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4 results about "Antisense RNA" patented technology
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Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein. asRNAs (which occur naturally) have been found in both prokaryotes and eukaryotes, antisense transcripts can be classified into short (<200 nucleotides) and long (>200 nucleotides) non-coding RNAs (ncRNAs). The primary function of asRNA is regulating gene expression. asRNAs may also be produced synthetically and have found wide spread use as research tools for gene knockdown. They may also have therapeutic applications.
Hepatocyte nuclear factor four alpha antisense RNA 1 targeting polynucleotide and method of use and treatment thereof
The present invention comprises a pharmaceutic composition comprising one or more hepatocyte nuclear factor four alpha antisense RNA 1 (HNF4A-AS1) targeting polynucleotides, wherein the one or more HNF4A-AS1 targeting polynucleotides is capable of repressing HNF4A-AS1 in a subject resulting in upregulation of HNF4A expression and / or increasing HNF4A P1:P2 isoform ratio in the subject. The present invention also provides a method of treatment of a HNF4A-associated disease in a subject comprising the step of administering a therapeutically effective amount of the pharmaceutical composition comprising one or more HNF4A- AS1 targeting polynucleotides of the present invention. The present invention also provides a method of downregulating HNF4A P2 isoform expression in a subject comprising the step of repressing HNF4A-AS1 in the subject.
Owner:GENECO PTY LTD
A set of production technical process of delayed puberty of largemouth bass
The application discloses a production technical process of gonad delayed development of large-mouth bass, and belongs to the technical field of aquatic animal biological breeding. The application creates new germplasm of large-mouth bass with significantly improved growth speed, significantly decreased gonad index and better muscle quality and flavor by parent cultivation, design of antisense RNA sequence and amplification, artificial insemination of the large-mouth bass after preparation of transfection reagent and introduction of the antisense RNA sequence of a key gender development gene, thereby providing technical support for promoting high-quality and sustainable development of the large-mouth bass industry.
Owner:FRESHWATER FISHERIES RES CENT OF CHINESE ACAD OF FISHERY SCI
Telomerase upregulating polynucleotide and method of use and treatment thereof
The present invention provides a composition comprising one or more polynucleotides capable of upregulating expression of telomerase wherein telomerase consists of a protein component with reverse transcriptase activity encoded by telomerase reverse transcriptase (TERT) gene and a non-coding RNA encoded by telomerase RNA component (TERC) gene, In an embodiment, the one or more polynucleotides of the present invention upregulates the telomerase by downregulating antisense RNA that regulates telomerase gene. In an embodiment, the one or more polynucleotides comprises an siRNA or an shRNA. In an embodiment, one or more polynucleotides of the present invention is delivered by a nanoparticle such as an exosome that encapsulates the one or more polynucleotides. The present invention also provides a method of treatment of telomerase deficiency related diseases or disorders using any embodiment of the one or more polynucleotides of the present invention.
Owner:GENECO PTY LTD
Alpha-1 Anti-trypsin upregulating polynucleotides and method of use and treatment thereof
The present invention provides a composition comprising one or more polynucleotides capable of upregulating expression of alpha- 1 anti-trypsin (Al AT). In an embodiment, the one or more polynucleotides of the present invention upregulates the expression of Al AT by downregulating antisense RNA that regulates the Al AT gene. In an embodiment, the one or more polynucleotides comprises an siRNA or an shRNA. In an embodiment, one or more polynucleotides of the present invention is delivered by a nanoparticle such as an exosome that encapsulates the one or more polynucleotides. The present invention also provides a method of treatment of Al AT deficiency related diseases or disorders using any embodiment of the one or more polynucleotides of the present invention.
Owner:GENECO PTY LTD