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Biodegradable composite material

A composite material and biological technology, applied in tissue regeneration, bone implants, medical science, etc., can solve the problems of inflammatory response, difficult to monitor the recovery process, difficult to distinguish bone grafts from healthy bone environment, etc.

Active Publication Date: 2014-09-10
CURASAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition to the stated risks, many materials of biological origin also have problems with respect to x-ray opacity: clinicians may find it difficult to distinguish bone grafts from healthy bony surroundings in x-ray images, and accordingly may not always be able to Satisfactory checking that filling of defects has been successful and sufficient, and difficulty monitoring healing progress
Furthermore, bone replacement and bone reconstruction materials whose particles are too small or fragmented into microparticles during the resorption process or due to wear and tear may cause an inflammatory response

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] The 1000-2000 μm component I particle fraction was separated by sieving, and the 5.6 g portion was suspended in 20 ml of component D, and 74 μl of component P was added thereto. After 0, 1, 3, 6, and 23 hours, the material was filtered, washed, and dried. The particles were then washed, filtered and dried, and the particle size was tested using a laser dispersion device (Fritsch Analysette), the surface integrity was tested by scanning electron microscopy, and the phase purity was tested by X-ray powder diffraction. Table 1 shows the d of tricalcium phosphate powder after the action of acetic acid for different time 10 , D 50 And d 90 value.

[0123] Table 1

[0124]

[0125] It can be seen from Table 1 that there is a significant particle size reduction only after 6 hours. Use d for the fine powder fraction 10 The value indicates that it undergoes greater degradation than coarser fractions of particles fragmented. Correspondingly, it is believed that surface etching of sm...

Embodiment 2

[0128] 16.5 g of component O was added to 3.5 ml of component D and suspended by a colloid mill. The component I particle fraction of 1000-2000 μm was separated by sieving, and 5.6 g was added to the suspension. After adding 74 μl of component P, the material was stirred at room temperature. After 0, 30, 120, and 165 minutes, the acid was neutralized and the mixture was poured into a mold and freeze-dried. X-ray powder diffraction method was used to test whether the action time of acid has an effect on the phase stability of calcium phosphate. The results show that the effect of acid has no effect on the phase stability of the material.

Embodiment 3

[0130] A 150-500 μm particle fraction is separated from component H by sieving. The 150-500 μm fraction and the 1000-2000 μm fraction are separated from component I by sieving. According to Table 2, these components were mixed together in various ratios. 190 g of component O was suspended in 1000 ml of component D and ground by a colloid mill. 760 g of the granular mixture is added and the mixture is mixed intimately. After adding 10 ml of component B, the mixture was neutralized and poured into a square high-grade steel mold and freeze-dried. Depending on the freeze-drying process (slow or fast), composite materials with a density of 0.2 or 0.4 g / ml can be obtained. Table 2 provides information on the different mixtures and densities and the measured specific surface area.

[0131] Table 2: Measurement results of various collagen / ceramic composite materials compared with collagen

[0132]

[0133] It can be seen that 100% pure collagen has a surface area 5-8 times higher. Th...

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Abstract

The invention relates to a biodegradable composite material and to a method for producing same. The biodegradable composite material according to the invention is preferably a bone-building material that can be used in the field of regenerative medicine, particularly as a temporary bone defect filler for bone regeneration.

Description

Technical field [0001] The invention relates to a biodegradable composite material and a preparation method thereof. The biodegradable composite material according to the present invention is preferably a bone reconstruction material that can be used in the field of regenerative medicine, especially as a temporary filler for bone defects in bone regeneration. Background technique [0002] Bone defects and their treatment have been known for a long time. For example, bone defects can occur in the event of a traumatic event (fracture). In addition, diseases, such as tumors, can also cause bone defects due to osteoporosis or unloading, such as osteolysis in the case of alveolar ridge atrophy. In all these cases, there are bone defects that must be dealt with through regeneration measures. [0003] The stock of endogenous (self-generating) bone suitable for transplantation is very limited: it can be in the iliac ridge area, in the chin or jaw angle, in the tibial head, or by removin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/56
CPCA61L27/56A61L2430/02A61L27/425B29C44/02A61L27/42C08L89/06A61F2/28A61F2002/2835A61F2210/0004A61F2310/00365A61L27/12A61L27/24A61L27/54A61L27/58A61L2300/412
Inventor F·彼得斯W-D·许布纳C·霍夫曼N·安迪克K·哈萨诺维奇T·赫尼奥佩克
Owner CURASAN
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