158 results about "Cerebrum" patented technology

A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

The invention discloses a method, device and equipment for generating a head model, a storage medium and a program product. The method is characterized by comprising the following steps of: receiving and verifying original three-dimensional T1 weighted image data and an original three-dimensional grid model; performing tissue segmentation based on the verified three-dimensional T1 weighted image data and the original three-dimensional T1 weighted image data to obtain a cerebral grey matter mask, a cerebral white matter mask, a scalp mask and a skull mask; performing topological structure repair on the brain grey matter mask and the brain white matter mask to obtain a brain mask; respectively converting the scalp mask, the skull mask and the brain mask into a scalp mesh model, a skull mesh model and a brain mesh model; calculating and applying a spatial transformation matrix from the verified three-dimensional grid model to the scalp grid model, and performing spatial registration and fusion on the scalp grid model, the skull grid model and the brain grid model to obtain a head model; the method has the advantages that the efficiency, precision and robustness of head model generation are effectively improved, and the method has good cross-platform deployment capability.

A portable device for detecting a large vessel occlusion in a patient's brain by transmitting a signal into both sides of the brain and receiving the reflections of the transmitted signals to capture a single reflection data point of the characteristics of the blood vessels and brain tissue on both sides of the brain. Using the captured single reflection data point values to perform a comparative analysis between the right and left side of the brain, and based on this analysis, assessing whether the patient is experiencing a large vessel occlusion. If so, the device generates an alert.

The invention provides an analogue simulation method for accumulated craniocerebral injury under the action of multiple shock waves, and relates to the technical field of data processing. The method comprises the following steps: constructing an explosive shock wave model; constructing a head geometric model; the brain, the cerebellum and the brainstem in the solid area are represented through a Mooney Rivlin model; representing the skin, muscles and skull in the solid area through a linear elastic constitutive model; the cerebrospinal fluid in the fluid area is represented through the fluid dynamic model; coupling the fluid region and the solid region through an embedded boundary method; calculating the explosion impact pressure when the explosion impact waves of each turn are transmitted to the head through an explosion impact wave model; through a finite element analysis method, accumulated skull displacement, skull acceleration, skull stress, skull strain and intracranial pressure under the action of each turn of explosion shock waves are determined, and a brain accumulated injury value is calculated.

The utility model relates to a monitoring head frame convenient to wear on the head, which comprises a head band, an electroencephalogram electrode, a brain oxygen probe, a TCD support and a fixing band, the head band can adjust the annular shape matched with the head, the electroencephalogram electrode is embedded on the head band and captures the electrical activity of the brain, the brain oxygen probe is arranged on the wearing inner side of the head band and measures the oxyhemoglobin saturation in the brain tissue, and the TCD support is used for supporting the brain. The TCD supports are arranged on the head band and located on the two sides of the head, TCD probes are arranged on the TCD supports and used for monitoring changes of cerebral blood flow, fixing holes are formed in the plate faces of the mounting supports, the fixing holes and the first adjusting holes are arranged up and down, the fixing holes are located above the first adjusting holes, and the two ends of the fixing band penetrate through the fixing holes in the two corresponding mounting supports to be fixed. Velcro tapes are arranged at the two ends of the fixing end, so that the brain oxygen probe, the electroencephalogram electrode and the TCD probe can be tightly attached to the head position, the accuracy of the monitoring result is improved, the fixing belt is fixed through the Velcro tapes, and the monitoring head frame can be adjusted according to different head shapes of different users.

The disclosure relates to devices and methods for applying a magnetic field on a body of a patient. The time-varying magnetic field may applied to a brain of the patient. The disclosure provides a method of finding the position suitable for application of the magnetic field to the brain. The devices and methods of the disclosure may be suitable for reducing of food craving.

