57 results about "Osteoporotic bone" patented technology

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention provides a Falcarindiol derivative, preparation thereof and application of the Falcarindiol derivative in preparation of medicines for preventing and / or treating bone diseases. The structural general formula of the Falcarindiol derivative is as shown in formula I in the specification. Experimental results show that the Falcarindiol derivative can significantly inhibit osteoclast differentiation, and is expected to be used for preparing novel drugs for preventing and / or treating osteoporosis, osteoporosis fracture, osteolysis, periprosthetic osteolysis, tumor bone metastasis, inflammatory bone loss, periodontitis inflammatory bone resorption and other bone diseases. # imgabs0 #

The invention discloses a preparation method and application of shape memory short fiber stiffened hydrogel, and the preparation method comprises the following steps: obtaining a copolymer PLCL nanofiber membrane of poly-L-lactic acid and caprolactone through electrostatic spinning, carrying out stretching shaping and cutting at a certain temperature, dispersing in a low-temperature homogenizer to form shape memory short fibers SMSFs, and carrying out shape memory short fiber reinforcement on the shape memory short fibers SMSFs to obtain the shape memory short fiber hydrogel. The SMSFs are added into the double-network hydrogel, and the shape memory short fiber stiffened hydrogel is obtained by exciting the shape memory effect of the SMSFs. The invention relates to an application of a shape memory short fiber, which is used for preparing shape memory short fiber stiffened hydrogel for promoting osteogenic differentiation and inhibiting osteoclast generation. According to the shape memory short fiber stiffened hydrogel and the application method thereof, the stiffening effect of the shape memory short fiber stiffened hydrogel has the direct regulation and control effect on stem cell osteogenic differentiation and indirectly has the ability of inhibiting osteoclast formation, and a new way is provided for preparing a bone regeneration scaffold for osteoporotic bone defect repair.

The invention relates to the field of food, in particular to colostrum basic protein as well as a preparation method and application thereof. The colostrum basic protein of the present invention can increase bone mass, increase bone density, promote skeletal development, promote skeletal regeneration or repair, promote calcium absorption, promote bone collagen production, and / or prevent and / or treat bone related diseases (such as osteoporosis, osteoporosis, rickets, osteoarthrosis).

The invention provides an osteoporosis fracture risk prediction method and system based on multi-modal imageomics. The method comprises the following steps: S1, acquiring multi-modal image data of the lumbar vertebra of a user; s2, performing feature correction according to the acquired multi-modal image data to obtain a time-space aligned multi-modal feature tensor; s3, according to the obtained multi-modal feature tensor, the integrity of the bone microstructure at each position is evolved based on the trained bone microstructure evolution model, and a bone microstructure integrity evolution result is obtained; and S4, according to the obtained bone microstructure integrity evolution result, extracting a fracture risk characteristic part, and further performing fracture risk prediction on the fracture risk characteristic part to obtain a fracture risk prediction result. According to the invention, the accuracy and reliability of osteoporotic fracture risk prediction can be improved.

The invention belongs to the technical field of medical biomaterial engineering application, and particularly relates to a bone repair scaffold for promoting diabetic bone defect repair. The stent main body is provided with a functional material, and the functional material comprises one or a combination of more than two of the following components: platelet-derived growth factors, copper ions and strontium ions; the weight part ratio of the platelet-derived growth factor to the copper ions to the strontium ions is (0.001-0.1): (0.005-1): (0.01-10). According to the bone repair scaffold provided by the invention, through the synergistic effect of the platelet-derived growth factor (PDGF-BB) and trace metal copper and strontium, the bone defect and osteoporotic bone defect of a diabetic patient are treated.

The embodiment of the application discloses a kind of bone repair materials and its preparation method and application.The preparation method includes: poly-L-lactic acid and barium titanate are added in hexafluoroisopropanol, fully stir, obtain PLLA / BTO suspension;Poly-L-lactic acid is dissolved in hexafluoroisopropanol, then add catalpol, obtain PLLA / CA solution;With the PLLA / BTO suspension as shell material, PLLA / CA solution as core material, coaxial electrospinning is carried out, to obtain composite nanomaterial, then remove solvent, obtain the bone repair material.The bone repair material of the application not only has higher anti-osteoporosis activity, but also can improve the stability of the material (low degradation rate, long complete degradation time) and enhance the piezoelectric effect, achieve excellent osteoporosis bone defect repair effect;Preparation process is relatively simple and convenient, key technology is easy to control, and manufacturing cost is lower.

