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2 results about "Antisense DNA" patented technology
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Antisense DNA: DNA normally has two strands, i.e., the sense strand and the antisense strand. In double-stranded DNA, only one strand codes for the RNA that is translated into protein. This DNA strand is referred to as the antisense strand.
Loaded vesicles, methods of making, kits, pharmaceuticals and uses thereof
The present application relates to a kind of loaded vesicle and its preparation method, kit, medicine and purposes.Loaded vesicle includes DNA modified nanoparticle, vesicle layer, the vesicle layer is coated in the outside of the DNA modified nanoparticle, antisense DNA, the antisense DNA is loaded on the nanoparticle and / or the vesicle layer;Preparation method includes: DNA modified nanoparticle and vesicle layer are assembled, obtain frame, antisense DNA is mixed with the frame and is reacted, so that the antisense DNA is loaded on the DNA modified nanoparticle or the vesicle layer, and loaded vesicle is prepared.After the loaded vesicle enters cell, it can release antisense DNA, it can target after mRNA complementary combination, inhibit mRNA translation, so as to promote cancer cell apoptosis, with the advantages such as strong stability and controllable release antisense DNA;And, the preparation method is simple to operate.
Owner:INST OF CHEM CHINESE ACAD OF SCI
Nucleic acid active agents against various plant pathogens
The invention relates to newly identified nucleic acids, ribonucleic acids (RNAs) and deoxyribonucleic acids (DNAs), specifically esiRNAs / ERNAs (effective small interfering RNAs) and RNAs derived therefrom, as well as eASO (effective antisense DNA oligonucleotides), collectively referred to as eNAs (effective nucleic acids), which can be used in RNA silencing / RNAi or RNA silencinglantisense methods, as active agents against various variable plant pathogens. To identify the eNAs, an “eNA screen” was applied for the first time in standardized form to target RNAs of various plant pathogens. As a result, a new class of active agents against pathogens was identified and successfully used. The invention further relates to the construction of double-stranded ribonucleic acids, edsRNAs (effectively double-stranded RNAs), which contain nucleotide sequences of identified esiRNAs / ERNAs or related RNAs derived therefrom, and which can be successfully used in the RNA silencing / RNAi methods as active agents in plant protection against variable plant pathogens.
Owner:UNIVERSITY OF HALLE WITTENBERG