133 results about "Vagus nerve stimulation" patented technology

The invention belongs to the field of cerebral apoplexy rehabilitation training, and provides a cerebral apoplexy upper limb dynamic rehabilitation method and system based on vagus nerve electrical stimulation, the excitement degree of a cortical spinal cord pathway of a patient is measured and evaluated by using motor evoked potential to obtain a motor function evaluation result, and an initial rehabilitation training task is set according to the motor function evaluation result; the training motion intention of the patient is determined by monitoring the electroencephalogram signal and the electromyographic signal of the patient, and percutaneous ear vagus nerve electrical stimulation is triggered; after percutaneous ear vagus nerve electrical stimulation, performing rehabilitation training analysis on basic clinical characteristics and multi-modal signals of the patient to determine intermuscular coordination, brain region connectivity and brain muscle coupling of the patient; the training condition of the patient is evaluated according to the rehabilitation training analysis result, and parameters of percutaneous ear vagus nerve electrical stimulation and training tasks are adjusted based on the evaluation result for iterative rehabilitation training; and stopping iteration until the rehabilitation training analysis result of the patient reaches a preset standard, and completing rehabilitation training.

The invention relates to the technical field of biomedical engineering and neuroscience, and discloses an in-ear vagus nerve stimulation control method, system and device based on scalp electroencephalography, and the method comprises the steps: collecting a scalp electroencephalogram signal, a body movement signal and a pulse signal of a to-be-detected user; performing preprocessing and frequency domain separation on the signal; calculating a sleep coupling score, and dividing a physiological state according to the sleep coupling score; dynamically adjusting the intensity and frequency of intra-ear vagus nerve stimulation of the user according to the physiological state, and generating feedback data; in-ear vagus nerve stimulation is performed and the dynamic adjustment parameters are updated based on the feedback data. According to the method, accurate sleep recognition is realized through multi-source signal parallel processing and SCS modeling, and the classification precision is remarkably improved; lSTM prediction and biphase modulation are combined to optimize stimulation parameters, sleep time is shortened, and side effects are reduced; a GPU acceleration and low-power-consumption framework is adopted, and efficient self-adaptive closed-loop regulation and control are achieved.

The invention discloses percutaneous nerve field vagus nerve stimulation diagnosis and treatment equipment and a diagnosis and treatment method thereof, and particularly relates to the technical field of neuromedicine, intelligent medical equipment and multi-mode physical therapy. The equipment comprises a neural signal acquisition module, a nerve positioning module, a data processing and analysis module, a treatment execution module and a diagnosis result output module; the system is further provided with a battery power management module, a self-adaptive closed-loop cloud platform and a wearable fixing device, by collecting bioelectricity signals, light absorptivity and temperature data of an ear nerve area, ear target cranial nerve branches are positioned, a dynamic diagnosis map is constructed, and a diagnosis result and personalized treatment parameters are generated. Electric pulse, near-infrared light and local thermal therapy multi-mode collaborative stimulation is adopted for treatment, and parameters are monitored and adjusted in real time through a cloud platform. According to the invention, accurate diagnosis and personalized treatment can be realized, the medical efficiency and the treatment effect are improved, and an effective means is provided for nerve disease diagnosis and treatment and pain relief.

Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and / or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.

A patient management system can include an implantable neurostimulation device configured to deliver vagus nerve stimulation (VNS) therapy to a patient and a non-invasive, external monitoring device comprising at least one sensor for detecting indicators of seizure or depression in the patient. In an example, the external monitoring device is configured to use information from the at least one sensor to detect a seizure event or a seizure precursor event, audibly ask questions of the patient and / or provide behavioral modification commands to the patient, and / or control the neurostimulation device to deliver the VNS therapy to the patient in response to a detected seizure event, seizure precursor event, or progression of depression symptoms.

The embodiment of the invention relates to the field of intelligent wearable equipment, in particular to intelligent ear vagus nerve regulation and control glasses and a control method, control device and regulation and control system thereof, and the method comprises the following steps: acquiring pupil dynamic characteristic parameters monitored by the intelligent ear vagus nerve regulation and control glasses; calling a trained machine learning model to analyze real-time physiological state information according to the pupil dynamic characteristic parameters; according to the real-time physiological state information obtained through analysis, generating an electrical stimulation control instruction corresponding to the real-time physiological state information; and controlling an ear vagus electrode in the intelligent ear vagus nerve regulation and control glasses to implement nerve regulation based on the electrical stimulation control instruction. According to the method, the limitation of fixed parameter output of a traditional ear vagus nerve stimulation device can be broken through, the individualization and accuracy of an ear vagus nerve stimulation scheme are improved, and the problem that the treatment effect is insufficient or discomfort is caused is solved.

Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and / or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and / or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

The invention discloses a treatment monitoring method and system for a percutaneous ear vagus nerve stimulation device, and the method comprises the steps: carrying out the multi-source treatment situation monitoring of a target user in a treatment course, obtaining the multi-source treatment situation monitoring data, and constructing a multi-mode treatment situation feature; real-time treatment situation analysis is carried out according to the multi-mode treatment situation features, and real-time treatment situation analysis information is generated; performing dynamic state classification based on the real-time treatment situation analysis information, evaluating the treatment condition of the target user in the current treatment course, and generating a treatment regulation and control scheme to perform treatment management and control on the current treatment course when an abnormal treatment condition exists; and constructing a treatment situation prediction model, obtaining the regulated and controlled multi-mode treatment situation characteristics, generating a floating regulation and control boundary in combination with the treatment situation prediction model, and dynamically correcting the diagnosis and treatment regulation and control scheme by using the floating regulation and control boundary to ensure the curative effect and treatment safety. The treatment effect can be accurately perceived; and the treatment safety is ensured.

A vagus nerve stimulation system for stimulating a vagus nerve in a biological subject, the system including a clip configured to be attached to a tragus of the subject, the clip including opposing arms configured so that a distal end of the arms are biased towards each other and electrodes positioned proximate a distal end of the arms on opposing faces so that the electrodes are urged into engagement with opposing faces of the tragus and a signal generator electrically connected to the electrodes, the signal generator being configured to generate at least one therapy signal that is applied to the vagus nerve within the tragus via the electrodes, to thereby modulate the vagus nerve.

The utility model discloses an ear hook type ear walking stimulator, relates to ear walking stimulator technical field, including stimulator main part and blood oxygen detection bracelet, stimulator main part is composed of ear hook, electrode seat and host casing, the back side of electrode seat is inlayed with two electrode slice that distributes up and down, the host casing is equipped with control chip inside, the control chip is equipped with the control chip, the control chip is equipped with the control chip. The electrode plate is electrically connected with the control chip, the front side of the control chip is electrically connected with a Bluetooth module, and the control chip is wirelessly connected with the blood oxygen detection bracelet through the Bluetooth module; the stimulator body is designed to be in an ear hanging type, the control chip in the stimulator body is further in wireless connection with the blood oxygen detection bracelet through the Bluetooth module to be used in a matched mode, the blood oxygen value of a user is detected through the blood oxygen detection bracelet, and when the blood oxygen value is reduced to exceed%, an electrode slice on the stimulator body immediately conducts ear vagus nerve stimulation; and the device can be used in a self-stimulation manner according to self conditions, so that the device is very convenient to use.

The invention relates to the technical field of medical instruments, in particular to a multi-mode biological feedback ear vagus nerve self-adaptive stimulation device and method.The device comprises a host, a stimulation electrode, a signal collection bracelet and an electroencephalogram collection module, and the host comprises core hardware configuration and a power management system; the signal acquisition bracelet comprises an ECG module, a PPG module, a GSR module, a six-axis acceleration sensor and the like. The ear vagus nerve stimulation parameter can be dynamically adjusted through real-time analysis of multi-mode data such as electrocardio, electroencephalogram, heart rate variability, respiration-heart rate synchronism and emotional state, personalized precise treatment is achieved, meanwhile, the wearing comfort and the durability of the device are improved, and the application range is wide. The traditional Chinese medicine composition can be used for auxiliary treatment of various diseases such as inflammatory bowel disease, epilepsy, chronic insomnia, depression, chronic pain, anxiety disorder, post-traumatic stress disorder and autonomic nerve dysfunction, and the functions of a nervous system are adjusted and the symptoms of a patient are improved by accurately stimulating the vagus nerve in the auricular concha area.

An auricular electroencephalogram (EEG) monitoring system may include an EEG recording module having a plurality of EEG sensor electrodes, configured to be coupled to a wearer's ear, and a processing unit configured to analyze EEG data recorded by the EEG recording module to detect presence or cessation of neuropsychiatric disorders of the wearer. An automatic detection-remedy system may include an auricular electroencephalogram (EEG) monitoring system and a transcutaneous auricular vagus nerve stimulation (taVNS) unit having a stimulating electrode in contact with vagus innervated auricular skin of the wearer's ear. When the presence of EEG signals suggestive of the neuropsychiatric disorder is detected by the processing unit, the processing unit is configured to immediately send signals to the taVNS unit to automatically start sending pre-determined electric stimuli to the vagus innervated auricular skin of the wearer's ear.

