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38 results about "Cortical tissue" patented technology

It houses capillaries that transport blood to the bone tissue. Some cortical bone tissue is lamellar, which is layered, strong, and formed by parallel fibers. Other cortical bone tissue is woven and forms quickly when bone tissue is growing or being repaired.

Method and system for cortical stimulation to provide adjunct (ADD-ON) therapy for stroke, tinnitus and other medical disorders using implantable and external components

A method and system for providing rectangular and / or complex electrical pulses to cortical tissues of a patient for providing therapy or alleviating symptoms for at least one of tinnitus, essential tremor (ET) including Parkinson's disease, depression, or for providing improvement of functional recovery following stroke. The intracranial electrodes may be implanted on the dura, or subdurally on the pia mater of the cortical surface. The placement of the electrodes may utilize cortical sensing and / or digital imaging techniques, such as fMRI, MRI, or CT. The pulse generator system comprises implantable and external components. The pulse generator may be an implanted pulse generator (IPG) or an external stimulator coupled with an implanted stimulus-receiver. The IPG may also comprise a rechargeable battery. In one embodiment the pulse generator may also comprise a selected number of predetermined / pre-packaged programs. In one embodiment, the pulse generation may also comprise telemetry means, for remote interrogation and / or programming of said pulse generator utilizing a wide area network, such as the internet.
Owner:BOVEJA BIRINDER R +1

Determining stimulation levels for transcranial magnetic stimulation

Induced movement in a patient is detected and correlated with a TMS stimulating pulse so as to determine the patient's motor threshold stimulation level. Direct visual or audible feedback is provided to the operator indicating that a valid stimulation has occurred so that the operator may adjust the stimulation accordingly. A search algorithm may be used to direct a convergence to the motor threshold stimulation level with or without operator intervention. A motion detector is used or, alternatively, the motion detector is replaced with a direct motor evoked potential (MEP) measurement device that measures induced neurological voltage and correlates the measured neurological change to the TMS stimulus. Other signals indicative of motor threshold may be detected and correlated to the TMS stimulus pulses. For example, left / right asymmetry changes in a narrow subset of EEG leads placed on the forehead of the patient or fast autonomic responses, such as skin conductivity, modulation of respiration, reflex responses, and the like, may be detected. The appropriate stimulation level for TMS studies are also determined using techniques other than motor cortex motor threshold methods. For example, a localized ultrasound probe may be used to determine the depth of cortical tissue at the treatment site. When considered along with neuronal excitability, the stimulation level for treatment may be determined. Alternatively, a localized impedance probe or coil and detection circuit whose Q factor changes with tissue loading may be used to detect cortical depth.
Owner:NEURONETICS

Use of miRNA-34a

The present invention relates to use of small RNA molecule, is especially use of miRNA-34a, and belongs to the field of biomedicine material technology. By means of Northern process and other process, miRNA-34a is determined to be the age related expression, and by means of the contrast to the prefrontal lobe cortical tissue miRNA' s of rats in different age sections, it is found that the expression of miRNA-34a in the pallium of rhesus and the prefrontal lobe cortex of rat exhibits age dependent change. The present invention establishes a rat neuron AD cell model for the research of possible action mechanism of miRNA-34a. By means of further transfecting miRNA-34a precursor, miRNA-34a antisense RNA and other contrasts, it is found that miRNA-34a possesses neuron apoptosis effect of antagonizing A-beta induction.
Owner:EAST CHINA NORMAL UNIV +1

Methods for therapeutic use of brain derived neurotrophic factor in the entorhinal cortex

InactiveUS20030124095A1Measured cognitive functionImprove cognitive functionBiocideSenses disorderFactor iiCortical tissue
A protocol for use of growth factors to stimulate neuronal cell growth and activity in trkB receptor containing cortical tissues, including the entorhinal and hippocampal cortices. The method introduces exogenous growth factor, such as BDNF, NT-4 / 5 and NT-3, into the EC. The method is useful in therapy of defective, diseased and damaged neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative conditions such as Alzheimer's disease or for normal aging.
Owner:RGT UNIV OF CALIFORNIA

