44 results about "Implantable Neurostimulators" patented technology

According to another disclosed embodiment, an energy efficient implantable neurostimulator for delivering one or more electrical pulses to a target region within a patient's body is provided. The neurostimulator includes a converter for generating the stimulation current, wherein the converter includes a voltage increasing circuit and a voltage reducing circuit. The stimulator may also include a current source that includes a pair of cascode arranged transistors that are controlled to maintain an amplitude of the stimulation current substantially constant. The neurostimulator may also include a bias voltage power supply that powers a selecting circuit for selecting one of the voltage increasing or voltage decreasing circuits.

A closed-loop neuromodulation system includes at least one implantable neurostimulator configured to deliver electrical stimulation to a target nerve innervating a muscle; at least one biosignal sensor configured to detect a physiological signal associated with the target muscle, wherein the physiological signal may include an electromyographic (EMG) or electroneurographic (ENG) signal; and a controller operatively coupled to the neurostimulator and the sensor. The controller is configured to receive the physiological signal from the sensor, determine whether the signal satisfies a predefined condition indicative of weakness, strength, fatigue, muscle underactivity, or overstimulation, and, in response to detecting that the condition is satisfied, automatically adjust one or more stimulation parameters selected from amplitude, frequency, pulse width, train duration, or train count.

The invention relates to an in-vitro program controller and a control method thereof. The in-vitro program controller comprises a sensor and a processor, and the processor sets the working power of the implantable nerve stimulator, a temperature early warning value and a temperature upper limit value greater than the temperature early warning value according to the stimulation parameters; when the movement of the in-vitro program control instrument is determined at every reference time interval or according to the posture change detected by the sensor, a data reading instruction is sent to the implantable nerve stimulator so as to read the working power and temperature of the implantable nerve stimulator; increasing, decreasing or maintaining the transmitting power according to the comparison between the read working power and the set working power; according to the fact that the read temperature is larger than or equal to the set temperature early warning value and smaller than the set temperature upper limit value, the transmitting power is reduced; and sending a stimulation stop instruction when the read temperature is greater than or equal to a set temperature upper limit value. According to the invention, the working power, temperature and the like of the implantable nerve stimulator can be monitored and adjusted, so that safe treatment of a patient is ensured.

The present invention relates to an implantable neuroregulator device comprising a hermetically sealed housing, in which an antenna for communicating with an external device and / or for wirelessly receiving electrical energy is positioned within the housing, in which a main part of the housing is electromagnetically transparent to radiation in a frequency range below 20 MHz, in particular between 5 MHz and 15 MHz.

A system may include one implantable pulse generator and at least one implantable lead. The pulse generator may include a processor, a driving system for driving electrodes, a communication circuit, and a housing configured to be subcutaneously implanted. The lead may be configured to extend from the pulse generator to at least one neural target on a left side of a head and a neural target on a right side of the head. The lead may include at least two electrode sets, each including at least two electrodes. The lead be configured to be used to subcutaneously place the at least two electrode sets near the at least two neural targets, respectively, and electrically connect the pulse generator to each of the at least two electrodes sets to enable the driving system to drive the at least two electrode sets to stimulate the at least two neural targets.

The utility model discloses a nerve stimulator assembly implanted into a skull, and belongs to the technical field of medical instruments. The nerve stimulator assembly implanted into the skull comprises a stimulator with a through hole, a fixing base and a fixing piece, the fixing base comprises a base plate and a limiting table arranged on the base plate, and the stimulator is detachably connected with the fixing base; the fixing column penetrates through the through hole to be fixedly held with the limiting table. According to the nerve stimulator assembly implanted into the skull, the stimulator and the fixed base can be fixedly connected, and the stimulator and the fixed base are prevented from being disengaged and losing efficacy.

The application provides an implantable nerve stimulator suitable for human limbs, and belongs to the technical field of medical devices, and comprises: sequentially connected cylindrical end part, shell part and tail part; the shell part is internally provided with a circuit board; the end part is internally provided with a wireless charging coil, and the central axis of the wireless charging coil is parallel to the length direction of the shell part; the tail part is internally provided with an electrode connector for inserting an electrode, and the electrode connector connection channel is arranged in parallel to the length direction of the shell part; the implantable nerve stimulator of the application optimizes the layout of internal components, thereby reducing the overall width and thickness of the nerve stimulation electrode, so as to facilitate implantation in the human limb part.

A system is provided for driving an implantable neurostimulator lead, the lead having an associated plurality of electrodes disposed in at least one array on the lead. The system comprises an implantable pulse generator (IPG), the IPG including an electrode driver, a load system for determining load requirements, an IPG power coupler, and an IPG communication system. The system also includes an external unit, which includes an external variable power generator, an external power coupler, an external communication system, and a controller for varying the power level of the variable power generator.

