31 results about "Immune defense" patented technology

The present invention belongs to the field of biotechnology. Disclosed are a plant immunity-inducing protein CcHE1 and a use thereof. The disclosed plant immunity-inducing protein CcHE1 secreted by a plant pathogenic fungus has an amino acid sequence shown as SEQ ID NO.2, and a nucleotide sequence of the gene encoding CcHE1 shown as SEQ ID NO.1. The present invention provides a novel plant immunity-inducing protein CcHE1, capable of inducing plant resistance and immune defense responses, significantly enhancing plant disease resistance, effective at low concentrations, and exhibiting remarkable disease-resistance effects. CcHE1 activates the plant's own immune system, providing a new approach to improving plant resistance, and has broad application prospects in areas such as green control of forest diseases.

This invention discloses the CAPE1 peptide at the C-terminus of the PtPR1 protein and its applications. There are three types of CAPE1 peptides in the PtPR1 protein: PtPR1f (amino acid sequence shown in SEQ ID NO.1), PtPR1j (amino acid sequence shown in SEQ ID NO.2), and PtPR1l (amino acid sequence shown in SEQ ID NO.3). Experimental results show that the three CAPE1 peptides at the C-terminus of the PtPR1 protein provided by this invention can induce an immune defense response in woody plants at low concentrations. The use of these three CAPE1 peptides can also significantly improve the disease resistance of woody plants to *Colletotrichum gloeosporioides*, *Pseudomonas aeruginosa*, *Botrytis cinerea*, or *Phytophthora spp.*, without inhibiting the growth of these pathogens. Therefore, it can be applied to the prevention and control of woody plant diseases, providing a new approach to improving the disease resistance of woody plants and showing broad application prospects in the green control of woody plant diseases.

The invention discloses a preparation method of an aluminum MOF nano adjuvant and application of the aluminum MOF nano adjuvant in a multi-combined vaccine, and belongs to the technical field of biology. The aluminum MOF nano adjuvant is prepared from Al < 3 + > and a ligand rich in carboxylic acid in a molar ratio of (2-4): (4-6) through a solvothermal method. The invention develops a novel aluminum MOF nano adjuvant, a multi-combined vaccine is prepared based on the adjuvant, and a more excellent long-acting immune response can be induced by combining the multi-combined vaccine with inactivated antigens of various epidemic diseases to play a wide delivery role. The nano adjuvant is proved to be capable of inducing an effective immune defense system of an organism, a new material is provided for preparation of a multi-combined vaccine, and powerful support is provided for prevention and control of live pig epidemic diseases.

The invention relates to the technical field of aquatic animal immune regulation and control, in particular to rHoLL-like stepped lectin-like recombinant protein as well as a preparation method and application thereof. The recombinant protein has pathogen-related molecular pattern recognition and combination capabilities, can promote aggregation of pathogens in a body fluid environment, and activates an aquatic animal complement system, so that the non-specific immune defense capability is enhanced. The preparation method comprises the following steps: amplifying a HoLL-like mature peptide coding sequence, constructing a recombinant expression vector, and converting the recombinant expression vector into an escherichia coli expression host for induced expression to obtain rHoLL-like lectin-like recombinant protein existing in an inclusion body form; and carrying out affinity chromatography purification on the inclusion body protein, and carrying out renaturation treatment in a manner of gradient reduction of denaturant concentration to obtain the rHoLL-like stepped lectin-like recombinant protein. The rHoLL-like stepped lectin-like recombinant protein has good biological safety, and can be applied to aquaculture as an aquatic animal immunopotentiator or a related biological product.

NEW SMALL MOLECULES AND METHODS USING THEM FOR SKIN TREATMENT. The disclosure relates to new biosynthetic gene clusters encoding type II polyketides, their products, extracts and compositions comprising the products, and methods for using the products, extracts, and compositions for skin treatment, e.g., to enhance the skin's barrier function and / or immune defenses. Figure for abstract: none

The invention discloses a micro-grid endogenous toughness control method and device, electronic equipment and a medium, and relates to the technical field of micro-grid safety. The method comprises the following steps: through accurate mapping of IGCC and immune three-layer defense and topological adaptation of a graph convolutional network, autonomous detection, isolation and recovery of communication attacks are realized, challenges of malicious attacks of a communication layer and destruction of a cooperative mechanism can be effectively coped with, deep fusion and autonomous evolution defense of a biological immune defense mechanism and the graph neural network are realized, and the security of the communication layer is improved. The self-adaptability and the stability level of the micro-grid control system in a complex attack environment are improved, and the problems that a traditional defense method lags in response and lacks self-organization are effectively solved.