The invention provides a memory enhancement system and method based on a closed-loop regulation brain-computer interface, and relates to the technical field of medical equipment, and the system comprises a multi-channel neural activity detection unit which is used for collecting the field potential waveforms of a plurality of brain regions, related to memory cognition, of the brain of a target object; the electroencephalogram signal analysis unit is used for sending a corresponding control signal to the electrical stimulation output unit under the condition that the field potential waveform of any target brain region meets a preset triggering condition; and the electrical stimulation output unit is used for applying electrical stimulation to the target brain area under the condition of receiving the control signal sent by the electroencephalogram signal analysis unit. According to the memory enhancement system and method based on the closed-loop regulation and control brain-computer interface provided by the invention, by synchronously implanting the microelectrodes of the hippocampus multi-subregion and the temporal lobe cortex of the brain in a cross-scale manner, the waveform information of the memory coding spike ripple is effectively identified, and the accurate stimulation output moment is fed back; and a customized closed-loop brain-computer interface system memory regulation strategy can be provided for different individuals.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and / or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and / or tissue hydration, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.

Disclosed is a method for determining a treatment to be applied to a brain of a patient, such as determining a transcranial magnetic stimulation (TMS) treatment location(s) and treatment strength to be applied to a brain of a patient suffering from depression. A search of the brain, based on coarse-scale parcellations, treatment metric and one or more anatomical metrics, is conducted to select the treatment location(s). In one embodiment, this involves progressively varying a value of a parameter associated with a gyrus threshold and for each value, identifying candidate treatment locations based on a functional connectivity of a subgenual anterior cingulate cortex during resting-state functional magnetic resonance imaging (fMRI) recorded over a plurality of multimodal brain imaging sessions, and selecting as the respective treatment location the candidate location that is closest to all other candidate treatment locations.

This invention belongs to the field of pharmaceutical technology, specifically relating to a quinazoline-azaindole compound, its preparation method, and its application in treating Alzheimer's disease. The quinazoline-azaindole compound of this invention regulates NF-κB by inhibiting DYRK1A. k B. A series of signaling pathways, including PI3k-Akt, achieve anti-neuroinflammatory effects; quinazoline-azaindole compounds can reduce the expression of inflammatory factor-related genes in an LPS-induced BV2 microglial inflammation model, thereby reducing the levels of inflammatory factors in the hippocampus and cortex, alleviating neuronal pathological damage caused by neuroinflammation, and improving cognitive impairment caused by neuroinflammation; in summary, quinazoline compounds inhibit DYRK1A and downregulate NF-κB signaling pathways. k It can reduce the expression and release of inflammatory factors, improve brain tissue pathology, and alleviate cognitive impairment through signaling pathways such as B, and has significant clinical application value.

Disclosed is a marking composition comprising a marker and a hydrogel. Disclosed is a process of forming a marking composition comprising mixing a marker and a hydrogel. Disclosed is an article comprising a marker, a hydrogel, and an implement. Disclosed is a kit comprising a marker, a hydrogel, and an implement, wherein the marker and hydrogel are combined. Disclosed is a method for marking a portion of the brain in a mammal comprising: (a) removing a portion of a mammal's skull to expose a portion of the brain matter; and (b) contacting the exposed portion of the brain with a marking composition. Disclosed is a method for recording electrical activity in a brain, comprising: (a) removing a portion of the skull, thereby exposing a portion of a brain; (b) inserting an electrode into the brain; and (c) recording electrical activity via the electrode, wherein the electrode is at least partially coated with a marking composition.

The invention provides a nutritional composition capable of influencing protein expression of brain hippocampus and application of the nutritional composition. The nutritional composition of the present invention comprises sialic acid, sphingomyelin and phosphatidylcholine, in which the ratio of the sum of the contents of sphingomyelin and phosphatidylcholine to the content of sialic acid is 1: 1 by weight, and the ratio of sphingomyelin to phosphatidylcholine is 0.2: 1 to 1.4: 1 based on the total weight of sphingomyelin and phosphatidylcholine. The composition can increase the gray matter volume of the brain and can improve the expression of BDNFmRNA of the hippocampus and the prefrontal cortex.

