229 results about "Cerebrum" patented technology

A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

The invention relates to the technical field of medical equipment, provides a non-intrusive closed-loop ear vagus nerve stimulator for improving cerebral apoplexy and a use method, and aims to improve the symptoms of a patient by stimulating the ear vagus nerve in a conchae area. The device integrates an electrical stimulation electrode, a host and a closed-loop feedback module, monitors brain blood flow changes and other physiological parameters of a patient in real time, and automatically adjusts stimulation parameters through an intelligent algorithm to realize personalized treatment. A microprocessor, a multi-mode monitoring unit and a data fusion analysis unit are arranged in the host, and accurate and efficient treatment is ensured. In addition, the equipment supports remote intelligent monitoring and guidance, a treatment plan can be remotely adjusted, and the treatment effect is improved. A user interaction interface is friendly, and operation of patients and medical staff is facilitated. The stimulator is light in design, the conductive silica gel electrode is adopted, through real-time monitoring and intelligent adjustment, accurate and efficient treatment is provided for a patient, the comfort level and treatment convenience of the patient are ensured, and a safe and effective rehabilitation scheme is provided for the stroke patient.

The invention provides a cheese protein hydrolysate as well as a preparation method and application thereof. The composition of the casein hydrolysate at least comprises at least one of a peptide fragment 1 with an amino acid sequence as shown in SEQ ID NO: 1, a peptide fragment 2 with an amino acid sequence as shown in SEQ ID NO: 2 and a peptide fragment 3 with an amino acid sequence as shown in SEQ ID NO: 3. The casein hydrolysate has good neuron protection and repair effects, and can improve cholinergic neuron and dopaminergic neuron damage; abeta protein deposition can be inhibited, so that neuronal synaptic disorder, neuronal apoptosis and brain injury caused by Abeta protein deposition are relieved; the cholinergic defect can be improved, so that the nerve development damage and the behavior and movement disorder caused by the cholinergic defect are relieved; and damaged neurons in hippocampus and hypothalamus can be repaired, so that the brain environment is kept stable.

The invention discloses a method, device and equipment for generating a head model, a storage medium and a program product. The method is characterized by comprising the following steps of: receiving and verifying original three-dimensional T1 weighted image data and an original three-dimensional grid model; performing tissue segmentation based on the verified three-dimensional T1 weighted image data and the original three-dimensional T1 weighted image data to obtain a cerebral grey matter mask, a cerebral white matter mask, a scalp mask and a skull mask; performing topological structure repair on the brain grey matter mask and the brain white matter mask to obtain a brain mask; respectively converting the scalp mask, the skull mask and the brain mask into a scalp mesh model, a skull mesh model and a brain mesh model; calculating and applying a spatial transformation matrix from the verified three-dimensional grid model to the scalp grid model, and performing spatial registration and fusion on the scalp grid model, the skull grid model and the brain grid model to obtain a head model; the method has the advantages that the efficiency, precision and robustness of head model generation are effectively improved, and the method has good cross-platform deployment capability.

A portable device for detecting a large vessel occlusion in a patient's brain by transmitting a signal into both sides of the brain and receiving the reflections of the transmitted signals to capture a single reflection data point of the characteristics of the blood vessels and brain tissue on both sides of the brain. Using the captured single reflection data point values to perform a comparative analysis between the right and left side of the brain, and based on this analysis, assessing whether the patient is experiencing a large vessel occlusion. If so, the device generates an alert.

The invention provides an analogue simulation method for accumulated craniocerebral injury under the action of multiple shock waves, and relates to the technical field of data processing. The method comprises the following steps: constructing an explosive shock wave model; constructing a head geometric model; the brain, the cerebellum and the brainstem in the solid area are represented through a Mooney Rivlin model; representing the skin, muscles and skull in the solid area through a linear elastic constitutive model; the cerebrospinal fluid in the fluid area is represented through the fluid dynamic model; coupling the fluid region and the solid region through an embedded boundary method; calculating the explosion impact pressure when the explosion impact waves of each turn are transmitted to the head through an explosion impact wave model; through a finite element analysis method, accumulated skull displacement, skull acceleration, skull stress, skull strain and intracranial pressure under the action of each turn of explosion shock waves are determined, and a brain accumulated injury value is calculated.

