96results about How to "Enhance phagocytic activity" patented technology

Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.

The present invention provides human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and / or treatment of a condition resulting from Staphylococcus.

The present invention provides human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and / or treatment of a condition resulting from Staphylococcus.

The invention discloses a concentrated feed containing Chinese herbal medicine for growing-finishing pig. The concentrated feed comprises soybean meal, fish meal, rapeseed meal, stone powder, calcium hydrogen phosphate, soybean oil, and premix; the following Chinese herbal medicine components are added into the concentrated feed: rhizoma atractylodis, processed fleece-flower root, gentian, tangerine peel, white peony root, parched medicated leaven, parched hawthorn, parched malt, medulla tetrapanacis, semen cuscutae, stir-fried betelnut, radix astragali, scutellaria, rhubarb powder, etc. The feed can improve the immunity, disease resistance, and stress resistance of growing-finishing pigs; the feed has improved quality, can enhance the appetite of the animals, and promote the digestion and the absorption; and the utilization rate of the feed is increased, and the breeding cost is reduced. The feed also has blood circulation invigorating, stomach-strengthening, parasite-expelling, and rapid fattening functions.

The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRPα) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor tissue. Methods of enhancing phagocytic activity and treating a tumor are also included.

Methods and compositions for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal are disclosed. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory tissue, such as dermis or at least one nerve segment, and are subsequently administered into the central nervous system of a mammal at or near a site of injury or disease. In an alternative embodiment, autologous monocytes, preferably stimulated autologous monocytes, are administered into the central nervous system of a mammal at or near a site of injury or disease. Methods for identifying stimulatory tissue and cells and methods and compositions for cryopreserved allogeneic mononuclear phagocytes are also disclosed.

The invention relates to a nasal cavity cleaning agent applied to health care of the nasal cavity of a human body. The nasal cavity cleaning agent comprises the following components in percentage by weight: 0.9 to 1.2 percent of sea salt, 0.05 to 0.2 percent of buffering agent and the balance of water, wherein the buffering agent is prepared from citric acid and sodium citrate in the weight proportion of 1 to 100. The nasal cavity cleaning agent has the advantages that: the environment in the nasal cavity is maintained because of sodium chloride with the physical concentration and pH value; 2, secretions in the nasal cavity can be diluted and discharged, nose scabs are eliminated, and breath becomes smooth; 3, the nasal cavity is moisturized and bleeding caused by dryness of the nasal cavity is avoided; 4, pathogenic bacteria and harmful substances in the nasal cavity are cleaned and the automatic secreting and cleaning function of the nasal cavity is recovered; 5, nasal mucosa is protected and the ciliated epithelium of the nasal mucosa is promoted to swing; and 6, the nasal cavity cleaning agent does not have any adverse reaction and any side effect on human bodies because no chemical drug is contained in the nasal cavity cleaning agent.

Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.

The invention discloses a fish compound traditional Chinese medicinal preparation prepared from raw materials including rhubarb, acanthopanax, radix astragali, hawthorn and liquorice according a certain weight ratio. A method for preparing fish compound traditional Chinese medicinal preparation comprises the following steps of: A. washing and drying the rhubarb, the acanthopanax, the radix astragali, the hawthorn and the liquorice in the sun; B. respectively crushing and sieving the rhubarb, the acanthopanax, the radix astragali, the hawthorn and the liquorice to ensure the granularity reaches 140-200 mu; and C. weighing up the rhubarb, the acanthopanax, the radix astragali, the hawthorn and the liquorice according to the ratio and mixing and subpackaging after uniformly mixed to obtain the fish compound traditional Chinese medicinal preparation. The method has the advantages of feasibility, convenient operation, reasonable formulation and convenient use; traditional Chinese medicines have wide sources, low price, remarkable effects and no toxic or side effects; various components mutually act; and the invention simultaneously has two properties of nutrition and medicament, not only contains nutrient substances, but also has components with antibacterial activity and other bioactivities, can improve the metabolism of cultivated fishes, promote the growth and the development, improve the immunologic function, prevent and treat diseases and the like.

The invention relates to the technical field of functional microbiological screening and provides novel Bacillus licheniformis DN29 which is collected under CCTCC NO: M2015482. The Bacillus licheniformis DN29 obtained by screening can effectively inhibit pathogenic bacteria such as Vibrio splendidus and pseudoalteromonas, can reduce disease probability of bred animals and can serve as a feed additive to remarkably increase feed utilization rate of the bred animals and promote growing of the animals. The Bacillus licheniformis DN29 can serve as a probiotic to be applied in the process of rearing and producing Stichopus japonicus, has remarkable promoting effect on growing of Stichopus japonicus and can effectively improve immunity of and resistance, to Vibrio splendidus, of Stichopus japonicus.

