144 results about "Implantable Electrodes" patented technology

Disclosed herein are systems, devices, and methods for implanting electrodes within a cerebral vessel of a subject. For example, disclosed are various types of implantable electrode arrays, stents carrying electrode arrays, delivery devices for implantable electrode arrays, electrical interfaces for an implantable electrode array, connector lead cable assemblies for an implantable electrode array, and methods of delivering and deploying implantable electrode arrays.

At least some embodiments of the present disclosure are directed to systems and methods for managing sleep disordered breathing (e.g., obstructive sleep apnea) for a patient. A first implantable electrode delivers a first stimulation signal proximate to a first nerve of the patient to stimulate the first nerve and activate at least one first muscle for an upper airway dilation of the person. A second implantable electrode delivers a second stimulation signal proximate to a second nerve to stimulate the second nerve and activate at least one second muscle for a caudal tracheal traction for an upper airway of the person. A stimulation signal generator generates the first and second stimulation signals and coordinates the delivery of the first stimulation signal with the delivery of the second stimulation signal.

Disclosed are an implantable electrode, a stimulator and a control method therefor, an electronic device, and a storage medium. The implantable electrode comprises: a control module, the control module being configured to receive a gating instruction from a pulse generator and generate a switch control signal; an array switch, the array switch being configured to establish multiple gating channels according to the switch control signal; an electrode array module, the electrode array module comprising multiple contacts, each contact being configured to deliver electrical stimulation to a tissue in a patient via the gating channels established by the array switch, or collect physiological signals from a tissue in a patient. The switch control signal is used to isolate the stimulation contacts from the collection contacts.

The invention discloses a magnetic resonance compatible implantable electrode wire with a shunt head end structure and medical equipment. An electrode head section comprises a spiral electrode electrically connected with an inner wire body and a ring electrode electrically connected with an outer wire body; the spiral electrode and the ring electrode transmit an electric signal sent by the implanted medical device to a targeted treatment part to be electrically stimulated; the spiral electrode comprises a spiral structure; the spiral structure is a multi-turn equidistant spiral structure, and under the action of a high-frequency energy field, the spiral structure can serve as a series inductor to generate large impedance so as to reduce induction current flowing to the spiral electrode and human tissue, and therefore electrode heating is reduced. The structure of the electrode tip section is improved, and the problems that electromagnetic field energy is coupled, eddy current and induction current are formed, induction heating is generated, and even wrong electric pulse signals are transmitted to a human body on the implantable medical device, so that adverse effects are generated on the safety of a patient are effectively solved.

At least some embodiments of the present disclosure are directed to systems and methods for managing sleep disordered breathing (e.g., obstructive sleep apnea) for a patient. An implantable electrode delivers a stimulation signal proximate to a nerve of the patient to stimulate the nerve and activate at least one muscle associated with an airway of the person. A controller generates a set of predicted stimulation settings for the stimulation signal using a trained machine learning model and provides the set of predicted stimulation settings to the stimulation signal generator.

An example method for electrically stimulating a subject includes creating a plurality of circuits using an implantable electrode placed within a subject, transmitting a signal at a first frequency through a first circuit of the plurality of circuits, and generating a first electric field, and transmitting a signal of a second frequency through a second circuit of the plurality of circuits, and the second circuit generating a second electric field. The implantable electrode is placed in a substantially linear configuration along a same axis such that the first electric field and the second electric field are in an axially biased configuration, and the first electric field and the second electric field interfere with each other in an overlapping region to produce a beat signal.