The utility model relates to a monitoring head frame convenient to wear on the head, which comprises a head band, an electroencephalogram electrode, a brain oxygen probe, a TCD support and a fixing band, the head band can adjust the annular shape matched with the head, the electroencephalogram electrode is embedded on the head band and captures the electrical activity of the brain, the brain oxygen probe is arranged on the wearing inner side of the head band and measures the oxyhemoglobin saturation in the brain tissue, and the TCD support is used for supporting the brain. The TCD supports are arranged on the head band and located on the two sides of the head, TCD probes are arranged on the TCD supports and used for monitoring changes of cerebral blood flow, fixing holes are formed in the plate faces of the mounting supports, the fixing holes and the first adjusting holes are arranged up and down, the fixing holes are located above the first adjusting holes, and the two ends of the fixing band penetrate through the fixing holes in the two corresponding mounting supports to be fixed. Velcro tapes are arranged at the two ends of the fixing end, so that the brain oxygen probe, the electroencephalogram electrode and the TCD probe can be tightly attached to the head position, the accuracy of the monitoring result is improved, the fixing belt is fixed through the Velcro tapes, and the monitoring head frame can be adjusted according to different head shapes of different users.

The disclosure relates to devices and methods for applying a magnetic field on a body of a patient. The time-varying magnetic field may applied to a brain of the patient. The disclosure provides a method of finding the position suitable for application of the magnetic field to the brain. The devices and methods of the disclosure may be suitable for reducing of food craving.

The invention provides a memory enhancement system and method based on a closed-loop regulation brain-computer interface, and relates to the technical field of medical equipment, and the system comprises a multi-channel neural activity detection unit which is used for collecting the field potential waveforms of a plurality of brain regions, related to memory cognition, of the brain of a target object; the electroencephalogram signal analysis unit is used for sending a corresponding control signal to the electrical stimulation output unit under the condition that the field potential waveform of any target brain region meets a preset triggering condition; and the electrical stimulation output unit is used for applying electrical stimulation to the target brain area under the condition of receiving the control signal sent by the electroencephalogram signal analysis unit. According to the memory enhancement system and method based on the closed-loop regulation and control brain-computer interface provided by the invention, by synchronously implanting the microelectrodes of the hippocampus multi-subregion and the temporal lobe cortex of the brain in a cross-scale manner, the waveform information of the memory coding spike ripple is effectively identified, and the accurate stimulation output moment is fed back; and a customized closed-loop brain-computer interface system memory regulation strategy can be provided for different individuals.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and / or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and / or tissue hydration, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.

The present invention relates to a method for making a non-human primate model of cerebral infarction comprising a step of administering endothelin to the brain basal nucleus-thalamic region of a non-human primate, thereby inducing brain basal nucleus disorders, thalamic disorders and endocystic disorders, and a method for treating subacute stages-containing NeuroD1 protein or a polynucleotide encoding a NeuroD1 protein The pharmaceutical composition can be used for treating chronic cerebral infarction, transbronchial infarction or cerebral infarction with brain disorder in a transbronchial dominating region.