Biological measuring system for combined iris and cortex tissue

The invention provides and realizes a bioassay system for combined iris and cortical tissues, which comprises an optical imaging device, detection and analysis of biological tissue activity, and an assay method based on image analysis. The bioassay system is suitable for all users, has the applicability of common population, and satisfies the scale application based on national level; the most reliable detection and analysis of the biological tissue activity ensure the self-reliability of the bioassay system; and the assay method based on image analysis improves the accuracy and reliability of the performance of the bioassay system.
Owner:SUZHOU SIYUAN KEAN INFORMATION TECH

Simple method for quickly collecting large quantity of female root-knot nematodes

The invention discloses a simple method for quickly collecting a large quantity of female root-knot nematodes. The method comprises the following steps of: decomposing epithelial tissues and cortical tissues of the roots of decayed plants by using bacteria at the temperature of 25-30 DEG C; removing epidermis and cortexes of the roots of decomposed decayed plants, releasing internal females, sieving with a 20-mesh sieve and a 80-mesh sieve and collecting residues on the 80-mesh sieve; and directly picking white female root-knot nematodes with a thin writing brush under a stereoscopic anatomical lens or at a light-sufficient place. By adopting the method, a large quantity of female root-knot nematodes can be collected within a short period of time, no special instrument equipment is needed, and the defects such as time wasting, labor wasting and easily breaking of nematode bodies in the conventional technology are overcome.
Owner:吴海燕

Compound filter membrane as well as processing device and method thereof

The invention discloses a compound filter membrane as well as a processing device and method thereof. The compound filter membrane is prepared by hot pressing multiple layers of ES fiber spun-bonded non-woven fabrics. According to the compound filter membrane as well as processing device and method thereof disclosed by the invention, as the characteristic of low cortical tissue melting point of a bi-component skin-core structure of ES fibers are fully utilized, in the premise without using an external adhesive, compounding of the non-woven fabrics can be achieved by utilizing hot-pressing adhesion of the fibers with one another due to self fiber melting; by carrying out permutation and combination and a hot-pressing adhesion process on the non-woven fabrics with different filtering accuracies, the compound filter membrane is accurate and uniform in controlling the filtering accuracy, large in pollutant holding quantity, high in filter flux and long in service life, and the using cost of a user is lowered.
Owner:HANGZHOU DARLLY FILTRATION EQUIP CO LTD

Microcrystal head and microneedle cosmetic instrument

The invention provides a microcrystal head and a microneedle cosmetic instrument, which relate to the field of cosmetic techniques. The microcrystalline head comprises a supporting bracket with a cavity structure, electrode plates for promote cells to form hydrophilic channels, and an outlet crystal head fixed in the supporting bracket, a needle plate for penetrating cortical tissues is fixed on the outlet crystal head, the needle plate is provided with a plurality of microneedles, the outlet crystal head comprises a transfusion tube and a crystal head body wrapping the transfusion tube, the crystal head body is fixed in the supporting bracket, the transfusion tube comprises a liquid inlet, a liquid duct, and a liquid outlet, and the liquid inlet, the liquid duct, the liquid outlet and the plurality of needles communicate with one another. The microcrystal head disclosed by the invention has the characteristics of good cosmetic effect and sufficient nutrient solution absorption.
Owner:珠海云动光电科技有限公司

Nanometer antibody vagina medicine delivery system, and preparation method and application thereof

The invention discloses a medicine delivery system for realizing specificity nanometer antibody medicine delivery through the vagina for the first time, and a preparation method and application thereof. The vector recipe is optimized, so that the nanometer antibody stability and the tissue penetration are maintained and enhanced; the application of the nanometer antibody vagina medicine delivery system to disease treatment and woman sanitation care is realized. Through the nanometer antibody vagina medicine delivery, the specificity nanometer antibody can realize the medicine effect in the vagina internal environment and positions near the organ local part; in addition, the nanometer antibody can penetrate through vagina tissues to enter human body blood for circulation; the goal of achieving the medicine effect in the preset focus position is realized. The nanometer antibody vagina medicine delivery system has the advantages that medicine is slowly released in the woman vagina and through vagina cortical tissues; no basic irritation and allergic reaction exists; the safe and efficient medicine delivery mode and the new dosage form of nanometer antibody biological medicine are opened up; the application prospects are very wide.
Owner:NANOLATTIX BIOTECH CO LTD