The present invention discloses a Pinctada martensii C-type lectin PmPLP, as well as its application in the preparation of drugs for inhibiting microorganisms and in promoting the release of pro-inflammatory factors induced by nucleation in Pinctada martensii. The present invention conducts preliminary research on the identification and immune function of Pinctada martensii C-type lectin PmPLP to determine the immune response of PmPLP molecules in the immune response of Pinctada martensii against the invasion of external pathogens, and to understand the antibacterial activity of PmPLP after in vitro expression, providing data support and research basis for the study of the immune defense mechanism of Pinctada martensii and other marine mollusks C-type lectins. The present invention conducts in-depth research on the immune response mechanism of Pinctada martensii, which helps to reveal its molecular regulatory mechanism in response to pathogen invasion, and is of great significance for improving aquaculture efficiency and disease prevention and control.

The invention discloses a pharmaceutical composition for rhinitis health care and respiratory tract circulation improvement and a preparation method thereof.The pharmaceutical composition is prepared from pogostemon cablin, osmanthus fragrans, geranium, wild chrysanthemum flowers, semen armeniacae amarae, astragalus membranaceus, pericarpium citri reticulatae, platycodon grandiflorum, mint and menthol through processing and liquefying, and through the synergistic effect of all the pharmaceutical ingredients, the pharmaceutical composition has the effects of inducing resuscitation with fragrance, dissolving turbidity and dredging resuscitation; the condition of unsmooth ventilation of the nose can be effectively improved, and uncomfortable symptoms such as nasal obstruction can be relieved; the spreading and descending of lung qi are regulated, and the normal physiological function of the respiratory tract is maintained; the whole resistance of the body and local qi and blood nourishing of the nose are enhanced, and repair and regeneration of nose tissues are promoted; the invasion of external heat toxin to the nose is resisted, and the inflammatory response is relieved. Long-term use of the nasal mask can significantly promote respiratory tract microcirculation, enhance the immune defense function of the nose, and effectively prevent occurrence and recurrence of nasal diseases.

An anti-CD47 monoclonal antibody and use thereof. The provided anti-CD47 monoclonal antibody can effectively inhibit tumor growth. Blocking human SIRP and human CD47 signals may enhance macrophage phagocytosis of tumor cells, prevent the tumor cells from escaping a tumor immune defense system, and have an anti-tumor function. Blocking association between the CD47 on a tumor cell surface and the SIRP on a macrophage surface may block a “do not eat me” signal from the tumor cells, promoting tumor cell recognition and uptake of macrophages, and thereby facilitating tumor cells to be phagocytosed. The association between the CD47 on a tumor cell surface and the SIRP on a macrophage surface is a common “do not eat me” signal. The anti-CD47 antibody, as a very promising target in the tumor immune system, will play a powerful and effective role in human cancer therapy.

This invention discloses a mixture of artemisia annua extract and rosemary extract and its application in the field of dermatology. The invention provides a mixture of artemisia annua extract and rosemary extract, a preparation method, and applications. This mixture can regulate the function of macrophages and epidermal cells, enhancing the phagocytic capacity of macrophages and initiating normal skin immune defense. Simultaneously, it can inhibit the overexpression of inflammatory factors, increase the expression of tight junction proteins in epidermal cells, and restore the skin barrier.

The application relates to a zero-trust medical network security immune defense method and system. The method comprises the following steps: constructing an abnormal behavior feature database based on an artificial immune system; dynamically adjusting vaccine resources distributed to a subserver by a central server based on the abnormal behavior feature database and a Lagrange optimization method; and optimizing attack detection rules of a firewall based on the vaccine resources and an artificial immune algorithm, and performing network attack defense by using the attack detection rules. That is to say, by constructing a fine-grained network abnormal behavior feature database, introducing a dynamic vaccine distribution mechanism to distribute detectors to all terminal nodes in a medical internal network, and using an artificial immune algorithm for abnormal detection, strict behavior monitoring is realized for each access, attack behaviors are discovered, blocked and traced in a timely manner, and the above-mentioned technologies can cope with network security problems in the current medical network environment and make up for the disadvantages of traditional medical network security boundary protection.

The invention belongs to the technical field of microorganisms, and particularly discloses bifidobacterium bifidum FL228.1 and application thereof. In particular to bifidobacterium bifidum: FL228.1. The bifidobacterium bifidum is preserved in China Center for Type Culture Collection on January 29th, 2024, the preservation address is Wuhan University, Wuhan, Hubei province, and the preservation number is CCTCC No.M 2024274. The invention further discloses a preparation method of the bifidobacterium bifidum. The invention discloses bifidobacterium bifidum FL228.1 and application thereof. The bifidobacterium bifidum FL228.1 is capable of effectively promoting the generation of IgA (Immunoglobulin A) in small intestines, enhancing the immune defense of the intestinal tracts and remarkably improving the intestinal injury caused by ETEC (Enterotoxin) infection.