The invention belongs to the technical field of robot intelligent control, and relates to a robot behavior decision-making method and device for simulating a brain learning and memory mechanism. According to the method, a development network DN2, reinforcement learning and a self-organizing map SOM are combined, functions of a cerebellum learning system, a basal ganglion and a hippocampus learning system are simulated, and a self-organizing reinforcement learning model based on the development network DN2 is obtained; the equipment comprises one or more processors and a computer readable medium in which one or more computer readable instructions are stored, and is used for realizing the robot behavior decision-making method. According to the method, the functions of the cerebellum learning system, the basal ganglion and the hippocampus learning system are properly utilized, and the fusion algorithm combines reinforcement learning and supervised learning methods, so that the robustness of the self-organizing reinforcement learning model based on the development network DN2 is enhanced, the capability of the algorithm for obtaining an effective obstacle avoidance strategy is improved, and the method is suitable for being applied to the self-organizing reinforcement learning of the self-organizing reinforcement learning of the self-organizing reinforcement learning of the self-organizing reinforcement learning. And the intelligent agent can be helped to quickly learn an efficient solution.

Lead fixation devices for mounting at a cranial burr hole and securing a medical lead implanted into a brain through the burr hole. One embodiment comprises a clamp having centrally disposed clamping walls activated by a plunger having actuating tabs. The clamping walls may be an integral part of a device base, or a separate part seated in a central opening of the base. The clamp is activated by pressing the actuating tabs of the plunger into apertures adjoining the clamping walls, which displaces the clamping walls to clamp the lead. Another embodiment comprises a base having a plurality of radial and peripheral lead retention grooves configured to securely retain a substantial segment of the lead at the exit from the burr hole. Still another embodiment comprises both a clamp and peripheral retention grooves to provide a dual fixation and strain relief of the lead within the lead fixation device.

The utility model relates to the technical field of head-mounted physiotherapy devices, and provides a portable transcranial light supply device for traumatic brain injury rehabilitation. A portable transcranial light supply device used for traumatic brain injury rehabilitation comprises a body, a light source, a light source, a light source, a light source, a light source and a light source, and is characterized in that the body is provided with a front arm and a rear arm; the two ends of the front arm are connected with one end of the first front telescopic arm and one end of the second front telescopic arm respectively. The two ends of the rear arm are connected with one end of the first rear telescopic arm and one end of the second rear telescopic arm respectively. The other end of the first front telescopic arm and the other end of the first rear telescopic arm are connected with a first clamping arm of the clamping part, and the other end of the second front telescopic arm and the other end of the second rear telescopic arm are connected with a second clamping arm of the clamping part. The device has the advantages that the two sides of the two telescopic arms connected with the front arm of the device extend to form the two side light supply modules with the adjustable positions, and the two light supply modules are used for supplying light to the positions close to the temples and correspond to the temporal lobe area of the brain of the human body, and auxiliary treatment can be conducted on the temporal lobe area.

A method for determination of an indicator representative of a change in the brain caused by a demyelinating disease, the method including, for each region of interest of the brain, determining a regional coefficient of one of the following diffusion coefficients: the radial diffusion, the axial diffusion, the mean diffusion, the anisotropy fraction, or a combination of several of these coefficients, the regional coefficients being determined from a diffusion MRI image; determining a number of changed regions, for which a condition relating to the value of the regional diffusion coefficient of each region is satisfied; and determining the indicator in accordance with the number of changed regions.

Active medicine materials of the traditional Chinese medicine composition comprise saffron, nutmeg, clove, sandalwood and apium graveolens according to the weight ratio of 100: n1-n2: n3-n4: n5-n6: n7-n8, n1, n2, n3, n4, n5, n6, n7 and n8 are all natural numbers, n1 is larger than or equal to 100 and smaller than or equal to 300, n3 is larger than or equal to 100 and smaller than or equal to 400, n5 is larger than or equal to 200 and smaller than or equal to 800, n7 is larger than or equal to 50 and smaller than or equal to 400, and n7 is larger than or equal to 400. The composition can prevent, treat, slow down or control stroke-heart syndrome, middle cerebral artery embolism and myocardial injury of subjects, and has popularization prospects.

The invention relates to the treatment of ischemic stroke at risk of brain swelling using SUR1-TRPM4 channel inhibitors in combination with mechanical thrombectomy. In some embodiments, the methods include treating patients suffering from a large hemispheric infarction. In certain embodiments, patients have a lesion volume of less than 140 cm3 or less than 125 cm3 as measured by MRI DWI or CTP. The patient may have suffered a wake-up stroke. Some embodiments involve treating patients who also undergo decompressive therapy.