The invention relates to the technical field of screening and application of functional microorganisms in particular to screening of Bacillus amyloliquefaciens and application thereof in Apostichopus japonicas culture. The Bacillus amyloliquefaciens is collected on 24th December, 2015 in China Center for Type Culture Collection, abbreviated as CCTCC with the address: Wuchang Luojiashan Wuhan University Collection Center, Wuhan, Hubei, is claimed by Ludong University under CCTCC No. M2015774 and is named as Bacillus amyloliquefaciens ZYTC1-1. The Bacillus amyloliquefaciens is screened from healthy intestines of Apostichopus japonicas, has great ability to produce protease and amylase, can improve the activity of amylase in the testiness of Apostichopus japonicas, promote growth of Apostichopus japonicas and improve immunity and disease resistance of Apostichopus japonicas, and is widely applicable to the field of Apostichopus japonicas culture and aquatic feeds.

Provided is a method of cross-priming CD8+ T cells to antigens using Dendritic Cells cultured in the presence of a type I Interferon and GM-CSF, and vaccines and methods of vaccination comprising said Dendritic Cells.

The invention discloses a polysaccharide from Trichoderma pseudokoningii, which is characterized in that (1) the high performance gel filtration chromatography test shows that the polysaccharide has a symmetrical peak with 18325 molecular weight; (2) an improved sulfuric acid-phenol method and a 3-aminophenol method test show that the neutral polysaccharide content is 65.2 percent, while the uronic acid content is 32.6 percent; (3) the GC analysis of the alditol acetate shows that the monosaccharide components are rhamnose, glucose and galactose, the molar ratio is Rha:Glc:Gal relates to 5.6:2.7:1.0, while when the polysaccharide is completely reduced, the molar ratio is Rha:Glc:Gal relates to 14.5:9.3: 1.0, having 26.6 molar percent glucuronic acid. The preparation method of the polysaccharide from Trichoderma pseudokoningii consists of the crude polysaccharide preparation and the polysaccharide purification. The polysaccharide from the Trichoderma pseudokoningii has broad applications in preparing the drugs or functional food for improving the mammal immunocompetence and for treating or adjuvant treating the tumors.

The invention provides a special clinical nutritional formula for lactose intolerance in children. The special clinical nutritional formula comprises the following components in parts by weight: 15-22parts of protein, 6-10 parts of fat, 43-58 parts of carbohydrates, 7-10 parts of dietary fibers, 0.01-0.15 part of major elements, 0.001-0.004 part of trace elements, 0.001-0.003 part of fat-solublevitamins, 0.01-0.03 part of water-soluble vitamins, 0.005-0.02 part of dietary essence, 0.0005-0.05 part of medicinal and edible components, 0.05-0.4 part of a natural plant compound and 0.01-0.02 part of new resource food. The invention also provides preparation methods of two clinical nutritional formulas. The clinical nutritional formula provides comprehensive nutritional support for children with lactose intolerance, intensifies calcium absorption, simultaneously relieves diarrhea symptoms of pediatric patients with lactose intolerance, conditions the intestinal tracts, promotes digestionand absorption of the intestinal tracts and enhances body immunity of children.

The invention relates to a biodegradable composite material and to a method for producing same. The biodegradable composite material according to the invention is preferably a bone-building material that can be used in the field of regenerative medicine, particularly as a temporary bone defect filler for bone regeneration.

The invention relates to a compound Chinese herbal medicine immunopotentiator for prawns. The immunopotentiator is prepared from Chinese herbal medicine active ingredients in percentage by mass as follows: 20%-50% of astragalus polysaccharides, 20%-50% of chlorogenic acid and 20%-50% of berberine. The immunopotentiator can substitute for antibiotics and chemicals after being produced and applied and can significantly enhance the immunity and disease resistance of the prawns. Three Chinese herbal medicine active ingredients of astragalus, eucommia bark and golden thread are extracted and applied to feed, so that adverse effects caused by multiple medicines are avoided; the immunopotentiator is simple to prepare, lower in cost and capable of increasing the economic benefit of the prawn culture industry.