The present invention relates to bacterial probiotics useful in aquaculture. Specifically, it discloses a selection of non-hemolytic, proteolytic, stress-tolerant bacterial strains with enhanced quorum- quenching capabilities. Moreover, the method allows detection of novel species of bacteria whose probiotic attributes could be massive for aquaculture. From the isolated bacteria, selected species were tested for their probiotic efficacy in Nile tilapia (Oreochromis niloticus), a key fish species in global finfish aquaculture. The species demonstrated significant efficacy in improving the health and growth performance of Nile tilapia juveniles. Specific growth rates and weight gain, and improved feed conversion ratios without adverse effects on fish health were observed. The gut microbiome was positively influenced by promoting beneficial bacteria while reducing harmful (opportunistic) species, leading to improved immune modulation. Survival rates were significantly boosted during a pathogenic challenge, and key immune genes were upregulated, indicating stronger local immune defenses. These findings show that the selected probiotic species offer substantial benefits for growth, feed efficiency, and disease resistance, emphasizing their potential for widespread application as probiotics in aquaculture.

This application discloses a method, device, electronic device, and medium for endogenous resilience control in microgrids, relating to the field of microgrid security technology. The method includes: achieving autonomous detection, isolation, and recovery from communication attacks through precise mapping of IGCC to an immune three-layer defense and topological adaptation of graph convolutional networks. This effectively addresses the challenges of malicious attacks on the communication layer and disruption of collaborative mechanisms, realizing deep integration and autonomous evolutionary defense between biological immune defense mechanisms and graph neural networks. This improves the adaptability and stability of the microgrid control system under complex attack environments, effectively solving the problems of slow response and lack of self-organization in traditional defense methods.

The invention relates to a bionic immune dynamic defense algorithm applied to the aspect of text map privacy protection. Aiming at the limitations of the existing generative model in privacy protection and against attack defense, the invention realizes active and adaptive protection of privacy risks by simulating a biological immune mechanism, and mainly comprises the following steps of: processing cue words by using an epigenetic coding technology to enhance the privacy protection capability of text embedding; identifying and evaluating a potential privacy risk through a privacy detection unit, and dynamically disturbing a potential space of the text graph model according to a risk level; the immune memory module is used for storing and recalling a historical threat mode so as to improve the response efficiency to repeated attacks; and when the risk is continuously higher than a preset threshold value, triggering a component operation mechanism, and selectively adjusting or disabling the model component to quickly block high risk generation. Compared with the prior art, the privacy protection capability and the antagonistic robustness can be remarkably improved while the image generation quality is maintained, and the balance between the performance and the safety is realized.

The invention discloses an antibacterial peptide Hyastatin gene of Eriocheir sinensis as well as a recombinant mature peptide and application of the antibacterial peptide Hyastatin gene. A unigene sequence obtained by transcriptome sequencing is utilized, a 5'and 3 'terminal rapid amplification technology is utilized to amplify in an Eriocheir sinensis blood lymphocyte cDNA library to obtain an antibacterial peptide Hyststin gene full-length sequence, and the gene plays an important role in the innate immune defense aspect of Eriocheir sinensis. According to the present invention, the Eriocheir sinensis antibacterial peptide Hyastatin recombinant mature peptide is obtained by using the in vitro recombinant expression technology, the antibacterial peptide Hyastatin recombinant mature peptide has significant inhibition effect on the common aquaculture pathogenic bacteria aeromonas hydrophila, and the foundation can be laid for Eriocheir sinensis disease control, medical product development and feed additive application.

The invention relates to the technical field of disposable hygienic products, in particular to a composite functional core material with antibacterial, repairing and skin barrier enhancing functions and a preparation method of the composite functional core material. Comprising a probiotic group component, a skin barrier component, an antibacterial component, a repairing component and other components, and the other components comprise starch, cyclodextrin, an emulsifier and a cross-linking agent. The composite functional core material can effectively inhibit bacterium breeding, regulate skin inflammatory response, enhance skin immune defense capability, promote skin repair and maintain a skin barrier function, so that the use safety and comfort of disposable hygienic products are improved.

