118 results about "Neuronal protection" patented technology

The invention reveals that endogenous cholesterol metabolic product cholestane-3 beta, 5 alpha, 6 beta-triol (YC-5) has protection function for neuronal damage caused by cerebral ischemia, ischemia ofspinal cord, epileptic seizure and convulsion and relates to an application of YC-5 in preparation of neuronal protection medicine. The YC-5 can be prepared from cholesterol through two steps. The primitive cell culture in vitro and spinal cord ischemia animal model proves that YC-5 has protection function for neuronal damage caused by cerebral ischemia, ischemia of spinal cord, epileptic seizureand convulsion. YC-5 in effective dose has no toxic and side reactions. YC-5 is an effective neural protectant which aims to multiple molecular mechanism and cures cerebral ischemia damage, spinal cord ischemia damage, epileptic seizure and convulsion.

The invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates and stereoisomers thereof, wherein A, B, E, G, W, X, Y, Z, o, and R1 are as disclosed herein (“Compound(s) of the Invention”), which are useful as cardio-protective and / or neuro-protective agents. The invention also provides pharmaceutical compositions comprising a Compound of the Invention and methods for treating, preventing and / or managing a vascular, cardiovascular or neurological disease or disorder, comprising administering to a patient in need thereof a Compound of the Invention.

Methods are disclosed for transducing neurons with heterologous genes using retrograde viral transport. The methods disclosed employ substantially non-toxic vectors, such as adeno-associated virus vectors, that are capable of retrograde axonal transport to introduce and express genes in the neurons. This method has applications in the mapping of neural pathways, in stimulating or inhibiting the growth of neurons, and in the treatment of various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

Methods of protecting cells against cytotoxic insults are provided. The methods involve administering a composition including a CpG oligonucleotide to a subject. The methods are applicable to the protection of neural and non-neural cells. For example, methods of protecting a neural cell against excitotoxic brain injury are provided. Methods for preparing medicaments for the prophylactic treatment of excitotoxic injury, ischemia and / or hypoxia are also provided. Also provided are compositions for use in the described methods.

Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

The invention discloses a pre-adaptation training method based on high-concentration oxygen and low-concentration oxygen combination. The method is characterized in that the training method is based on gas, with different oxygen concentrations, output by a pre-adaptation training system; and the gas is inhaled by a user at different duration and frequencies, so that protection substances in the body of the user are stimulated. The method provides a safe and effective training measure for a trainee, and can be used for improving the human body anoxia-resistant or hypoxia-resistant capability through high-concentration oxygen and low-concentration oxygen alternate pre-adaptation training as a measure different from conventional medicine. The resistance capability of myocardial cells on ischemia and anoxia can be improved; endogenetic protection substances generated through stimulation are trained, and can achieve the nerve protection effect; the occurrence of serious ischemic stroke is prevented; endogenetic protection substances can also achieve the protection effect on important organs such as kidneys, intestines and lungs.

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to hydroxydihydrobovolide extracted, separated and identified from portulaca oleracea for the first time, and an extraction and separation method of the hydroxydihydrobovolide. The molecular formula of the hydroxydihydrobovolide is C11H18O3 and the hydroxydihydrobovolide is named as 5-hydroxy-3,4-dimethyl-5-pentyl-2(5H)-furanone. The invention also provides an extraction and separation method of the unsaturated lactone compound. The alpha-beta-unsaturated gamma-lactone compound, namely the hydroxydihydrobovolide, is extracted and separated from the portulaca oleracea successfully for the first time by sequentially adopting 50 percent ethanol reflux extraction, macroporous adsorption resin chromatography, ethyl acetate extraction, polyamide column chromatography, silica gel column chromatography, ODS (octadecylsilyl) medium-pressure column separation as well as Sephadex LH-20 separation and purification; and the hydroxydihydrobovolide has anti-inflammatory and neuroprotective effects. The hydroxydihydrobovolide and derivatives thereof can serve as primers for synthesis of other compounds and serve as raw materials for new medicine development and pharmacological activity research to be used for preparing anti-inflammatory and neuroprotective medicines or health-care products.

