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Antisense DNA: DNA normally has two strands, i.e., the sense strand and the antisense strand. In double-stranded DNA, only one strand codes for the RNA that is translated into protein. This DNA strand is referred to as the antisense strand.
Nucleic acid active agents against various plant pathogens
The invention relates to newly identified nucleic acids, ribonucleic acids (RNAs) and deoxyribonucleic acids (DNAs), specifically esiRNAs / ERNAs (effective small interfering RNAs) and RNAs derived therefrom, as well as eASO (effective antisense DNA oligonucleotides), collectively referred to as eNAs (effective nucleic acids), which can be used in RNA silencing / RNAi or RNA silencinglantisense methods, as active agents against various variable plant pathogens. To identify the eNAs, an “eNA screen” was applied for the first time in standardized form to target RNAs of various plant pathogens. As a result, a new class of active agents against pathogens was identified and successfully used. The invention further relates to the construction of double-stranded ribonucleic acids, edsRNAs (effectively double-stranded RNAs), which contain nucleotide sequences of identified esiRNAs / ERNAs or related RNAs derived therefrom, and which can be successfully used in the RNA silencing / RNAi methods as active agents in plant protection against variable plant pathogens.
Owner:UNIVERSITY OF HALLE WITTENBERG