19 results about "Neuronal protection" patented technology

The application discloses a cardiovascular maintenance functional wine based on a composite fermentation process and a preparation method thereof. Through synergistic fermentation of rosewood flavones, five-grain nutrients and rhizoma notopterygii blood-activating components, a cardiovascular maintenance wine with multiple effects of blood pressure regulation, microcirculation improvement, nerve protection and anti-inflammation is developed. Process parameters are optimized and designed to ensure efficient reservation and release of active components, and the cardiovascular maintenance wine is suitable for daily auxiliary conditioning of sub-healthy people and cardiovascular risk groups.

The application discloses a preparation method and application of a conjugate targeting pelvic autonomic nerves, wherein the conjugate is NE-RH formed by coupling of rhein and norepinephrine, the conjugate can realize precise targeting of norepinephrine neurons, improve the accumulation effect of RH in the norepinephrine neurons, and further enhance the nerve protection effect of RH. The conjugate has a molecular weight of less than 1000 Da, can help to penetrate the blood-brain barrier, and can avoid the defects of being easily removed by a mononuclear phagocyte system and having a short half-life. The production process of the conjugate is simple, the chemical coupling reaction is clear, the yield can reach 38%, and the purity of the product is greater than 99%, so that the conjugate is convenient to popularize and use. The conjugate and the preparation method have important significance for the damage repair of pelvic autonomic nerves.

This invention belongs to the field of biomedical technology, specifically relating to an engineered exosome and its applications. This invention is the first to discover that PCDH12 is specifically highly expressed in the trabecular meshwork tissue of glaucoma patients. Based on this target, engineered exosomes loaded with PCDH12 antibodies were successfully developed. These engineered exosomes can achieve non-invasive and precise targeted delivery to the trabecular meshwork tissue. In glaucoma model mouse experiments, they not only significantly reduced intraocular pressure but also effectively protected the optic nerve. The non-invasive and precise delivery strategy proposed in this invention combines potent intraocular pressure reduction with direct neuroprotection, providing a candidate solution with direct clinical translational potential for integrated "pressure reduction-neuroprotection" treatment of glaucoma.

MicroRNA modified umbilical cord mesenchymal stem cells and exosomes and applications. The present application provides a treatment technology based on miR-210 mutant umbilical cord mesenchymal stem cells and exosomes. By specifically modifying the miR-210 sequence, a mutant with enhanced stability and targeting efficiency is obtained. After being introduced into umbilical cord mesenchymal stem cells, exosomes with high expression of the mutant can be prepared. The exosomes show significant therapeutic effect in various disease models, including promoting angiogenesis, accelerating wound repair and neuroprotection. The present application simultaneously protects the mutant sequence, recombinant vector, recombinant cell and its preparation method, and the application of the exosomes in the preparation of drugs for treating ischemic diseases and tissue damage. This technology optimizes the sequence and delivery system of miR-210, providing a new solution for tissue repair.

This invention belongs to the field of biomedical technology and relates to the application of PAX8 gene inhibitors in the preparation of drugs for treating optic nerve degeneration. The PAX8 gene inhibitor is a shRNA that targets and inhibits the PAX8 gene or a vector expressing a shRNA that targets and inhibits the PAX8 gene. The vector uses the astrocyte-specific promoter gfabc1d. Experiments have demonstrated that by specifically inhibiting PAX8 expression in astrocytes, axoplasmic transport obstruction in the optic nerve is relieved, optic nerve degeneration is alleviated, and a new gene therapy strategy is provided for the protective treatment of optic nerve degeneration in glaucoma.

The application discloses a preparation method of adamantane nitroketone derivatives and application of the adamantane nitroketone derivatives in ischemic stroke drugs. The adamantane nitroketone derivatives are combined by 2,3,5,6-tetramethylpyrazine and adamantane compounds through nitroketone. The compound not only has strong free radical scavenging capacity, but also integrates the nerve protection function of the adamantane compound.

The application provides a kind of neuroprotective small molecule peptide from brewing yellow water and its preparation method and application, belongs to the technical field of food processing.The preparation method includes yellow water pretreatment, enzymatic hydrolysis-ultrasonic coupling extraction, ultrafiltration fractionation purification, refining and drying and other steps, through the compounding of protease and the cooperation of low-frequency ultrasonic, 1-3kDa small molecule peptide is enriched, the purity of product peptide is greater than or equal to 80%, rich in proline and glycine, containing 12 characteristic active sequences.The small molecule peptide has significant neuroprotective activity, the DPPH clearance rate of 1mg / mL solution is greater than or equal to 75%, can inhibit neuroinflammation, protect nerve cells and improve cognitive impairment.The small molecule peptide can be applied to oral liquid, tablet candy and other neuroprotective functional foods, the preparation process is green and environmentally friendly, and has strong industrialization adaptability, realizes the resource utilization of brewing by-products, provides natural and safe core raw materials for neuroprotective functional foods, and has wide market prospect.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

