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Nerve stimulator and manufacturing method thereof

A nerve stimulation and production method technology, applied in the field of biomedical engineering, can solve the problems of large surgical implant opening, large wiring width, and large trauma surface, and achieve the effects of short production cycle, reduced wiring width, and simple method

Active Publication Date: 2016-01-06
WENZHOU INST OF BIOMATERIALS & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] For this reason, the technical problem to be solved by the present invention is the neural stimulator of the prior art, the microelectrode of the neural stimulator is connected with the stimulation chip by wires, which causes the wiring width to be large, the surgical implantation opening to be large, and the problem that the wound surface is large, and then Propose a neurostimulator and its manufacturing method

Method used

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  • Nerve stimulator and manufacturing method thereof
  • Nerve stimulator and manufacturing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] A neurostimulator such as figure 1 As shown, including the substrate 1, a number of through holes are opened;

[0042] Several microelectrodes 2 are used to stimulate neurons; the microelectrodes 2 are arranged on the substrate by filling through holes, and the stimulation part 7 of the microelectrode 2 leaks out on one side of the substrate, and the microelectrode 2 is on the other side. Connecting part 6;

[0043] The stimulation chip 3 is used to control the microelectrodes 2 to send stimulation signals to neurons and receive feedback signals; the connection part 6 of the microelectrodes 2 is directly flip-chip welded on the stimulation chip 3;

[0044] The casing 4 is sealed and connected to the base 1 , and forms a cavity with the base 1 , and is used for encapsulating the connection part 6 of the microelectrode 2 and the stimulation chip 3 .

[0045] Above-mentioned technical scheme is the core technical scheme of the present invention, and the microelectrode 1 ...

Embodiment 2

[0055] The difference from Example 1 is that the materials of the base 1 and the shell 4 in this embodiment are both glass with good biocompatibility, and the preferred material of the base 1 and the shell 4 in this embodiment is borosilicate glass. As a variant, the material of the base 1 and the housing 4 can also be soda lime glass. In this embodiment, the microelectrode array is 30*30. Others are the same as in Example 1.

[0056] The details are as follows, a nerve stimulator includes a base 1 with several through holes;

[0057] Several microelectrodes 2 are used to stimulate neurons; the microelectrodes 2 are arranged on the substrate by filling through holes, and the stimulation part 7 of the microelectrode 2 leaks out on one side of the substrate, and the microelectrode 2 is on the other side. Connecting part 6;

[0058] The stimulation chip 3 is used to control the microelectrodes 2 to send stimulation signals to neurons and receive feedback signals; the connectio...

Embodiment 3

[0069] The difference from Embodiment 1 is that the material of the substrate 1 in this embodiment is polyimide, and the substrate material of this embodiment can also be silicon or parylene. As a modification, the base material of this embodiment may also be silicon. Others are the same as in Embodiment 1, and will not be repeated here.

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Abstract

The invention relates to the technical field of bio-medical engineering, and particularly relates to a nerve stimulator. The nerve stimulator comprises a substrate provided with a plurality of through holes, a plurality of microelectrodes arranged on the substrate through being filled in the through holes, a stimulus chip and a shell. One side of each microelectrode, leaks out of the substrate, serves as the stimulus part of the microelectrode, while the other side of the microelectrode serves as the connection part of the microelectrode. The connection parts of the microelectrodes are directly inverted and welded onto the stimulus chip. The shell is hermetically connected with the substrate. The manufacturing method of the nerve stimulator is composed of the laser drilling step, the through hole plating step and other machining steps, and the packaging manner thereof is realized through the laser welding step. According to the technical scheme of the invention, the microelectrodes are connected with the stimulus chip through the flip-chip bonding process, so that the tissue damage caused during the implantation process of the nerve stimulator can be greatly reduced. The manufacturing method is simple in process, and short in period. Based on the method, a high-density and orderly-arranged three-dimensional microelectrode array can be implemented. Meanwhile, the high-density selective stimulating and recording function can be realized. Therefore, the nerve stimulator and the manufacturing method thereof have a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to a nerve stimulator and a manufacturing method. Background technique [0002] Implantable neurostimulators have a wide range of applications in medicine, such as cochlear implants, artificial vision restoration, and deep brain stimulation systems. As an important tool to reveal the working mechanism of the nervous system and treat neurological diseases, microelectrodes have attracted more and more attention, and have become an important research direction at present. [0003] The application of microelectrodes is usually to implant microelectrodes into animals or patients, to stimulate or inhibit neural activity by loading electrical signals, or to convert neural activity into electrical signals and record them for research. Due to different targets, various microelectrode arrays based on micromachining technology have been developed. Among them, high-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/372
CPCA61N1/37211
Inventor 杨佳威陈景雄王健
Owner WENZHOU INST OF BIOMATERIALS & ENG
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