33 results about "Bone metabolism disorder" patented technology

The invention relates to the technical field of bone metabolism disease related markers, in particular to application of CASQ1 protein in preparation of bone metabolism related disease diagnosis and / or screening products. It is found that when the muscle function is abnormal or damaged, the content of CASQ1 protein in exosomes secreted by muscle cells is increased, the exosomes can be transferred to adjacent bone tissue, the osteogenic differentiation of bone marrow mesenchymal stem cells is inhibited, and then bone metabolism disorder is caused. The invention provides a diagnostic kit and a pharmaceutical composition taking CASQ1 protein as a detection target. The diagnostic kit and the pharmaceutical composition are used for early screening and diagnosis of bone metabolic diseases such as myogenic osteoporosis, fracture healing disorder and bone dysplasia. By detecting the content change of the CASQ1 protein in tissues or body fluids, quantitative evaluation of muscle dysfunction related bone metabolism abnormality can be realized, and a new detection means and a biological target are provided for clinical diagnosis and treatment intervention of related diseases.