The invention discloses injectable and degradable composite drug-loading hydrogel as well as a preparation method and application thereof. The injectable and degradable composite drug-loading hydrogel comprises sodium alginate hydrogel, piezoelectric nanofibers and triamcinolone acetonide and / or ropivacaine, wherein the piezoelectric nanofibers and the triamcinolone acetonide and / or the ropivacaine are loaded on the sodium alginate hydrogel; the piezoelectric nanofibers are poly-L-lactic acid nanofibers. Through the synergistic effect of controllable release of the medicine and piezoelectric stimulation, the dual effects of continuous analgesia and neural restoration are achieved in the PHN treatment process, more effective treatment selection is provided for a PHN patient, complications caused by a traditional implantable electrode can be avoided, a more minimally invasive, convenient and safe treatment mode can be provided for the patient, and the treatment effect is good. And a theoretical basis is provided for future clinical practice.

The invention provides an electroencephalogram synchronous acquisition system compatible with nuclear magnetic resonance. The problem of interference of traditional equipment in a strong magnetic field environment is solved through innovative material selection and structural design. According to the system, a platinum-iridium alloy multi-contact implantable electrode probe is adopted and is matched with a nuclear magnetism compatible electrode wire formed by a silver-plated copper wire core body and a silver-plated nylon shielding layer, so that indoor and outdoor long-distance signal transmission of MRI (Magnetic Resonance Imaging) is realized. The signal acquisition and processing unit integrates a non-magnetic ceramic packaging pre-amplifier and an optical fiber isolation transmission data acquisition card, and is matched with a fan-free design computer, so that the influence of a magnetic field on signal processing is thoroughly avoided. According to the scheme, real-time electroencephalogram monitoring in experimental animal task state functional nuclear magnetism is supported, experiments prove that the signal-to-noise ratio is reduced by 30% or above, the distortion rate is controlled to be 2% or below, the advantages of high biocompatibility, low cost and operability are achieved, and the accuracy and reliability of scientific research data collection are remarkably improved.

The utility model relates to the technical field of nerve stimulation, and discloses an electrode contact, an implantable electrode and a nerve stimulation system. The electrode contact comprises a plurality of contact surfaces, each contact surface can independently serve as a stimulation source, and at least two contact surfaces in the plurality of contact surfaces face different directions, so that the electrode contact has a plurality of stimulation directions. According to the electrode contact scheme provided by the embodiment of the utility model, more stimulation directions can be provided, and the effectiveness and accuracy of nerve stimulation can be improved.

This document discusses a neurostimulation device to monitor electrical neural activity when connected to implantable electrodes. The neurostimulation device includes a sensing circuit configured to sense sensing a local field potential (LFP) signal of a patient when connected to implantable electrodes and signal processing circuitry operatively coupled to the sensing circuit. The signal processing circuitry is configured to compute a power spectral density (PSD) of the sensed LFP signal, compute a slope of the PSD of the sensed LFP signal, and determine a physiological state of the patient using the computed slope of the PSD of the sensed LFP signal.

The present disclosure relates generally to the field of neurological disease treatment, and in particular to devices and methods for treating neurological diseases based on adaptive stimulation, and methods for controlling such devices. In particular, the present disclosure relates generally to a neurological disease adaptive treatment device (10) including an implantable electrode (11) configured to sense neural activity signals and apply electrical stimulation signals, and a processing and stimulation unit (14) connected to the implantable electrode (11). The processing and stimulation unit includes at least a stimulation module (16) configured to generate a stimulation signal delivered by the implantable electrode (11), the stimulation signal characterized by at least one stimulation parameter, an acquisition module (20) configured to record a neural activity signal record of the neural activity signal sensed by the implantable electrode, and a processing module (18). The processing module (18) is configured to process the neural activity signal recordings recorded by the acquisition module (20) based on a first control logic (22) and adjust at least one stimulation parameter (A) based on the at least one neural activity signal recording processed according to the first control logic (22), the first control logic being a function dependent on at least one signal feature (Fi) of the neural activity signal recordings and composed of a plurality of different function elements based on at least one control parameter (Cj), each function element of the plurality of different function elements being associated with a respective range of the at least one signal feature (Fi), and the processing module (18) is configured to process the neural activity signal recordings recorded by the acquisition module (20) based on a second control logic (23) and adjust the at least one control parameter (Cj) of the first control logic (22) based on the at least one neural activity signal recording processed according to the second control logic (23).

