156 results about "Vagus nerve stimulation" patented technology

The invention belongs to the field of cerebral apoplexy rehabilitation training, and provides a cerebral apoplexy upper limb dynamic rehabilitation method and system based on vagus nerve electrical stimulation, the excitement degree of a cortical spinal cord pathway of a patient is measured and evaluated by using motor evoked potential to obtain a motor function evaluation result, and an initial rehabilitation training task is set according to the motor function evaluation result; the training motion intention of the patient is determined by monitoring the electroencephalogram signal and the electromyographic signal of the patient, and percutaneous ear vagus nerve electrical stimulation is triggered; after percutaneous ear vagus nerve electrical stimulation, performing rehabilitation training analysis on basic clinical characteristics and multi-modal signals of the patient to determine intermuscular coordination, brain region connectivity and brain muscle coupling of the patient; the training condition of the patient is evaluated according to the rehabilitation training analysis result, and parameters of percutaneous ear vagus nerve electrical stimulation and training tasks are adjusted based on the evaluation result for iterative rehabilitation training; and stopping iteration until the rehabilitation training analysis result of the patient reaches a preset standard, and completing rehabilitation training.

The invention discloses a vagus nerve stimulation parameter closed-loop adjustment method and system based on electroencephalogram characteristics. The method comprises the steps that real-time electroencephalogram signals of a patient are obtained, and time domain information and frequency domain information of the electroencephalogram signals of all frequency bands in the real-time electroencephalogram signals are extracted; on the basis of the time domain information and the frequency domain information of the electroencephalogram signals of all the frequency bands, electroencephalogram signal index features are calculated, and the electroencephalogram signal index features comprise an electroencephalogram signal power spectrum, a brain dynamic symmetry feature, a brain function connection feature and a rhythm feature; determining the state type of the patient according to the electroencephalogram signal index characteristics; determining parameter configuration information of vagus nerve stimulation according to the state type of the patient; and adjusting parameters of the vagus nerve electrical stimulation equipment according to the parameter configuration information of vagus nerve stimulation. According to the invention, timely and accurate electrical stimulation can be applied to a patient, the treatment accuracy is improved, the stimulation efficiency and the treatment effect are enhanced, side effects are reduced, and more accurate and individualized treatment management is realized.

The invention relates to the technical field of biomedical engineering and neuroscience, and discloses an in-ear vagus nerve stimulation control method, system and device based on scalp electroencephalography, and the method comprises the steps: collecting a scalp electroencephalogram signal, a body movement signal and a pulse signal of a to-be-detected user; performing preprocessing and frequency domain separation on the signal; calculating a sleep coupling score, and dividing a physiological state according to the sleep coupling score; dynamically adjusting the intensity and frequency of intra-ear vagus nerve stimulation of the user according to the physiological state, and generating feedback data; in-ear vagus nerve stimulation is performed and the dynamic adjustment parameters are updated based on the feedback data. According to the method, accurate sleep recognition is realized through multi-source signal parallel processing and SCS modeling, and the classification precision is remarkably improved; lSTM prediction and biphase modulation are combined to optimize stimulation parameters, sleep time is shortened, and side effects are reduced; a GPU acceleration and low-power-consumption framework is adopted, and efficient self-adaptive closed-loop regulation and control are achieved.

A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.

The invention discloses percutaneous nerve field vagus nerve stimulation diagnosis and treatment equipment and a diagnosis and treatment method thereof, and particularly relates to the technical field of neuromedicine, intelligent medical equipment and multi-mode physical therapy. The equipment comprises a neural signal acquisition module, a nerve positioning module, a data processing and analysis module, a treatment execution module and a diagnosis result output module; the system is further provided with a battery power management module, a self-adaptive closed-loop cloud platform and a wearable fixing device, by collecting bioelectricity signals, light absorptivity and temperature data of an ear nerve area, ear target cranial nerve branches are positioned, a dynamic diagnosis map is constructed, and a diagnosis result and personalized treatment parameters are generated. Electric pulse, near-infrared light and local thermal therapy multi-mode collaborative stimulation is adopted for treatment, and parameters are monitored and adjusted in real time through a cloud platform. According to the invention, accurate diagnosis and personalized treatment can be realized, the medical efficiency and the treatment effect are improved, and an effective means is provided for nerve disease diagnosis and treatment and pain relief.

Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and / or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.