The invention provides a nutrient enrichment feed for parent fish of wild sal-ammoniac larimichthys crocea and a nutrient regulation and control method, and belongs to the technical field of breeding of the wild sal-ammoniac larimichthys crocea. According to the wild sal family large yellow croaker parent fish nutrition enrichment feed provided by the invention, through targeted scientific proportioning, the physique recovery, immune defense and gonad development efficiency of parent fish is systematically improved, and the technical bottlenecks that wild parent fish is difficult to domesticate and low in breeding efficiency in a traditional breeding mode are remarkably improved. A staged nutrition regulation and scientific feeding management strategy is further adopted, the content of protein, fat and a functional immunomodulator in the feed is dynamically adjusted according to the nutritional requirements of the Pseudosciaena crocea parent fish in different stages of domestication and sexual maturity, the gonad function and the overall health can be promoted, and the survival rate of the Pseudosciaena crocea is increased. The feed utilization efficiency and the sustainability of the breeding environment are improved to the maximum extent, the breeding benefits are remarkably improved, and the method has remarkable popularization value and industrial application prospects.

The invention provides a sugarcane ScSnRK1.1 gene with a disease-resistant function, a protein and an application, belongs to the technical field of biology, and particularly discloses the sugarcane ScSnRK1.1 gene and the application of the sugarcane ScSnRK1.1 gene in improving the disease-resistant function. According to the application disclosed by the invention, the aspect of response of ScSnRK1.1 to pathogenic bacterium stress is preliminarily explored, multiple defense signal channels can be integrated to regulate immune defense of plants, and an important theoretical basis and gene resources are provided for sugarcane disease-resistant molecular breeding.

The invention relates to processes for preparing plant extracts comprising an autofermentation step and optionally extraction steps allowing enrichment of the extracts with small molecular weight RNA. The invention also relates to compositions comprising such extracts and their cosmetic uses to combat the signs of skin aging. loss of firmness or tone. improve barrier function and hydration. lighten the skin or improve the skin's innate immune defenses and well-being in vivo.

The invention provides a PD-L2 inhibitor, a preparation method and application and an anti-cancer composition, the PD-L2 inhibitor has the following structural formula: # imgabs0 #, in which R group is one of hydrogen, deuterium, methyl, methoxyl, trifluoromethoxyl, halogen, amino, carbamido, sulfamido and sulfonyl or a combination of the above substituent groups, and R group is one of hydrogen, deuterium, methyl, methoxyl, trifluoromethoxyl, halogen, amino, carbamido, sulfamido and sulfonyl; x, Y and Z are respectively carbon atoms, nitrogen atoms and sulfur atoms, and the positions of the carbon atoms, the nitrogen atoms and the sulfur atoms can be mutually replaced; the PD-L2 inhibitor can inhibit expression and glycosylation of PD-L2 on the surfaces of tumor cells, so that the recognizability and aggressiveness of an immune system to the tumor cells are improved, and the immune defense capability of a human body is improved.

The invention discloses an application of methyl ferulate in prevention and treatment of apple anthrax leaf blight, which is characterized in that the methyl ferulate is prepared into a solution with the concentration of 0.05 microgram / mL-0. 5 microgram / mL, and the solution is uniformly sprayed on the surfaces of apple leaves or fruits. The methyl ferulate can simultaneously induce the activity of key disease-resistant enzymes in apple bodies to be remarkably improved, promote accumulation of secondary metabolites, namely flavonoid substances, and regulate and control synthesis and signal channels of various defense-related hormones, so that a multi-layer and systematic plant immune defense network is constructed. Expression of multiple disease course related protein genes of apples is remarkably up-regulated, a salicylic acid signal channel is activated, a system obtains resistance, and the effectiveness of the compound as a plant immune resistance inducer is proved from the molecular level. The methyl ferulate provided by the invention is derived from a natural metabolite of a plant, is low in use concentration and small in residual risk, realizes disease prevention and control by inducing the resistance of the plant, does not easily cause pathogenic bacteria to generate drug resistance, meets the requirements of green agriculture and sustainable development, and has important ecological and economic values.

Embodiments of the disclosure concern engineered auto / allo-immune defense receptor (ADR)-expressing T cells that selectively target activated T cells, including pathogenic T cells, to incapacitate them. The chimeric receptors comprise moieties for targeting 4-1BB, 0X40, and CD40L, for example, whose expression is indicative of activated T cells. In particular embodiments, there are methods of preventing or treating conditions associated with activated T cells using adoptive T-cell transfer of cells encoding the ADRs.

The disclosure relates to new biosynthetic gene clusters that encode for type II polyketides, products thereof, extracts and compositions comprising the products, and methods of using the products, extracts, and compositions for treating skin, for example to enhance skin's barrier function and / or immune defense.