The present invention belongs to the field of brain-computer interface, and specifically relates to an ECoG electrode and a preparation method thereof. The implantable electrode of the present invention includes a flexible support layer, an electrode metal layer and a packaging layer, wherein the electrode metal layer includes an electrode contact array area, a pad area and a conductive wire; the electrode contact array area contains one or more electrode contacts, and the pad area contains one or more solder joints; each of the electrode contacts and a corresponding solder joint is connected by a conductive wire to form a connection path, and different connection paths are electrically isolated from each other. The present invention sets different materials on the exposed surfaces of the electrode contacts and solder joints, so that different materials can give full play to their respective advantages, which not only optimizes the electrode performance, but also helps to maintain the consistency of signal transmission. At the same time, the manufacturing process required for the electrode is also relatively simple, the cost is lower, and it is also more environmentally friendly.

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

At least some embodiments of the present disclosure are directed to systems and methods for managing sleep disordered breathing (e.g., obstructive sleep apnea) for a patient. A first implantable electrode delivers a first stimulation signal proximate to a first nerve of the patient to stimulate the first nerve and activate at least one first muscle for an upper airway dilation of the person. A second implantable electrode delivers a second stimulation signal proximate to a second nerve to stimulate the second nerve and activate at least one second muscle for a caudal tracheal traction for an upper airway of the person. A stimulation signal generator generates the first and second stimulation signals and coordinates the delivery of the first stimulation signal with the delivery of the second stimulation signal.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.

Electrical stimulation devices can be used to treat tinnitus. For example, tinnitus can be treated using implantable electrodes and stimulation devices for delivering electrical stimulation to a patient's cochlear region, such as the cochlear promontory. Intraosseous cochlear promontory electrode(s), endosteal electrode(s), subendosteal electrode(s), or short intracochlear electrode(s) (or a combination thereof), connected to a cochlear implant receiver / stimulator device, can provide a successful model for long-term treatment of tinnitus in a large number of patients. In some cases, patients can simply turn on the tinnitus implant when experiencing troublesome tinnitus and gain instant relief.

The embodiment of the invention discloses a testing device. The testing device comprises a cable, a connecting assembly and a stimulating assembly which are connected in sequence. Wherein the connecting assembly is provided with a limiting groove for limiting and fixing the implantable electrode, a plurality of conductive elastic sheets in conductive connection with the cable are arranged in the limiting groove, and the conductive elastic sheets are used for being detachably and electrically connected with a wire of the implantable electrode, so that the implanted implantable electrode is tested. The stimulation assembly is provided with a conductive probe electrically connected with the cable, and can apply a test electric signal to the nervous tissue to carry out a stimulation reaction test, thereby assisting in accurately confirming the position of the target spot. According to the testing device, the electrode testing function and the nerve stimulation testing function are integrated into a single device, the structure is compact, operation is visual, and the accuracy, smoothness and convenience of an operation are remarkably improved.

The utility model provides a connector, an implantable electrode piece using the connector, an electrode assembly and an implantation device, the connector is used for being connected with the implantable electrode piece and comprises an insulation main body and a conductive terminal connected with the insulation main body; the conductive terminals extend along a first direction and are connected with the insulating main body, so that the electrode piece can be vertically connected with the conductive terminals along a second direction, and the first direction is different from the second direction. According to the connector, the implantable electrode piece using the connector, the electrode assembly and the implantation device, the circuit stability can be effectively improved, and the service life of the electrode is prolonged.

The application provides a connector, an implantable electrode member using the connector, an electrode assembly, an implantable device and a preparation method thereof. The connector is used for connecting with an implantable electrode member and comprises an insulating body and a conductive terminal connected with the insulating body. The conductive terminal extends along a first direction and is connected with the insulating body, so that the electrode member can be connected with the conductive terminal in a vertical type along a second direction, and the first direction is different from the second direction. The connector, the implantable electrode member using the connector, the electrode assembly, the implantable device and the preparation method thereof can effectively improve circuit stability and prolong the service life of the electrode.