The present invention relates to a stimulation generator suitable for use in an implantable neurostimulator, including an injectable neurostimulator. The stimulation generator is adapted to provide a configurable stimulation signal comprising a component, such as a pulse. The stimulation generator comprises circuitry to receive and combine an amplitude control signal and a duty cycle signal to produce a preliminary output voltage signal which includes the component of the stimulation signal. It further comprises a voltage-controlled current source adapted to be driven by the preliminary output voltage signal; and a mode selector controlled by a stimulation mode signal to output the component from the preliminary output voltage signal as a current-controlled component of the stimulation signal via the voltage-controlled current source or as a voltage-controlled component of the stimulation signal.

The present disclosure provides a potential signal acquisition method and an implantable nerve stimulator, wherein the method comprises: outputting a pulse stimulation signal to a stimulation target; performing passive charge balance on the stimulation target after the end of the stimulation pulse of the pulse stimulation signal; and acquiring a potential signal of the target stimulation target after the end of the passive charge balance and before the start of the next stimulation pulse.

A system may include one implantable pulse generator and at least one implantable lead. The pulse generator may include a processor, a driving system for driving electrodes, a communication circuit, and a housing configured to be subcutaneously implanted. The lead may be configured to extend from the pulse generator to at least one neural target on a left side of a head and a neural target on a right side of the head. The lead may include at least two electrode sets, each including at least two electrodes. The lead be configured to be used to subcutaneously place the at least two electrode sets near the at least two neural targets, respectively, and electrically connect the pulse generator to each of the at least two electrodes sets to enable the driving system to drive the at least two electrode sets to stimulate the at least two neural targets.

A method of treatment with an implantable neurostimulator device in which a low frequency waveform is applied by a pulse generator configured therein through a plurality of electrodes to a network of target interactive brain regions subject to an abnormal communication connection, in particular a central execution network, a default mode network and / or a highlight network, in some embodiments, the network may be configured to restore normal correlation or anti-correlation communication connections within and between networks to deal with brain-related dysfunctions.

The invention provides an electrode preparation method of an implantable nerve stimulator and a nerve stimulator system.The method comprises the steps that an insulating tube is arranged on a first fixing device with wire grooves in a sleeving mode, all wires extending out of a pulse stimulator penetrate through the insulating tube through the different wire grooves, the insulating tube is fixed to a pulse generator, and the first fixing device is fixed to the pulse generator; the first fixing device and the insulating tube are fixed; all the wires penetrate through the electrode ring, the electrode ring makes contact with the insulating tube, one wire is electrically connected with the electrode ring, a second fixing device with wire grooves is inserted into the electrode ring, all the wires are located in the different wire grooves, and an insulating spacer ring is arranged on the second fixing device in a sleeving mode and fixedly connected with the electrode ring to form an electrode ring section; according to the nerve stimulator prepared by the method, the risk of electrode end breakage can be reduced, the size is small, a battery does not need to be replaced, the nerve stimulator can be closer to the skin during implantation, operative complications are reduced, and the influence on the human body is small.

The invention relates to an RFID protocol based communication method for an implantable nerve stimulator system. The implantable nerve stimulator system comprises an in-vitro program control instrument and an implantable nerve stimulator, and the in-vitro program control instrument and the implantable nerve stimulator are in wireless communication by adopting a predetermined RFID protocol. The in-vitro program controller is configured to send a signal containing energy and control information to the implantable nerve stimulator. The implantable nerve stimulator is configured to: generate a sequence of stimulation pulses for application to the electrodes using the received stimulation parameters; self-state self-checking is executed according to a preset self-checking period; and when a query instruction from the in-vitro program controller is received, a state self-checking result is fed back to the in-vitro program controller. The frame structure of the predetermined RFID protocol comprises a seeker and a command field, and the seeker adopts a configuration mode of forbidding a lead code extension control bit; the command field includes a 4-bit command code, 8-bit or more valid data bits, and 5-bit CRC check bits.

The present disclosure provides a potential signal acquisition method and an implantable nerve stimulator, wherein the method comprises: outputting a pulse stimulation signal to a stimulation target; actively balancing charges of the stimulation target after the stimulation pulse of the pulse stimulation signal ends; and acquiring a potential signal of the target after the active charge balancing ends and before the next stimulation pulse starts.

