173 results about "Neuronal protection" patented technology

The invention belongs to the field of drug preparation, and particularly relates to a preparation method and application of a drug delivery system based on hollow mesoporous polydopamine nanoparticles. The drug delivery system comprises hollow mesoporous polydopamine nanoparticles, a drug loaded inside and / or outside the hollow mesoporous polydopamine nanoparticles, and pectin wrapping the hollow mesoporous polydopamine nanoparticles, the medicine is a medicine with a nerve protection effect and an acetylcholin esterase inhibitor. The drug delivery system can reduce proinflammatory cytokines, regulate functions of target immune cells, synergistically reduce necrosis of neurons in intestinal tracts and induce neural crest stem cells in the intestinal tracts to be differentiated into neurons.

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative as well as a pharmaceutical composition, application and a preparation method thereof. The piperidine derivative has the following general formula. The piperidine derivative can be effectively used for treating or preventing multiple sclerosis, and shows an unexpected synergistic effect in an animal model: the piperidine derivative not only can significantly improve neurological function impairment and promote recovery, but also can deeply reduce the levels of key proinflammatory cytokines IFN-gamma and IL-17 at the same time. The invention provides a novel small molecule candidate drug with central permeability, neuroprotection and comprehensive immune regulation functions for treatment of multiple sclerosis.

The invention discloses novel application of notoginsenoside Rg1, namely application of the notoginsenoside Rg1 in preparation of a cathepsin D (CTSD) inhibitor, the notoginsenoside Rg1 can inhibit CTSD enzyme activity so as to recover lysosome structure and function, relieve endoplasmic reticulum stress reaction and relieve alpha-syn aggregation and dopaminergic neuron apoptosis, has a remarkable protection effect on a Parkinson's disease model, and can be used for preparing a novel anti-inflammatory drug. The invention provides a new thought and a potential drug basis for targeted intervention of Parkinson's disease. The invention discloses a new mechanism that Rg1 plays a role in neuroprotection through a CTSD-lysosome-endoplasmic reticulum stress pathway.

The invention discloses a curcumin-loaded brain-targeted drug delivery system as well as a preparation method and application thereof. The delivery system comprises a carrier macrophage and a curcumin drug, the curcumin nano-drug is prepared by encapsulating curcumin with a lipoic acid modified cyclodextrin conjugate, then macrophages and the curcumin nano-drug are mixed, and co-incubation is carried out, so that the curcumin nano-drug is constructed. The brain-targeted macrophage drug delivery system loaded with curcumin is a multifunctional composite drug with brain targeting property for treatment of cerebral arterial thrombosis. A brain-targeted macrophage drug delivery system loaded with the curcumin nano-drug gathers in cerebral apoplexy tissues, phenotypic transformation of inflammatory microglial cells is promoted, and a pro-inflammatory microenvironment is improved; the oxidative stress pressure of the stroke part is improved; the two effects promote each other, the stroke microenvironment is improved, the functions of neuronal cells are saved, the synergistic nerve protection effect can be achieved in the aspect of treating ischemic cerebral apoplexy, and potential safety hazards are reduced.

The invention discloses a manufacturing and application method of a lower jawbone sagittal splitting deboning and nerve protection guide plate, and belongs to the field of medical instruments in surgical operations. The manufacturing method comprises the following steps: S01, acquiring CT data of the lower jawbone of a patient; s02, importing the CT data of the lower jawbone of the patient into three-dimensional software to segment and reconstruct a model of the lower jawbone and the inferior alveolar nerve of the patient; s03, on the segmented and reconstructed mandible model, simulating a sagittal splitting operation of the mandible; s04, according to the simulated osteotomy line, designing a boning and nerve protection guide plate matched with the mandible model; and S05, the boneless and nerve protection guide plate is manufactured through 3D printing. Compared with the prior art, the deboning and nerve protection guide plate matched with the lower jawbone of the patient is customized in a personalized mode through the CT image digital design and the 3D printing technology, and the deboning position of the patient is accurately positioned; and meanwhile, a hand doctor can be helped to control the position of the inferior alveolar nerve, and the inferior alveolar nerve is prevented from being injured during boning.