The invention discloses a crucian carp feed containing a compound Chinese herbal medicine immunity enhancer. The crucian carp feed comprises the raw materials of corn flour, wheat bran, bean pulp, wheat, bagasse, fish bone powder, vinegar dregs, corn straw, rice bran, rapeseed dregs, silkworm chrysalis meal, Chinese chives, spinach leaves, the compound Chinese herbal medicine immunity enhancer and phagostimulant. The compound Chinese herbal medicine immunity enhancer is prepared from folium cortex eucommiae, isatis roots, honeysuckle flowers, dried tangerine peel, folium artemisiae argyi, hawthorn fruit, Chinese mugwort, tea, milkvetch roots, lignum sappan, common andrographis herb and cortex cinnamomi according to certain proportions. According to the crucian carp feed containing the compound Chinese herbal medicine immunity enhancer, raw material matching and proportioning of the crucian carp feed are optimized, the feed is high in use ratio and good in palatability, the weight increasing speed of crucian carps is significantly increased, and the added compound Chinese herbal medicine immunity enhancer can effectively enhance the immunity function of the crucian carps and improve the disease resistance of the crucian carps, so that the survival rate of the bred crucian carps is greatly increased. Therefore, application of antibiotics can be reduced, the yield of the crucian carps can be increased, the quality of the crucian carps can be improved, and important industrial value is achieved.

The invention relates to a medicament for treating constipation and a preparation method thereof, and belongs to a Chinese medicine composition, wherein the medicament is a functional health-care food and is a fermenting product of morehella esculenta (L.) Pers mother seeds and black fungus mother seeds by using a water extract of a mixture of Chinese bulk pharmaceutical medicines as a culture medium; and the mixture of the Chinese bulk pharmaceutical medicines comprises 10-25 parts of bunge cherry seeds, 5-15 parts of cistanche and 3-5 parts of semen cannabis. The preparation method of the medicament comprises the step of vaccinating the morehella esculenta (L.) Pers mother seeds and the black fungus mother seeds to the water extract for fermentation. The medicament can be used for treating both the incidental and fundamental aspects of patients with constipation, fundamentally avoids factors resulting in the constipation on the functions of metabolization and lung and has the advantages of no harm for bodies and high cure rate.

The invention relates to a microecological preparation used for improving penaeus vannemei immunity. The preparation comprises bacillus subtilis, bnfillus licheniformis, and fermentation auxiliary materials. The components are composed according to a weight ratio of 3-8:2:1, such that the microbial preparation is prepared. The microbial preparation provided by the invention contains two high-quality effective bacteria. The strains are strictly selected and cultivated according to microecological regularities. The high quality of the strains is ensured, and viable bacteria content is high. The shelf life of the preparation reaches 24 months. The microbial preparation has good microecosystem regulating and immunity enhancing functions, and especially has substantial function in improving penaeus vannemei immunity.

A Chinese herbal medicine compound polysaccharide immunity-enhanced feed additive for prawns has the characteristic of enhancing immunity and disease resistance of the prawns. The additive is preparedfrom active ingredients of Chinese herbal medicines in percentage by mass as follows: 40%-70% of astragalus polysaccharide, 10%-20% of rhizoma atractylodis macrocephalae polysaccharide and 10%-40% ofsaposhnikovia divaricata polysaccharide. The additive is simple to prepare, lower in cost and convenient to use. After being produced and applied, the preparation can effectively improve the immune defense capacity of the prawns, prevent and treat diseases of the prawns and reduce use of antibiotics and chemical drugs, meanwhile, the problems of effective component uncertainty, multiple impurities, poor palatability and the like caused by addition of original powder of Chinese herbal medicines are solved, and technical support is provided for green and healthy culture of the prawns.

The invention discloses ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity. In terms of 1000 parts, the health care oral liquid consists of the following Chinese herbal raw materials: 4-6 parts of ocellated puffer liver oil, 10-15 parts of fructus arctii, 8-12 parts of houttuynia cordata, 10-15 parts of radix puerariae, 15-20 parts of rhizoma ligustici wallichii, 10-13 parts of cortex phellodendri, 8-12 parts of herba andrographitis, 10-15 parts of dandelion, 10-16 parts of fruit of Chinese wolfberry, 10-18 parts of cyrtomium rhizome, 5-10 parts of rhizoma polygoni cuspidati, 5-10 parts of radix achyranthis bidentatae, 10-15 parts of liquorice root and 10-15 parts of chlorella vulgaris, and the health care oral liquid is prepared through combined technologies of ultrasonic-assisted extraction, volatile oil distillation, water decoction and alcohol extraction. The product has the advantages of being good in functions of resisting tumors and enhancing immunity, safe and free from side effects, convenient to drink and the like.