The invention discloses an ear and neck percutaneous vagus nerve stimulation device based on an internal feeling signal, which belongs to the related technical field of percutaneous vagus nerve stimulation and is composed of a physiological signal acquisition module, a data transmission module, a signal processing and analyzing module, a control module, ear and neck integrated stimulation equipment, an interaction module and a power supply. The device supports neck or ear vagus nerve stimulation and a stimulation mode of combined use of the neck and the ear vagus nerve. And the same or different stimulation parameters can be used for the vagus nerves of the ears and the neck. According to the non-invasive design, the electrode does not need to be placed in a human body through an operation, nerves are stimulated through an external stimulator, and the risk of injury to the human body is reduced; and meanwhile, the output of two stimulation parameters taVNS and tcVNS can be adjusted adaptively through physiological signals and internal feeling indexes, and the fusion effect is improved.

Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and / or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and / or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

A patient management system can include an implantable neurostimulation device configured to deliver vagus nerve stimulation (VNS) therapy to a patient and a non-invasive, external monitoring device comprising at least one sensor for detecting indicators of seizure or depression in the patient. In an example, the external monitoring device is configured to use information from the at least one sensor to detect a seizure event or a seizure precursor event, audibly ask questions of the patient and / or provide behavioral modification commands to the patient, and / or control the neurostimulation device to deliver the VNS therapy to the patient in response to a detected seizure event, seizure precursor event, or progression of depression symptoms.

The invention discloses a closed-loop vagus nerve stimulation system acting on depression, which comprises a data acquisition unit, a core analysis unit, a signal regulation and control unit and a nerve stimulation unit, and is characterized in that patient heart rate data and combined treatment data of a depression patient are acquired through the data acquisition unit; the core analysis unit is used for analyzing the influence function of the medicine and electrotherapy combined treatment on the physical signs of the patient so as to obtain an optimal collaborative treatment scheme and a corresponding electrotherapy design scheme, and the signal regulation and control unit is used for carrying out targeted parameter regulation and control on the electrotherapy signal and outputting an electrotherapy optimization signal; personalized electrotherapy is carried out on the depression patient through the nerve stimulation unit, targeted parameter regulation and control are carried out on the closed-loop vagus nerve stimulation system according to the personalized illness state of the patient, and the actual application accuracy of the closed-loop vagus nerve stimulation system is improved by analyzing the combined action mechanism of electrical stimulation and drug therapy. More comprehensive and effective depression auxiliary monitoring and diagnosis and treatment effects are realized.

The embodiment of the invention relates to the field of intelligent wearable equipment, in particular to intelligent ear vagus nerve regulation and control glasses and a control method, control device and regulation and control system thereof, and the method comprises the following steps: acquiring pupil dynamic characteristic parameters monitored by the intelligent ear vagus nerve regulation and control glasses; calling a trained machine learning model to analyze real-time physiological state information according to the pupil dynamic characteristic parameters; according to the real-time physiological state information obtained through analysis, generating an electrical stimulation control instruction corresponding to the real-time physiological state information; and controlling an ear vagus electrode in the intelligent ear vagus nerve regulation and control glasses to implement nerve regulation based on the electrical stimulation control instruction. According to the method, the limitation of fixed parameter output of a traditional ear vagus nerve stimulation device can be broken through, the individualization and accuracy of an ear vagus nerve stimulation scheme are improved, and the problem that the treatment effect is insufficient or discomfort is caused is solved.

Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and / or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and / or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

The invention discloses a treatment monitoring method and system for a percutaneous ear vagus nerve stimulation device, and the method comprises the steps: carrying out the multi-source treatment situation monitoring of a target user in a treatment course, obtaining the multi-source treatment situation monitoring data, and constructing a multi-mode treatment situation feature; real-time treatment situation analysis is carried out according to the multi-mode treatment situation features, and real-time treatment situation analysis information is generated; performing dynamic state classification based on the real-time treatment situation analysis information, evaluating the treatment condition of the target user in the current treatment course, and generating a treatment regulation and control scheme to perform treatment management and control on the current treatment course when an abnormal treatment condition exists; and constructing a treatment situation prediction model, obtaining the regulated and controlled multi-mode treatment situation characteristics, generating a floating regulation and control boundary in combination with the treatment situation prediction model, and dynamically correcting the diagnosis and treatment regulation and control scheme by using the floating regulation and control boundary to ensure the curative effect and treatment safety. The treatment effect can be accurately perceived; and the treatment safety is ensured.