Provided is a method for preventing or treating optic neuropathy, comprising administering a pharmaceutical composition including neural progenitor cells as an active ingredient, where the neural progenitor cells not only exhibit remarkably superior neuroprotective and pro-regenerative effects compared to mesenchymal stem cells such as placenta-derived stem cells (e.g., PSCs), but also can be administered by non-invasive and safe subtenon injection, and therefore the method may be advantageously used as a cell therapy for treating optic neuropathy.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

The invention discloses a bipeptide modified bionic nano-vesicle as well as a preparation method and application thereof, and belongs to the field of biological medicines. The dipeptide modified bionic nano-vesicle comprises nano-particles formed by PLGA (poly (lactic-co-glycolic acid)), and the nano-particles are loaded with a medicine with a nerve protection or nerve repair effect; the surface of the nanoparticle is coated with a macrophage membrane for expressing RVG peptide and T7 peptide. The bipeptide modified bionic nano-vesicle simultaneously presents T7 peptide and RVG peptide through an engineered macrophage membrane, the T7 peptide is combined with a blood-brain barrier transferrin receptor through high affinity to realize efficient brain entry, astrocytes in the brain are specifically recognized by virtue of the RVG peptide, accurate recognition and delivery of target cells in a focus area are realized, and the bipeptide modified bionic nano-vesicle has a good application prospect. Meanwhile, the natural inflammation tropism and immune escape ability of a macrophage membrane are reserved, and the problems that a traditional drug delivery system is low in targeting precision, and cross-barrier distribution and intracerebral distribution are difficult to cooperate are solved.

The invention discloses application of ginsenoside Rg5 in preparation of a medicine for treating Alzheimer's disease and an evaluation method, and relates to application of ginsenoside Rg5 in preparation of a medicine for treating Alzheimer's disease. The medicine improves A beta deposition, tau protein phosphorylation and neuron damage by adjusting the intestinal flora structure and metabolite level, and is used for relieving the pathological process of the Alzheimer's disease. The invention has the characteristics of multi-target effect, nerve protection, inflammation resistance and oxidation resistance.

A handheld ultrasound guiding system for the transcutaneous delivery of a needle into blood vessel that can be used to then deliver a guidewire, the battery powered light-weight device consisting of a phased array ultrasound generator, a transducer probe, a screen, computer processor that is mechanically coupled to a needle holder mounted at an angle to the ultrasound probe, the needle is mounted such that it can be advanced into a target blood vessel that is being visualized real-time by the ultrasound probe.

The invention provides an antioxidant peptide as well as a preparation method and application thereof, and belongs to the technical field of biology. The invention provides an antioxidant peptide with an amino acid sequence as shown in SEQ ID NO. 2 and / or an antioxidant peptide with an amino acid sequence as shown in SEQ ID NO. 4. Two antioxidative peptides are identified from the gastrodia elata protein hydrolysate through enzymolysis, ultrafiltration, gel chromatography purification and mass spectrometry technologies in combination with ABTS and DPPH free radical scavenging activity, the molecular weights of the two antioxidative peptides are 937.08 Da and 1153.50 Da respectively, and the two antioxidative peptides have high antioxidative activity, heat stability and in-vitro safety and can be used for preparing antioxidative peptides for the gastrodia elata protein hydrolysate. The cell viability decline and ROS level rise caused by oxidative stress injury of cells can be effectively relieved, and the neuroprotective effect can be achieved by activating an Nrf2 pathway. The antioxidant peptide is suitable for daily chemical products, skin care and beauty cosmetics, health foods and medicines with antioxidant efficacy requirements.

