9results about How to "Good transdermal effect" patented technology

The invention provides recombinant VII type collagen with a whitening effect as well as a preparation method and application thereof, and belongs to the technical field of bioengineering. Research finds that the recombinant VII type collagen with a whitening effect, the expression quantity of the recombinant VII type collagen is improved by taking a genetic engineering technology as a means, and expression production of the recombinant VII type collagen is carried out by using a pichia eukaryotic expression system; the recombinant VII type collagen disclosed by the invention is expressed in pichia pastoris, can be efficiently secreted and expressed outside cells, and is not easy to degrade in a purification stage, so that the purification difficulty is reduced; the recombinant VII type collagen has an excellent whitening effect, is suitable for sensitive skin, does not cause skin irritation, itching and scorching hot, and has good practicability.

The present application provides a rhodiolide composition with a core-shell-shell structure, a preparation method thereof comprising the steps of: 1) EGCG inclusion: adding beta-cyclodextrin and EGCG into water, ultrasonic, forming an inclusion compound; 2) liposome assembly: weighing soybean phospholipid and cholesterol, dissolving in chloroform to form a uniform solution; weighing rhodiolide, dissolving in the uniform solution, rotary evaporation to remove chloroform, then adding the inclusion compound and PBS buffer into the container, hydrating, forming a liposome wrapping rhodiolide and inclusion compound; 3) shell loading: weighing collagen, mixing with chitosan solution uniformly to form a complex; adding the complex into the liposome, the complex is coated on the outer layer of the liposome, centrifugal purification, obtaining a rhodiolide composition with a core-shell-shell structure. The present application belongs to the technical field of cosmetic raw materials, and the rhodiolide composition provided has the advantages of high stability, good transdermal effect, and significant anti-aging effect.

The present application discloses a kind of hibiscus compound extract, its preparation method and application.The composite extract includes hibiscus exosome, hibiscus traditional active ingredient, snowbank flower extract and microalgae extracellular polysaccharide, wherein the hibiscus exosome and hibiscus traditional active ingredient are simultaneously extracted from hibiscus raw materials by integrated extraction process.The preparation method includes raw material pretreatment, integrated extraction, separation and purification, synergistic compounding and post-processing, and two types of active substances are efficiently and synchronously obtained by optimizing solvent, temperature, time and purification parameters.The composite extract exhibits excellent anti-aging, anti-inflammatory and moisturizing effects in cosmetics, and has excellent effects of regulating intestinal flora and enhancing immunity in functional foods.The process produces significant synergistic effect by combining specific synergistic components, and the effect is much better than single component or simple mixture, realizing the maximization of plant resources and the synergistic promotion of efficacy.

The present invention discloses an anti-hair loss care component and a preparation method thereof and a shampoo, wherein the anti-hair loss care component is an ionic salt formed by R-Lys-Gly-His-Lys-NH2 and oleanolic acid; wherein R is a palmitoyl or myristoyl group; and it has high temperature storage stability, transdermal permeability and a proliferation promoting effect of HDPCs in an aqueous solution environment, thereby promoting anti-hair loss and hair growth. The present invention prepares the ionic salt by atomization mixing, and has the characteristics of high product purity, high reaction efficiency and simple process. The present invention also provides a shampoo containing the above-mentioned anti-hair loss care component, which has a suitable viscosity and pH value.

The invention provides a four-yellow composition soluble microneedle and application thereof, and relates to the technical field of transdermal drug delivery. The invention relates to a four-yellow composition soluble microneedle, which is prepared by the following preparation method: mixing polyvinylpyrrolidone, sodium carboxymethyl cellulose and an aqueous solution of DES four-yellow extract, and centrifuging to obtain mother liquor; preparing a 3-7wt% hyaluronic acid DES four-yellow extract aqueous solution as a substrate solution; putting the mother liquor into a microneedle mold, performing ultrasonic treatment, then performing vacuum treatment, and drying to obtain a first layer; absorbing mother liquor on the first layer for the second time, and performing ultrasonic treatment and drying to obtain a second layer; and taking the substrate liquid on the second layer, and carrying out ultrasonic treatment, drying and demolding to obtain the four-yellow composition soluble microneedle. The four-yellow composition soluble microneedle prepared by the preparation method disclosed by the invention can break through'obstruction 'of a skin cuticle, so that active substances reach a skin corium layer, and the effects of inhibiting acnes, removing acnes and soothing skin of DES four-yellow extract raw materials are efficiently improved.