Disclosed are various examples and embodiments of systems, devices, components and methods configured to treat mood disorders in a patient using a compact implantable neurostimulator and corresponding lead(s) that are shaped, sized and configured to be implanted beneath a patient's skin in the head or neck, and to stimulate one or more target cranial nerves. The one or more medical electrical leads comprising electrode(s) are positioned adjacent to, in contact with, or in operative positional relationship to, the one or more target cranial nerves of the patient. In some embodiments, electrical stimulation is provided to the one or more target cranial nerve(s) of the patient for periods of time ranging between 30 and 60 minutes, once or twice per day. In some embodiments, power is provided to the implantable neurostimulator transcutaneously by inductive, wireless, RF, acoustic, microwave, or other suitable non-invasive means.

The invention relates to an implantable nerve stimulator, an in-vitro program controller and an implantable nerve stimulator system. The implantable nerve stimulator comprises an antenna, a stimulation parameter register, a CRC register and a processor. The processor generates a stimulation voltage by using the received energy and generates a stimulation pulse sequence by using stimulation parameters stored in a stimulation parameter register; when it is determined that the position of the antenna deviates according to the stimulation voltage in the stimulation period, stimulation is paused, and the stimulation pause state is sent to the in-vitro program controller; when it is determined that the in-vitro program controller reads the CRC code stored in the CRC register, the CRC register is used for calculating the CRC code of the stimulation parameter stored in the stimulation parameter register, and the calculated CRC code is sent to the in-vitro program controller; and determining whether the position offset of the antenna causes the stimulation parameters stored in the stimulation parameter register to change or not by the in-vitro program controller. According to the invention, stimulation voltage reduction and stimulation parameter mutation caused by antenna offset can be coped with.

The invention relates to a wireless directional energy transfer system of a medical in-vitro program controller. The wireless directional energy transfer system comprises: a control device configured to generate a control signal for stimulation parameters of an in-vivo implantable nerve stimulator; a transceiver configured to convert the received control signal into an initial radio frequency signal; the transmitting link is used for transmitting the received initial radio-frequency signal to each of the plurality of transmitting branches, and each of the plurality of transmitting branches is used for processing the initial radio-frequency signal into a transmitting radio-frequency signal; the in-vitro antenna is used for transmitting a transmitted radio-frequency signal to the in-vivo antenna or receiving a radio-frequency signal from the in-vivo antenna; and the receiving link sends the received radio frequency signal to one of the plurality of receiving branches, and each of the plurality of receiving branches processes the received radio frequency signal into a received radio frequency signal and sends the received radio frequency signal to the transceiver, so that the transceiver converts the received radio frequency signal into a control signal and sends the control signal to the control device.

Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.

An implanted neurostimulator has a processor which controls stimulation parameter values to create stimulation signals which are applied to a patient's body to maintain relative proportional amplitudes of a set of linked stimulation signals during stimulation in accordance with a stimulation protocol. An external programmer receives user input data and can adjust the stimulation protocol. A set of independently operable electrode contacts are electrically coupled to the neurostimulator and the set of independently operated electrode contacts have at least two subset electrode contacts which are linked together to receive the set of linked stimulation signals. An information transmission system has telemetry circuitry to transmit to the neurostimulator the set of stimulation signal values in accordance with the stimulation protocol.

An extendable and retractable electrical lead for providing electrical stimulation including an elongated lead body extending from a proximal portion to a distal portion, one or more electrical contacts carried by the proximal portion of the lead body configured to be coupled to an implantable neurostimulator, one or more electrodes carried by the distal portion of the lead body configured to electrically communicate with the one or more electrical contacts to deliver neurostimulation therapy to a target treatment site based on a stimulation therapy provided by an implantable neurostimulator; and a protective sheath coaxially aligned with the lead body along a common axis and extending over part of a length of the lead body, where the protective sheath is configured to slide relative to the lead body and the common axis between an extended state and a retracted state.

Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.

Systems and methods for delivering sub-threshold therapy to a patient are provided, in which an external control device for programming an implantable neurostimulator coupled to an electrode array implanted within a patient is provided, comprising: a user interface; a telemetry circuit configured to communicate with the neurostimulator; and a controller / processor circuit configured to, in response to input to the user interface, direct the neurostimulator via the telemetry circuit to deliver super-threshold electrical modulation energy according to a set of super-threshold modulation parameters and to deliver sub-threshold electrical modulation energy according to a set of sub-threshold modulation parameters, wherein the super-threshold modulation program and the sub-threshold modulation program are contained in a hybrid modulation program. A neurostimulation system is also provided.