Flexible penetrating cortical multielectrode arrays, sensor devices and manufacturing methods

A preferred conformal penetrating multi electrode array includes a plastic substrate that is flexible enough to conform to cortical tissue. A plurality of penetrating semiconductor micro electrodes extend away from a surface of the flexible substrate and are stiff enough to penetrate cortical tissue. Electrode lines are encapsulated at least partially within the flexible substrate and electrically connected to the plurality of penetrating semiconductor microelectrodes. The penetrating semiconductor electrodes preferably include pointed metal tips. A preferred method of fabrication permits forming stiff penetrating electrodes on a substrate that is very flexible, and providing electrical connection to electrode lines within the substrate.
Owner:RGT UNIV OF CALIFORNIA

Cunninghamia lanceolata phosphorus efficient utilization fine breed authentication method capable of applying arbuscular mycorrhizal fungi

The invention discloses a cunninghamia lanceolata phosphorus efficient utilization fine breed authentication method capable of applying arbuscular mycorrhizal fungi, and belongs to the technical fieldof the vegetative propagation of cunninghamia lanceolata. By use of the method, the indoor simulation of a low phosphorus stress condition is observed, and a cunninghamia lanceolate clone of which the root system cortical tissue cell is obviously dissolved and is infected and colonized by a arbuscular mycorrhizal fungus propagule is screened, i.e., the phosphorus efficient utilization fine breedis obtained. By use of the method, the cunninghamia lanceolata fine clone which efficiently utilizes soil phosphorus can be quickly and accurately screened, and the method is suitable for applying tocunninghamia lanceolata high density plantation standing forests.
Owner:FUJIAN AGRI & FORESTRY UNIV

Methods of in vitro Oocyte Development

Methods of preparing ovarian tissue for primordial follicle growth are presented comprising the steps: providing an ovarian tissue sample comprising cortical tissue and stromal tissue; removing damaged tissue from the ovarian tissue sample where present; removing excess stromal tissue from the ovarian tissue sample where present; and then mechanically stretching the ovarian tissue sample along at least one dimension of the ovarian tissue sample, such that the size of the ovarian tissue sample along the at least one dimension is increased by at least 10%. Methods of growing viable oocyte in vitro, and methods of preparing individual ovarian follicles for growth are also presented.
Owner:THE UNIV COURT OF THE UNIV OF EDINBURGH

Internal-standard-based apple scar skin viroid RT-PCR (reverse transcription-polymerase chain reaction) detection technique

The invention relates to an internal-standard-based apple scar skin viroid RT-PCR (reverse transcription-polymerase chain reaction) detection technique. The technique comprises the following steps: by using a 0-5cm cortical tissue on the top end of an apple annual branch with leaf buds as a test piece, extracting total tissue RNA (ribonucleic acid) by an RNA extraction improved process; by using the total RNA as a template, carrying out RT-PCR reaction by using apple scar skin viroid specific primers and apple endogenous gene primers; and judging whether the apple tissue has apple scar skin viroid according to the existence and quantity of the amplification product in agarose gel electrophoresis. The judgment standards are as follows: no existence of amplified endogenous gene specific segments indicates an aborted experiment; the existence of amplified endogenous gene specific segments indicates an effective experiment; the existence of amplified endogenous gene specific segments and apple scar skin viroid specific segments indicates that the apple tissue has the apple scar skin viroid; and the existence of amplified endogenous gene specific segments and no existence of amplified apple scar skin viroid specific segments indicate that the tissue does not have the apple scar skin viroid.
Owner:HEBEI AGRICULTURAL UNIV.

