95 results about "Cochlea" patented technology

The invention relates to a cochlea spiral neuron in-vitro organ as well as a construction method and application thereof, and provides a method for obtaining a mature inner ear neuron by utilizing human pluripotent stem cell differentiation in vitro and further constructing an inner ear neuron in-vitro organ on the basis of the mature inner ear neuron. The internal ear neuron in-vitro organoid function stage obtained by the method and the application thereof are also provided.

The present description relates to an acoustic output device, comprising: a housing; a bone conduction vibrator, which is used for generating bone-conducted sound waves, the bone-conducted sound waves being transmitted to the cochlea by means of the housing to generate sound; an air conduction vibrator, which is used for generating air-conducted sound waves, the air-conducted sound waves being transmitted to the ear of a user by means of sound guide holes in the housing; and a processing circuit, which is configured to provide a first audio signal for the bone conduction vibrator, and provide a second audio signal for the air conduction vibrator, wherein the processing circuit is further configured to adjust a low-frequency component in the first audio signal or adjust a high-frequency component in the second audio signal. The low-frequency component in the first audio signal or the high-frequency component in the second audio signal are adjusted by means of the processing circuit, such that the ratio of bone-conducted components to air-conducted components in the output of the acoustic output device is variable, so as to adjust high and low frequency output effects of the acoustic output device. Thus, the acoustic output device is suitable for different scenarios, thereby enhancing the use experience of the acoustic output device.

The present invention relates to a method for automatically segmenting the cochlea of a person comprised in an image (M) comprised of voxels (v) each voxel comprising an intensity value being indicative of the intensity of the respective voxel (v).

The invention provides a cognitive impairment monitoring method and system for a senile deaf person group. The method comprises the following steps: acquiring cognitive scale data of the senile deaf person group implanted into an artificial cochlea at different evaluation times; converting the cognitive scale data into standardized cognitive scale data based on a preset scoring standard; based on a plurality of preset signal-to-noise ratio levels, obtaining a processing signal of the artificial cochlea and a response behavior signal of the senile deaf group; filtering the processed signal to obtain a filtered audio signal, a response correctness result and a response parameter; and performing correlation analysis on the response correctness result, the response time parameter and the standardized cognitive scale data to generate a trend curve representing the change of the cognitive function of the senile deaf people group along with time so as to realize cognitive impairment monitoring of the senile deaf people group. According to the technical scheme provided by the invention, the dynamic change of the cognitive function of the senile deaf people is accurately monitored, and the accuracy of early recognition of cognitive impairment is improved.

Presented herein are adaptive electroporation techniques in which the electroporation parameters are adjusted / adapted based on the location within a body chamber, such as the cochlea, at which the electroporation electrical field is generated.

The invention discloses a sleeping posture self-adaptive pillow and a sleeping posture judging and adjusting method thereof. The sleeping posture self-adaptive pillow comprises a pillow body, a pressure matrix sensing system and a height adjusting executing mechanism, wherein the pressure matrix sensing system and the height adjusting executing mechanism are arranged in the pillow body. The pressure matrix sensing system is connected with the height adjustment executing mechanism and is positioned above the height adjustment executing mechanism; the pressure matrix sensing system comprises a pressure sensing matrix formed by a plurality of sensing unit arrays, and is used for carrying out pressure sampling to generate a pressure distribution diagram, recognizing and positioning head and face feature anatomical point locations through the pressure distribution diagram and carrying out sleeping posture judgment, and the anatomical point locations comprise a cochlea region, a cochlea upper region and a cochlea lower front region; and the height adjustment executing mechanism adopts 17-area linkage air bags to adjust the height, and the air bag in each area is provided with an independent air pump and a piezoelectric proportional valve and is used for adjusting the height of the corresponding area according to the detection result of the pressure matrix sensing system. Gradient pressure adjustment can be carried out, and accurate judgment and accurate adjustment of sleeping postures are achieved.

A headpiece including a housing, a headpiece magnet carried by the housing, and a headpiece antenna carried by the housing.