Interleukin-34 is a cytokine involved in the differentiation and survival of macrophages, monocytes, and dendritic cells in response to inflammation. IL-34 has been shown to be involved in a wide range of areas, such as neuronal protection, autoimmune diseases, infection, cancer, and transplantation. Recent studies have also demonstrated that IL-34 acts as a regulator of Foxp3. + New possible therapeutic effects of cytokines secreted by Tregs that mediate transplant tolerance. The inventors have now generated new mutant IL-34 polypeptides that can be used as agonists or antagonists.

The application discloses a cardiovascular maintenance functional wine based on a composite fermentation process and a preparation method thereof. Through synergistic fermentation of rosewood flavones, five-grain nutrients and rhizoma notopterygii blood-activating components, a cardiovascular maintenance wine with multiple effects of blood pressure regulation, microcirculation improvement, nerve protection and anti-inflammation is developed. Process parameters are optimized and designed to ensure efficient reservation and release of active components, and the cardiovascular maintenance wine is suitable for daily auxiliary conditioning of sub-healthy people and cardiovascular risk groups.

The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.

The application discloses a preparation method and application of a conjugate targeting pelvic autonomic nerves, wherein the conjugate is NE-RH formed by coupling of rhein and norepinephrine, the conjugate can realize precise targeting of norepinephrine neurons, improve the accumulation effect of RH in the norepinephrine neurons, and further enhance the nerve protection effect of RH. The conjugate has a molecular weight of less than 1000 Da, can help to penetrate the blood-brain barrier, and can avoid the defects of being easily removed by a mononuclear phagocyte system and having a short half-life. The production process of the conjugate is simple, the chemical coupling reaction is clear, the yield can reach 38%, and the purity of the product is greater than 99%, so that the conjugate is convenient to popularize and use. The conjugate and the preparation method have important significance for the damage repair of pelvic autonomic nerves.

The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.

The invention discloses a benzothiazole-carbazole hetero-conjoined compound as well as a preparation method and application thereof. The general formula of the compound is # imgabs0. The benzothiazole-carbazole hetero-conjoined compound provided by the invention has multi-target anti-AD (Alzheimer's Disease) effects of nerve protection, cholinesterase activity inhibition, amyloid protein deposition inhibition, copper ion chelation and the like.

The invention discloses a walnut derived peptide with high antioxidant activity and learning and memory improving functions of removing A beta 1-42 protein deposition. The amino acid sequence of the walnut derived peptide is Tyr-Val-Tyr-Tyr-Pro-Ser-Pro-Lys. The invention also discloses application of the compound in preparation of medicines for protecting nerves and improving learning and memory, and application of the compound in preparation of medicines for delaying occurrence and development of AD (Alzheimer's disease). Leucine at the third site and leucine at the fourth site of the C terminal of the original peptide YVLLPSPK are replaced with tyrosine to form the derived peptide YVYYPSPK, so that the antioxidant activity of the derived peptide YVYYPSPK is remarkably improved, and the derived peptide YVYYPSPK has higher neuroprotective activity and can improve learning memory. The derived peptide YVYYPSPK disclosed by the invention can be used for effectively eliminating A beta1-42 protein deposition of an AD early-stage clinical symptom, can be used for preventing or delaying nerve cell injury so as to delay the occurrence and development of AD, can be used for preparing medicines for delaying the occurrence and development of AD, and has huge market potential.

The invention discloses a system for predicting the risk of nerve injury caused by radiotherapy based on deep learning, and belongs to the technical field of medical artificial intelligence and radiotherapy, and the system comprises a neural structure automatic segmentation module, a dose-neural response modeling module, an individualized risk assessment module, a radiotherapy plan optimization module and a closed-loop feedback regulation unit. The system adopts an encoder-decoder deep network to perform high-precision segmentation on nervous tissues, establishes a dose-nerve response quantitative model by fusing dosiomics and radiomics characteristics, and realizes individualized risk assessment based on a multi-factor risk quantitative network. An optimization scheme for balancing tumor control and neuroprotection is generated through Pareto optimal search, collaborative optimization of all the modules is achieved through closed-loop feedback, and decision support is provided for precise radiotherapy.

