73 results about "Multielectrode array" patented technology

Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and / or produce micturition, and / or provide male / female sexuality responses, and / or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.

Leadless neurostimulation (NS) device including a device body and electrodes positioned along an active side of the device body. The electrodes form a multi-electrode array that is configured to interface with nervous tissue of a patient and supply electrical pulses to the nervous tissue. The NS device also includes an electronic sub-system that is coupled to the device body. The electronic sub-system includes switching circuitry, a power source, and an inductive coil that is operably coupled to the power source. The inductive coil is configured to receive electrical power through inductive coupling with an external coil. The device body, including the inductive coil coupled thereto, is sized and shaped to be disposed within an epidural space of a patient.

An electrical medical lead is provided having two or more electrodes, electrically insulated from each other and electrically coupled to individually insulated filars in a multi-filar coiled conductor. When the lead is used with a medical device equipped with a switch matrix, electrodes are selected individually or simultaneously to serve as an anode or cathode in any unipolar, bipolar or multi-polar configuration for delivering stimulation and / or sensing signals in excitable tissue. In one embodiment, a tip electrode array is expandable for improving electrode contact with targeted tissue and stabilizing lead position.

It is disclosed a device for image processing and learning comprising at least a “multi electrode array” (MEA), over which an homogeneous culture of interconnected neurons, so that forming a cell network, is grown on, wherein said MEA is able to stimulate and record the electric activity of said neurons. Methods for image processing and learning utilizing the device are disclosed too.

Thin-film multi-electrode arrays (MEA) having one or more electrically conductive beams conformally encapsulated in a seamless block of electrically insulating material, and methods of fabricating such MEAs using reproducible, microfabrication processes. One or more electrically conductive traces are formed on scaffold material that is subsequently removed to suspend the traces over a substrate by support portions of the trace beam in contact with the substrate. By encapsulating the suspended traces, either individually or together, with a single continuous layer of an electrically insulating material, a seamless block of electrically insulating material is formed that conforms to the shape of the trace beam structure, including any trace backings which provide suspension support. Electrical contacts, electrodes, or leads of the traces are exposed from the encapsulated trace beam structure by removing the substrate.

Existing epiretinal implants for the blind are designed to electrically stimulate large groups of surviving retinal neurons using a small number of electrodes with diameters of several hundred μm. To increase the spatial resolution of artificial sight, electrodes much smaller than those currently in use are desirable. In this study we stimulated and recorded ganglion cells in isolated pieces of rat, guinea pig, and monkey retina. We utilized micro-fabricated hexagonal arrays of 61 platinum disk electrodes with diameters between 6 and 25 μm, spaced 60 μm apart. Charge-balanced current pulses evoked one or two spikes at latencies as short as 0.2 ms, and typically only one or a few recorded ganglion cells were stimulated. Application of several synaptic blockers did not abolish the evoked responses, implying direct activation of ganglion cells. Threshold charge densities were typically below 0.1 mC / cm2 for a pulse duration of 100 μs, corresponding to charge thresholds of less than 100 pC. Stimulation remained effective after several hours and at high frequencies. To demonstrate that closely spaced electrodes can elicit independent ganglion cell responses, we utilized the multi-electrode array to stimulate several nearby ganglion cells simultaneously. From these data we conclude that electrical stimulation of mammalian retina with small-diameter electrode arrays is achievable and can provide high temporal and spatial precision at low charge densities. We review previous epiretinal stimulation studies and discuss our results in the context of 32 other publications, comparing threshold parameters and safety limits.

An electrode arrangement for electrical stimulation of biological material has at least one stimulation electrode via which the biological material can be fed a stimulus signal. Furthermore, a counter electrode is present which forms a counter pole to the stimulation electrode, one sensor electrode is provided with the aid of which it is possible to determine a polarization voltage across the stimulation electrode.

Method for manufacturing a parylene-based electrode array that includes an underlying parylene layer, one or more patterned electrode layers comprising a conductive material such as a metal, and one or more overlying parylene layers. The overlying parylene is etched away or otherwise processed to expose the electrodes where stimulation or recording is to occur. All other conductive material in the device is occluded from the environment by the two layers of parylene surrounding it.

The present invention provides a nerve monitoring device. The device includes a cannula, a sensor for monitoring the nerve and an alignment device. The cannula can be any surgical cannula, and is preferably an endotracheal tube. The sensor can be an electrode or other sensor that is capable of sensing nerve activity. The alignment device is a device that ensures that after insertion of the nerve sensor into a patient, the sensors are aligned to properly monitor the target nerve or muscle. The internal alignment device may communicate externally to surgeon by using electromagnetic energy as either a transmittor or a receiver. The mismatch of triangular laryngeal anatomy to circular cannula anatomy can be compensated for by a) altering the geometry (external shape) of the cannula and b) using soft, felt-like expandable electrodes. Rotational error can be compensated for by using a multi-electrode array wherein the optimized recording montage can be simply selected on the external recording device.

A method of measuring localized corrosion, using a multi-electrode array sensor. The method eliminates the effect of internal current in corroded electrodes, and thus provides a more accurate corrosion measurement. In one embodiment, the potential of a common node of the sensor is adjusted so that the sensor's most cathodic current is close to zero.