The invention discloses a fixing device for osteoporotic fracture, which comprises a tightening mechanism and a mounting mechanism, the tightening mechanism comprises a fixing plate and a fixing cylinder, the fixing cylinder is welded on the left side of the fixing plate, and a plurality of partition plates are uniformly welded in the fixing cylinder. According to the fixing device for the osteoporotic fracture, stable fixation is provided for the osteoporotic fracture part through the tightening mechanism, the loosening problem caused by infirm fixation is avoided, fracture healing is facilitated, the ratchet wheel is installed on the outer ring of the rotating shaft to be matched with the pawl, and the fixing stability is further guaranteed; the fixing effect is prevented from being affected by loosening of the lacing rope caused by reverse rotation of the rotating shaft, the fracture position of the leg of a patient can be conveniently installed and fixed through the installation mechanism when the leg of the patient is fractured and the leg is inconvenient to lift, operation of medical staff is facilitated, and through cooperative use of a ratchet wheel and a pawl, the fixing stability is guaranteed, and meanwhile the fixing effect is improved. And the fixing device can be conveniently and quickly loosened in emergency, so that the safety of the patient is guaranteed.

The invention relates to the technical field of biology, in particular to application of a GGPS1 activator, a pharmaceutical composition, a kit and a method. The invention relates to bone metabolism regulation and bone regeneration. It is found that improvement of GGPS1 expression / activity can activate TGF-beta / Smad2 / 3 by down-regulating LTBP1, so that human bone marrow mesenchymal stem cells are converted from adipogenesis to osteogenesis, and bone formation and bone defect repair are promoted. The invention provides a drug containing a GGPS1 activator and a controlled release composition for implantation, which are used for osteoporosis, bone mass reduction, delayed fracture healing and the like. The invention also provides an in-vitro screening and evaluation method and a detection kit, and the indexes such as p-Smad2 / 3, alizarin red, oil red O and the like are used for judgment. The invention realizes upstream heavy balance and has the advantages of bone promotion and fat suppression.

The invention discloses a bionic type tibia intramedullary nail and a matched instrument thereof, and relates to the technical field of medical instruments, and the bionic type tibia intramedullary nail comprises an intramedullary nail body; the intramedullary nail body comprises an intramedullary nail near end, an intramedullary nail middle section and an intramedullary nail far end, the intramedullary nail middle section is inserted into the intramedullary nail near end in a threaded mode, and the intramedullary nail far end is inserted into the intramedullary nail middle section in a threaded mode; according to the intramedullary nail, through the sectional type thread inserting design of the intramedullary nail near end, the intramedullary nail middle section and the intramedullary nail far end and the matching of the variable pitch gradient structures of the near end thread, the middle section thread and the far end thread, precise adaptation of the intramedullary nail and the anatomical form of the tibia marrow cavity is achieved, and a gradient mechanical buffering system is formed by the near end thread, the middle section thread and the far end thread; the problem of stress shielding caused by the fact that rigidity of a traditional intramedullary nail is not matched with a skeleton is effectively solved, meanwhile, the variable-pitch threads and the thread depth gradual change design are adopted, damage to an endosteum during nail placement is reduced, uniform stress conduction is achieved, local stress concentration is avoided, and the risks of osteoporosis, delayed fracture healing and secondary fracture are reduced.

The invention relates to the technical field of diagnosis of thyroid cancer postoperative TSH inhibition treatment patient osteoporosis risk assessment, in particular to a thyroid cancer postoperative TSH inhibition treatment osteoporosis fracture risk assessment method, which comprises the following steps: step 1, determining a research object, and setting an inclusion standard and an exclusion standard of the assessment method for the research object; 2, confirming a research method according to the step 1, and refining a specific inspection method of a specific part; and 3, according to the check result in the step 2, determining an FRAX calculation and TSH level weighted assignment method. In the medical evaluation process, all evaluation modes are based on statistics, a new FRAX algorithm assigned according to the TSH level is used for evaluating the osteoporosis fracture risk of a patient subjected to differentiated thyroid cancer postoperative TSH inhibition treatment, the fracture prediction value of an FRAX tool on a specific crowd is optimized, and the risk of osteoporosis of the patient subjected to differentiated thyroid cancer postoperative TSH inhibition treatment is improved. Therefore, the evaluation accuracy of the subject to the specific crowd and the pertinence of evaluating the coverage crowd range are greatly improved.