Application of dracocephalum moldavica total flavonoids to preparation of drug for preventing and treating AD (Alzheimer's disease)

The invention discloses an application of dracocephalum moldavica total flavonoids to preparation of a drug for preventing and treating the AD (Alzheimer's disease). An AD mouse model is established through hypodermic injection of sodium nitrite / D-galactose, the learning and memory capacity and biochemical indexes are scientifically assessed through mouse positioned navigation tests and space exploration tests, it proves that the dracocephalum moldavica total flavonoids can improve the space learning and memory capacity of AD model mice, dose dependence is formed, escape incubation of the AD mice is shortened, and platform crossing times in the space exploration tests are significantly increased; meanwhile, the content of MDA in cortical tissue in the AD mice can be significantly decreased, the content of SOD can be significantly increased, and the oxidative stress level in brain tissue can be reduced; also, through reduction of expression of pro-inflammatory factors IL-1beta and TNF-alpha, inflammatory injuries to the brain tissue can be relieved, the neuron protection role can be played, and the learning and memory capacity of the AD mice can be improved finally. Thus, a reference basis can be provided for clinic application of the dracocephalum moldavica total flavonoids in the future.
Owner:胡艳丽

Culture soil for improving survival rate of camellia oleifera seedlings and preparation method thereof

The invention discloses culture soil for improving the survival rate of camellia oleifera seedlings. The culture soil comprises, by weight, 80-100 parts of a cultivating matrix, 0.8-1 part of perlite,0.6-0.8 part of vermiculite, 7-9 parts of a slow-release compound fertilizer, 0.1-0.15 part of quicklime powder and 0.05-0.08 part of compound hormone. The invention also discloses a preparation method of the culture soil. According to the method, a small amount of compound hormone is added into the culture soil raw materials so that roots can be taken from cortical tissue and callus at the sametime, improvement of stress resistance and survival rate of camellia oleifera seedling afforestation is facilitated, and the growth speed of camellia oleifera at a young forest stage is improved; by adopting the cultivating matrix obtained by heaping and composting coconut bran, cassava peel and bagasse, waste reutilization is realized, and the obtained cultivating matrix is green and environmentally friendly; the slow-release compound fertilizer is mixed into the culture soil so that the shortcoming of slow release of organic fertilizer components in the cultivating matrix can be overcome toensure nutrient supply for early growth of the seedlings, the growth of the seedlings is facilitated, and the survival rate of the seedlings is improved.
Owner:ANHUI DECHANG OIL & TEA PROFESSIONAL COOP

Medicine and dressing for skin wound healing and preparation method of medicine and dressing

The invention discloses a medicine for skin wound healing. The medicine comprises traditional Chinese medicine raw materials, an adhesive and a lubricant, the traditional Chinese medicine raw materials comprise 1 part of dragon's blood, 1 part of pseudo-ginseng, 1 part of leech, 1 part of astragalus membranaceus, 1 part of angelica sinensis, 1 part of bletilla striata and 1 part of honeysuckle, honey is selected as the adhesive, and rapeseed oil is selected as the lubricant. The invention further discloses a dressing for skin wound healing. The dressing is prepared from ointment prepared from the medicine for skin wound healing and gauze, and the ointment is uniformly smeared on the gauze. According to the invention, the dragon's blood, the leech, the astragalus membranaceus and the bletilla striata have the effects of diminishing swelling and promoting flesh regeneration, the mutual compatibility can promote rapid growth of granulation tissues and is beneficial to rapid repair of cortical tissues, and the pseudo-ginseng and the honeysuckle have the effects of diminishing inflammation, resisting bacteria and promoting blood circulation of local tissues, so that the cortical tissues are prevented from inflammation in the repair process, the activity of the tissue at the wound surface is improved, and a good condition is created for rapid healing of the tissue of the wound surface.
Owner:昆明市第二人民医院

