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Nanometer antibody vagina medicine delivery system, and preparation method and application thereof

A technology of nano-antibody and drug delivery system, which is applied in the field of medicine to achieve the effect of no skin irritation and allergic reaction, large drug loading capacity and good affinity

Inactive Publication Date: 2017-01-04
NANOLATTIX BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] There are no relevant reports at home and abroad on the vaginal drug delivery system of nanobodies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The purpose of this example is to provide a transvaginal mucosal sustained-release drug delivery system with a water-soluble polymer protein material as the main matrix, a preparation method of the drug delivery system, and an application of the drug delivery system.

[0044] The drug delivery system is a transvaginal mucosal drug delivery system with water-soluble polymer biosaccharide gum as the main antibody drug carrier. In this drug delivery system, the weight parts of a typical antibody drug carrier are: water-soluble polymer 18 parts of bio-sugar base, 5 parts of polyvinyl alcohol, 10 parts of polyamino acid, 10 parts of glycerin, 8 parts of phospholipids, 2.5 parts of gelatin, 1 part of sodium carboxymethyl cellulose, and 20 parts of water.

[0045] For different nanobodies, the above-mentioned antibody drug carriers can be adjusted accordingly to better maintain and increase the stability and tissue penetration of nanobodies.

[0046] The above-mentioned transv...

Embodiment 2

[0050] In this example, collagen was used as an antibody drug carrier to prepare preparations related to the nanobody vaginal drug delivery system.

[0051] The collagen can be collagen peptides, collagen, or gelatin.

[0052] The collagen peptide used in this example can be prepared from gelatin, donkey-hide gelatin, new donkey-hide gelatin, pigskin, cowhide, pig bone, beef bone, pig Achilles tendon or bovine Achilles tendon by enzymatic hydrolysis, and its relative molecular weight is not higher than 100kD.

[0053] The collagen used in this example can be obtained from pig skin, cowhide, pig bone, beef bone, pig Achilles tendon or bovine Achilles tendon through enzymatic hydrolysis, and its relative molecular weight is 250-300 kD.

[0054] In the nanobody vaginal drug delivery system prepared in this example, the ratio by weight of the nanobody active ingredient to collagen is 0.001-0.1:1, preferably 0.1:5-50. Wherein, the weight ratio of the nanobody active ingredient to ...

Embodiment 3

[0066] A nanobody drug delivery system through vaginal mucosa, the nanobody in the drug delivery system can eliminate IL-1alpha (Interleukin 1 alpha), TNF-alpha, IL-8 (Interleukin 8) and other inflammatory factors.

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Abstract

The invention discloses a medicine delivery system for realizing specificity nanometer antibody medicine delivery through the vagina for the first time, and a preparation method and application thereof. The vector recipe is optimized, so that the nanometer antibody stability and the tissue penetration are maintained and enhanced; the application of the nanometer antibody vagina medicine delivery system to disease treatment and woman sanitation care is realized. Through the nanometer antibody vagina medicine delivery, the specificity nanometer antibody can realize the medicine effect in the vagina internal environment and positions near the organ local part; in addition, the nanometer antibody can penetrate through vagina tissues to enter human body blood for circulation; the goal of achieving the medicine effect in the preset focus position is realized. The nanometer antibody vagina medicine delivery system has the advantages that medicine is slowly released in the woman vagina and through vagina cortical tissues; no basic irritation and allergic reaction exists; the safe and efficient medicine delivery mode and the new dosage form of nanometer antibody biological medicine are opened up; the application prospects are very wide.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a vaginal drug delivery preparation system for specific nanobody biomedicine, preparation of the vaginal drug delivery system, and the application of the product for focus and health care. Background technique [0002] The vagina is an elastic tubular organ composed of mucous membrane and musculature, rich in capillaries and lymphatic vessels, and without well-defined nerve endings. The vagina is more permeable than the rectum, mouth, and skin. Vaginal administration has less pain stimulation for patients, and it is an effective drug release site for specific diseases and drugs, making it a very potential non-invasive route of drug delivery, thereby exerting local and systemic effects of drugs. Vaginal administration can be used not only locally, but also systemically. Vaginal administration has unique advantages in use and treatment. Vaginal administration can bypass the first-...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K39/395A61K39/44A61K47/36A61K47/32A61K47/34A61K47/10A61K47/24A61K47/42A61K47/38C07K16/00A61P15/02A61P31/00A61P15/00A61P35/00A61P15/08
CPCA61K9/0034A61K39/395A61K39/44A61K47/10A61K47/24A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42C07K16/00A61K39/39591A61K2039/54A61K2039/541A61P15/00A61P15/02A61P31/00A61P35/00C07K2317/569A61K47/183C07K16/14C07K16/22C07K16/2863C07K16/2866C07K16/2878C07K16/32C07K2317/24
Inventor 渠志灿李少平
Owner NANOLATTIX BIOTECH CO LTD
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