The present invention relates to 5,6,5',6'-tetraphenyl-3,3'-(1,4-phenylene)-bis[1,2,4]triazine, or a composition comprising it, for its use in preserving the immune defenses of the skin, in particular preserving innate immunity.

The invention discloses a non-antigen-dependent antibody rapid enhancement method and application, and relates to the technical field of biology. The method comprises the following steps: applying a non-antigen-dependent antibody rapid enhancer to an organism containing a pre-stored antibody in vivo so as to increase the content of the pre-stored antibody; the non-antigen-dependent antibody rapid enhancer comprises lipid nanoparticles coated with single-stranded oligonucleotide, the nucleotide sequence of the single-stranded oligonucleotide is as shown in SEQ ID NO. 1. According to the method, the level of the pre-stored antibody can be rapidly and remarkably improved in the body with the established immune memory under the condition that the exogenous antigen is completely not required to be stimulated again. The limitation that an existing antibody enhancement strategy must depend on antigens is broken through, and a brand-new technical tool and solution with wide application prospects are provided for quick awakening of vaccine efficacy, emergency enhancement of immune defense and controllable adjustment of in-vivo antibody level in antibody preparation.

The invention provides enterococcus faecium R8 and application thereof, and relates to the technical field of microorganisms, the enterococcus faecium R8 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.15229, and the preservation date is January 17, 2018. The enterococcus faecium R8 is named as enterococcus faecium R8. The invention further provides a preparation method of the enterococcus faecium R8. According to the method, the optimal effective concentration of enterococcus faecium is defined, and the conversion and utilization rate of prawns to the feed can be effectively increased, so that the growth of the prawns is accelerated while the culture cost is saved. Meanwhile, the multi-enhancement effect of the enterococcus faecium on the immune system of the penaeus monodon is effectively improved, the immune defense system of the penaeus monodon is activated and enhanced, and the anti-oxidative stress capability of the penaeus monodon is enhanced, so that the resistance of the penaeus monodon to diseases is possibly improved.

The invention discloses a CAPE1 peptide fragment at the C terminal of PtPR1 protein and application thereof, the CAPE1 peptide fragment of the PtPR1 protein has three types, namely PtPR1f, the amino acid sequence of which is shown as SEQ ID NO.1; the amino acid sequence of the PtPR1j is as shown in SEQ ID NO. 2; the amino acid sequence of the PtPR1l is as shown in SEQ ID NO. 3. Experimental results show that the CAPE1 peptide fragments at the C terminals of the three PtPR1 proteins provided by the invention can induce the woody plant to generate immune defense reaction at lower concentration; by using the three CAPE1 peptide fragments at the C terminal of the PtPR1 protein provided by the invention, the disease resistance of the woody plant to colletotrichum gloeosporioides, valsa poplar, botryosphaeria dothidea or phytophthora parasitica can be remarkably improved, and the CAPE1 peptide fragments have no inhibition effect on the growth of various pathogenic bacteria. Therefore, the strain can be applied to prevention and treatment of woody plant diseases, a new way is provided for improving the disease resistance of the woody plants, and the strain has a wide application prospect in the aspects of green prevention and control of the woody plant diseases and the like.

This invention relates to a promoter for increasing hBD-2 expression and its application, comprising rose extract, lily extract, and iris extract in a mass ratio of 1:(0.2-5):(0.2-5), and applying the promoter in children's skincare products. Compared with existing technologies, this invention can promote the expression of β-defensin 2 in children's skin under non-pathological conditions, thereby enhancing the skin's innate immune defense capabilities and helping to maintain skin microecological homeostasis, and has the potential for new uses as β-defensin 2.

The invention discloses a Pinctada martensii C-type lectin PmPLP, an application of the Pinctada martensii C-type lectin PmPLP in preparation of drugs for inhibiting microorganisms and an application of the Pinctada martensii C-type lectin PmPLP in promotion of release of pro-inflammatory factors induced by nucleus implantation of Pinctada martensii. According to the invention, preliminary research is carried out on identification and immune functions of Pinctada martensii C-type lectin PmPLP, so that immune response of PmPLP molecules in immune response of Pinctada martensii for resisting invasion of external pathogenic bacteria is determined, and antibacterial activity of PmPLP after in-vitro expression is known; and data support and a research basis are provided for researching C-type lectin immune defense mechanisms of pinctada martensii and other marine mollusks. The immune response mechanism of the pinctada martensii is deeply studied, the molecular regulation mechanism of the pinctada martensii for coping with pathogen invasion is disclosed, and the method has important significance for improving the breeding efficiency and preventing and controlling diseases.