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to two indole new alkaloid compounds extracted, separated and identified from purslane, andan extraction and separation method and application thereof.The molecular formulas of the two new indole alkaloid compounds separated from purslane medicinal materials are respectively C17H13NO4 and C18H15NO5, and are respectively named as oleraindole A and oleraindole B.The invention also provides theextraction and separation method of the two new alkaloid compounds, which comprises the followingsteps of: sequentially adopting water decoction and extraction, silica gel column chromatography, polyamide column chromatography, ODS medium pressure column, and Sephadex LH-20 purification and liquid phase separation to preparethe two new alkaloid compounds. The structure of thetwo new alkaloid compounds is determined by ultraviolet, infrared, mass spectrum, hydrogen spectrum, carbon spectrum and two-dimensional nuclear magnetic spectrum analysis.The two indole new alkaloid compounds extracted from the purslane have anti-inflammatory, anti-tumor and nerve protection effects, and the salt orderivative of thetwo indole new alkaloid compounds can be used as a leading substance for synthesizing other compounds, as well as raw materials for new drug development and pharmacological activityresearch, and can be used for preparing anti-inflammatory, anti-tumor and nerve protection drugs.

The invention relates to the technical field of medicines, and relates to a steroid compound caulerpenone which is extracted and separated from C. racemesa and is novel in branch, a preparation method thereof and application to prepare nerve protective agents and medicines preventing Alzheimer's disease. In-vitro SH-SY5Y cellular-damage nerve protection effect experiment proves that the compound has obvious protective effect on SH-SY5Y cell with damaged beta-amyloid protein 25-35(Abeta-25-35) and is applicable to prepare nerve protective agents and medicines preventing Alzheimer's disease.

The invention belongs to the technical field of drug synthesis, and particularly relates to novel arctigenin amino-acid ester derivatives, and a preparation method and application thereof. The structure of the arctigenin amino-acid ester derivatives is disclosed as General Formula I. The preparation method comprises the following steps: dissolving amino acids and arctigenin in a solvent, adding a condensing agent in an ice bath, stirring at room temperature or in a heating state for 1-24 hours, and tracking the reaction by thin-layer chromatography; and after the reaction finishes, evaporating to remove the solvent, and purifying by silica gel column chromatography to obtain the arctigenin amino-acid ester derivatives. The preparation method is reasonable in design and easy for synthesis. The synthesized compounds have a novel chemical structure; the in-vitro cell activity experiment proves that the most synthesized amino-acid ester derivatives have an obvious neural protection action; and the compounds I-2, I-5 and I-6 have higher activity than arctigenin, and thus, provide new therapeutic drugs for preventing and treating parkinsonism and other neurodegenerative diseases.

The invention provides a preparation method and application of a nerve growth factor controlled-release nano-carrier. A nerve growth factor and polylactic acid-hydroxyacetic acid copolymer are prepared into spherical nano-particles by an emulsion evaporation solvent method. A nerve growth factor nano controlled-release system packaged with the polylactic acid-hydroxyacetic acid copolymer is of a core-shell structure, wherein the core is the nerve growth factor, and the shell is uniform and compact polylactic acid-hydroxyacetic acid copolymer. According to the invention, proble that the existing nerve growth factor has a short body distribution half-life period and biological activity half-life period, can be metabolized quickly and degraded by enzyme easily and extremely unstable in an aqueous solution is solved. The method disclosed by the invention is simple to operat, and controllable in process. Moreover, secondary development on range of application of the nerve growth factor is carried out, the medicinal range of the nerve growth factor is expanded, and the never growth factor can be applied to preparation of a drug for treating the coronary heart disease with diabetes on the basis of the nerve protection effect of the nerve growth factor nano controlled-release system.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and / or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and / or increasing neuron protection, growth and / or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and / or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzherimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.

The invention relates to a compound pharmaceutical composition containing midazolam and a neuro protective agent and particularly relates to a pharmaceutical composition. The compound medicament composition provided by the invention comprises an effective amount of midazolam or pharmaceutically acceptable salt thereof for treatment and / or prevention, the neuro protective agent and an optional andpharmaceutically acceptable carrier. The invention also relates to an application of a combination of midazolam or the pharmaceutically acceptable salt thereof and the neuro protective agent in the aspect of preparing medicaments for resisting anxiety, sedating and hypnotizing, resisting convulsion, resisting epilepsy and treating central muscular flaccidity and the like. The invention further relates to a method for preparing the pharmaceutical composition. By virtue of combining midazolam with the neuro protective agent such as vitamin B12, not only can the medical effect of midazolam be effectively exerted, but also cerebral nerve functions can be protected, and the pharmaceutical composition can be conveniently administrated and can take effect rapidly.

Provided are compounds, pharmaceutical compositions, cosmetic and dermatological compositions or nutritional supplement compositions, comprising omega-3 very-long-chain polyunsaturated fatty acids (n-3 VLC-PUFAs) and / or their endogenous hydroxylated derivatives thereof, known as elovanoids. This disclosure provides methods for neuroprotection, organ and tissue protection or restoration, prevention or slowing down of aging-related diseases and conditions, and sustainment of function during the aging process.