The invention discloses dendrobium officinale leaf fermented wine which is prepared from fresh dendrobium officinale leaves, olive fruits, white granulated sugar, bacteria powder and distilled water according to certain weight part proportions, wherein the bacteria powder is prepared by mixing lactobacillus plantarum, rhamnose bacteria, lactic acid bacteria DU-106, saccharomycetes, NaCl, glucose,inulin and dietary fiber according to proportions. The preparation method of the dendrobium officinale leaf fermented wine comprises the following steps: raw material selection; blanching with boiledwater; preparation of alcohol liquid; diastatic fermentation; aging fermentation; clarification and degerming; distillation of the alcohol liquid to obtain the dendrobium officinale leaf fermented wine. The dendrobium officinale leaf fermented wine has mellow wine flavor. Tastes smooth and mellow, and has sour-sweet and tasty taste; the wine is light pink, clarified, stable and uniform. The dendrobium officinale leaf fermented wine has nutritional effects of the fresh dendrobium officinale leaves, and also has physiological and health-care effects achieved by fermentation and metabolism of lactic acid-production bacillus and saccharomyces cerevisiae. The alcohol content is 6 to 15 percent, the total acid content is 0.5 to 1.5 percent, and the polysaccharide content is 0.5 to 0.8 percent. The dendrobium officinale leaf fermented wine has an outstanding immunobiological activity; the phagocytosis activity of RAW 264.7 mice macrophage and the secretion volume of relevant immunocytokines can be improved.

The invention discloses a sugar-free shark fin bone meal tablet candy for preventing tumors and improving immunity, and a production technology thereof. Raw materials of the tablet candy comprise, by mass, 30-50 parts of shark cartilage meal, 5-10 parts of sorbitol, 5-10 parts of magnesium stearate, 20-30 parts of soybean protein powder, 4-6 parts of spirulina, and 2-3 parts of composite Chinese herbal medicine extract, wherein the composite Chinese herbal medicine extract is aqueous extract of a mixture of Herba Houttuyniae, Herba Taraxaci, hawthorn fruit, purslane, sea-tangle, Radix Scutellariae, fig, dark plum, wild chrysanthemum flower, Sarcandra glabra, licorice root and Stevia Rebaudiana Bertoni. The tablet candy has the advantages of synergism of the shark cartilage meal and other raw materials due to scientific compatibility, tumor and fatigue preventing efficacy, safety, no side effects, convenient eating, and good market application prospect.

The invention discloses a filtering device used for a disease-resistant air purifier and an installation and application method thereof. The device comprises a frame structure, a coarse filtration layer, an adsorption layer, an antibacterial and antivirus layer, a fine filtration layer, a negative-ion generation layer and a bacillus licheniformis culture medium which are successively arranged according to an air flow direction, wherein the coarse filtration layer, the adsorption layer, the fine filtration layer, the negative-ion generation layer, the antibacterial and antivirus layer and the bacillus licheniformis culture medium are arranged on the frame structure; the area of the frame structure corresponding to an air outlet pipeline is provided with at least two culture medium installation platforms used for installation of the bacillus licheniformis culture medium; the antibacterial and antivirus layer is arranged between the adsorption layer and the fine filtration layer; the negative-ion generation layer is arranged under the fine filtration layer; and the frame structure can be installed and removed from a position corresponding to an air purifier body. The filtering device provided by the invention has the advantages of good air permeability, strong filtering ability and strong comfortableness, is bacteriostatic, antivirus and disease-resistant, can everlastingly maintain a negative-ion environment suitable for the human body, and is favorable for human health.

The present invention presents a Kunitz-type recombinant inhibitor obtained from a gene cloned from a cDNA library of salivary glands of the Amblyomma cajennense, and the inhibitor named Amblyomin-X has molecular mass of 13,500 Da.

The invention provides a feed additive capable of improving the quality of marine culture fish and a preparation method thereof, and belongs to the technical field of marine culture. The feed additivecomprises an organic chromium complex which contains at least two kinds of amino acid ligands, wherein the at least two kinds of amino acids are selected from methionine, cysteine, alanine, glycine,proline, glutamic acid or histidine. The preparation method comprises the following steps: preparing the organic chromium complex by a microwave heating solid phase synthesis method, and mixing the organic chromium complex with a chitosan oligosaccharide complex to obtain the feed additive, wherein sodium citrate and D-alanine are added in the microwave heating solid phase synthesis reaction. Thefeed additive provided by the invention can participate in carbohydrate metabolism in bodies, improve the immune function and anti-stress ability of animals, and improve the flavor and muscle qualityof fish to be more approximate to wild fish; and the preparation method has low energy consumption and high yield, and the prepared organic chromium complex has moderate stability.