A micropower neural amplifier with adaptive power biasing for use in multi-electrode arrays is provided. The micropower neural amplifier includes a low noise gain stage. The low noise gain stage is implemented using an amplifier and pseudoresistor elements.

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and / or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and / or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and / or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.

A method of measuring localized corrosion, using a multi-electrode array sensor. The method eliminates the effect of internal current in corroded electrodes, and thus provides a more accurate corrosion measurement. In one embodiment, the potential of a common node of the sensor is adjusted so that the sensor's most cathodic current is close to zero.

The exemplary embodiments of the method, system and arrangement according to the present invention enables an estimation of reaching movements. For example, using the exemplary embodiments of the present invention, it is possible to derive a Bayesian-optimal discrete time state equation to support real-time filters that incorporate observations about the target position and arm trajectory. The exemplary embodiments of the present invention may be compatible with any filtering method, such as point process or Kalman filters, and any recording methods, such as multielectrode arrays, intracortical EEG, or eye trackers.

Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and / or produce micturition, and / or provide male / female sexuality responses, and / or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.

A multielectrode array with fault-tolerance for use in conjunction with a brain implantable device includes a sensor grid composed of a plurality of sensors, the plurality of sensors including primary sensors and spare sensors. The multielectrode array also includes signal processing circuitry associated with the plurality of sensors and a control system associated with the sensor grid for replacing faulty primary sensors with spare sensors.

A multi-electrode array is composed of a pinhole array, multiple right-angle electrodes made of metal wire and arranged in the vertical pinholes of pinhole array, and fixing resin on the top surface of pinhole array for fixing the horizontal parts of said electrodes.

The invention provides an FPGA-based multi-electrode array simulation experiment platform. The experiment platform comprises an FPGA development board and a principal computer which are connected with each other via a USB interface. The FPGA development board is used for implementing an STN neuron network model and a multi-electrode array algorithm. The software interface of the principal computer is designed based on LabVIEW, and the principal computer communicates with the FPGA development board. With the FPGA neural network experiment platform which is taken as a biological neuron network, free of animal experiment and based on high-speed operation, synchronous record of multiple sites of the field potential of a neuron network through a multi-electrode array is realized, and the consistency with real biological neurons in time scale can be ensured. A visual study platform closer to a real neural network is provided for the study of the discharge mechanism of a sub-thalamic nucleus STN nuclei and the study of a multi-electrode array. The platform is of important practical value to the study and treatment of a variety of neurological diseases including the Parkinson's disease.

The invention provides a culture of patterned cardiomyocytes, the culture including a support substrate bearing a multielectrode array, a negative surface resistant to cell attachment and deposited on the support substrate covering the multi-electrode array, a pattern ablated on the negative surface, a positive surface promoting cell attachment deposited on the pattern ablated on the negative surface; and cardiomyocytes adherent to the positive surface and growing aligned along the pattern ablated on the negative surface. The invention also includes a method of making the culture of patterned cardiomyocytes and a method of in vitro method of testing the effect of a compound on cardiac function by measuring electrical output from the patterned cardiomyocytes.

A multielectrode array with a fluidic channel and its method of fabrication are presented here. In accordance with various embodiments, the present invention allows for scalability, reproducibility, and precision dimension control by utilizing a lithography dependent process. In one embodiment, the present invention provides for a microelectrode that is a neural implant, with the microelectrode configured for connection to a fluidic channel. In another embodiment, the fluidic channel may deliver growth factors and / or drugs.

A micropower neural amplifier with adaptive power biasing for use in multi-electrode arrays is provided. The micropower neural amplifier includes a low noise gain stage. The low noise gain stage is implemented using an amplifier and pseudoresistor elements.

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and / or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

The invention relates to a detection device and method for multi-electrode array corrosion sensor micro current. The detection device consists of a corrosion array connection circuit, an electronic changeover switch circuit, a current-to-voltage amplifying circuit, a voltage conversion circuit within AD range and a single chip microcomputer control and sampling system that are connected in order. The single chip microcomputer control and sampling system is connected to the current-to-voltage amplifying circuit through an operational amplifier input offset voltage cancelling circuit, and is also connected to the electronic changeover switch circuit, and the electronic changeover switch circuit and the current-to-voltage amplifying circuit are also connected to a negative voltage conversion circuit simultaneously. Therefore, the device and the method provided by the invention have the advantages that: 1. DAC is utilized to eliminate the offset voltage of operational amplifier; and 2. real-time switching comparison is carried out to improve the measurement accuracy.

The invention discloses an electrode measurement device based on electromyographic signals of a genioglossus muscle. The electrode measurement device comprises a low jaw support, a reference electrode and array collection electrodes arranged in two rows and at least two lines, wherein the low jaw support is used for fixing the electrodes distributed on the low jaw support, the reference electrode is arranged in the middle of the upper portion of the lower jaw support and corresponds to the middle combination portion of the two side portions of the lower jawbone of a human body, and the array collection electrodes are sequentially arranged on the two sides of the lower portion of the reference electrode and correspond to the lower jaw tongue muscles of the human body. Compared with the prior art, the multi-electrode array measurement mode is adopted, the electrodes are large in number and wide in distribution range, the space resolution is high, the resolution ratio of the electromyographic signals of the genioglossus muscle can be increased, the electrodes are made of silver wire non-woven fabric fibers, the electrical resistivity is low, the polarized electromotive force is small, and the electrode measurement device is comfortable to wear.