A vagus nerve stimulation system for stimulating a vagus nerve in a biological subject, the system including a clip configured to be attached to a tragus of the subject, the clip including opposing arms configured so that a distal end of the arms are biased towards each other and electrodes positioned proximate a distal end of the arms on opposing faces so that the electrodes are urged into engagement with opposing faces of the tragus and a signal generator electrically connected to the electrodes, the signal generator being configured to generate at least one therapy signal that is applied to the vagus nerve within the tragus via the electrodes, to thereby modulate the vagus nerve.

The utility model discloses an ear hook type ear walking stimulator, relates to ear walking stimulator technical field, including stimulator main part and blood oxygen detection bracelet, stimulator main part is composed of ear hook, electrode seat and host casing, the back side of electrode seat is inlayed with two electrode slice that distributes up and down, the host casing is equipped with control chip inside, the control chip is equipped with the control chip, the control chip is equipped with the control chip. The electrode plate is electrically connected with the control chip, the front side of the control chip is electrically connected with a Bluetooth module, and the control chip is wirelessly connected with the blood oxygen detection bracelet through the Bluetooth module; the stimulator body is designed to be in an ear hanging type, the control chip in the stimulator body is further in wireless connection with the blood oxygen detection bracelet through the Bluetooth module to be used in a matched mode, the blood oxygen value of a user is detected through the blood oxygen detection bracelet, and when the blood oxygen value is reduced to exceed%, an electrode slice on the stimulator body immediately conducts ear vagus nerve stimulation; and the device can be used in a self-stimulation manner according to self conditions, so that the device is very convenient to use.

The invention relates to the technical field of medical instruments, in particular to a multi-mode biological feedback ear vagus nerve self-adaptive stimulation device and method.The device comprises a host, a stimulation electrode, a signal collection bracelet and an electroencephalogram collection module, and the host comprises core hardware configuration and a power management system; the signal acquisition bracelet comprises an ECG module, a PPG module, a GSR module, a six-axis acceleration sensor and the like. The ear vagus nerve stimulation parameter can be dynamically adjusted through real-time analysis of multi-mode data such as electrocardio, electroencephalogram, heart rate variability, respiration-heart rate synchronism and emotional state, personalized precise treatment is achieved, meanwhile, the wearing comfort and the durability of the device are improved, and the application range is wide. The traditional Chinese medicine composition can be used for auxiliary treatment of various diseases such as inflammatory bowel disease, epilepsy, chronic insomnia, depression, chronic pain, anxiety disorder, post-traumatic stress disorder and autonomic nerve dysfunction, and the functions of a nervous system are adjusted and the symptoms of a patient are improved by accurately stimulating the vagus nerve in the auricular concha area.

A transcutaneous nerve stimulation system includes a multifunctional earphone assembly that receives a sound signal from a sound source or other sources (such as a signal generator). An amplifier receiving the sound signal from the sound source or independent signal generator amplifies the sound signal to generate an amplified electrical signal. A stimulator, which includes multiple conductive electrode contacts, is coupled to the amplifier to receive the amplified electrical signal. The electrode contacts may protrude from an earbud / headphone or extend from an adjustable probe arm. The amplified electrical signal is used to apply electrical stimulation while the earphone assembly emits audible sounds according to the sound signal. The combined functionality enhances compliance with treatment regimens involving electrical stimulation of vagus nerves and other regions of a subject. Potential indications include, without limitation, major depressive disorder, epilepsy, chronic pain, pre-diabetes, insomnia, cardiovascular disorders, tinnitus, autism, daily stress, and anxiety.

An auricular electroencephalogram (EEG) monitoring system may include an EEG recording module having a plurality of EEG sensor electrodes, configured to be coupled to a wearer's ear, and a processing unit configured to analyze EEG data recorded by the EEG recording module to detect presence or cessation of neuropsychiatric disorders of the wearer. An automatic detection-remedy system may include an auricular electroencephalogram (EEG) monitoring system and a transcutaneous auricular vagus nerve stimulation (taVNS) unit having a stimulating electrode in contact with vagus innervated auricular skin of the wearer's ear. When the presence of EEG signals suggestive of the neuropsychiatric disorder is detected by the processing unit, the processing unit is configured to immediately send signals to the taVNS unit to automatically start sending pre-determined electric stimuli to the vagus innervated auricular skin of the wearer's ear.