The invention provides an artificial cochlea in-vitro machine and an artificial cochlea system. The artificial cochlea in-vitro machine comprises a first in-vitro machine and a second in-vitro machine, the first extracorporeal machine is configured to perform LE Audio broadcast to wait for connection of a playing device; after the first external machine is connected with the playing device, the second external machine sends the broadcast information to the second external machine after receiving a command for transmitting the broadcast information from the playing device; and the first extracorporeal machine and the second extracorporeal machine synchronize to periodic broadcasts sent by the playing device based on the broadcast information, obtain corresponding broadcast isochronous streams, and synchronously play the broadcasts. According to the configuration, power consumption and delay are reduced based on LE Audio transmission. Furthermore, the first extracorporeal machine and the second extracorporeal machine can synchronously acquire the broadcast isochronous stream and synchronously play the broadcast, so that the left and right ear sides can receive the audio played by the playing device at the same time.

Presented herein are techniques for dynamically generating test materials for implementing speech test to, for example, hearing aid users or users of cochlear implants. Dynamic word list generation techniques are disclosed. Such techniques generate word lists with qualities intended to implement specific speech tests. For example, the disclosed techniques may be used to generate word lists with predetermined phonetic balance and / or perceptual balance. The disclosed techniques also provide for the generation of audio signals associated with the word lists used during the speech tests.

The application discloses a cochlear implant multi-channel stimulation pulse half-wave detection system and method, and relates to the technical field of cochlear implants, in particular to a cochlear implant multi-channel stimulation pulse half-wave detection system and method. The system comprises a test board, a head piece and a speech processor, and further comprises a half-wave detection unit and a multi-channel collector. The test board comprises a receiving coil, a stimulator, a stimulation electrode and a test electrode terminal. The speech processor receives and processes sound signals and encodes the sound signals. The encoded signals are transmitted to the receiving coil through the head piece. After decoding processing by the stimulator, pulse signals with corresponding frequencies and current intensities are generated and transmitted to each stimulation electrode. The stimulation electrode is connected to the test electrode terminal. The test electrode terminal is connected to the multi-channel collector. The multi-channel collector is connected to the half-wave detection unit. The multi-channel collector combines n stimulation electrodes to transmit signals to the half-wave detection unit for half-wave detection. The application utilizes the multi-channel collector and the half-wave detection unit to realize automatic half-wave detection, reduce labor costs, and improve the efficiency and success rate of half-wave detection.

The invention discloses a pharmaceutical composition and application thereof in preparation of a medicine for treating sudden deafness, pharmacodynamic data shows that all components of the composition have a synergistic effect, the solubility and bioavailability of the composition in water can be remarkably improved, and the pharmaceutical composition can be used for treating sudden deafness. Through an oral administration mode, the hearing threshold of cochlear ischemia reperfusion model animals can be remarkably reduced, release of inflammatory factors such as serum IL-1beta and TNF-alpha is inhibited, oxidative stress is relieved (the malondialdehyde level is reduced), so that multi-target synergistic treatment of sudden deafness is realized, the effect is remarkable, the defects that an existing drug is single in target and inconvenient to administrate are overcome, and the application prospect is wide. The important clinical application value is realized.

The invention discloses an agricultural machinery equipment driving motor fault diagnosis method and system based on signal collaborative analysis, and belongs to the technical field of bearing fault diagnos.The method comprises the steps that a motor vibration signal is subjected to multi-stage preprocessing, the vibration signal is converted into a cochlea graph, and the preprocessed cochlea graph is obtained through preprocessing; calculating an auditory saliency map by counting effective values in the cochlea by adopting a self-adaptive cochlea saliency feature extraction method from the preprocessed cochlea to obtain a saliency feature cochlea; extracting channel level and frame level features based on the significant feature cochlea and fusing the channel level and frame level features to obtain multi-scale fusion features; and forming a fusion feature dictionary through the label samples based on the multi-scale fusion features, performing sparse representation on the test samples by using the constructed dictionary, and realizing fault diagnosis of the agricultural machinery equipment driving motor based on the sparse representation. The method has excellent diagnosis performance in a strong noise environment and a variable speed working condition, and the diagnosis robustness is remarkably improved.

