with a fixing long needle; the top of the fixed long needle is fixed to the bottom end of the rotating ball body, a locking mechanism is arranged at the bottom of the threaded pipe, and the locking mechanism acts between the rotating ball body and the fixed ball body to achieve relative locking of the rotating ball body and the fixed ball body. According to the spinal canal stenosis minimally invasive nerve protection decompression equipment, a second rotating block drives a threaded pipe to move downwards, an arc-shaped ball is driven to extrude two sets of symmetrical locking blocks, the position of a drag hook can be accurately controlled, and the complexity and injury risk of manual nerve traction are avoided; through the cooperation of the penetrating type cleaning pipe and the one-way nozzle, the operation area can be cleaned synchronously, the pollution hidden danger in the operation is reduced, and the multiple requirements for nerve protection, operation efficiency and operation precision in the minimally invasive scene are met on the whole.

An adhesive ulnar nerve protection device for protecting the ulnar nerve of a patient comprises a foam member and a first releasably-adhesive component. The foam member comprises a first side and a second side, and is sized and shaped to accommodate substantially the entire ulnar nerve region of a patient's arm. The first releasably-adhesive component is disposed upon the first side of the device, and the first side of the device is disposed around and adhesively attached to substantially the entire ulnar nerve region of the patient's arm during use. In some embodiments, the adhesive ulnar nerve protection device further comprises a second releasably-adhesive component disposed upon the second side of the device. In such embodiments, the second side of the device can be disposed upon and adhesively attached to a medical furnishing and / or another portion of the patient's body during use.

MicroRNA modified umbilical cord mesenchymal stem cells and exosomes and applications. The present application provides a treatment technology based on miR-210 mutant umbilical cord mesenchymal stem cells and exosomes. By specifically modifying the miR-210 sequence, a mutant with enhanced stability and targeting efficiency is obtained. After being introduced into umbilical cord mesenchymal stem cells, exosomes with high expression of the mutant can be prepared. The exosomes show significant therapeutic effect in various disease models, including promoting angiogenesis, accelerating wound repair and neuroprotection. The present application simultaneously protects the mutant sequence, recombinant vector, recombinant cell and its preparation method, and the application of the exosomes in the preparation of drugs for treating ischemic diseases and tissue damage. This technology optimizes the sequence and delivery system of miR-210, providing a new solution for tissue repair.

The invention discloses application of salvianolic acid C in preparation of a medicine for preventing and / or treating retinal ischemia hypoxic nerve injury diseases, and relates to the technical field of biological medicines. The invention proposes and verifies for the first time that salvianolic acid C can significantly promote the formation of stress particles in photoreceptor cells under retinal ischemia and hypoxia conditions, and drives the salvianolic acid C to be assembled into a stress particle-mitochondrial micro-region in a mitochondrial adjacent region. The microcell is enriched in DDX3X, LARP1 and other key RNA binding proteins and multiple mitochondrial related proteins to cooperatively maintain mitochondrial membrane potential, inhibit mPTP opening and reduce ROS generation, so that an endogenous apoptosis pathway is inhibited, and the neuroprotective effect on a photoreceptor is achieved. On the basis, the salvianolic acid C is used for preparing the medicine for preventing and / or treating the retinal ischemia hypoxia nerve injury disease, can be used as a nerve protection supplement for existing anti-VEGF treatment, and has innovativeness and application value.