The invention provides a construction method and equipment of a fracture risk prediction model, a medium and a program product, and relates to the field of intelligent medical treatment. The method comprises the following steps: acquiring basic data of a T2DM osteoporosis patient as a training set sample; the training set samples are divided into a fracture group and a fracture-free group; performing statistical analysis on the basic data, representing continuous variables conforming to normal distribution by using mean + / -standard deviation, and comparing the difference between the two groups through independent sample t inspection; adopting median and quartile to describe continuous variables which do not conform to normal distribution; through single-factor and multi-factor analysis, screening fracture influence characteristics of the osteoporosis patient from the basic data; and constructing a prediction model of the fracture risk of the osteoporosis patient based on the prediction variables. A special group of postmenopausal female diabetes is used as a research object, difference characteristics are analyzed, a prediction model is constructed, and early prevention and treatment of osteoporosis fracture patients are achieved.

The invention provides a shape memory nano short fiber stent with self-adaptive capacity and preparation and application thereof, and belongs to the technical field of tissue engineering materials. The preparation method comprises the following steps: firstly, preparing flexible polylactic acid-fullerol composite nanofibers containing uniformly dispersed fullerol nanocrystals by utilizing an electrospinning technology, then dividing the flexible polylactic acid-fullerol composite nanofibers into short fibers by virtue of homogenization and freeze-drying processes, and assembling the short fibers into a three-dimensional porous scaffold by taking chitosan as an adhesive. The porous scaffold material disclosed by the invention has excellent biological characteristics and a water-triggered shape memory effect, and due to the fact that chitosan has excellent antioxidant activity and inherent bone induction characteristics, the nanofiber scaffold with the controllable and recoverable shape developed by the invention is expected to effectively promote osteoporotic bone healing.

The invention discloses a bone targeting exosome polypeptide delivery system based on a biological orthogonal strategy and a preparation method and application thereof, and relates to the technical field of biological medicine and drug delivery. The bone targeting exosome polypeptide delivery system based on the biological orthogonal strategy comprises an engineered exosome as a carrier and an osteogenesis-promoting therapeutic polypeptide, wherein the osteogenesis-promoting therapeutic polypeptide is anchored on the membrane surface of the engineered exosome; a fusion protein is displayed on the membrane surface of the engineered exosome, and the fusion protein is formed by fusing a bone targeting ligand and an industrial exosome transmembrane scaffold protein; the osteogenesis-promoting therapeutic polypeptide is connected with the industrial exosome through the flexible spacer arm, and the membrane surface steric hindrance is reduced through the flexible spacer arm so as to improve the accessibility of the active fragment of the polypeptide; the delivery system provided by the invention can improve the targeted enrichment and treatment efficiency of osteogenesis promoting drugs in bone tissues, and is suitable for intervention of bone metabolism related diseases such as osteoporosis, delayed fracture healing, bone defects and the like.

The application provides a traditional Chinese medicine granule for improving osteoporosis and a preparation method and application thereof, and belongs to the technical field of medicines. Codonopsis pilosula, drynaria rhizome, epimedium and eucommia are subjected to deep eutectic solvent extraction, purification, and preparation of a traditional Chinese medicine extract, water extraction, dialysis and drying of pilose antler to prepare pilose antler protein peptide; water extraction and alcohol precipitation of cistanche to prepare cistanche polysaccharide; after modification of hydroxyapatite by citric acid, sodium dihydrogen phosphate and beta-cyclodextrin, the product is prepared by inclusion of calcium salt, alpha-cholecalciferol and vitamin D3, and then mixed with the traditional Chinese medicine extract, the pilose antler protein peptide and the cistanche polysaccharide to prepare the traditional Chinese medicine granule for improving osteoporosis. The prepared traditional Chinese medicine granule for improving osteoporosis can promote the synthesis of collagen and bone matrix protein, inhibit bone resorption, promote bone remodeling and enhance the activity of osteoblasts, and has a good improvement effect on osteoporosis, bone fracture and other symptoms, and has a wide application prospect.

The invention provides a risk prediction method and device for suffering from osteoporotic fracture. The method comprises the following steps: counting basic information of a target person; performing VBQ scoring based on the magnetic resonance imaging of the target person; calculating an HU value based on the CT image of the target person; and substituting the counted basic information of the target person and the calculated VBQ score and HU value into a score table to obtain the osteoporosis fracture risk grade of the target person. According to the invention, the risk of the osteoporotic fracture of the target person can be predicted more accurately, so that targeted prevention is carried out, and the harm of the osteoporotic fracture to middle-aged and elderly people is reduced.