The present invention discloses a Chinese herbal medicinal preparation with stable medicine properties for immunological enhancement and sterilization of penaeus orientalis and a method thereof. The Chinese herbal medicinal preparation comprises the following ingredients in mass percentages: 20%-50% of astragalus polysaccharide, 20%-50% of chlorogenic acid, 20%-50% of allicin, 5%-10% of sodium hydrogen sulfite, and 3%-6% of dimethyl-beta-propionic acid thialdine. The method comprises the following steps: radix astragali is crushed, the crushed radix astragali is screened, the screened radix astragali is mixed evenly with distilled water to be boiled, filtrate is concentrated, ethanol is added until the ethanol content is 80%, and the materials are subjected to suction filtration overnight to obtain the astragalus polysaccharide; cortex eucommiae is crushed, the crushed cortex eucommiae is screened, the screened cortex eucommiae is mixed evenly with ethyl acetate, the mixture is subjected to stirring and reflux extracting at water bath at 65 DEG C, filtrates are blended, ethyl acetate is separated, and the chlorogenic acid is obtained. The Chinese herbal medicinal preparation is simple in preparation processes, relatively low in costs and convenient in applications, can effectively improve the immune defense ability and sterilization function of the penaeus orientalis after the production application, effectively prevents and cures diseases of the penaeus orientalis, reduces the uses of antibiotics and chemical drugs, provides technical supports for sustainable development of breeding health of the penaeus orientalis, and provides technical supports for ecological environment protection of water areas.

The invention discloses fish meal feed capable of improving meat quality for shrimps. The fish meal feed capable of improving the meat quality for the shrimps is prepared from, by weight, 60-70 parts of fish blocks, 6-7 parts of peaches, 2-3 parts of bitter gourds, 6-7 parts of ulva, 16-17 parts of rice noodles, 7-8 parts of waste molasses, 6-7 parts of palm oil, sugar yeast, bacillus subtilis, astaxanthin, glycyrrhizic acid, vitamin C and an adequate amount of water. The fish meal feed capable of improving the meat quality for the shrimps is reasonable and balanced in nutrition arrangement, the palatability is good, nutrient loss in water is less, the quality of shrimp meat is improved, the trace elements needed by growth can be supplemented in time, and the absorbing effect is good.

The invention discloses a traditional Chinese medicine veterinary drug ultra-micro powder for treating livestock and poultry immunosuppression disease and a preparation method thereof and solves problems of complex preparation technology, high cost and difficult clinical popularization and application in the prior art. The traditional Chinese medicine veterinary drug ultra-micro powder for treating livestock and poultry immunosuppression disease is a powdery product which is prepared from 5-55 parts of spatholobus suberctu, 5-35 parts of radix codonopsis and 5-40 parts of astragalus. The traditional Chinese medicine veterinary drug ultra-micro powder can enhance immune functions of livestock and poultry and is mainly used for enhancing the immune functions of livestock and poultry. All of the components of the traditional Chinese medicine veterinary drug ultra-micro powder are natural traditional Chinese medicine raw materials. The traditional Chinese medicine veterinary drug ultra-micro powder is easy to prepare, has effects of expelling evil and activating collaterals, clearing heat and removing toxic, and tonifying the middle and boosting qi. Meanwhile, the traditional Chinese medicine veterinary drug ultra-micro powder is wide in medicine source, is low in cost, is free of medicine residue and is slight in toxic and side effects. The invention belongs to ultra-micro crushing so that the medicine is easier to absorb.

The invention discloses a breeding method for promoting growth of Chinese softshell turtles. According to nutrient requirements and physiological characteristics of the Chinese softshell turtles, by cooperation of artificial feed, vegetable feed and animal feed, low cost of a formula and food feeding effect can be achieved, the economic benefit of the Chinese softshell turtles is increased, and high-quality selenium-enriched Chinese softshell turtles are obtained. The artificial feed is obtained by adding pachymaran, immunopolysaccharide, complex beneficial microorganisms and antimicrobial peptide in basic feed.