The embodiment of the invention provides a cochlea object description method and system, equipment, a storage medium and a program product, and the method comprises the steps: extracting a region-of-interest image of a cochlea object from a medical image comprising the cochlea object, carrying out the segmentation of the cochlea object, obtaining a segmentation result of the cochlea object, and carrying out the segmentation of the cochlea object according to a plurality of preset radiomics feature types, respectively extracting corresponding radiomics features from the region-of-interest image, obtaining voxels of the cochlea object from the segmentation result, calculating respectively corresponding morphological parameter values based on voxel coordinates of the voxels of the cochlea object according to a plurality of preset morphological parameters, and determining the cochlea object according to the plurality of preset morphological parameters and the plurality of morphological parameter values based on the plurality of radiomics features and the plurality of morphological parameter values. A description data set of the cochlea object is constructed to describe the cochlea object using the plurality of radiomics features and the plurality of morphological parameter values. According to the scheme provided by the embodiment of the invention, the comprehensiveness and accuracy of description aiming at the cochlea are improved.

A cochlear and / or vestibular cell-specific promoter and use thereof, and specifically relates to specific promoters STRC, Slc26a5, otof, Sox10, Ngfr 1, Ngfr 2, Dnah5 and use thereof in cochlear and / or vestibular cells. The nucleotide sequences of the specific promoters are shown as SEQ ID Nos: 1, 6, 11, 16, 21, 26, 31, respectively. A recombinant vector comprising the specific promoters. Based on the fact that the promoters are characterized by specific expression in the cochlea and / or vestibule, the use of the tissue-specific promoters, an amplification primer, the recombinant vector or a pharmaceutical composition in gene therapies, construction of related animal models, pathogenesis-related studies, and the like for hearing-related diseases is provided.

To provide a system for diagnosing cochlear hydrops of a person or an animal.SOLUTION: The system comprises an acoustic stimulus generating unit comprising a stimulus generator and an output transducer, where the acoustic stimulus generating unit is configured to provide an audio stimulus by the stimulus generator to at least one of ears of a person or animal via the output transducer, wherein the acoustic stimulus generating unit is configured to provide a plurality of audio stimuli comprising at least a first click audio stimulus and at least a first chirp audio stimulus, or at least a first and a second chirp audio stimuli, a recording unit configured to record one or more auditory electrophysiological response of the person or animal in response to one or more audio stimuli being provided by the acoustic stimulus generating unit to at least one of the ears of the person or animal, and a diagnostic unit configured to process a recorded ABR.SELECTED DRAWING: Figure 1

An exemplary system comprises memory that stores instructions and a processor communicatively coupled to the memory and configured to execute the instructions to perform a process. The process may comprise obtaining a pre-operative audiogram of a recipient, the pre-operative audiogram generated prior to a lead insertion procedure during which an electrode lead having a plurality of electrodes is inserted into a cochlea of the recipient, obtaining one or more attributes associated with the lead insertion procedure, and determining, based on the pre-operative audiogram and the one or more attributes, one or more stimulation frequencies for stimulation that is to be used during the lead insertion procedure to elicit evoked responses within the recipient, the evoked responses usable to monitor an insertion condition associated with the electrode lead.

Presented herein are techniques for monitoring a condition associated with a recipient of a medical device. A model is trained based on historical electrophysiological measurements associated with a recipient of a medical device over a period of time. One or more current electrophysiological measurements associated with the recipient of a medical device are obtained. A condition associated with the recipient is monitored based on the one or more current electrophysiological measurements and the model.

The embodiment of the invention provides acoustic output equipment. The acoustic output equipment comprises a shell; the bone conduction vibrator is used for generating bone conduction sound waves and transmitting the sound waves to the cochlea through the shell to generate sound; the air conduction oscillator is used for generating air conduction sound waves, and the air conduction sound waves are transmitted to the ear parts through sound conduction holes in the shell; the signal processing module is used for providing a first audio signal and a second audio signal for the bone conduction oscillator and the air conduction oscillator respectively, the first audio signal and the second audio signal are provided with frequency division points, and the first audio signal and the second audio signal respectively comprise components with frequencies above and below the frequency division points, the bone conduction oscillator has a first harmonic peak at a first resonant frequency, the air conduction oscillator has a second harmonic peak at a second resonant frequency, and the frequency division point is larger than the first resonant frequency and the second resonant frequency.