This invention relates to a method for preparing polysaccharides from *Phyllostachys edulis* root with antioxidant and neuroprotective activities, and is a method for preparing natural drugs. The invention involves reflux extraction of pulverized *Phyllostachys edulis* root with ethanol to remove small molecules, followed by extraction with hot water reflux to obtain crude polysaccharides. The crude polysaccharides are then purified through a series of separation and purification processes, including protein removal, depigmentation, and column chromatography, to obtain four new natural polysaccharides: PPLR-W, PPLR-1, PPLR-2, and PPLR-3. The natural polysaccharides prepared by this invention lay the foundation for the development of antioxidant-related drugs and clinical research on the prevention or treatment of neurodegenerative diseases. The four new *Phyllostachys edulis* root polysaccharides possess DPPH and ABTS free radical scavenging abilities and exhibit significant neuroprotective effects against hydrogen peroxide-induced SH-SY5Y cell damage models.

The application belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine supramolecular nanoparticle, which is prepared from Uncaria as a raw medicinal material, is extracted by heating reflux with 68-72% ethanol, is filtered, and is dried after being dialyzed after being dispersed in pure water, centrifuged, resuspended, and centrifuged again. The traditional Chinese medicine supramolecular nanoparticle has uniform particle size, a narrow particle size distribution, and high stability. The nanoparticle has obvious anti-nerve oxidation and obvious nerve protection effects according to in-vitro cell activity detection. The nanoparticle has good in-vivo nerve protection effect, can improve memory impairment and cognitive impairment, and can prevent hippocampal neuron reduction. Compared with Uncaria effective parts, the effective administration dose of the traditional Chinese medicine supramolecular nanoparticle is obviously reduced. The application also discloses a use of the traditional Chinese medicine supramolecular nanoparticle in preparation of a medicine for treating nervous system diseases.

The application discloses a superparamagnetic nanomedicine targeting an Alzheimer's disease A beta protein pathological area and a preparation method and application thereof, and a structure of the superparamagnetic nanomedicine targeting the Alzheimer's disease A beta protein pathological area is Fe3O4-HS-PEG 600 -CO-NH2 complex polypeptide; the complex polypeptide is composed of a targeting A beta protein locating sequence, a transmembrane sequence, a Sema3A inhibiting peptide and a nerve protection peptide in sequence from N to C; the targeting A beta protein locating sequence is FFXXK. The application can effectively reduce hippocampal A beta protein deposition plaques by reducing the introduction of the Sema3A inhibiting peptide and the nerve protection peptide in the Alzheimer's disease A beta protein deposition pathological area, is beneficial to the repair of hippocampal nerve networks, and has great potential for treating Alzheimer's disease.

The application provides application of an indole diterpenoid compound in nerve protection. Penicillium The compound can be obtained from fermentation of Penicillium sp. UJNMF0740 with a preservation number of CGMCC No: 40521. Activity test finds that the compound has obvious improvement effect on 6-OHDA-induced PC12 caused cell apoptosis, and has no toxicity, and has good application prospect in development of drugs or drug intermediates with nerve protection effect.

This invention relates to the field of nanomedicine technology and discloses the application of nano-Amy@NPs-MM / PL1 in the treatment of endometriosis. The nano-Amy@NPs-MM / PL1 comprises a nanocarrier PEG-PLGA, a nanomedicine Amy, a nano-coated macrophage membrane, and a targeting peptide PL1. The steps are: S1, macrophage membrane extraction: using a cell membrane extraction kit, macrophage membranes are separated; S2, targeting peptide insertion into the macrophage membrane: the targeting peptide PL1 is inserted into the macrophage membrane to obtain the targeting macrophage membrane MM / PL1; S3, preparation of PEG-PLGA-loaded Amy. This invention demonstrates that Amy@NPs-MM / PL1 inhibits the activation of the TNF-α / TNFR1 / NF-κB signaling pathway, blocks the downstream caspase-1 / GSDMD-mediated pyroptosis cascade, reduces the release of inflammatory factors, and inhibits angiogenesis and the expression of invasive factors. It achieves multi-level intervention from anti-oxidation and anti-pyroptosis to neuroprotection and metabolic regulation, providing a new strategy with both theoretical innovation and clinical translational potential for the comprehensive treatment of endometriosis.

This invention relates to the field of medical auxiliary equipment technology and discloses a nerve protection device for thyroid surgery, comprising a nerve detector, a probe, and a nerve detection cannula. The probe includes a handle and a ball-tipped needle, the ball-tipped needle being slidably inserted into the handle. The probe also includes a marking component. The ball-tipped needle has a first flow channel inside, and the marking component can squeeze out a marking solution through the first flow channel of the ball-tipped needle when pressure is applied to the nerve site. The marking component also includes a homogenization mechanism for maintaining the uniformity of the marking solution. By using the marking component, after medical personnel confirm that a tissue is a nerve site, they can easily apply a marking solution to the nerve site by gently pressing the handle, facilitating timely identification during subsequent surgery and avoiding the need for repeated confirmation of the nerve site during the procedure.