The invention belongs to the field of biological medicines, and provides a construction method of a photochemically induced mouse cerebral ischemia model, which comprises the following steps: S1, inducing anesthesia of a mouse, and ensuring that the mouse is continuously in an anesthesia state; s2, in the lateral position of the mouse, unhairing and disinfecting the face on one side, and cutting from the face of the mouse to expose the proximal end position of the M3 segment of the middle cerebral artery of the mouse or the cross point of reverse extension lines of branch blood vessels of the middle cerebral artery; s3, injecting a photosensitizer into the mouse, and after the photosensitizer circulates uniformly in the body of the mouse, irradiating the proximal end of the M3 segment of the middle cerebral artery or the cross point of the reverse extension line of the branch blood vessel of the middle cerebral artery after laser focusing; s4, after laser irradiation is finished, the skin is sutured, anesthesia is stopped, and the wound of the mouse is coated with an analgesic. The model obtained by the construction method of the photochemically induced mouse cerebral ischemia model provided by the invention has a larger infarct volume, and the infarct invades the subcortical brain region, so that the pathological characteristics of ischemic brain tissues are more obvious.

Disclosed is a method for determining a treatment to be applied to a brain of a patient, such as determining a transcranial magnetic stimulation (TMS) treatment location(s) and treatment strength to be applied to a brain of a patient suffering from depression. A search of the brain, based on coarse-scale parcellations, treatment metric and one or more anatomical metrics, is conducted to select the treatment location(s). In one embodiment, this involves progressively varying a value of a parameter associated with a gyrus threshold and for each value, identifying candidate treatment locations based on a functional connectivity of a subgenual anterior cingulate cortex during resting-state functional magnetic resonance imaging (fMRI) recorded over a plurality of multimodal brain imaging sessions, and selecting as the respective treatment location the candidate location that is closest to all other candidate treatment locations.

[Problem] The purpose of the present invention is to provide a brain activity measuring device that is capable of measuring brain activity over a wide region. [Solution] The brain activity measuring device comprises: a brain diagnosis probe; a detection signal reception unit for receiving a detection signal from the brain diagnosis probe; and a signal analysis unit for analyzing the detection signal received by the detection signal reception unit and obtaining measurement information for measuring brain activity. The brain diagnosis probe has multiple sheet-shaped probe units, and each of the multiple sheet-shaped probe units is placed inside the skull via a hole prepared in the skull of the living organism in question.

This invention belongs to the field of pharmaceutical technology, specifically relating to a quinazoline-azaindole compound, its preparation method, and its application in treating Alzheimer's disease. The quinazoline-azaindole compound of this invention regulates NF-κB by inhibiting DYRK1A. k B. A series of signaling pathways, including PI3k-Akt, achieve anti-neuroinflammatory effects; quinazoline-azaindole compounds can reduce the expression of inflammatory factor-related genes in an LPS-induced BV2 microglial inflammation model, thereby reducing the levels of inflammatory factors in the hippocampus and cortex, alleviating neuronal pathological damage caused by neuroinflammation, and improving cognitive impairment caused by neuroinflammation; in summary, quinazoline compounds inhibit DYRK1A and downregulate NF-κB signaling pathways. k It can reduce the expression and release of inflammatory factors, improve brain tissue pathology, and alleviate cognitive impairment through signaling pathways such as B, and has significant clinical application value.

The invention relates to application of a ventral hippocampal region transferrin receptor 1 inhibitor in preparation of a medicine for preventing and / or treating anxiety disorder, and belongs to the technical field of biological medicine. The application of the inhibitor for interfering with the animal brain ventral hippocampal region transferrin receptor 1 (TfR1) in the drugs for preventing and / or treating anxiety is discovered and proposed for the first time. Animal experiments prove that anxiety disorder caused by social isolation stress is closely related to TfR1 in a brain abdominal side hippocampus area of an animal, and when the animal shows anxiety symptom, the expression level of TfR1 is improved, so that the iron concentration in the brain abdominal side hippocampus area is improved to cause iron disorder. On the basis of the research, an inhibitor for interfering with the TfR1 in the belly hippocampus area of the brain of the animal is injected into an anxiety model animal, social isolation treatment is continued, the anxiety behavior of the animal in a social isolation treatment group is improved, and the effect of treating the anxiety is achieved.

A Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction having neuroglobin (Ngb) activation and neuroprotective effects and, on the basis thereof, a neuroprotective composition containing, as an active ingredient, a Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction. The neuroprotective composition can be used, through the activation of neuroglobin (Ngb), as a pharmaceutical composition or a food composition for treatment, alleviation and prevention of a stroke, a cerebral infarction, thrombosis, cerebral degenerative disease, vascular dementia, memory loss, short-term memory impairment, a concentration disorder, anxiety, nervousness and the like, and for brain damage protection, brain function improvement and cranial nerve cell protection.

The present disclosure relates to the treatment and prevention of impaired cognitive function, cognitive decline and / or dementia or cerebral nervous system degenerative conditions in a subject suffering from diabetes mellitus by administering a pharmaceutical composition comprising a compound capable of reducing copper levels or amounts elsewhere in the hippocampus or brain of the subject.

Disclosed is a marking composition comprising a marker and a hydrogel. Disclosed is a process of forming a marking composition comprising mixing a marker and a hydrogel. Disclosed is an article comprising a marker, a hydrogel, and an implement. Disclosed is a kit comprising a marker, a hydrogel, and an implement, wherein the marker and hydrogel are combined. Disclosed is a method for marking a portion of the brain in a mammal comprising: (a) removing a portion of a mammal's skull to expose a portion of the brain matter; and (b) contacting the exposed portion of the brain with a marking composition. Disclosed is a method for recording electrical activity in a brain, comprising: (a) removing a portion of the skull, thereby exposing a portion of a brain; (b) inserting an electrode into the brain; and (c) recording electrical activity via the electrode, wherein the electrode is at least partially coated with a marking composition.

The invention provides a nutritional composition capable of influencing protein expression of brain hippocampus and application of the nutritional composition. The nutritional composition of the present invention comprises sialic acid, sphingomyelin and phosphatidylcholine, in which the ratio of the sum of the contents of sphingomyelin and phosphatidylcholine to the content of sialic acid is 1: 1 by weight, and the ratio of sphingomyelin to phosphatidylcholine is 0.2: 1 to 1.4: 1 based on the total weight of sphingomyelin and phosphatidylcholine. The composition can increase the gray matter volume of the brain and can improve the expression of BDNFmRNA of the hippocampus and the prefrontal cortex.

The invention belongs to the technical field of robot intelligent control, and relates to a robot behavior decision-making method and device for simulating a brain learning and memory mechanism. According to the method, a development network DN2, reinforcement learning and a self-organizing map SOM are combined, functions of a cerebellum learning system, a basal ganglion and a hippocampus learning system are simulated, and a self-organizing reinforcement learning model based on the development network DN2 is obtained; the equipment comprises one or more processors and a computer readable medium in which one or more computer readable instructions are stored, and is used for realizing the robot behavior decision-making method. According to the method, the functions of the cerebellum learning system, the basal ganglion and the hippocampus learning system are properly utilized, and the fusion algorithm combines reinforcement learning and supervised learning methods, so that the robustness of the self-organizing reinforcement learning model based on the development network DN2 is enhanced, the capability of the algorithm for obtaining an effective obstacle avoidance strategy is improved, and the method is suitable for being applied to the self-organizing reinforcement learning of the self-organizing reinforcement learning of the self-organizing reinforcement learning of the self-organizing reinforcement learning. And the intelligent agent can be helped to quickly learn an efficient solution.

Methods and compositions for the treatment of cognitive disorders are provided herein.The present disclosure generally relates to the field of methods for delivering gene therapy to the entorhinal / hippocampal region accurately and safely to treat cognitive disorders and other diseases of the central nervous system (CNS).The present disclosure describes the specific parameters for targeting this network of brain regions, including accurate anatomical target, vector concentration and vector volume, and the subject may be at risk of suffering from a condition selected from Alzheimer's disease (AD), mild cognitive impairment, pre-symptomatic AD, frontotemporal dementia, or Lewy body dementia.