The invention discloses a red-removing and whitening conveying body for skin and a preparation method and application of the red-removing and whitening conveying body. The red-removing and whitening conveying body is prepared from special liquid serving as a phase A; an ionic liquid mixture of plant seed meal active matters serves as a phase B, an emulsifier and water are mixed to serve as a phase C, micro-emulsion is prepared according to a pseudo-ternary phase diagram method, the plant seed meal active matters comprise grape seed meal, peony seed meal and tea seed meal in a ratio of 2: 1: 1, and the transporter can be applied to cosmetics as a red-removing and whitening component.

This invention discloses a Chlamydomonas reinhardtii synergistic exosome hydrogel microneedle, its preparation method, and its application, belonging to the field of biomedical materials and microneedle delivery technology. The hydrogel microneedles prepared in this invention use methacryloxymethyl carboxymethyl chitosan and methacryloxyhyaluronic acid as the hydrogel matrix. After adding a photoinitiator to the hydrogel matrix, the microneedles are obtained through molding and ultraviolet crosslinking. The tips of the hydrogel microneedles are loaded with Chlamydomonas reinhardtii exosomes to improve transdermal delivery efficiency. The backing layer or matrix portion of the hydrogel microneedles is loaded with Chlamydomonas reinhardtii to maintain its photosynthetic activity and provide continuous local oxygen supply. This invention constructs a multifunctional therapeutic system for the synergistic effect of Chlamydomonas reinhardtii and exosomes. This system integrates in-situ photosynthetic oxygen supply, exosome anti-inflammatory repair, and local microneedle delivery onto the same platform, and can simultaneously intervene in key aspects of osteoarthritis such as hypoxia, inflammation, and insufficient tissue repair, showing promising application prospects.

The invention relates to the technical field of traditional Chinese medicine plasters, in particular to a navel administration plaster for treating transportation type constipation, which comprises radix bupleuri, immature bitter orange, scutellaria baicalensis, cape jasmine, mulberry, peach kernel and auxiliary materials. The traditional Chinese medicine ointment is prepared from radix bupleuri, fructus aurantii immaturus, radix scutellariae, fructus gardeniae, mulberries, peach kernels and auxiliary materials. The preparation method of the traditional Chinese medicine ointment comprises the following steps: S1, weighing a proper amount of pharmaceutical raw materials; s2, grinding the medicinal raw materials into powder, and mixing the powder with the medicinal raw materials; s3, preparing all the mixed medicine powder into medicine micro powder; s4, filling the medicine micro powder into a container, adding mature vinegar, soaking, and uniformly mixing to obtain traditional Chinese medicine juice; and S5, adding auxiliary materials into the medicine juice, and uniformly mixing to prepare the traditional Chinese medicine ointment. The method gets rid of traditional treatment methods of oral medicines, operations and the like for traditional slow-transport constipation diseases, the aim of noninvasively, safely and effectively improving the clinical treatment effect can be achieved, and the life quality of patients is obviously improved.

The present invention belongs to the technical field of pharmaceutical preparations, and in particular to a ketoprofen gel and a preparation method thereof. The ketoprofen gel of the present invention is composed of ketoprofen, tragacanth gum, thioglycerol, L-phenylalanine, glycerol triacetate, ethanol, an antibacterial agent, and water. By optimizing the prescription and improving the preparation process, the transdermal effect is improved, the skin irritation is small, and the moisture retention performance and content stability of the ketoprofen gel are significantly improved.