Methods of treating one or more eating disorders including anorexia nervosa, bulimia, and related clinical syndromes in a subject in need thereof are described. In some cases, electric stimulation and / or one or more active agents are administered to a subject in need thereof to reduce or inhibit the activity of CeA PKC-δ neurons and ovBNST PKC-δ neurons in the brain of the subject. Preferably, the disclosed methods are effective to increase or excite the activity of the brain regions downstream of CeA PKC-δ neurons and ovBNST PKC-δ neurons including medial part of CeA and ventral lateral part of BNST.

The invention discloses a lipophilic modified nucleic acid medicine composition and application thereof, the lipophilic modification is saturated or unsaturated C4-C30 alkyl, the composition comprises an absorption enhancer, and the method is that the lipophilic modified nucleic acid medicine is delivered to the brain through the nasal mucosa. Nucleic acid drugs are transmitted into the olfactory bulb region through a neural pathway, namely, cross-olfactory mucosa, bypass BBB and directly enter the brain, the drug concentration content of the olfactory bulb is far higher than that of other tissues of the brain, and the tissues except the olfactory bulb are uniformly distributed, so that the olfactory bulb can be used as a drug reservoir and gradually and slowly spread to the other tissues of the brain; the long-time drug effect can be maintained by one-time drug administration, so that the drug administration frequency can be reduced. Compared with intrathecal injection, by adopting the composition disclosed by the invention for nasal administration and using 1 / 2 of intrathecal administration dosage, the same intrathecal steady-state distribution as intrathecal distribution can be achieved, so that the method disclosed by the invention is safer, noninvasive and efficient.

The invention discloses a dummy head injury testing device and method for an impact test, the testing device comprises a head assembly, the head assembly comprises a skull, brain tissue, head skin and a sensing device, eye sockets are arranged on the skull, and bionic eyeballs are arranged at the eye sockets; the brain tissue comprises bionic brain tissue and bionic cerebrospinal fluid; the head skin comprises a head skin body and flexible sensing skin arranged on the outer surface of the head skin body, the flexible sensing skin comprises a flexible substrate layer, wire electrodes arranged on the two end faces of the flexible substrate layer respectively and insulating layers covering the wire electrodes, and a plurality of wire electrodes are arranged on the two end faces at intervals. The wire electrodes on the two end faces are orthogonally arranged to form an array structure, and raw materials of the flexible substrate layer comprise silicone rubber and a conductive material. The testing device is good in biological simulation degree, the testing result is closer to the real situation, multiple sensor configuration schemes are provided, and more head injury data can be obtained.

To provide a gene construct for use in the treatment of a metabolic disorder in a mammal, particularly a human.SOLUTION: A gene construct provided comprising a nucleotide sequence encoding fibroblast growth factor 21 (FGF21) for use in the treatment and / or prevention of a metabolic disorder, wherein the therapy involves expression of the gene construct in the central nervous system (CNS), preferably in the brain, more preferably in the hypothalamus and / or cortex and / or hippocampus and / or cerebellum and / or olfactory bulb, and most preferably in the hypothalamus.SELECTED DRAWING: None

The present application relates to endogenous NMDA receptor subtypes in brain tissue and their assembly and structure. The present application provides a method for evaluating the function of endogenous NMDA receptors in brain tissue (cortex and hippocampus), comprising obtaining data on the structure and / or quantity of endogenous NMDA receptors (NMDAR) in the brain tissue, wherein the NMDA receptor comprises a GluN1-N2A-N2B triheteromer; and comparing the structure and / or quantity of the GluN1-N2A-N2B triheteromer with a reference structure and / or quantity reference value, thereby giving an evaluation result of the function of endogenous NMDA receptors in brain tissue. The present application also provides a device for performing the evaluation and a method for drug screening based on changes in the structure and / or quantity of specific NMDA receptors.