The invention relates to the technical field of medical equipment, in particular to an intelligent closed-loop vagus nerve stimulation regulation and control method and system. The method comprises the following specific steps: collecting an electroencephalogram signal and a stimulation signal during real-time stimulation, and obtaining an electroencephalogram signal prediction value of future N steps through an ambulatory electroencephalogram signal prediction model; calculating a depression biomarker estimated value for representing the brain activity state at the next moment according to the electroencephalogram signal predicted values of the next N steps; calculating an optimal stimulation signal at the next time according to a difference value between the depression biomarker target value and the depression biomarker estimated value; and updating the stimulation signal according to the optimal stimulation signal to stimulate the vagus nerve, and updating the stimulation signal. Meanwhile, the invention discloses a system for executing the method, the optimal stimulation parameter is calculated according to the difference between the predicted brain activity state at the next moment and the target state, so that the neural activity is controlled, and the adjusting efficiency and the control precision of the percutaneous vagus nerve stimulation system are improved.

A method to treat a predetermined subject population diagnosed with Alzheimer's disease (AD), including: selecting subjects diagnosed with early AD or having at least one symptom of early AD, with a goal to improve a score of the subjects in an assessment scale in at least one point, wherein the assessment scale comprises at least one of, an Alzheimer's Disease Assessment Scale– Cognitive Subscale (ADAS-Cog) or variations thereof, and / or a Mini-Mental State Examination (MMSE) scale or variations thereof; delivering auricular VNS treatment to the subjects for a time period of at least one month; identifying an improvement of at least one point in the scale in the subjects following the delivering.

The invention relates to an ear walking electrical stimulator, which comprises a stimulation piece capable of being worn in an ear, and is characterized in that the stimulation piece comprises a main body, and a control module is arranged in the main body; the first electrode tip is connected to the main body, is in electric signal connection with the control module and is used for being placed at the auricular conchae position in a matched manner; the motor is fixed on the main body and is in electric signal connection with the control module; the second electrode tip is connected to the driving end of the motor, is in electric signal connection with the control module and is used for being placed in the ear hole in a matched mode. The invention further relates to a working method of the ear-walking electrical stimulator, when the stimulation piece is controlled to work, the motor is firstly controlled to work, so that the first part of the second electrode tip clings to the stimulation position in the ear hole and swings back and forth, and the cleaning work of the stimulation position in the ear hole is realized; then the motor is controlled to work to drive the second electrode tip to rotate, so that the second part of the second electrode tip rotates to cling to the stimulation position in the ear hole; and then the first electrode tip and the second electrode tip are controlled to work at the same time to carry out rosemary electrical stimulation work. According to the ear walking electrical stimulator and the working method thereof, dirt in ears can be effectively cleaned, and the vagus nerve stimulation effect is improved.

Wearable electrocardiogram (ECG) systems configured to record ECG from ears (auricular ECG systems), fingers (ear-finger or finger-finger ECG systems) or toes, comprising a processing unit configured to analyze the ECG data to detect serious cardiac arrhythmias or impending serious cardiac arrhythmia. Automatic anti-arrhythmia systems comprise one of the ECG systems and a transcutaneous auricular vagus nerve stimulation (taVNS) unit. When serious cardiac arrythmias are detected, the anti-arrhythmia systems may automatically send pre-determined electric stimuli to a vagus nerve to alleviate or stop the cardiac arrhythmias. The ECG electrodes and the stimulating electrode of the taVNS unit are located on a surface of a housing structure made of flexible elastic and adaptable material such that these electrodes will be naturally and snugly contacting the wearer's skin. These wearable ECG and anti-arrhythmia systems are suitable for easy self-installation, self-removal and daily ambulatory use.

The present application relates to the technical field of neuromodulation, and discloses a neuromodulation system and method for dual-task gated taVNS. The present application collects kinematic data and cognitive performance data of a patient performing a motor-cognitive dual task; obtains an objective maximum load paradigm according to the kinematic data and the cognitive performance data, obtains a subjective maximum load paradigm according to a subjective work load score, and combines the two to obtain a maximum intensity dual-task load paradigm; applies multiple trial dual-task training to the patient under the maximum intensity dual-task load paradigm, and in each trial, determines in real time whether to trigger transcutaneous auricular vagus nerve stimulation according to a dual-dimension gating condition, triggers to generate a stimulation signal when the cognitive correctness condition and the motor safety condition are both satisfied, and suspends the presentation of a new task during the stimulation duration. The present application realizes precise coupling of dual-task training and neuromodulation in the time dimension, and improves the timing specificity and individualization of neuromodulation.

