The invention discloses a medicine for treating a stroke and a preparation method of the medicine, and belongs to the field of traditional Chinese medicines. The medicine disclosed by the invention comprises the following effective components: botrychiam ternatum, exocarpium benincasae, poncirus bark, radix scrophulariae, chestnut involucre, uncaria rhynchophylla, herba zephyranthis candidae, schizonepeta, farges fir cone, gastrodia elata, Indian bread hostwood, semen brassicae, alpinia japonica, cortex acanthopanacis, earthworm and benzoin. According to the medicine disclosed by the invention, the selected medicinal materials are appropriate in compatibility, are in complement each other, have the efficacies of clearing away heat and toxic materials, calming liver wind, dispelling wind, removing obstruction in the meridians, inducing resuscitation, refreshing, eliminating phlegm and repelling foulness, and are combined, so that the medicine effect can be through to the lesion position; and the medicine has the advantages of being fast in acting, high in recovery rate, free of a toxic or side effect, safe and convenient on treatment of the symptoms such as facial atrophy balance disorders, carotid plaque, microcirculation disturbance and a cerebrovascular accident caused by the stroke, and is low in price, easy to prepare, and worthy of wide popularization and application in clinical.