External-use scald and burn drug capable of restraining keloid hyperplasia

The invention discloses an external-use scald and burn drug capable of restraining keloid hyperplasia. The external-use scald and burn drug is characterized by being powder and being prepared from the following medicinal raw materials in parts by weight: 1-3 parts of mercury, 10-15 parts of sulfur, 15-20 parts of borax, 1-3 parts of borneol, 1-3 parts of musk, 20-30 parts of gypsum and 20-30 parts of calamine. A preparation method for the external-use scald and burn drug comprises the following steps: putting the sulfur, the mercury, the borax, the borneol, the calamine and sesame oil into a marmite in parts by weight; reversely buckling a seal cover by using a china bowl, heating after completely sealing junction of a porcelain bowl and the calamine through mud; after firstly heating for half an hour with strong fire and then heating for two hours with slow fire, naturally cooling to the room temperature, opening the calamine to scrape off medicinal raw materials coated in the porcelain bowl, adding an appropriate amount of musk into the medicinal raw materials to obtain a mixture, mixing and grinding the mixture into powder and passing the powder through a 100-mesh sieve, so as to prepare the external-use scald and burn drug capable of restraining keloid hyperplasia. The external-use scald and burn drug disclosed by the invention has effects of being quick in relieving pain, remarkable in curative effect and capable of restraining keloid hyperplasia, sterilizing, killing insects and inhibiting bacteria, and can be used for quickly restoring an injured cortical tissue and relieving pains of a patient.
Owner:杨淑珍

Externally-used medicine for recovering burned cortical tissue and preparation method thereof

The invention discloses an externally-used medicine for recovering a burned cortical tissue and a preparation method thereof. The externally-used medicine is prepared from the following raw materials in parts by weight: 3-8 parts of elephant skin, 10-15 parts of sulfur, 15-20 parts of sodium borate, 1-3 parts of borneol, 1-3 parts of musk, 20-30 parts of calamine, 20-30 parts of gypsum and 100-120 parts of sesame oil. The preparation method comprises the following steps: (1) putting the sulfur, the elephant skin, the sodium borate, the borneol, the calamine and the gypsum into a marmite, sealing the marmite by a porcelain bowl and totally sealing the joint of the porcelain bowl and the marmite with mud; (2) heating for half an hour by strong fire, subsequently heating for two hours by soft fire and cooling to room temperature; (3) opening the marmite, removing the medicine attached to the porcelain bowl, adding musk, uniformly mixing, grinding into powder and sieving by a sieve of which the size is 100 meshes to obtain medicine powder; (4) mixing the obtained medicine powder with the sesame oil according to a ratio of 1:20 to obtain an oily externally-used medicine for recovering the burned cortical tissue. The externally-used medicine disclosed by the invention has the advantages of being rapid in healing, good in treatment effect, capable of being used for recovering the burned cortical tissue and the like.
Owner:定西华医中西医结合医院

An internal standard-based RT‑PCR detection technique for apple rust viroids

The invention relates to an internal-standard-based apple scar skin viroid RT-PCR (reverse transcription-polymerase chain reaction) detection technique. The technique comprises the following steps: by using a 0-5cm cortical tissue on the top end of an apple annual branch with leaf buds as a test piece, extracting total tissue RNA (ribonucleic acid) by an RNA extraction improved process; by using the total RNA as a template, carrying out RT-PCR reaction by using apple scar skin viroid specific primers and apple endogenous gene primers; and judging whether the apple tissue has apple scar skin viroid according to the existence and quantity of the amplification product in agarose gel electrophoresis. The judgment standards are as follows: no existence of amplified endogenous gene specific segments indicates an aborted experiment; the existence of amplified endogenous gene specific segments indicates an effective experiment; the existence of amplified endogenous gene specific segments and apple scar skin viroid specific segments indicates that the apple tissue has the apple scar skin viroid; and the existence of amplified endogenous gene specific segments and no existence of amplified apple scar skin viroid specific segments indicate that the tissue does not have the apple scar skin viroid.
Owner:HEBEI AGRICULTURAL UNIV.

Application of collagen for producing frozen green body flour product

The invention belongs to the technical field of food, and relates to application of collagen for producing a frozen green body flour product, in particular to a frozen green body flour product and a preparation method thereof. The collagen deviates from the muscle, the bones and the cortical tissues of animal pigs, cows, sheep or poultry and contains 100-5000 pieces of amino acid units. When the animal protein is applied to the frozen green body flour product, the animal protein has the effects of prolonging an expiration date, improving the structure and the texture of the frozen green body flour product, improving air inflation stability and enlarging the volume of dough. When the collagen disclosed by the invention is used for producing the frozen green body flour product, fermentationtime is shortened, quality frost crack defects which are common in a frozen green body flour product preservation process can be overcome, and the quality and the taste of a reprocessed product are improved, wherein the quality frost crack defects include that stability gets worse, volume becomes small, a surface skin white degree gets worse, a tangent plane tissue state gets worse and the like.
Owner:苏州闻达食品配料有限公司

