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Therapeutic uses of factors which inhibit or neutralize MIF activity

a technology of factors and mif, which is applied in the field of therapeutic uses of factors which inhibit or neutralize mif activity, can solve the problems of preventing the precise biological profile of this molecule, unable to find a reliable source of purified mif, etc., and achieves the effect of suppressing the production or neutralizing the activity and suppressing the production of mi

Inactive Publication Date: 2004-08-12
CYTOKINE PHARMASCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Until very recently, however, the lack of a reliable source of purified MIF has continued to hamper investigation of the precise biological profile of this molecule.

Method used

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  • Therapeutic uses of factors which inhibit or neutralize MIF activity
  • Therapeutic uses of factors which inhibit or neutralize MIF activity
  • Therapeutic uses of factors which inhibit or neutralize MIF activity

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Embodiment Construction

[0020] The present invention relates to methods of treating disorders related to cellular overproliferation by neutralizing the production or activity of MIF. The invention also relates to therapeutic compositions comprising factors which inhibit MIF release or which inhibit or neutralize MIF activity, such as, MIF antisense RNA molecules and MIF monoclonal antibodies and derivatives or analogs thereof.

[0021] The invention relates to the uses of therapeutic compositions which inhibit the activity of MIF for the treatment or prevention of tumor related disorders. In a specific embodiment of the invention, therapeutic compositions comprising neutralizing MIF monoclonal antibodies or MIF antisense RNA molecules are used to treat B and T cell lymphomas.

[0022] The present invention also relates to therapeutic and diagnostic methods and compositions based on anti-MIF monoclonal antibodies and MIF antisense RNA molecules. The invention encompasses therapeutic compositions comprising MIF an...

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Abstract

The present invention relates to methods of treating disorders related to cellular overproliferation comprising neutralizing the production or activity of macrophage migration inhibitory factor (MIF). The invention also relates to therapeutic compositions comprising factors which inhibit or neutralize MIF activity, such as, MIF antisense RNA molecules and MIF monoclonal antibodies and derivatives or analogs thereof. The invention further relates to the uses of such compositions and methods for the treatment of malignancies, including, but not limited to, B and T cell lymphomas.

Description

[0001] The present application is a continuation-in-part of co-pending U.S. patent application Ser. No. 08 / 462,350, filed Jun. 5, 1995, which is a continuation-in-part of co-pending U.S. patent application Ser. No. 08 / 243,342, filed May 16, 1994, which is a continuation-in-part of U.S. patent application Ser. No. 08 / 063,399, filed May 17, 1993 (now abandoned), each of which is incorporated by reference herein in its entirety.1. INTRODUCTION[0002] The present invention relates to methods of treating disorders related to cellular overproliferation comprising neutralizing the production or activity of macrophage migration inhibitory factor (MIF). The invention also relates to therapeutic compositions comprising factors which inhibit or neutralize MIF activity, such as, MIF antisense RNA molecules and MIF monoclonal antibodies and derivatives or analogs thereof. The invention further relates to the uses of such compositions and methods for the treatment of malignancies, including, but n...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N15/09A01K67/027A61K31/7076A61K38/00A61K39/395A61K45/00A61K48/00A61P35/00A61P43/00C07K14/52C07K14/575C07K14/72C07K16/00C07K16/24C07K16/26C12N15/113C12N15/85C12P21/08
CPCA01K67/0271C12N2310/315A01K2217/075A01K2227/105A01K2267/03A01K2267/0331A01K2267/0337A61K38/00A61K48/00A61K2039/505C07K14/52C07K14/575C07K14/72C07K16/24C07K16/26C07K2316/96C07K2317/73C12N15/113C12N15/1136C12N15/1138C12N15/8509A01K2217/05A61P35/00A61P43/00
Inventor BUCALA, RICHARD J.CHESNEY, JASON
Owner CYTOKINE PHARMASCI
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