This invention belongs to the field of biomedical technology, specifically relating to an engineered exosome and its applications. This invention is the first to discover that PCDH12 is specifically highly expressed in the trabecular meshwork tissue of glaucoma patients. Based on this target, engineered exosomes loaded with PCDH12 antibodies were successfully developed. These engineered exosomes can achieve non-invasive and precise targeted delivery to the trabecular meshwork tissue. In glaucoma model mouse experiments, they not only significantly reduced intraocular pressure but also effectively protected the optic nerve. The non-invasive and precise delivery strategy proposed in this invention combines potent intraocular pressure reduction with direct neuroprotection, providing a candidate solution with direct clinical translational potential for integrated "pressure reduction-neuroprotection" treatment of glaucoma.

The invention discloses a colla corii asini in-vivo bioactive component cyclic dipeptide and a discovery method thereof, and belongs to the technical field of bioactive component analysis and application. The method comprises the following steps: establishing a rat donkey-hide gelatin administration model and collecting a sample, performing solid-phase extraction on the sample, performing LC-MS / MS peptidomics analysis and PEAKS database search, screening exogenous oligopeptides based on a feature-based molecular network (FBMN), performing cyclic dipeptide targeted metabonomics identification, and verifying cell viability. According to the method, 29 cyclic dipeptides are produced by metabolism in donkey-hide gelatin, and the cyclic dipeptides containing hydroxyproline (Hyp) can significantly improve the survival rate of HT-22 cells damaged by glutamic acid or hydrogen peroxide induction and have neuroprotective activity.

The invention provides a duodenum ablation system and method combined with three-dimensional reconstruction. The duodenum ablation system combined with three-dimensional reconstruction comprises a main control unit, a three-dimensional reconstruction module, an intelligent ablation planning module, a neurological function surveying and mapping module, an ablation execution device and a real-time monitoring and feedback control module, through an integrated intracavity electrical stimulation surveying and mapping technology, functional evaluation and mapping can be performed on nerve excitability of a target area before ablation, and a'nerve high-risk area 'is visually marked on a three-dimensional mucous membrane model. When the system performs automatic path planning, the areas can be actively avoided, or verified safe energy parameters are adopted in the areas, so that important intestinal nerve functions are protected to the greatest extent, and the risk of nerve injury related complications is reduced from the source. Therefore, the purposes of intelligent navigation, automatic planning, individualized self-adaptive control and functional nerve protection are achieved.

Compound for use in a method of treating a coronavirus infection, wherein the compound comprises Artemether, Atazanavir, Efavirenz, Fosamprenavir or Saquinavir, and wherein the method includes administering to a subject in need of the treatment an effective amount of the compound; wherein the term “compound” is inclusive of pharmaceutically acceptable salts of the compound; and wherein the coronavirus infection is an infection by a human coronavirus (e.g. SARS-CoV-2). Also claimed for use are the same compounds for use in a method of treating a coronavirus infection, or for use in a prophylaxis method to prevent Covid-19 infection. Further claimed, is compounds for use in a method of treating a coronavirus infection, wherein the compounds comprise: (A) Atazanavir, Efavirenz, Fosamprenavir, Saquinavir or Remdesivir (GS-5734); and (B) an antimalarial drug, an anti-hypertensive drug, an immunomodulatory drug, a neuroprotective drug, or an anti-inflammatory drug, each of which is as defined herein; wherein the method includes administering to a subject in need of the treatment or prophylaxis an effective amount of the compounds.