The invention discloses a bionic scaffold for treating osteoporotic bone defect, and relates to a bionic material, the scaffold is composed of three parts, namely melatonin-loaded PLGA sustained release microspheres, a silk fibroin / nano-hydroxyapatite (SF / n-HA) composite scaffold and methacrylic anhydride gelatin (GelMA) hydrogel wrapping bone marrow mesenchymal stem cells. The preparation method comprises the following steps: firstly, preparing PLGA sustained-release microspheres by an emulsion solvent evaporation method, and encapsulating melatonin in a PLGA matrix; secondly, mixing SF and n-HA according to a specific proportion, and freeze-drying to form a porous scaffold; then, the microspheres are compounded in pores of the stent through vacuum adsorption; and finally, performing negative pressure perfusion on the stem cell-containing GelMA hydrogel, and performing ultraviolet light crosslinking and curing on the surface of the composite scaffold. According to the scheme, the synergistic effect of drug sustained release, bone conduction and stem cell osteogenesis activity is achieved through layered structure design, and the problems that in the prior art, drug release is unstable, cell distribution is uneven, and stent degradation and bone regeneration are not matched are solved.

The invention discloses an allogeneic bone composite amniotic membrane particle material and preparation and application thereof, and belongs to the technical field of medical materials.The preparation method comprises the steps that a decellularized amniotic membrane is sequentially subjected to crushing and ultrasonic treatment to obtain amniotic membrane particles, an amniotic membrane particle solution is sprayed to an allogeneic bone subjected to EDC / NHS surface treatment, and the allogeneic bone composite amniotic membrane particle material is obtained. And treating the obtained material under negative pressure to generate amino-carboxyl crosslinking. The amniotic membrane is prepared into amniotic membrane particles, the amniotic membrane particles are uniformly dispersed in the allogeneic bone in combination with a spraying technology, so that the allogeneic bone and the amniotic membrane are organically combined, meanwhile, the amniotic membrane particles are combined with the allogeneic bone subjected to surface treatment through a cross-linking reaction, and the degradation rate of the amniotic membrane is effectively reduced. The allogeneic bone composite amniotic membrane particle material provided by the invention can provide long-term and effective support for osteoporotic bone defect repair, and has a good application prospect.

The invention discloses hydrogel for osteoporotic bone defect repair and a preparation method of the hydrogel. The hydrogel comprises basic hydrogel and mineralized photosynthetic microorganisms, the mineralized photosynthetic microorganism comprises a photosynthetic microorganism, a mineralized shell layer arranged on the surface of the photosynthetic microorganism, and rare earth up-conversion nano-particles loaded in cells of the photosynthetic microorganism, and the rare earth up-conversion nano-particles can convert near-infrared light into visible light. According to the present invention, the oxygen production type mineralized microalgae composite hydrogel with characteristics of deep tissue activation, controllable oxygen production and simultaneous realization of four-effect synergy of acid neutralization, continuous oxygen supply, angiogenesis promotion and osteogenesis mineralization can be provided, such that osteoblast activity can be promoted, osteoclast activity can be inhibited, in-vivo osteogenesis can be promoted, and the technical support can be provided for osteoporotic bone defect repair.

The invention discloses a sampling device for an osteoporotic bone sample, and relates to the technical field of sample collection, the sampling device comprises a workbench and a support frame, the support frame is provided with a positioning mechanism, a drilling mechanism and a filtering mechanism, the workbench is provided with a collecting mechanism, and the drilling mechanism comprises an air cylinder, a third motor and a drill bit. Dustproof mechanisms are arranged on the air cylinder, the third motor and the drill bit. Bone dust generated by drilling can be sealed in the dustproof cover through the dustproof cover, the fan can suck the bone dust into the cavity during drilling and filter the bone dust through the filter cotton cloth, and when the drill bit drills out a bone sample, the fan stops running, so that the drill bit can drill out the bone sample. Meanwhile, bone dust on filtering cotton cloth automatically falls onto a partition plate in a cavity under the action of gravity, a fifth motor drives a scraping plate to scrape out the bone dust on the partition plate through an air inlet and fall into a filtering hopper, and the situation that the bone dust splashes, so that samples are wasted, the working environment is polluted, and the body health of workers is harmed is effectively avoided.