The invention relates to the technical field of medical equipment, in particular to an intelligent closed-loop vagus nerve stimulation regulation and control method and system. The method comprises the following specific steps: collecting an electroencephalogram signal and a stimulation signal during real-time stimulation, and obtaining an electroencephalogram signal prediction value of future N steps through an ambulatory electroencephalogram signal prediction model; calculating a depression biomarker estimated value for representing the brain activity state at the next moment according to the electroencephalogram signal predicted values of the next N steps; calculating an optimal stimulation signal at the next time according to a difference value between the depression biomarker target value and the depression biomarker estimated value; and updating the stimulation signal according to the optimal stimulation signal to stimulate the vagus nerve, and updating the stimulation signal. Meanwhile, the invention discloses a system for executing the method, the optimal stimulation parameter is calculated according to the difference between the predicted brain activity state at the next moment and the target state, so that the neural activity is controlled, and the adjusting efficiency and the control precision of the percutaneous vagus nerve stimulation system are improved.

A method to treat a predetermined subject population diagnosed with Alzheimer's disease (AD), including: selecting subjects diagnosed with early AD or having at least one symptom of early AD, with a goal to improve a score of the subjects in an assessment scale in at least one point, wherein the assessment scale comprises at least one of, an Alzheimer's Disease Assessment Scale– Cognitive Subscale (ADAS-Cog) or variations thereof, and / or a Mini-Mental State Examination (MMSE) scale or variations thereof; delivering auricular VNS treatment to the subjects for a time period of at least one month; identifying an improvement of at least one point in the scale in the subjects following the delivering.

The invention relates to an ear walking electrical stimulator, which comprises a stimulation piece capable of being worn in an ear, and is characterized in that the stimulation piece comprises a main body, and a control module is arranged in the main body; the first electrode tip is connected to the main body, is in electric signal connection with the control module and is used for being placed at the auricular conchae position in a matched manner; the motor is fixed on the main body and is in electric signal connection with the control module; the second electrode tip is connected to the driving end of the motor, is in electric signal connection with the control module and is used for being placed in the ear hole in a matched mode. The invention further relates to a working method of the ear-walking electrical stimulator, when the stimulation piece is controlled to work, the motor is firstly controlled to work, so that the first part of the second electrode tip clings to the stimulation position in the ear hole and swings back and forth, and the cleaning work of the stimulation position in the ear hole is realized; then the motor is controlled to work to drive the second electrode tip to rotate, so that the second part of the second electrode tip rotates to cling to the stimulation position in the ear hole; and then the first electrode tip and the second electrode tip are controlled to work at the same time to carry out rosemary electrical stimulation work. According to the ear walking electrical stimulator and the working method thereof, dirt in ears can be effectively cleaned, and the vagus nerve stimulation effect is improved.

Wearable electrocardiogram (ECG) systems configured to record ECG from ears (auricular ECG systems), fingers (ear-finger or finger-finger ECG systems) or toes, comprising a processing unit configured to analyze the ECG data to detect serious cardiac arrhythmias or impending serious cardiac arrhythmia. Automatic anti-arrhythmia systems comprise one of the ECG systems and a transcutaneous auricular vagus nerve stimulation (taVNS) unit. When serious cardiac arrythmias are detected, the anti-arrhythmia systems may automatically send pre-determined electric stimuli to a vagus nerve to alleviate or stop the cardiac arrhythmias. The ECG electrodes and the stimulating electrode of the taVNS unit are located on a surface of a housing structure made of flexible elastic and adaptable material such that these electrodes will be naturally and snugly contacting the wearer's skin. These wearable ECG and anti-arrhythmia systems are suitable for easy self-installation, self-removal and daily ambulatory use.

The present application relates to the technical field of neuromodulation, and discloses a neuromodulation system and method for dual-task gated taVNS. The present application collects kinematic data and cognitive performance data of a patient performing a motor-cognitive dual task; obtains an objective maximum load paradigm according to the kinematic data and the cognitive performance data, obtains a subjective maximum load paradigm according to a subjective work load score, and combines the two to obtain a maximum intensity dual-task load paradigm; applies multiple trial dual-task training to the patient under the maximum intensity dual-task load paradigm, and in each trial, determines in real time whether to trigger transcutaneous auricular vagus nerve stimulation according to a dual-dimension gating condition, triggers to generate a stimulation signal when the cognitive correctness condition and the motor safety condition are both satisfied, and suspends the presentation of a new task during the stimulation duration. The present application realizes precise coupling of dual-task training and neuromodulation in the time dimension, and improves the timing specificity and individualization of neuromodulation.