This utility model relates to the field of medical devices, and more particularly to an MRI-compatible implantable electrode lead and implantable medical device. The implantable electrode lead includes: a conductive core, which may be single-core or multi-core; an insulating layer covering the conductive core; and a shielding layer covering or embedded within the insulating layer. The shielding layer has a mesh structure and is braided from conductive wires with curved sections. This utility model provides a mesh shielding layer made of a biocompatible, electrically conductive material outside the implantable electrode lead. This shielding layer can shield magnetic fields to prevent the internally protected conductive core from overheating, thereby ensuring the safety of the implantable electrode lead during MRI scanning. Furthermore, the shielding layer has a certain degree of elasticity to accommodate the elastic conductor core.

1. The name of the design product: implantable electrode device. 2. The use of the design product: the design product is used for intracranial tumor electric field therapy. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view. 5. The rear view is the same as the front view, and the rear view is omitted; the left view is the same as the front view, and the left view is omitted; the right view is the same as the front view, and the right view is omitted.

The present invention relates to a deep brain electrical stimulation system, and more particularly to a neural electrical stimulation system capable of being equipped with multiple electrodes, comprising a pulse generator, an extension wire, an electrode, and a fixing device, wherein the pulse generator is a multi-channel, multi-contact pulse generator, the extension wire is connected to the multi-channel, multi-contact pulse generator via contacts, the electrode is connected to the extension wire, and the fixing device is used to fix the electrode during use. The electrical stimulation system of the present invention can adjust the matching relationship between the number of pulse contacts and the number of electrodes according to the requirements of system precision, thereby achieving multi-channel, multi-pulse electrical stimulation output; the present invention also adjusts the structure of the extension wire so that, while the number of pulse contacts remains unchanged, more electrodes can be added as needed, thereby meeting the requirements of more complex electrode stimulation.

The invention discloses a magnetic resonance compatible implantable electrode wire with an artifact weakening structure and medical equipment, an electrode tip section of the electrode wire is provided with a ring electrode, and one end, far away from a spiral electrode, of an outer wire body is nested on the outer peripheral wall of an outer wire body supporting section of the ring electrode; an inner hole of a contact ring of the ring electrode is fixed with the outer wall of the position, far away from the spiral electrode, of the electrode insulating part, so that an integral insulating structure of the ring electrode and the outer wire body to the internal conductor is formed; the position of the electrode insulator close to the spiral electrode is fixed with the inner hole surface of the rear section of the electrode sleeve; a medicine plug is arranged at the position, close to the spiral electrode, of the electrode sleeve; the ring electrode is provided with a hollow thin wall, and magnetic flux holes distributed in the circumferential direction and / or the axial direction of the ring electrode are formed in the ring electrode. The magnetic flux holes are formed in the ring electrode or other metal parts, the overall artifact area of the metal part is reduced, self heating of the metal part is reduced, and meanwhile the heat dissipation effect of the wire is enhanced through the magnetic flux holes.

The invention discloses an implantable electrode and a system for treating hypertension by adopting the same. The implantable electrode for treating hypertension comprises a catheter, a stimulating electrode slice, a guide wire and an insulating film, the two stimulating electrode plates are arranged on the two sides of the exterior of the catheter respectively, are connected with the exterior through guide wires arranged in the catheter respectively and are used for emitting current to stimulate nerves according to external signals; one end of the insulating film is arranged outside the catheter and located between the two stimulating electrode slices and used for wrapping the stimulating electrode slices making contact with the nerves and the outside of the nerves so that the stimulating electrode slices can be insulated from the outside. The invention discloses a system for treating hypertension by adopting an implantable electrode. The system comprises an implantable electrical stimulation device, a blood pressure monitoring device and a remote analysis monitoring platform. According to the implantable electrode and the system for treating hypertension by adopting the implantable electrode disclosed by the invention, extremely low-intensity electrical stimulation is given to renal sympathetic nerve introduced nerve fibers in dorsal root nerves through the stimulation electrode to inhibit the activity of the nerve fibers, so that the blood pressure of a patient is kept relatively stable, and the risk of complications caused by blood pressure fluctuation is reduced; the medicine taking amount of a hypertensive patient can be greatly reduced, and even the hypertensive patient may stop taking hypertensive medicines.