Lead fixation devices for mounting at a cranial burr hole and securing a medical lead implanted into a brain through the burr hole. One embodiment comprises a clamp having centrally disposed clamping walls activated by a plunger having actuating tabs. The clamping walls may be an integral part of a device base, or a separate part seated in a central opening of the base. The clamp is activated by pressing the actuating tabs of the plunger into apertures adjoining the clamping walls, which displaces the clamping walls to clamp the lead. Another embodiment comprises a base having a plurality of radial and peripheral lead retention grooves configured to securely retain a substantial segment of the lead at the exit from the burr hole. Still another embodiment comprises both a clamp and peripheral retention grooves to provide a dual fixation and strain relief of the lead within the lead fixation device.

The utility model relates to the technical field of head-mounted physiotherapy devices, and provides a portable transcranial light supply device for traumatic brain injury rehabilitation. A portable transcranial light supply device used for traumatic brain injury rehabilitation comprises a body, a light source, a light source, a light source, a light source, a light source and a light source, and is characterized in that the body is provided with a front arm and a rear arm; the two ends of the front arm are connected with one end of the first front telescopic arm and one end of the second front telescopic arm respectively. The two ends of the rear arm are connected with one end of the first rear telescopic arm and one end of the second rear telescopic arm respectively. The other end of the first front telescopic arm and the other end of the first rear telescopic arm are connected with a first clamping arm of the clamping part, and the other end of the second front telescopic arm and the other end of the second rear telescopic arm are connected with a second clamping arm of the clamping part. The device has the advantages that the two sides of the two telescopic arms connected with the front arm of the device extend to form the two side light supply modules with the adjustable positions, and the two light supply modules are used for supplying light to the positions close to the temples and correspond to the temporal lobe area of the brain of the human body, and auxiliary treatment can be conducted on the temporal lobe area.

A method for determination of an indicator representative of a change in the brain caused by a demyelinating disease, the method including, for each region of interest of the brain, determining a regional coefficient of one of the following diffusion coefficients: the radial diffusion, the axial diffusion, the mean diffusion, the anisotropy fraction, or a combination of several of these coefficients, the regional coefficients being determined from a diffusion MRI image; determining a number of changed regions, for which a condition relating to the value of the regional diffusion coefficient of each region is satisfied; and determining the indicator in accordance with the number of changed regions.

The present application discloses a method, device and storage medium for extracting brain symmetry planes. The method comprises: inputting the cranial brain image data of the brain symmetry plane to be extracted into a trained brain partitioning network model to perform a brain partitioning operation to obtain a brain partitioning result; sampling spatial coordinate points in the left brain area and the right brain area respectively according to the brain partitioning result to obtain corresponding sampling point coordinates; and inputting the sampling point coordinates into the brain symmetry plane extraction model to perform a symmetry plane extraction operation to extract the brain symmetry plane. Using the scheme of the present application, the symmetry plane of the brain can be segmented quickly and accurately on normal and abnormal cranial brain images.

A stent for insertion into an intracranial blood vessel of the cerebral venous sinus system includes a proximal end, a distal end, a body between the proximal end and the distal end, the body comprising a plurality of wires in a closed pattern, wherein the stent is configured for insertion into an intracranial blood vessel of the cerebral venous sinus system. The stent is further capable of being repositioned, retrieved / re-sheathed, and removed for more precise delivery.

Active medicine materials of the traditional Chinese medicine composition comprise saffron, nutmeg, clove, sandalwood and apium graveolens according to the weight ratio of 100: n1-n2: n3-n4: n5-n6: n7-n8, n1, n2, n3, n4, n5, n6, n7 and n8 are all natural numbers, n1 is larger than or equal to 100 and smaller than or equal to 300, n3 is larger than or equal to 100 and smaller than or equal to 400, n5 is larger than or equal to 200 and smaller than or equal to 800, n7 is larger than or equal to 50 and smaller than or equal to 400, and n7 is larger than or equal to 400. The composition can prevent, treat, slow down or control stroke-heart syndrome, middle cerebral artery embolism and myocardial injury of subjects, and has popularization prospects.