The present application relates to the technical field of nerve stimulation, and discloses a closed-loop vagus nerve precise blocking system and method based on physiological signal feedback, comprising a physiological signal monitoring unit for acquiring physiological signals of an individual in real time; a data acquisition and analysis module connected with the physiological signal monitoring unit, for receiving and analyzing the physiological signals, judging the physiological state of the individual, and generating a feedback signal; a stimulation device unit for outputting an electric stimulation signal based on the feedback signal, so that the vagus nerve stimulation reaches a functional block state; and a closed-loop feedback unit connected with the data acquisition and analysis module and the stimulation device unit, for dynamically adjusting the stimulation parameters according to the feedback signal and controlling the electric stimulation signal of the stimulation device in real time. Through the real-time monitoring and real-time feedback mechanism, the present application realizes functional block of the vagus nerve, and ensures the accuracy, safety and individualization of the inhibition operation.

The telemedicine system includes a gateway for transmitting monitoring information including a stimulation signal and a biosignal corresponding to the stimulation signal to a cloud; and a server for extracting the stimulation signal and the biosignal from the transmitted monitoring information, providing the extracted stimulation signal and biosignal as inputs of a pre-stored artificial intelligence machine learning algorithm-based stimulation control model, regenerating the biosignal as an output of the stimulation control model into a stimulation signal to be regulated for the balance between sympathetic and parasympathetic nerves, and feeding back the regenerated stimulation signal to a personalized vagus nerve stimulation and pulse electromagnetic field treatment device.

The invention relates to an audio-electric cooperation ear vagus nerve stimulation method, earphone and system based on multi-mode disease information, and belongs to the technical field of vagus nerve stimulation, and the method comprises the steps: obtaining the disease information of a user; determining a disease type based on the disease information; determining a treatment scheme based on the disease type, wherein the treatment scheme comprises stimulation parameters of the electrical stimulation module and music to be played; and playing the to-be-played music by using the earphone, and controlling the electrical stimulation module to stimulate the ear vagus nerve based on the stimulation parameters. According to the invention, two adjusting modes of music and ear vagus nerve stimulation are combined, and the synergistic effect of the two adjusting modes is brought into full play, so that the effect of more efficient and accurate emotion and cognition adjustment is achieved.

A vagus nerve stimulation system for stimulating a vagus nerve in a biological subject, the system including a clip configured to be attached to a tragus of the subject, the clip including opposing arms configured so that a distal end of the arms are biased towards each other and electrodes positioned proximate a distal end of the arms on opposing faces so that the electrodes are urged into engagement with opposing faces of the tragus and a signal generator electrically connected to the electrodes, the signal generator being configured to generate at least one therapy signal that is applied to the vagus nerve within the tragus via the electrodes, to thereby modulate the vagus nerve.

A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.

The invention relates to an ear vagus nerve stimulation system which comprises an ear vagus nerve stimulator, terminal equipment and a background server. The ear vagus nerve stimulator is in communication connection with the terminal equipment and is used for applying current stimulation to the ear vagus nerve of a user, collecting a sign signal of the user and transmitting the sign signal to the terminal equipment; the terminal equipment is in communication connection with the background server and transmits the physical sign signals to the background server, and the background server generates music recommendation information and current stimulation parameters corresponding to music according to the physical sign signals and transmits the music recommendation information and the current stimulation parameters to the terminal equipment; and the terminal device controls the ear vagus nerve stimulator to play music according to the music recommendation information, and controls the ear vagus nerve stimulator to output current stimulation according to the current stimulation parameters corresponding to the music. The ear vagus nerve stimulation system overcomes the defects that an ear vagus nerve stimulation instrument is limited in stimulation waveform, single in stimulation mode, weak in pertinence, limited in earphone main body space and the like.