The application provides an auditory bionic voiceprint recognition method and device, electronic equipment and a storage medium. The auditory bionic voiceprint recognition method comprises the following steps: obtaining a to-be-recognized voice signal, and performing cutting processing on the to-be-recognized voice signal to obtain a plurality of to-be-recognized voice segments; inputting each to-be-recognized voice segment into a cochlea bionic filter to obtain a voice frequency feature; inputting the voice frequency feature into a pre-trained voiceprint recognition model to obtain a voiceprint recognition result; and the voiceprint recognition model is obtained based on a cochlea nucleus bionic network. The cochlea bionic filter and the voiceprint recognition model provided by the application have higher adaptability to noise and complex environments, thereby improving the reliability and efficiency of voiceprint recognition.

The invention discloses a curcumin-loaded targeted cell membrane derived vesicle delivery system and application thereof, and belongs to the field of biological medicine. The invention relates to a curcumin-loaded targeted cell membrane derived vesicle delivery system, which comprises a cell membrane vesicle; the IETP2 ear-targeted polypeptide is modified on the surface of the cell membrane vesicle; and the curcumin is encapsulated in the cell membrane vesicles. Compared with the prior art, the curcumin has the advantages that the curcumin is systematically illuminated for the first time to improve the mitochondrial function and inhibit oxidative stress and apoptosis to prevent and treat the drug-induced deafness by regulating cAMP / PKA / CREB pathways; the cell membrane derived vesicles modified by the IETP2 polypeptide are used as a targeted delivery system of curcumin, and accumulation of drugs in cochlea is remarkably improved; an animal model verifies that the delivery system has a stronger hearing protection effect and better biological safety compared with free curcumin.

The present application relates to a system for diagnosing cochlear hydrops of a person or an animal. The system comprises an acoustic stimulus generating unit comprising a stimulus generator and an output transducer, where the acoustic stimulus generating unit is configured to provide an audio stimulus by the stimulus generator to at least one of the ears of the person or animal via the output transducer, wherein the acoustic stimulus generating unit is configured to provide a plurality of audio stimuli comprising at least a first click audio stimulus and a first chirp audio stimulus or at least a first and a second chirp audio stimuli, a recording unit configured to record one or more auditory electrophysiological response of the person or animal in response to the one or more audio stimulus being provided by the acoustic stimulus generating unit to at least one of the ears of the person or animal, and a diagnostic unit configured to process the recorded ABR.

The invention relates to a single-source-domain generalization motor fault diagnosis method, system and device based on cochlea perception enhancement and parameter space integration and a medium, and the method comprises the steps: carrying out the multiband modal decomposition of an original vibration signal, and generating a two-dimensional time-frequency image through the combination of Mel frequency mapping; disturbance is applied to a frequency domain amplitude spectrum of the two-dimensional time-frequency image, a phase spectrum is kept unchanged, and an enhanced image is generated through time domain reconstruction and dynamic range normalization; constructing a fault diagnosis model, inputting the two-dimensional time-frequency image into a main branch for fault feature modeling, and inputting an enhanced image into an auxiliary branch to learn potential features so as to update parameters of the auxiliary branch; parameters of the auxiliary branch are obtained through periodic snapshot sampling and fused to the main branch to form a fault diagnosis model. The robustness and generalization ability of a single-source domain fault diagnosis model are improved through the synergistic effect of signal representation optimization inspired by biological perception, physical consistency disturbance enhancement and a double-branch progressive knowledge fusion mechanism.

According to one embodiment, a method, computer system, and computer program product for performing in-situ stimulation adjustments of a cochlear implant. The embodiment may include identifying, dynamically, a first set of magnetic coils and a second set of magnetic coils based on dominant frequency components of a received sound. The first set and the second set are implanted within a cochlea of a user having a cochlear implant (CI). The embodiment may include activating, according to a stimulator profile of the user, the first set via an electric current sent to the first set in order to stimulate cochlear neurons. The embodiment may include determining that an in-situ adjustment to the activation of the first set is required based on analysis of a cochlear neuronal response recorded via the second set. The embodiment may include adjusting the stimulator profile.