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to novel alkaloid compounds which are extracted, separated and identified from portulaca oleracea, and an extraction and separation method of the novel alkaloid compounds. The molecular formulae of the novel alkaloid compounds are C17H26N2O3 and C17H26N2O4 in sequence, and the novel alkaloid compounds are named as oleraciamide A and oleraciamide B. The invention further provides the extraction and separation method of the novel alkaloid compounds. The extraction and separation method comprises the following steps: performing water boiling extraction in sequence, performing ethyl acetate extraction, performing silica-gel column chromatography, performing ODS medium-pressure column and Sephadex LH-20 purification, and performing liquid-phase separation preparation, thereby successfully extracting and separating the two novel alkaloid compounds. The novel alkaloid compounds have the functions of inflammation resistance, tumor resistance and nerve protection, and the novel alkaloid compounds and salts or derivatives of the novel alkaloid compounds provided by the invention can be used as synthesis primers of other compounds, and raw materials for novel medicine development and pharmacological activity study, and can be used for preparing medicines or health products with functions of inflammation resistance, tumor resistance and nerve protection.

Novel compounds of the formula Iin whichR, X, n and m are as defined herein are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.

The invention discloses phenyl nitrone compounds containing stilbene sections and pharmaceutically acceptable salts thereof. The compounds can be used for treatment for cell hyperplasia of mammals, such as cancers, or be used as nerve protective agents. The invention also discloses a preparation method thereof, medicine composites containing the compounds and an application for preparing anti-tumour medicines.

The invention discloses a pentoxifylline derivative shown as the formula (1) or pharmaceutically acceptable salt, solvate, optical isomer or polymorph and a pharmaceutical composition containing the compounds, wherein R represents straight chain or branch chain C1-C5 alkyl, C3-C6 naphthenic base or C4-C8 naphthenic alkyl. The invention also discloses a preparation method of the pentoxifylline derivative and application in preparing a medicament with nerve protection function. The compound has favorable effects of hemangiectasis and nerve protection and higher application value in the field ofmedicines.

The invention discloses an effective part of a traditional Chinese medicine for treating Alzheimer disease and a preparation method and an application thereof. The effective part of the traditional Chinese medicine for treating Alzheimer disease is prepared by a method consisting of the following steps of: taking 6 parts of gambir plant, 4 parts of radix bupleuri, 6 parts of angelica sinensis, 6 parts of ligusticum wallichii, 8 parts of rhizoma atractylodis, 8 parts of poria cocos and 3 parts of liquorice; adding alcohol or water of which the weight is 5-15 times more than the total weight of all medicine materials, and extracting for 2-4 times by refluxing, wherein each extraction is performed for 1.5-4 hours; combining extracting solutions, concentrating to be without the smell of alcohol, and thus obtaining the concentrated solution; and putting the concentrated solution on a macroporous resin column, eluting in gradient by using ethyl alcohol solutions with the ethyl alcohol concentrations of 0-95%, collecting ethyl alcohol eluent with the concentration of 30%-50%, recovering solvent, and thus obtaining the effective part of the traditional Chinese medicine. According to the preparation method of the effective part of the traditional Chinese medicine for treating Alzheimer disease, a certain separating means is utilized to separate the effective part from liver restricting powder, and a modern pharmacological experiment method is used for proving that the neuroprotective effect of the effective part is obviously superior to that of the extract of the liver restricting powder, and thus the preparation method can be used for preparing medicines for resisting Alzheimer disease.

The invention discloses an indole N-glycoside compound, an extraction method, and an application in preparing drugs for preventing and treating nervous system diseases. The indole N-glycoside compoundhas a structure represented by a formula (I) in the specification. The indole N-glycoside compound of the invention can effectively protect PC12 cell damages caused by CoCl2, and the result suggeststhat the compound of the invention can be used as a neuroprotective drug.

The invention discloses an N-(4-benzylpiperidyl)-feruloylagmatine compound, a preparation method and application thereof. The compound has remarkable inhibition activity on self aggregation of butyryl cholinesterase and Abeta1-42, also has very strong antioxidant activity and has an obvious nerve protection function for hydrogen peroxide induced PC12 cell injury, thereby showing that the compound (I) is a multi-target inhibitor. Further in vivo experiments reflect that the compound has a favorable effect for treating the Alzheimer's disease, is low in toxicity and has good clinical application prospects.