The invention relates to a hearing aid capable of being used for vagus nerve stimulation, which is characterized in that a supporting assembly is hung on the head of a user, at the moment, a first hearing aid is placed in one ear of the user for hearing aid, and a first electrode plate is attached to the vagus nerve part of one ear of the user. The second hearing aid is placed in the other ear of the user and used for hearing aid, and the second electrode plate is attached to the vagus nerve part of the other ear of the user. When the supporting assembly is worn, the first maintaining assembly and the second maintaining assembly are both converted from the unused state to the unused state, and at the moment, the supporting assembly is more firmly worn on the head of a user through the first maintaining assembly and the second maintaining assembly. And the first maintaining assembly and the second maintaining assembly can be switched from the use state to the non-use state by stretching the supporting assembly after a period of time, so that the situation that the first maintaining assembly and the second maintaining assembly extrude the same position of the head of the user for a long time is avoided.

The invention provides an ear vagus nerve stimulation device and system based on artificial intelligence control, and relates to the technical field of artificial intelligence and medical equipment, and the method comprises the steps: obtaining multi-source data of a corresponding tinnitus patient; preprocessing the multi-source data based on a statistical method to obtain preprocessed multi-source data; performing feature extraction on the preprocessed multi-source data based on a random forest feature selection algorithm to obtain corresponding key feature data; historical key feature data are obtained, a tinnitus prediction model and a treatment effect evaluation model are constructed based on a recurrent neural network and a long-short term memory network, and then a tinnitus prediction result and treatment effect evaluation are obtained; the tinnitus prediction model and the treatment effect evaluation model are optimized; based on the deep Q network of the reinforcement learning algorithm, according to the trained tinnitus prediction model and treatment effect evaluation model and the real-time data of the patient, a personalized treatment scheme is generated, then a stimulation parameter adjustment instruction is obtained, and the accuracy is improved.

Disclosed is apparatus for providing stimulation to an ear of a user. The apparatus has a body that is at least partly receivable into the ear canal. A plurality of electrodes are coupled to the body. The plurality of electrodes are positioned to contact surfaces of the ear. Methods and systems for applying one or more electrical pulses to an ear are also disclosed.

The invention discloses an ear vagus nerve stimulation system and ear stimulation equipment, and relates to the technical field of nerve stimulation, the ear vagus nerve stimulation system comprises a signal acquisition module, a central control module and an ear stimulation module, the signal acquisition module is used for synchronously acquiring EEG signals of F3, F4, C3, C4, O1 and O2 brain regions, and the central control module is used for synchronously acquiring EEG signals of F3, F4, C3, C4, O1 and O2 brain regions based on the EEG signals. The detection module is used for detecting whether a user enters an N2 sleep period or not by combining structure perception symbolic identification of filtering waveform characteristics, the ear stimulation module is used for responding to a sleep period identification result, and when it is detected that the user enters the N2 sleep period, an equipment starting instruction is sent out to stimulate vagus nerves in auricles and auricular conchae areas. Sleep staging can be recognized through the multi-brain-region electroencephalogram signals, it is ensured that stimulation pulses and neural oscillation rhythms are synchronous, the sleep staging accuracy is improved, auricular conchae cavity vagus nerve targeted stimulation is automatically triggered when N2-phase characteristics are recognized, and the synergistic effect of cognitive function repair and sleep quality improvement can be formed.

The invention relates to a neck vagus nerve stimulation device and a preparation method thereof. The neck vagus nerve stimulation device comprises a carrier sheet, an electrical stimulation generation module and a conductive adhesion part. The electrical stimulation generation module is used for generating electric pulses, and the conductive adhesion part is arranged on the carrier sheet and is electrically connected with the electrical stimulation generation module. Wherein the whole neck vagus nerve stimulation device is circular or approximately circular, and the conductive adhesion part is configured to be capable of adhering to the neck skin of the human body and serve as an electrode to stimulate the neck vagus nerve through the neck skin by means of the electric pulse generated by the electric stimulation generation module. Through the integrated design of the carrier sheet, the electrical stimulation generation module and the conductive adhesion part, the neck vagus nerve stimulation device is simplified into a light, thin and flexible patch which can be directly attached, and the portability, wearing comfort, use convenience and stimulation position stability of the device are greatly improved.

The invention discloses a taVNS and six-character table combined slow respiration training method, which comprises the following steps of: synchronously acquiring electrocardio and electromyographic signals of a user, analyzing heart rate variability (HRV) and respiratory electromyographic characteristics in real time, and dynamically judging a respiratory phase; parameters and target spots of ear vagus nerve stimulation (taVNS) are adjusted in a self-adaptive mode based on a breathing phase-target region mapping table, and closed-loop control is formed in combination with six-character table breathing training. The defects that a traditional open-loop taVNS system is fixed in stimulation parameter and poor in adaptability are overcome.