84 results about "Phagocyte" patented technology

A vegetative additive for the mixed feed used to culture quatic animals is proportionally prepared from adhesive, allicin, and 8 Chinese-medicinal materials including dandelion herb, phellodendron bark, scutellaria root, liquorice root, etc. Its advantage is high effect to kill bacteria and virus and promote the development of immune organs.

Disclosed herein are isolated and purified Staphylococcus aureus bi-component leukocidin, referred to herein as LukAB, and its components LukA and LukB, antibodies specific to LukA, antibodies specific to LukB, therapeutic compositions containing LukA and/or LukB, or anti-LukA and/or anti-LukB antibodies, uses of the compositions to treat acute inflammatory conditions or S. aureus infection, methods for identifying inhibitors of LukAB-mediated cytotoxicity of human phagocytes, and methods for using LukAB as a marker to predict severity of S. aureus infection.

Methods and compositions are disclosed for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory tissue, such as skin, dermis or at least one nerve segment, and are subsequently administered into the central nervous system of a mammal at or near a site of injury or disease. In an alternative embodiment, autologous monocytes, preferably stimulated autologous monocytes, are administered into the central nervous system of a mammal at or near a site of injury or disease. CNS administration of mononuclear phagocytes may optionally be combined with administration of an adjuvant factor (e.g. aFGF) to the CNS, anti-inflammatory therapy of the mammal, or both. Methods for screening stimulatory tissue and cells and methods and compositions for cryopreserved allogeneic mononuclear phagocytes are also disclosed.

This invention relates to a method of inhibiting the overactivity of phagocytes or lymphocytes in an individual by administering to said individual an effective amount of a lignan, wherein i) the phagocytes are neutrophils and the lignan is hydroxymatairesinol or matairesinol or mixtures thereof, or ii) the phagocytes are cells of myeloid origin and the lignan is enterolactone or hydroxymatairesinol or mixtures thereof, or iii) the lymphocytes are T-lymphocytes and the lignan is hydroxymatairesinol, matairesinol or enterolactone or mixtures thereof. Furthermore, this invention concerns a method of treating or preventing an acute ischemia-reperfusion injury or a chronic condition, caused by overactivity of phagocytes or lymphocytes in an individual, said method comprising decreasing the activity of phagocytes in an individual by administering to said individual an effective amount of a lignan.

The present invention features methods of monitoring or detecting a neurological or inflammatory condition in a patient. The method comprises (1) obtaining from the patient a fluid sample from outside of a brain tissue of the patient, wherein the fluid sample contains a circulating phagocyte, and (2) detecting for one or more biomarkers (e.g., a panel of biomarkers) inside the phagocyte, wherein the biomarker is associated with the respective neurological or inflammatory condition.

Methods and compositions for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal are disclosed. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory tissue, such as dermis or at least one nerve segment, and are subsequently administered into the central nervous system of a mammal at or near a site of injury or disease. In an alternative embodiment, autologous monocytes, preferably stimulated autologous monocytes, are administered into the central nervous system of a mammal at or near a site of injury or disease. Methods for identifying stimulatory tissue and cells and methods and compositions for cryopreserved allogeneic mononuclear phagocytes are also disclosed.

Computer controlled methods, systems and apparatus for detecting an infectious agent in a host cell, an animal cell, or plant cell, a body fluid or tissue sample to provide information useful to diagnose a disease or prognosticate disease susceptibility, extent or outcome are provided. In one illustrative embodiment, the infected animal cell is a Chlamydia infected mononuclear phagocyte in a blood sample. In another illustrative embodiment, the infected body fluid is a blood sample infected with “fee floating”Chlamydia. Detection and preferably, quantification of such an infected mononuclear phagocyte(s) or blood sample provides information useful in diagnosing or prognosticating susceptibility, extent or outcome of patients suspected of suffering from vascular, coronary or central nervous disease(s) or disorder(s).

A digested phagocyte prepared by contacting in vitro a phagocyte with a foreign microorganism and isolating the phagocyte so contacted; a process for producing the same; and a process and a kit in which these are utilized are disclosed. An experimental model, which enables in vitro evaluation of a phagocytotic function of phagocytes, is provided.

The present invention includes a method of modulating the phagocytic activity of at least one phagocyte in a subject. The present invention also includes a method of providing a composition resistant to phagocytosis to a subject. The present invention further includes a method of treating, ameliorating or preventing an inflammatory disease in a subject.

The present invention is directed to methods and pharmaceutical compositions, e.g., nanoparticulate drug delivery vehicles, for delivering pharmaceutically active agents to tissues and areas containing mononuclear phagocytes e.g., macrophages in order to treat inflammatory diseases or disorders, e.g., a mononuclear phagocyte-associated disease or disorder, infected biological areas or tissue, injured tissue, or disease tissue. The inflamed, infected, injured, or diseased tissue can be accessible through the blood stream, using a nanoparticulate drug delivery vehicle injected into vascular beds (such as for example arterial and venous beds). Alternatively, the nanoparticulate drug delivery vehicle and pharmaceutically active agent of the invention may be administered locally, to treat specific areas or tissues, e.g., inflamed, infected, injured, or diseased tissue. In one embodiment, the nanoparticulate drug delivery vehicle is formulated as a contrast agent. Accordingly, imaging of the target area or tissue may be carried out prior to, during, or after administration of the nanoparticulate drug delivery vehicle.