Method for forming a multielectrode conformal penetrating array

A preferred conformal penetrating multi electrode array includes a plastic substrate that is flexible enough to conform to cortical tissue. A plurality of penetrating semiconductor micro electrodes extend away from a surface of the flexible substrate and are stiff enough to penetrate cortical tissue. Electrode lines are encapsulated at least partially within the flexible substrate and electrically connected to the plurality of penetrating semiconductor microelectrodes. The penetrating semiconductor electrodes preferably include pointed metal tips. A preferred method of fabrication permits forming stiff penetrating electrodes on a substrate that is very flexible, and providing electrical connection to electrode lines within the substrate.
Owner:RGT UNIV OF CALIFORNIA

Physiologically responsive mechanically adaptive polymer optical fibers, production and methods of use

Physiologically responsive mechanically adaptive optical fibers that are suitable for optical interfacing with living organisms. The optical fibers are particularly suited for applications in optogenetics. Dry, stiff fibers display a desirable tensile storage modulus and can be readily inserted into biological and in particular cortical tissue. Exposure to conditions encountered in vivo results in reduction, often a drastic reduction in modulus. When coupled with a suitable light source, the construction can be utilized to stimulate neurons in vivo. Methods for producing and utilizing the optical fibers and devices including the optical fibers are disclosed.
Owner:ADOLPHE MERKLE INST UNIV OF FRIBOURG

Polypeptide PFAP1 for activating primordial follicles so as to treat or assist in treating premature ovarian failure and application of polypeptide PFAP1

The invention discloses a polypeptide PFAP1 for activating primordial follicles so as to treat or assist in treating premature ovarian failure and application of the polypeptide PFAP1. The invention discloses a polypeptide PFPA1 for activating primordial follicles so as to treat or assist in treating premature ovarian failure. The amino acid sequence of the polypeptide PFPA1 is SGLIYEETRGVLKV. The applicant screens the polypeptide PFAP1 with high expression abundance in normal ovarian cortex tissues and obviously reduced abundance in the ovarian cortex tissues of POF patients by virtue of a tandem mass spectrometry method, and the polypeptide PFAP1 can obviously promote the activation of primordial follicles. The PFAP1 has the characteristics of being easy to absorb, strong in specificity, not easy to accumulate in vivo, good in targeting property and the like, so that the PFAP1 possibly becomes a potential therapeutic drug for treating the POF.
Owner:NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL

A kind of medicine for external application of reviving scalded cortex tissue and preparation method thereof

The invention discloses an externally-used medicine for recovering a burned cortical tissue and a preparation method thereof. The externally-used medicine is prepared from the following raw materials in parts by weight: 3-8 parts of elephant skin, 10-15 parts of sulfur, 15-20 parts of sodium borate, 1-3 parts of borneol, 1-3 parts of musk, 20-30 parts of calamine, 20-30 parts of gypsum and 100-120 parts of sesame oil. The preparation method comprises the following steps: (1) putting the sulfur, the elephant skin, the sodium borate, the borneol, the calamine and the gypsum into a marmite, sealing the marmite by a porcelain bowl and totally sealing the joint of the porcelain bowl and the marmite with mud; (2) heating for half an hour by strong fire, subsequently heating for two hours by soft fire and cooling to room temperature; (3) opening the marmite, removing the medicine attached to the porcelain bowl, adding musk, uniformly mixing, grinding into powder and sieving by a sieve of which the size is 100 meshes to obtain medicine powder; (4) mixing the obtained medicine powder with the sesame oil according to a ratio of 1:20 to obtain an oily externally-used medicine for recovering the burned cortical tissue. The externally-used medicine disclosed by the invention has the advantages of being rapid in healing, good in treatment effect, capable of being used for recovering the burned cortical tissue and the like.
Owner:定西华医中西医结合医院
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