7 results about "Phagocyte" patented technology

The present invention relates to a solid synthetic particle (SSP). The SSP may comprise a synthetic polymer, which may form a crosslinked structure. The SSP may have a diameter of 0.2 - 20 µm. A method for producing extracellular vesicles (EVs) by host cells is provided, comprising (a) exposing host cells to a plurality of the SSPs; internalizing the SSPs by the host cells through phagocytosis; and (c) secreting EVs by the host cells. Also provided are host cells comprising the SSPs, and EVs produced by the host cells. Further provided is a method for modulating a biological activity of target cells, for example, immune cells.

The invention relates to the technical field of preparation of probiotic fermented beverages, in particular to a probiotic fermented fruit and vegetable beverage with functions of resisting fatigue and enhancing immunity. The hawthorn fruit beverage specifically comprises the following components in parts by mass: 60-80 parts of Zhongtian big hawthorn fruits, 10-20 parts of autumn pears, 11-15 parts of grapes, 9-15 parts of kiwi fruits, 6-10 parts of pomegranates, 3-5 parts of figs, 3-5 parts of beet roots, 3-5 parts of pumpkins, 1-2 parts of kale, 1-2 parts of honey and 2-3 parts of zymophyte. The beverage product provided by the invention can significantly prolong exhaustive swimming time, improve liver glycogen reserve, reduce serum urea nitrogen level after exercises, and effectively relieve physical fatigue; meanwhile, the food can comprehensively enhance the immune function of the organism, including improving the activity of phagocytes, promoting the proliferation of lymphocytes and enhancing humoral immune response, and provides a natural and healthy solution for resisting fatigue and enhancing the immunity function through daily diet for consumers.

A novel use of P44 as a marker for predicting or diagnosing anaplasmosis is disclosed. A diagnostic composition for anaplasmosis containing a P44 gene, a primer set or probe for detecting Anaplasma phagocytophilum, a kit for diagnosing anaplasmosis, and a method for providing information to diagnose infection with Anaplasma phagocytophilum are also disclosed. P44, which is a novel biomarker for diagnosing anaplasmosis, is a multi-copy gene and exists in a large number of copies in the Anaplasma phagocytophilum genome, thus having the effect of detecting Anaplasma phagocytophilum infection at high sensitivity using only a small amount of DNA compared to conventional diagnostic marker genes. In addition, the primer set or probe for detecting and amplifying P44 is capable of providing rapid and easy detection of anaplasmosis with high specificity and sensitivity, making it appropriate for early detection of anaplasmosis.

The invention discloses a sequence combination, a kit and a method for co-detecting a new bunyavirus and an anaplasma phagocytophilum based on RPA-CRISPR, and application of the sequence combination, the kit and the method. Comprising a first RPA primer pair and a first crRNA which are designed according to an SFTSV L segment conserved region, a second RPA primer pair and a second crRNA which are designed according to an AP 16S rRNA gene conserved region, an optimized universal T7 auxiliary primer, a kit prepared by using the sequence combination, and a detection method for detecting the new bunyavirus and the anaplasma phagocytophilum by using the kit. According to the detection method disclosed by the invention, an RPA amplification method and a CRISPR detection method are combined to detect the new bunyavirus and the anaplasma phagocytophilum at the same time, and the bottlenecks in co-amplification efficiency and orthogonal detection sensitivity in the prior art can be effectively overcome.

The application discloses one aspect of a kind of drug for treating atopic dermatitis in the preparation of targeting MIF application, another aspect discloses a kind of drug for treating atopic dermatitis.The drug for treating the atopic dermatitis is MIF small molecule inhibitor.The MIF small molecule inhibitor is MIF antagonist ISO-1.The application confirms that MIF has good therapeutic effect in HDM allergic mouse AD model by studying the therapeutic effect of phagocyte migration inhibitory factor MIF in HDM allergic mouse AD model.

This invention discloses a sequence combination, kit, method, and application for the co-detection of novel Bunyavirus and Anaplasma phagocytophila based on RPA-CRISPR. It includes a first RPA primer pair and a first crRNA designed based on the conserved region of the SFTSV L fragment, a second RPA primer pair and a second crRNA designed based on the conserved region of the AP 16S rRNA gene, an optimized universal T7 helper primer, a kit prepared using this sequence combination, and a detection method for novel Bunyavirus and Anaplasma phagocytophila using this kit. The detection method of this invention combines RPA amplification with CRISPR detection to simultaneously detect novel Bunyavirus and Anaplasma phagocytophila, effectively overcoming the bottlenecks of existing technologies in co-amplification efficiency and orthogonal detection sensitivity.

The invention discloses a phycophage specific antibody and application thereof to detection of phycophage in a water sample, the phycophage specific antibody can specifically recognize the phycophage in the water sample, a detection method of the phycophage in the water sample is developed based on the phycophage specific antibody, rapid detection of the phycophage in the water sample can be achieved, and the detection efficiency is improved. The method has the advantages of being high in specificity and sensitivity, short in detection period, low in cost and easy and convenient to operate, the abundance and distribution of host cyanobacteria in a water sample can be evaluated according to the abundance, obtained through detection, of the phycophage in the water sample, and reliable data support is provided for algal bloom early warning.