An implantable medical device includes a plurality of implantable electrodes for sensing and pacing a heart of a patient. The plurality of electrodes includes cardiac conduction system electrodes positionable proximate a portion of a cardiac conduction system of a patient. A computing device includes processing circuitry and is operably coupled to a plurality of implantable electrodes. A computing device monitors a precardiac ejection (HS-PEP) of a heart of a patient. A change in the HS-PEP is determined based on the monitoring. A change in HS-PEP is determined to be greater than or equal to a specified threshold. Delivery of cardiac conduction system pacing therapy to the cardiac conduction system of the patient using the cardiac conduction system electrode is initiated based on the HS-PEP being greater than or equal to a specified threshold.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

In one example, a method includes selecting, by one or more processors and based on a sensed electrical signal representation for a particular patient and a plurality of sensed electrical signal representations for a plurality of other patients, an electrode combination from a plurality of combinations of one or more implantable electrodes for delivering electrical stimulation to the particular patient.

The present disclosure generally relates to the field of treatment of neurological disease, and in particular to devices for treating neurological diseases based on adaptive stimulation and to methods for controlling such devices. In detail, the present disclosure generally relates to a device (10) for adaptive treatment of neurological diseases comprising an implantable electrode (11) configured to sense neural activity signals and apply electrical stimulation signals, and a processing and stimulation unit (14) connected to the implantable electrode (11), wherein the processing and stimulation unit at least comprises: a stimulation module (16) configured to generate a stimulation signal to be carried at the implantable electrode (11), the stimulation signal being characterized by at least one stimulation parameter; an acquisition module (20) configured to record neural activity signal records of neural activity signals sensed by the implantable electrode; and a processing module (18) configured to process the neural activity signal records recorded by the acquisition module (20) based on a control logic (22) and to tune the at least one stimulation parameter (A) based on at least one neural activity signal record processed according to the control logic (22), the control logic being a function depending on at least one signal feature (Fi) of the neural activity signal records, being based on at least one control parameter (Cj) and being made of a plurality of function pieces, wherein each function piece of the plurality of function pieces is related to a respective range of the at least one signal feature (Fi), wherein the processing module (18) is further configured to process the neural activity signal records recorded by the acquisition module (20) based on an initializing logic (23,23') and / or to receive at least one neural activity signal record processed according to the initialization logic (23,23') and to initialize the at least one control parameter (Cj) of the control logic (22) based on at least one neural activity signal record processed according to the initializing logic (23); and wherein the initializing logic (23,23') is configured to extract at least one signal feature (Fi) form the neural activity signal records and to determine a distribution of the least one extracted signal feature (Fi) based on the number of times that the extracted signal feature (Fi) substantially reaches a given value of a plurality of given values or is comprised in a given range of a plurality of given ranges.

Presented herein is an electroporation shield configured to be removably coupled to an implantable stimulating assembly that includes one or more stimulation electrodes. The electroporation shield is coupled to stimulating assembly such that the electroporation shield electrically insulates the one or more of the stimulation electrodes from an electroporation electrical field generated by one or more electroporation electrodes coupled to the electroporation shield. The electroporation shield may be coupled to the stimulating assembly in a manner that facilitates removal of the electroporation shield and the one or more electroporation electrodes. After electroporation, without having to remove or reinsert the stimulating assembly, thereby exposing the one or more stimulation electrodes to the cells of the recipient for subsequent delivery of stimulation.