The utility model discloses an artificial cochlea quadrant sub-control electrode which comprises a flexible electrode tip and a colloidal silica body, the flexible electrode tip is located at one end of the colloidal silica body, the artificial cochlea quadrant sub-control electrode further comprises a sub-control electrode array group located on the colloidal silica body, and the sub-control electrode array group comprises four quadrant contact electrodes. The four quadrant contact electrodes surround the silica gel body by one circle, and the directions of the four quadrant contact electrodes are different; each quadrant contact electrode can work independently; the quadrant sub-control electrode provided by the utility model can solve the problem of potential ineffective or inefficient stimulation caused by fixed unidirectional discharge of the existing artificial cochlea, and further optimizes the sound hearing effect of an implanter.

The utility model relates to the field of medical machinery auxiliary equipment, and particularly discloses a cochlea post-operation head supporting frame which comprises a supporting mechanism, the supporting mechanism comprises a neck pillow seat, a cotton cushion is installed on the outer side wall of the neck pillow seat, and an air bag cushion is installed between the inner side wall of the cotton cushion and the outer side wall of the neck pillow seat. A sliding groove is formed in the left side wall of the neck pillow seat, a two-way screw rod is installed in the sliding groove, two sliding blocks distributed front and back are in threaded connection with the outer side wall of the two-way screw rod, moving plates are installed on the left side walls of the two sliding blocks, and limiting grooves are formed in the left side walls of the moving plates; a movable rod is slidably connected into the limiting groove, so that the supporting plate is matched with the neck pillow base to support the head of a patient, the two hands of medical staff are liberated, the medical staff can conveniently use gauze to bind the wound position after the cochlea operation, the problems of tube disengaging and cervical dislocation are avoided in the binding process, and use is convenient.

The invention discloses a method for separating cochlea related cells in situ based on a patch clamp system. The method comprises the following steps: contacting an electrode with a target single cell under a microscope, and carrying out in-situ grabbing on the target single cell through negative pressure adsorption; the target single cell and surrounding cells are kept in a connection state before in-situ grabbing; before the electrode approaches the target single cell, positive pressure is continuously applied, and when the electrode is in contact with the surface of the target single cell, the positive pressure is instantly stopped and switched to negative pressure. According to the method provided by the invention, high-quality cochlea related cells can be obtained in situ for deep sequencing analysis, and the method can be used for basic research and accurate diagnosis and treatment of clinical hearing impairment, and has a good application prospect.

A method and a system for one or more acoustically-evoked responses to acoustic stimulation to determine a frequency map, wherein the frequency map that associates respective frequencies of the acoustic stimulation to respective electrodes of an electrode array.

The sound output device 100 includes a housing 10, a bone conduction vibrator 11 that generates bone-conducted sound waves and transmits them to the cochlea through the housing 10 to generate sound, an air-conducted vibrator 12 that generates air-conducted sound waves and transmits them to the ear through a sound guide hole in the housing 10, and a processing module that supplies a first audio signal and a second audio signal to the bone conduction vibrator 11 and the air-conducted vibrator 12, respectively, where the first audio signal and the second audio signal have a crossover frequency and include frequency components above and below the crossover frequency, respectively, the crossover frequency being 600 Hz or higher. The device can effectively reduce the power consumption of the entire device, while achieving sufficient volume output and low sound leakage.

Provided is an expression cassette for expressing GJB2 protein, which comprises a cochlear supporting cell and cochlear lateral wall-specific promoter and a nucleic acid encoding GJB2 protein. Also provided is a recombinant adeno-associated viral vector, the genome of which comprises an expression cassette for expressing GJB2 protein inserted between two ITR sequences; and a combination of at least two recombinant adeno-associated viral vectors. The recombinant adeno-associated viral vector or combination thereof can be used for treating or preventing hearing loss associated with defects in the GJB2 gene.