The invention discloses a vagus nerve stimulation device compatible with a magnetic resonance environment, which comprises a host, an electrode and a connecting wire, two ends of the connecting wire are electrically connected with the host and the electrode respectively, and the host comprises a shell and a circuit board arranged in the shell; the circuit board comprises a processing module, and a power supply module, a pulse waveform modulation module and an output module which are electrically connected with the processing module; the output module is electrically connected with the connecting wire; the processing module is used for controlling the power supply module to input current to the pulse waveform modulation module, controlling the pulse waveform modulation module to generate waveform pulse and transmit the waveform pulse to the output module, and controlling the output module to output stimulation current to the electrode through the connecting wire; the shell is a magnetic shielding shell, a through hole is formed in the shell, one end of the connecting wire penetrates through the through hole to be connected with the circuit board, a gasket is arranged between the connecting wire and the through hole, and the gasket is a magnetic shielding gasket, so that the vagus nerve stimulation equipment can be compatible with a magnetic resonance environment generated by magnetic resonance imaging equipment.

The present application relates to the technical field of nerve stimulation, and discloses a closed-loop vagus nerve precise blocking system and method based on physiological signal feedback, comprising a physiological signal monitoring unit for acquiring physiological signals of an individual in real time; a data acquisition and analysis module connected with the physiological signal monitoring unit, for receiving and analyzing the physiological signals, judging the physiological state of the individual, and generating a feedback signal; a stimulation device unit for outputting an electric stimulation signal based on the feedback signal, so that the vagus nerve stimulation reaches a functional block state; and a closed-loop feedback unit connected with the data acquisition and analysis module and the stimulation device unit, for dynamically adjusting the stimulation parameters according to the feedback signal and controlling the electric stimulation signal of the stimulation device in real time. Through the real-time monitoring and real-time feedback mechanism, the present application realizes functional block of the vagus nerve, and ensures the accuracy, safety and individualization of the inhibition operation.

The telemedicine system includes a gateway for transmitting monitoring information including a stimulation signal and a biosignal corresponding to the stimulation signal to a cloud; and a server for extracting the stimulation signal and the biosignal from the transmitted monitoring information, providing the extracted stimulation signal and biosignal as inputs of a pre-stored artificial intelligence machine learning algorithm-based stimulation control model, regenerating the biosignal as an output of the stimulation control model into a stimulation signal to be regulated for the balance between sympathetic and parasympathetic nerves, and feeding back the regenerated stimulation signal to a personalized vagus nerve stimulation and pulse electromagnetic field treatment device.

The present invention relates to a method for applying electrical stimulation to the vagus nerve through an electrode in contact with the skin of a human body, the method comprising: an electrical stimulation guideline input step of inputting electrical stimulation guidelines including numerical values for electrical stimulation; an initial input value derivation step of measuring the impedance between the electrode and the skin, and using the measured impedance before applying electrical stimulation, so as to derive an input value that matches the electrical stimulation guidelines; and an electrical stimulation application step of applying electrical stimulation by using the derived initial input value. The present invention applies electrical stimulation to the electrode by reflecting the impedance between the electrode and the skin of a user, and thus can more accurately apply electrical stimulation. In addition, electrical stimulation is applied by reflecting changes in the impedance between the skin and the electrode during use, and thus accurate electrical stimulation can be continuously applied

The invention relates to an audio-electric cooperation ear vagus nerve stimulation method, earphone and system based on multi-mode disease information, and belongs to the technical field of vagus nerve stimulation, and the method comprises the steps: obtaining the disease information of a user; determining a disease type based on the disease information; determining a treatment scheme based on the disease type, wherein the treatment scheme comprises stimulation parameters of the electrical stimulation module and music to be played; and playing the to-be-played music by using the earphone, and controlling the electrical stimulation module to stimulate the ear vagus nerve based on the stimulation parameters. According to the invention, two adjusting modes of music and ear vagus nerve stimulation are combined, and the synergistic effect of the two adjusting modes is brought into full play, so that the effect of more efficient and accurate emotion and cognition adjustment is achieved.

A vagus nerve stimulation system for stimulating a vagus nerve in a biological subject, the system including a clip configured to be attached to a tragus of the subject, the clip including opposing arms configured so that a distal end of the arms are biased towards each other and electrodes positioned proximate a distal end of the arms on opposing faces so that the electrodes are urged into engagement with opposing faces of the tragus and a signal generator electrically connected to the electrodes, the signal generator being configured to generate at least one therapy signal that is applied to the vagus nerve within the tragus via the electrodes, to thereby modulate the vagus nerve.

A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.