The invention relates to a hydrogel composite scaffold, and discloses a hydrogel scaffold and a preparation method and application thereof.Cerium alendronate nanoparticles are obtained on the basis of alendronate sodium and cerium chloride, the alendronate cerium nanoparticles are blended with methacrylated silk fibroin or methacrylated collagen, and the hydrogel composite scaffold is obtained. And injecting into a 3D printed beta-tricalcium phosphate scaffold, and carrying out ultraviolet crosslinking to obtain the multi-scale cerium ion hydrogel scaffold which can be applied to bone defect repair products. Cerium ions are combined with alendronate sodium to form nano particles with a more stable structure, the defects of alendronate sodium in the aspects of osteogenesis performance, angiogenesis performance, anti-inflammatory performance and the like can be overcome, meanwhile, mechanical support is provided through beta-tricalcium phosphate, the local microenvironment of osteoporotic bone defects can be better simulated, and the osteoporotic bone defect can be effectively inhibited. A better solution is provided for treating the osteoporotic bone defect.

The application provides a strontium-doped polypeptide hydrogel and a preparation method, a composite biological scaffold and an application, and belongs to the technical field of biomedical materials.The strontium-doped polypeptide hydrogel comprises a three-dimensional nanofiber network formed by self-assembly of polypeptide phosphonated derivatives, and the three-dimensional nanofiber network is loaded with strontium ions.The three-dimensional nanofiber network is formed by self-assembly of strontium ions and polypeptide phosphonated derivatives, a novel hydrogel with mechanical adaptability, controllable degradability and bidirectional regulation function of osteogenesis-osteoclast is obtained, local targeted delivery of strontium ions is realized, and the functional regeneration of osteoporotic bone defects is realized in cooperation with the bone adhesion properties of polypeptides.

The utility model discloses an absorbable osteoporotic fracture fixing device which comprises a fixing plate, suture anchor knots and suture lines, the fixing plate is made of absorbable materials, the fixing plate and the suture anchor knots are located on the two sides of a fracture part respectively, and the fixing plate is located on the side close to a wound; the suture line is arranged on the fixing plate and the suture anchor knot in a penetrating mode and used for connecting the fixing plate and the suture anchor knot, and the suture line is tensioned so as to drive the fixing plate and the suture anchor knot to conduct compression fixation on the fracture part. The absorbable fixing plate and the suture anchor knots are arranged on the two sides of the fracture position to pressurize and fix the fracture position, the fixing plate can be absorbed, the step of opening a wound to take out the fixing plate in the later period is avoided, and the operation is more convenient.

The application discloses a kind of prediction method and prediction device of osteoporosis patient fracture risk.The prediction method includes: the individualized factor data and bone density data of batch osteoporosis patients are carried out multiple regression analysis, and multiple regression equation is established;Establish the lumbar finite element model of each osteoporosis patient;Simulation analysis each lumbar finite element model is biomechanics change when being stressed under several daily scenes, obtain the proportion of the vertebral cancellous bone unit microstrain of each lumbar finite element model exceeding threshold value;According to the proportion of the vertebral cancellous bone unit microstrain exceeding threshold value, the bone density corresponding to each lumbar finite element model is carried out correlation analysis, and obtains osteoporosis fracture risk prediction equation;According to the individualized factor data of to-be-predicted object, multiple regression equation and osteoporosis fracture risk prediction equation, fracture risk assessment result is obtained.The method considers the influence of individualized factor on bone density, and it is favorable to accurately carry out fracture risk prediction.

The invention discloses an osteoporotic bone sample sampling device, and belongs to the technical field of sample sampling, the osteoporotic bone sample sampling device comprises a sampling platform, one side of the sampling platform is provided with a control panel, and the center of the surface of the top end of the sampling platform is welded with a material guide disc; meanwhile, the surface of the top end of the material guiding disc is communicated with a collecting box at the bottom of the sampling platform, adjustable fixed rotating assemblies are welded to the two sides of the material guiding disc and used for clamping and fixing bone tissue samples of different positions and different densities, and multi-direction rotating assemblies are welded to the tops of the adjustable fixed rotating assemblies and used for drilling the bone samples from multiple angles. By adopting the adjustable fixed rotating assembly and the multi-direction rotating assembly, the equipment can perform multi-angle and multi-direction sampling at the same position and in the same direction, the heterogeneity of bone tissues can be captured more comprehensively, and errors or local deviation possibly generated by single-direction sampling are avoided.

