The invention discloses a manipulation stability and smoothness cooperative optimization method in vehicle dynamics simulation analysis. The method comprises the following steps of S1, determining a simulation test investigation index, that is, the manipulation stability and smoothness of a vehicle; S2, determining simulation test factors and level values of the simulation test factors, and choosing an orthogonal table according to the settings of the test factors and the level values; S3, according to a test scheme determined according to the orthogonal table, conducting a whole-vehicle manipulation stability and smoothness test under an ADAMS simulation platform, recording all test results, and utilizing a range analysis method to obtain a range analysis result of all factors of an orthogonal test; S4, utilizing a matrix type weight analysis method to analyze the range analysis result of the orthogonal test, and choosing a test factor optimization level combination scheme. The manipulation stability and smoothness cooperative optimization method in the vehicle dynamics simulation analysis has the advantages of being simple in principle, high in operability, flexible in design, high in reliability, wide in application range and the like, and has important guidance and reference significance in studies of vehicle dynamics performance optimization, dynamics control and the like.