3results about How to "Good transdermal effect" patented technology

The present application provides a rhodiolide composition with a core-shell-shell structure, a preparation method thereof comprising the steps of: 1) EGCG inclusion: adding beta-cyclodextrin and EGCG into water, ultrasonic, forming an inclusion compound; 2) liposome assembly: weighing soybean phospholipid and cholesterol, dissolving in chloroform to form a uniform solution; weighing rhodiolide, dissolving in the uniform solution, rotary evaporation to remove chloroform, then adding the inclusion compound and PBS buffer into the container, hydrating, forming a liposome wrapping rhodiolide and inclusion compound; 3) shell loading: weighing collagen, mixing with chitosan solution uniformly to form a complex; adding the complex into the liposome, the complex is coated on the outer layer of the liposome, centrifugal purification, obtaining a rhodiolide composition with a core-shell-shell structure. The present application belongs to the technical field of cosmetic raw materials, and the rhodiolide composition provided has the advantages of high stability, good transdermal effect, and significant anti-aging effect.

The present application discloses a kind of hibiscus compound extract, its preparation method and application.The composite extract includes hibiscus exosome, hibiscus traditional active ingredient, snowbank flower extract and microalgae extracellular polysaccharide, wherein the hibiscus exosome and hibiscus traditional active ingredient are simultaneously extracted from hibiscus raw materials by integrated extraction process.The preparation method includes raw material pretreatment, integrated extraction, separation and purification, synergistic compounding and post-processing, and two types of active substances are efficiently and synchronously obtained by optimizing solvent, temperature, time and purification parameters.The composite extract exhibits excellent anti-aging, anti-inflammatory and moisturizing effects in cosmetics, and has excellent effects of regulating intestinal flora and enhancing immunity in functional foods.The process produces significant synergistic effect by combining specific synergistic components, and the effect is much better than single component or simple mixture, realizing the maximization of plant resources and the synergistic promotion of efficacy.

This invention discloses a Chlamydomonas reinhardtii synergistic exosome hydrogel microneedle, its preparation method, and its application, belonging to the field of biomedical materials and microneedle delivery technology. The hydrogel microneedles prepared in this invention use methacryloxymethyl carboxymethyl chitosan and methacryloxyhyaluronic acid as the hydrogel matrix. After adding a photoinitiator to the hydrogel matrix, the microneedles are obtained through molding and ultraviolet crosslinking. The tips of the hydrogel microneedles are loaded with Chlamydomonas reinhardtii exosomes to improve transdermal delivery efficiency. The backing layer or matrix portion of the hydrogel microneedles is loaded with Chlamydomonas reinhardtii to maintain its photosynthetic activity and provide continuous local oxygen supply. This invention constructs a multifunctional therapeutic system for the synergistic effect of Chlamydomonas reinhardtii and exosomes. This system integrates in-situ photosynthetic oxygen supply, exosome anti-inflammatory repair, and local microneedle delivery onto the same platform, and can simultaneously intervene in key aspects of osteoarthritis such as hypoxia, inflammation, and insufficient tissue repair, showing promising application prospects.