The present invention relates to a composition comprising prebiotic (prebiotic adjuvant) for decreasing inflammatory process by improving the homeostasis of non-specific immune parameters and of lymphocyte subpopulations. It also relates to the use of a prebiotic formulation in the manufacture of a medicament or a food or petfood composition for decreasing inflammatory process and/or abnormal activation of non-specific immune parameters, such as phagocytes.

The invention belongs to the field of functional foods and relates to a multi-component compounded functional solid drink for enhancing human immunity and a preparation method thereof. The functionalsolid drink comprises 20-30 parts of sorbitol, 15-25 parts of dried skim milk, 10-25 parts of resistant dextrin, 5-20 parts of xylooligosaccharide, 5-15 parts of yeast beta-glucan, 1-10 parts of bovine colostrum powder, 1-10 parts of orange powder, 1-10 parts of soybean peptide, 1-10 parts of fish collagen powder, 0.1-1 part of casein phosphopeptides, 0.1-1 part of composite amino acid powder and0.01-1 part of vitamin C. The functional solid drink is capable of improving human immunity from six aspects of stimulating immune cell regeneration, promoting mitosis of phagocyte, providing immunityactive factors, providing basic constitution substances for establishing cells of bodies, replenishing vitamin C and regulating intestinal tract health, and is high in security and remarkable in effect. The functional solid drink is prepared by using a modern process, multiple components are compounded, the components play a role of synergism, and the human immunity can be well improved; and compared with a conventional product in the market, the functional solid drink has a comprehensive replenishing function and good advantages.

Methods for enhancing destruction and killing of bacterial spores via phagocytosis, where phagocytosis of bacterial spores is enhanced by using a glycoconjugate. In one embodiment, the method includes the steps of modifying a surface of a bacterial spore to increase adherence to a phagocyte; and ingesting the adherence-increased spore with the phagocyte, thereby destructing and killing the spore by blocking spore-induced phagocyte cell death, while increasing phagocyte activation level and production of antimicrobial and cytocidal agents such as NO and inflammatory cytokines. The adherence of spore to a phagocyte is increased after the surface thereof is coated with a glycoconjugate to form a glycoconjugate-coated spores. The glycoconjugate-coated spores also increase ingestion of the spores by phagocytes and facilitate phagosome-lysosome fusion, which in turn results in destruction and killing of bacterial spores via phagocytosis. The method enhances adherence, ingestion, destruction and killing of bacterial spores via phagocytes, which otherwise may be resistant to phagocytosis.

The present invention discloses a plant extracted immune-enhancing refined substance and a preparation method thereof, and belongs to the technical field of bioactive substance preparation. The refined substance consists of aronia melanocarpa extract (52%), radix ginseng rubra extract (16%), mixed Chinese herbal medicine extract (16%) and mixed fruit extract (16%) in mass percentage. Mixed extract of the above-mentioned aronia melanocarpa extract, radix ginseng rubra extract, mixed Chinese herbal medicine extract and mixed fruit extract is used to prepare the pharmaceutical refined substance with an immune-enhancing effect. In conclusion, the refined substance can impact granular leukocytes and phagocytes with bactericidal function and cells with virucidal function to produce media immunity and humoral immunity. The refined substance is safe without any side effects, and has the effect on recovering and enhancing immune function; and long-term taking the refined substance provides effects on resisting senility and ageing, and maintaining exuberant energy and stamina for middle-aged and elderly people.

The invention tests liver protection and immune regulation functions by feeding a rat and a mouse with an antradiacomphora capsule which is prepared by adopting a special process and solid-state culture, wherein a liver protection test comprises the following steps of: inducing chronic hepatitis of the rat by using carbon tetrachloride twice a week for eight weeks, and measuring GPT and GOT, water content of liver, spleen and liver, liver protein and hydroxyproline content. The antradiacomphora capsule can lighten the rat chronic hepatitis induced by the carbon tetrachloride. A specific immunity test: the test matter is fed to the BALB/c mouse and egg albumen is injected, thereby accelerating the immune cell proliferation capacity and the effect of the immune regulation function generated by an antibody with serological specificity. A non-specific immunity test comprises the following step of: doing an oral test for consecutive six weeks by means of the BALB/c mouse. The invention accelerates the abdominal cavity phagocyte activity, regulates the anti-tumor cytohormone secretion and promotes the effect of the immune regulation function generated by a serological antibody.

Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB 10 and virB11) useful in the ELISA detection of Anaplasma pathogen. The recombinant expression of virB 10 and virB 11 and their use as kits for ELISA are also disclosed.