The invention relates to the technical field of bone metabolism disease related markers, in particular to application of CASQ1 protein in preparation of bone metabolism related disease diagnosis and / or screening products. It is found that when the muscle function is abnormal or damaged, the content of CASQ1 protein in exosomes secreted by muscle cells is increased, the exosomes can be transferred to adjacent bone tissue, the osteogenic differentiation of bone marrow mesenchymal stem cells is inhibited, and then bone metabolism disorder is caused. The invention provides a diagnostic kit and a pharmaceutical composition taking CASQ1 protein as a detection target. The diagnostic kit and the pharmaceutical composition are used for early screening and diagnosis of bone metabolic diseases such as myogenic osteoporosis, fracture healing disorder and bone dysplasia. By detecting the content change of the CASQ1 protein in tissues or body fluids, quantitative evaluation of muscle dysfunction related bone metabolism abnormality can be realized, and a new detection means and a biological target are provided for clinical diagnosis and treatment intervention of related diseases.

The invention relates to an orthopaedic screw (1) for the sacroiliac joint (71), the screw comprising a core (2) extending between a distal end (1a) and a proximal end (1b), and a first thread (3), wherein the core (1) comprises a central conical portion (21) having a first slope (α1), a distal portion (20) having a second slope (α2) smaller than the first slope (α1), and a proximal portion (22) having a third slope (α3) smaller than the first slope (α1), and wherein the first thread (3) has a height (D) that increases from the proximal end (21b) towards the distal end (21a) of the central conical portion (21), over a retaining portion (210) of the central conical portion (21), so as to enhance screw retention, in particular in osteoporotic bone.

The application belongs to the technical field of biomedical materials, and provides a composite gel loaded with strontium ions / zoledronic acid and a preparation method thereof, which comprises the following steps: preparing thiol-modified sodium hyaluronate and double bond-modified carboxymethyl chitosan; preparing strontium ion-doped mesoporous silica microspheres, thiol-modified strontium ion-doped mesoporous silica microspheres and thiol-modified strontium ion-doped mesoporous silica microspheres loaded with zoledronic acid in sequence; dissolving the thiol-modified sodium hyaluronate and the double bond-modified carboxymethyl chitosan in deionized water respectively, and then stirring and mixing the thiol-modified sodium hyaluronate, the double bond-modified carboxymethyl chitosan and the thiol-modified strontium ion-doped mesoporous silica microspheres loaded with zoledronic acid, and adding a photoinitiator and irradiating under ultraviolet light. The composite gel prepared by the application integrates mechanical support, biocompatibility, intelligent drug release and synergistic osteogenesis / angiogenesis, and can be applied to the preparation of high-performance osteoporotic bone defect repair materials.

The application discloses a borosilicate bioactive glass and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The bioactive glass comprises the following components in terms of molar percentage: Na2O 2~15%, K2O 3~20%, MgO 1~25%, CaO 5~30%, B2O3 8~50%, P2O5 1~18%, SiO2 5~35% and SrO 2~30%. The glass is prepared through a melting-ice water quenching-milling-screening process. The glass utilizes the synergistic effect of magnesium and strontium to regulate the release of boron ions, and the degradation rate is matched with bone regeneration; the glass has high bioactivity, good cell compatibility and excellent osteogenesis promotion performance, and is suitable for dental, orthopedic and plastic surgery bone repair materials, especially suitable for rapid bone regeneration and osteoporotic bone defect scenes, and solves the problem of cytotoxicity caused by the burst release of the existing boron.

This invention relates to a rapid screening method for bone-repairing surface structures, belonging to the field of bone repair materials technology. It aims to solve the technical problems of low efficiency and low individual / group adaptability of traditional screening methods. This invention constructs a titanium dioxide nanotube array with a continuous gradient diameter of 0-200 nm using a four-electrode bipolar electrochemical method. Immunofluorescence staining of key bone repair factors BMP-2, RUNX2, OPN, and OCN, combined with panoramic scanning analysis, is used to normalize the average fluorescence intensity of each of the four factors and then sum them to obtain a comprehensive osteogenic coefficient. Based on this coefficient, the optimal bone-repairing surface structure corresponding to bone marrow mesenchymal stem cells (BMSCs) from different age groups or different pathological conditions (such as osteoporosis, osteoarthritis, etc.) can be precisely located. This invention achieves high-throughput screening covering multiple surface structures in a single experiment, providing an efficient technical path for the precise and personalized design of bone repair materials, and has significant clinical translational value.