The invention discloses a triterpenoid component cyclatraine A in stems and leaves of astragalus membranaceus and application of the triterpenoid component cyclatraine A in neuroprotection, and belongs to the field of medicines. According to the method, separation methods such as normal-phase silica gel column chromatography, reversed-phase ODS column chromatography and high-performance liquid chromatography are adopted, chemical components in the ethanol extract of the stems and leaves of astragalus membranaceus are separated and purified, and a new triterpenoid component is successfully found and identified. Meanwhile, through an A beta 25-35 induced damaged PC12 cell model, the protection effect of the new triterpenoid component on nerve cells is researched. Experimental results show that the new triterpenoid components in the stems and leaves of the astragalus membranaceus can remarkably protect PC12 cells from being damaged through an anti-inflammatory and apoptosis inhibiting mechanism. The discovery provides an important scientific basis for further development and utilization of the stems and leaves of astragalus membranaceus, and also provides a new research direction for research and development of neuroprotective drugs.

The invention belongs to the technical field of orthopedic sports medicine surgery, and discloses a knee arthroscopic surgery vascular nerve protection device which comprises a foldable protection baffle which is a folding fan-shaped baffle and is composed of a folding baffle and fixing plates, the fixing plates are fixed to the two end faces of the folding plate, and a folding element is arranged at the tail end of the protection baffle; the propeller is a slender rod-shaped object, one end of the propeller is connected with the guide-in opening of the protection baffle, the other end of the propeller is provided with an operating handle, the length of the propeller is larger than that of the protection baffle, and the propeller can move in the axis direction of the protection baffle so as to move the position of the protection baffle; and the controller is electronic equipment, is electrically connected with the folding element of the protective shell and the operating handle of the propeller, and can control the opening and closing angle of the protective baffle and the movement of the propeller.

The present invention relates to a composition for protecting nerve cells, comprising a supercritical extract of Cannabis sativa and, more specifically, to a composition for protecting nerve cells, comprising a supercritical extract of Cannabis sativa, thereby exhibiting an antioxidant effect and a nerve cell death inhibitory effect.

The invention particularly discloses application of an outer vesicle to treatment of neuron injury, and relates to the technical field of biological medicines. The extracellular vesicle is secreted after exercise, a mouse SCI model is used for proving that the plasma extracellular vesicle of an athlete can remarkably inhibit neuronal ferroptosis, so that the recovery of the exercise function after injury is promoted, and further mechanism research shows that the extracellular vesicle can be used for inhibiting neuronal ferroptosis of the athlete. The plasma extracellular vesicles of athletes play a key role in ferroptosis inhibition and functional recovery after SCI through RNF216. Generally speaking, the invention discloses an important role of the plasma extracellular vesicles of athletes in neuronal protection and motor function recovery after SCI, provides a theoretical basis and an experimental basis for developing a new treatment strategy, and has good clinical transformation and clinical application prospects.

Interleukin-34 is a cytokine that is involved in the differentiation and survival of macrophages, monocytes, and dendritic cells in response to inflammation. The involvement of IL-34 has been shown in areas as diverse as neuronal protection, autoimmune diseases, infection, cancer, and transplantation. Recent work has also demonstrated a new and possible therapeutic role for IL-34 as a Foxp3+ Treg-secreted cytokine mediator of transplant tolerance. New mutated IL-34 polypeptides have been generated, which can be used as agonists or antagonists.

The invention relates to application of NADH (nicotinamide adenine dinucleotide) in preparation of drugs for preventing or treating autism, and further provides a liposome nanoparticle oral preparation for preventing or treating autism, the NADH can reduce central nervous system inflammation, and tests prove that the NADH can remarkably reduce neural immune inflammation of autism model rats, and can be used for preventing or treating autism. The method has the advantages that the method is simple and convenient to operate and has neuroprotection and progeny rat behavioral correction capacity, social experiment defects of progeny rats are overcome, the engraving behaviors of the progeny rats are reduced, the influence of autism-related behaviors of the progeny rats is reversed, and a new scheme is provided for prevention or treatment of autism.