11 results about "Selective stimulation" patented technology

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

The present disclosure provides orthogonal chimeric cytokine receptor / orthogonal cytokine pairs and compositions and methods for modified immune cells or precursors thereof (e.g., modified T cells) comprising an orthogonal chimeric cytokine receptor (e.g., an oIL2R-IL9R chimeric receptor) and a chimeric antigen receptor (CAR) or a T cell receptor (TCR). The present disclosure further provides an oncolytic adenoviral vector comprising a nucleic acid sequence encoding an orthogonal cytokine (e.g., oIL2), as well as methods of using the modified cells and the vector for treating cancer in a subject in need thereof.

A system for controlling selective stimulation of neural tissue of a subject is provided. Said system comprises a first electrode arrangement, comprising a plurality of electrodes, configured to be arranged in in relation to a first longitudinal position of the neural tissue, a second electrode arrangement, comprising at least one electrode and configured to be arranged at a second longitudinal position of the neural tissue, and a stimulation signal generating unit. The stimulation signal generating unit is configured to generate a first intermittent current waveform comprising a first pulse and a second intermittent current waveform comprising a second pulse, for causing interferential stimulation of a plurality of nerve fibers of the neural tissue. The stimulation signal generating unit is further configured to generate and output a blocking pulse to the second electrode arrangement, for temporally selectively blocking propagation of signals through the neural tissue at the second longitudinal position.

The invention belongs to the technical field of thrombus removal, and discloses a sublingual sympathetic nerve targeting-based thrombus removal method, which can promote the loosening, decomposition or dissolution of thrombus by applying selective stimulation to a sublingual area and inducing the change of hemodynamics or endogenous fibrinolytic system. The supralingual sympathetic nerve can be acted by combining electrical stimulation, ultrasonic, optical or thermal means, and synergistic thrombus cleaning can be realized by matching with a drug carrier or ultrasonic microbubbles sensitive to stimulation. According to the method, autonomous adjustment can be achieved through closed-loop control, and the method can also be used in cooperation with conventional means such as mechanical thrombus extraction and medicine thrombolysis. Compared with the prior art, the medicine dosage and systemic side effects can be reduced, the operation risk is reduced, the thrombus removing efficiency is remarkably improved, and the good clinical application prospect is achieved.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

The invention relates to the technical field of biomedical engineering and implantable medical instruments, and discloses a flexible spiral beam inner electrode with a stress buffer structure and a nerve regulation and control system. The electrode comprises a flexible spiral carrier made of a biocompatible elastic material, wherein the carrier is provided with a tube cavity along the central axis for accommodating a temporary support rod; a plurality of stimulation contacts distributed on the surface of the carrier form a three-dimensional contact array; the conductive traces are serpentine and release stress through geometric expansion when the carrier is deformed. The system further comprises a multi-channel pulse generator for realizing space-time cooperative selective stimulation. According to the application, the problems that a flexible electrode wire is easy to break and difficult to implant are solved, selective activation of sports fibers is realized, and pain caused by activation of sensory fibers is avoided.

Methods for electrical modulation of inflammation or serum TNF levels in a subject.

The invention provides a multi-channel electrode-based selective stimulation system and method and a storable medium, relates to the field of electronic information and control, and solves the technical problem that an existing multi-channel electrode stimulation system is difficult to meet the requirements of high precision, controllability and repeatability. The system comprises a control unit, a stimulation voltage regulation unit, an electrode selection latch unit, a pulse width control unit, a logic control unit and an electrode channel selection unit, wherein the control unit is used for receiving control information and generating a control command; the stimulation voltage adjusting unit is used for realizing output of voltage gears; the electrode selection latch unit is used for outputting a corresponding channel code; the pulse width control unit is used for adjusting the pulse width of the electrical stimulation signal; the logic control unit is used for performing logic synchronization on the input signal and outputting an enable signal; and the electrode channel selection unit is used for receiving the enable signal and outputting a stimulation pulse signal. The multi-channel electrode is used in the selective stimulation process of the multi-channel electrode.

The instant disclosure provides improved pegylated IL-2 compositions that are selective Treg stimulator and methods of using these compositions for treating autoimmune diseases that provide a selective increase in numbers and activation of regulatory T cells over effector T cells.

The invention belongs to the technical field of biomedical materials and nerve regulation and control, and particularly relates to magnetic hydrogel for selectively stimulating vagus nerve outgoing fibers as well as a preparation method and application of the magnetic hydrogel. The magnetic hydrogel capable of selectively stimulating vagus nerve outgoing fibers, provided by the invention, comprises a hydrogel substrate and a nano-composite loaded by the hydrogel substrate, the nano-composite is a complex of chitosan modified superparamagnetic iron oxide nano-particles and an exosome loaded with capsaicin. The magnetic hydrogel and a magnetic field control unit form a vagus nerve outgoing fiber selective magnetic stimulation system. Selective regulation and control of vagus nerve efferent fibers are achieved, and the vagus nerve efferent fibers have good biocompatibility and nerve regulation and control accuracy and can be used for preparing drugs or instruments for treating cardiovascular diseases such as atherosclerosis.

This disclosure relates generally to electrically stimulating dilators for selectively stimulating nerves during surgical procedures. A dilator for use in surgery includes a body extending from a proximal end to a distal end, with a clip attachment area at the proximal end of the body for receiving a stimulating clip. The clip attachment area includes an anterior electrode and a posterior electrode, the anterior electrode and posterior electrode insulated from each other. The dilator also includes a first conductive pathway extending from the anterior electrode to the distal end of the body and a second conductive pathway extending from the posterior electrode to the distal end of the body. An anterior emitter is at a distal end of the first conductive pathway and a posterior emitter is at a distal end of the second conductive pathway, with the posterior emitter disposed opposite the anterior emitter.