The invention relates to the technical field of medical products, and discloses an implantable nerve stimulator, a wire, a nerve stimulator system and an assembling method of the nerve stimulator system. The implantable nerve stimulator comprises a channel module and a main body, the channel module comprises at least one connecting assembly, the connecting assembly forms a connecting channel for insertion of a wire, the connecting assembly comprises a plurality of first conductive sheets and a plurality of first conductors, the plurality of first conductors are in one-to-one correspondence with the plurality of first conductive sheets, and the plurality of first conductors are in one-to-one correspondence with the plurality of first conductive sheets. The first conductors are electrically connected to the first conducting strips, the multiple first conducting strips are arranged at intervals in the circumferential direction of the connecting channel, and the first conducting strips are used for being electrically connected to wires; the main body is provided with a circuit board electrically connected with the first conductor. According to the implantable nerve stimulator, the size of the implantable nerve stimulator is reduced, more contacts can be provided, and the product structure requirement is met.

Devices and systems for providing neurostimulation to a target location, may include an implantable neurostimulator device including a first transducer device that includes a gas matrix piezoelectric (GMP) array or a piezoelectric micromachined ultra-sound transducer (pMUT) array; the implantable neurostimulator device has a length of 5 mm to 20 mm and a diameter of 1 mm to 5 mm and an energy delivery device including a second transducer device; the second transducer device includes a gas matrix piezoelectric (GMP) array, a polymer matrix piezocomposite array, a capacitive micro-machined acoustic transducer (cMUT) array, or a pMUT ar-2024 / 097917 ray; and a beam-forming processor to cause the second transducer device to produce an acoustic wave, the implantable neurostimulator device is to receive the acoustic wave from the energy delivery device, convert the acoustic wave to an electrical energy signal, and apply the electrical energy signal.

An implant system is provided, which includes an implant, including an implant body and an electrode disposed on the implant body; and a hollow needle, which is configured to be percutaneously advanceable into tissue of a subject. The hollow needle is shaped so as to define a lumen dimensioned to house the implant; at a distal end of the hollow needle, a distal end opening configured to facilitate passage of the implant therethrough from the lumen; and a lateral wall shaped so as to define a window therethrough to the lumen. Other embodiments are also described.

The application discloses a closed-loop synergistic electrical stimulation system for diuresis and defecation dysfunction. The closed-loop synergistic electrical stimulation system comprises an implantable nerve stimulator, a bladder puncture probe electrode, a pressure sensor integrated with a tip for real-time acquisition of intravesical pressure signals, a sacral nerve stimulation electrode for implantation of sacral foramen to regulate micturition reflex and defecation reflex, the implantable nerve stimulator adjusts the pulse electrical stimulation output to the sacral nerve stimulation electrode to assist the user in urination according to the intravesical pressure signals collected by the pressure sensor, and the implantable nerve stimulator outputs pulse electrical stimulation to the sacral nerve stimulation electrode to assist the user in defecation in response to a manual trigger instruction issued by the user through an external program control instrument. The application realizes the integration and synergy of automatic regulation of micturition and manual assistance of defecation, adopts a single nerve stimulator two-drag-two design which can be implanted for a long time, and provides a safe and effective solution for diuresis and defecation dysfunction.

The present application relates to an implantable nerve stimulator, an external programmer and an implantable nerve stimulator system. The implantable nerve stimulator comprises an antenna, a stimulation parameter register, a CRC register and a processor. The processor generates a stimulation voltage by using received energy, and generates a stimulation pulse sequence by using stimulation parameters stored in the stimulation parameter register; when antenna position offset is determined according to the stimulation voltage during stimulation, the stimulation is paused, and a state of the stimulation pause is sent to the external programmer; when it is determined that the external programmer reads the CRC code stored in the CRC register, the CRC code of the stimulation parameters stored in the stimulation parameter register is calculated by using the CRC register, and the calculated CRC code is sent to the external programmer to determine whether the antenna position offset causes the stimulation parameters stored in the stimulation parameter register to change. The present application can cope with the decrease of the stimulation voltage and the mutation of the stimulation parameters caused by the antenna offset.

The invention relates to an implantable nerve stimulator system and a control method thereof. The system comprises an in-vitro energy controller and an implantable nerve stimulator. The in-vitro energy controller sends an input signal including energy and control information to the implantable nerve stimulator, and the implantable nerve stimulator maintains operation according to the energy and forms a stimulation signal having a stimulation period, effective stimulation time and stimulation intensity according to the control information; the in-vitro energy controller is configured to continuously send energy in an initial energy supply time period after starting so as to maintain the implantable nerve stimulator to configure a stimulation signal; energy is sent according to a specific duty ratio in each energy supply period after the initial energy supply time period, the duty ratio is determined by the stimulation period, the effective stimulation time and the stimulation intensity of the stimulation signal, and the energy supply periods are in one-to-one correspondence with the stimulation periods, so that synchronization of energy supply of the in-vitro energy controller and stimulation of the implantable nerve stimulator is realized. According to the invention, the problem that an in-vitro energy controller and an implantable nerve stimulator are severe in heating is solved.