Embodiments disclosed herein mitigate motion sickness by disrupting, controlling, or influencing anatomy of the vestibular system. An embodiment may induce vibrations in the vestibular system, including otoliths and / or semicircular canals of the inner ear, causing noisy or unreliable sensory information to be sent to the brain from the vestibular system. Due to the noisy or unreliable quality, the brain, as part of a normal physiological response, may rely less on sensory information from the vestibular system and rely more on other sources, thereby mitigating the motion sickness response, vertigo, vestibular migraines, and other physiological responses to inconsistent sensory information. Vibrations in the vestibular system may be induced by an agitator placed on an individual's head near the vestibular system, or by a transducer placed near the eardrum or directly on an individual's head. Some embodiments may optionally include implantable components in addition to extracorporeal components.

The invention relates to a multi-mode eye-brain collaborative maintenance intelligent device, and belongs to the technical field of eye-brain nursing equipment.The device is provided with an impression stimulation module, the impression stimulation module stimulates mild energy of an impression acupoint, the mild energy can be directly conducted to a paranasal sinus olfactory bulb in the deep part of a nasal cavity, the area is the starting end of paranasal sinus nerves, the paranasal sinus nerves are branches of cranial nerves, and therefore the paranasal sinus acupoint can be stimulated; the neural pathway directly extends to brain hippocampus, brain marginal tissue, pituitary gland and other core structures related to neuronutrition and brain metabolism; after stimulation, the paranasal sinus olfactory bulb and paranasal sinus nerves are activated to form a neural pathway for targeted delivery of the atomized liquid, so that the atomized particles of the brain care liquid are adsorbed on the surface of the paranasal sinus olfactory bulb and permeate into the brain along the activated neural pathway, and meanwhile, the permeability of the blood brain barrier is improved, so that the delivery resistance of the atomized liquid to related functional areas of the brain is further reduced, and the targeted delivery of the atomized liquid is realized. Precise nutrition for cranial nerves is achieved, and the problem that brain maintenance is invalid due to the fact that conventional nasal cavity atomized liquid enters the lung is thoroughly solved.

Methods and systems for programming stimulation parameters for assisting deep brain stimulation (DBS) in experimental patients are described. A cumulative database includes data from multiple historical adaptation / programming sessions. The data may include various sets of stimulation parameters tried for patients in the database; data relating to the position of electrode leads relative to the anatomical features of the patient's brain, such as alignment with the subthalamic nucleus (STN); scores indicating the therapeutic effectiveness of the stimulation parameters; and data relating to stimulation field models (SFM) of the various sets of stimulation parameters. This database can be used to predict stimulation parameter sets that may be therapeutically effective for experimental patients.

The invention provides traditional Chinese medicine compound essential oil and application thereof in preparation of anti-depression products, and relates to the technical field of traditional Chinese medicine essential oil pharmacy. The traditional Chinese medicine compound essential oil is prepared from 3-15 parts of benzoin essential oil, 2-10 parts of China rose essential oil, 2-10 parts of immature bitter orange essential oil, 1-8 parts of amomum cardamomum essential oil and 1-8 parts of fennel essential oil. The traditional Chinese medicine compound essential oil disclosed by the invention is administered in a sniffing manner, and improves cerebral depression symptoms by stimulating olfactory nerves and influencing cerebral cortex edges and neurotransmitters. After a CUMS depression animal model is treated by the traditional Chinese medicine compound essential oil disclosed by the invention, the symptom of pleasant sensation disappearance is well reversed and improved, and the state of animal movement reduction and the behavior state of despair and struggling abandoning of the depression animal model are obviously improved; meanwhile, the levels of DA, 5-HT and NE in brain tissues of the depression animal model are remarkably improved, and the pathological change of the brain-sea horse area of the depression animal model is remarkably improved. The traditional Chinese medicine compound essential oil disclosed by the invention can be used for preparing medicines for aromatherapy, has no adverse reaction and high acceptability, and provides a new way for treating depression.

The Great Cerebral Vein, or Vein of Galen is comprised of a unique structure having a location which both implicates it in various clinical conditions, and can be treated by systems which, for example, go around corners of the Transverse and Straight sinuses for minimally invasive therapy embedded in the Vein of Galen the present inventions constitute progress in science and the useful arts worthy of protection as US Letters patent as novel.