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62 results about "Functional role" patented technology

Functional roles. A functional role describes a set of skills and activities that are typically performed by a department within an organization, for example, a manager, director, or vice president. Functional roles are defined by the organizational structure of a company. Resources are assigned to these roles within that department.

Genetic system and self-cleaving inteins derived therefrom, bioseparations and protein purification employing same, and methods for determining critical, generalizable amino acid residues for varying intein activity

A self-cleaving element for use in bioseparations has been derived from a naturally occurring, 43 kDa protein splicing element (intein) through a combination of protein engineering and random mutagenesis. A mini-intein (18 kDa) previously engineered for reduced size had compromised activity and was therefore subjected to random mutagenesis and genetic selection. In one selection a mini-intein was isolated with restored splicing activity, while in another, a mutant was isolated with enhanced, pH-sensitive C-terminal cleavage activity. The enhanced cleavage mutant has utility in affinity fusion-based protein purification. The enhanced splicing mutant has utility in purification of proteins such as toxic proteins, for example, by inactivation with the intein in a specific region and controllable splicing. These mutants also provide new insights into the structural and functional roles of some conserved residues in protein splicing. Thus, disclosed and claimed are: a genetic system and self-cleaving inteins therefrom; bioseparations employing same; protein purification by inactivation with inteins in specific regions and controllable intein splicing; methods for determining critical, generalizable residues for varying intein activity; and products.
Owner:RENESSELAER POLYTECHNIC INST +1

Lightning arrester operation analog simulation system

InactiveCN103207336AAchieving dual output characteristicsFirmly connectedElectrical testingHuman–machine interfaceElectric power system
The invention provides a lightning arrester operation analog simulation system. The lightning arrester operation analog simulation system mainly comprises a data processing center, a data interactive processing interface module, a human-computer interface, an optical fiber data communication module, a power supply control measurement module, a harmonic wave power module, a power frequency high-voltage power module, a voltage divider, a high-voltage lightning arrester, a temperature and humidity measuring module, a lightning arrester resistive current precision measurement module and a SO2 environmental testing module. The data processing center, the human-computer interface and the data interactive processing interface module perform operation through a computing control platform, a host machine of the computing control platform is an industrial control computer and is provided with an optical fiber conversion module, and the host machine of the computing control platform is respectively connected with the power supply control measurement module, the lightning arrester resistive current precision measurement module and the SO2 environmental testing module through the optical fiber conversion module. In functional roles, the system can simulate joint effects of double factors including an electrical characteristic and a natural environment to simulate operation condition of an actual electric power system lightning arrester.
Owner:CHINA ELECTRIC POWER RES INST +1

CCN1 compositions and methods

The angiogenesis inducer CCN1 (cysteine-rich 61, CYR61) is a secreted stromal cell protein of the CCN family, including α 6 beta 1 Ligands for various integrins. Previous studies have shown that CCN1 interacts with integrin α 6 beta 1 The interaction mediates cell adhesion of fibroblasts, endothelial cells, and smooth muscle cells, as well as migration of smooth muscle cells. Recently, we reported that CCN1-induced tubule formation in unactivated endothelial cells is also mediated by integrin α 6 beta 1 mediate. In this study, we demonstrate that human dermal fibroblasts specifically adhere to the T1 sequence (GQKCIVQTTSWSQCSKS) in domain III of CCN1, and that this process is inhibited by a 6 and anti-b 1 blocked by monoclonal antibodies. Alanine substitution mutagenesis of the T1 sequence further identified the sequence TTSWSQCSKS as mediator of α 6 beta 1 Key determinants of dependent adhesion. Soluble T1 peptide specifically inhibits fibroblast adhesion to CCN1 in a dose-dependent manner. Moreover, T1 also inhibits cell adhesion to other α 6 beta 1 Ligands, including CCN2 (CTGF), CCN3 (NOV) and laminin, but not ligands that inhibit other integrins. Furthermore, in a collagen gel matrix containing CCN1, T1 specifically inhibited the α 6 beta 1 Dependent tubule formation. To confirm that T1 directly binds integrin α 6 beta 1 , we performed affinity chromatography showing that integrin α was isolated from octyl glucoside extracts of fibroblasts on T1-conjugated Affi-gel 6 beta 1 . Taken together, these findings identify the T1 sequence in CCN1 as a novel integrin α 6 beta 1 Binding motifs for developing peptidomimetics form a detection alpha 6 beta 1 Basis for a functional role in angiogenesis.
Owner:MUNIN

Reflecting plate

The invention discloses a reflecting plate which comprises a substrate layer, a bottom color layer used for preventing light rays from penetrating, a metal light reflection layer for reflecting the light rays and a protection layer for preventing the metal light reflection layer from being oxidized and damaged; by taking the transmission direction of the light rays as a reference, the bottom color color layer is fixed on the rear surface of the metal light reflection layer; the substrate layer is fixed on the rear surface of the bottom color layer; the protection layer is fixed on the front surface of the metal light reflection layer; the metal light reflection layer is a main material layer which plays a functional role; when the light rays irradiate to the metal light reflection layer, the light rays can be reflected back; more particularly, due to the existence of the bottom color layer, the light rays can be prevented from penetrating the metal light reflection layer so that the light rays can be completely reflected by the metal light reflection layer; and the protection layer covers the metal light reflection layer and can prevent the metal light reflection layer from being damaged or oxidized. The reflecting plate disclosed by the invention has the advantages of good light reflection property, long service life, simple structure and easiness in implementation and can be widely applied to various products having light reflection requirements.
Owner:盛玉林

Prefabricated fabricated type anti-collision wall structure with pulley device

The invention discloses a prefabricated fabricated type anti-collision wall structure with a pulley device. The prefabricated fabricated type anti-collision wall structure with the pulley device is suitable for strengthening structural design of protective handrails on the two sides of a motor vehicle road. The prefabricated fabricated type anti-collision wall structure comprises a carriageway, steel stand columns, steel guardrail plates, steel track grooves, a reinforced concrete prefabricated plate wall, a pulley, a damper, I-shaped steel, a steel track groove, a plate wall facing and an alarming device. The steel stand columns and the steel guardrail plates are arranged on the two sides of the carriageway. The steel track grooves are formed in the steel guardrail plates. The reinforcedconcrete prefabricated plate wall is connected with the steel track grooves through the pulley and the damper. The I-shaped steel is arranged at the lower part of the reinforced concrete prefabricatedplate wall. Sliding and moving are achieved through the steel track grooves in the carriageway. The plate wall facing has multi-functional roles, the alarming device can transmit an accident signal in real time and performs positioning. The prefabricated fabricated type anti-collision wall structure with the pulley device is reasonable in structural design, the reinforced concrete prefabricated plate wall is used as an anti-collision wall, and by combining the pulley device, the damage degree of impact of a vehicle is reduced.
Owner:IANGSU COLLEGE OF ENG & TECH
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