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75 results about "Larynx" patented technology

The larynx (/ˈlærɪŋks/), commonly called the voice box, is an organ in the top of the neck involved in breathing, producing sound, and protecting the trachea against food aspiration. The larynx houses the vocal folds, and manipulates pitch and volume, which is essential for phonation. It is situated just below where the tract of the pharynx splits into the trachea and the esophagus. The word larynx (plural larynges) comes from a similar Ancient Greek word (λάρυγξ lárynx).

Bionic TENG sensor unit for artificial throat and preparation method

The invention discloses a bionic TENG sensor unit for an artificial throat and a preparation method thereof, and relates to the field of artificial throats, and the sensor unit comprises a gradient micro-dome friction layer, a strain amplification layer, an electrode layer and a back cavity substrate layer. The gradient micro-dome array realizes gradual contact through gradient change of height and diameter; the strain amplification layer converts vertical vibration into horizontal strain by using a cantilever beam-sliding block structure; the back cavity array selectively amplifies vibration at a specific frequency based on the Helmholtz resonance principle. The invention further provides a corresponding preparation method. The preparation method comprises the steps of back cavity forming, electrode deposition, microstructure manufacturing, surface treatment and the like. The sensor has the advantages of high sensitivity, good frequency selectivity and strong durability, and is particularly suitable for detecting weak laryngeal vibration signals of laryngeal patients.
Owner:FUZHOU UNIV

Emergency clinical emetic device

The invention relates to the technical field of medical instruments, in particular to emergency clinical emetic equipment which comprises a support, an emetic part arranged on the support and expansion parts symmetrically arranged on the two sides of the emetic part. The retreating assembly is used for driving the support to move so that the expansion pieces and the emetic piece can retreat from the oral cavity of the patient, the support is provided with a first reset piece capable of enabling the emetic piece to be away from the throat and a second reset piece capable of enabling the two expansion pieces to be closed, and the guide rail is provided with a control switch. The vomiting promoting driver drives the vomiting promoting piece to vibrate in the throat of the patient, the vomiting promoting process of the patient is achieved, and when the patient feels strong nausea and is about to have vomiting reaction, the control switch is pressed down in advance; and the emesis promoting piece and the expanding piece quickly restore to original positions under the action of the first resetting piece and the second resetting piece and move out of the oral cavity of the patient through the support, so that the vomiting process is smooth, and the risk that vomit blocks or is inhaled into the airway by mistake is avoided.
Owner:ZHOUSHAN HOSPITAL

A method and system for self-monitoring of infant asphyxia risk based on laryngeal breath sounds

The present application relates to the technical field of health monitoring, in particular to a kind of infant asphyxia risk autonomous monitoring method and system based on laryngeal respiratory sound, comprising: utilize high sensitivity MEMS microphone to collect the airflow and respiratory sound signal of infant larynx, and utilize micro accelerometer to monitor the thoracic movement data of infant synchronously;The airflow and respiratory sound signal are denoising, and the denoising respiratory sound signal is obtained;The denoising respiratory sound signal is separated according to respiratory event Signal, and is enhanced and combined into respiratory sound data set;Respiratory sound feature is extracted in respiratory sound data set, and asphyxia anomaly classification model is constructed based on respiratory sound feature by machine learning model, and dynamic baseline model that adapts individual respiratory difference is established according to respiratory sound feature.The present application utilizes the hardware device of high sensitivity MEMS microphone and micro accelerometer and artificial intelligence model to combine, realizes the use of laryngeal respiratory sound signal in home environment and autonomously completes infant asphyxia risk identification and early warning.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Method for instantly forming individualized child tracheal catheter through 3D printing technology

The invention relates to the technical field of medical instrument manufacturing, and discloses a method for instantly forming an individualized child tracheal catheter through a 3D printing technology. The method comprises the following steps: acquiring CT (Computed Tomography) or MRI (Magnetic Resonance Imaging) body layer image data of neck and chest areas of a target child patient, wherein the data is used for reflecting anatomical structures of a throat and a trachea; importing the image data into three-dimensional reconstruction software, executing structure identification and segmentation operation, and constructing a three-dimensional model of the throat and trachea of the child patient; performing parameter modeling according to the model, and designing an individualized tracheal catheter model which is fit with the inner diameter of a target airway and is matched with the target airway in length and curvature; the model is converted into a printing data file matched with 3D printing equipment; and a biocompatible 3D printing device is called, the catheter model is printed through a medical implant material, and the solid catheter meeting the size requirement is obtained. The pediatric intubation system improves the matching degree and safety of pediatric intubation, and has good clinical practical value.
Owner:SHENGJING HOSPITAL OF CHINA MEDICAL UNIVERSITY

Intelligent speech synthesis system based on electronic artificial throat audio input signal

PendingCN120412534ASpeech recognitionSpeech synthesisLarynxElectrolarynx
The invention discloses an intelligent speech synthesis system based on an electronic artificial throat audio input signal. The intelligent speech synthesis system is characterized by comprising a signal processing module, a speech recognition module, a speech synthesis module and a user interface module. Compared with the prior art, the method has the advantages that STFT is used for converting the electronic throat signals into frequency domain features, meanwhile, a Conformer model is adopted for semantic extraction, natural voice is generated in combination with FastSpeech2 and Hi Fi-GAN, and emotion expression and voice quality are improved.
Owner:GUANGXI UNIV FOR NATITIES +1

Systems and methods for obtaining cardiovascular parameters

A system for measuring cardiovascular data includes an elongate member having a channel, a first expandable member carried by the elongate member and movable between a collapsed state and an expanded state by adjustment initiated externally of a subject, a first sensor disposed on a surface of the elongate member, second and third sensors disposed on a surface of the first expandable, a first optical sensor located at a first location in relation to the distal end of the elongate member and configured for obtaining photoplethysmographic data, and wherein the first expandable member in its expanded state is configured to interface with the subject's larynx for delivery of at least oxygen gas into the respiratory system of the subject, and the second and third sensors are configured to contact tissue in proximity to the larynx when the first expandable member is in its expanded state.
Owner:COVIDIEN LP

Nasopharyngolaryngoscope

ActiveCN309400165SLarynxNose
1. Name of the design product: Nasopharyngolaryngoscope. 2. Use of the design product: For medical units to conduct examinations and treatments on the mouth, nose, pharynx, and larynx in clinical practice, and to be used in conjunction with equipment such as electronic endoscope image processors. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Perspective view 1.
Owner:MACROLUX MEDICAL TECH CO LTD

A throat clearing and larynx benefiting composition and its use

The application discloses a throat clearing and larynx relieving composition and application thereof. The throat clearing and larynx relieving composition is mainly composed of raw oils of vitex oil, rhododendron oil, patchouli oil, eucalyptus oil, mint oil and star anise oil and optional added oil and diluent, is stirred and mixed, and has the main function of clearing throat and relieving larynx, and can also achieve the effects of freshening breath, refreshing brain, detoxifying and moistening lung, swelling and pain relieving, and phlegm and cough relieving.
Owner:YUNNAN INST OF MATERIA MEDICA

Rehabilitation treatment device and method for swallowing dysfunction patient

A rehabilitation treatment device and method for a patient with swallowing dysfunction comprises a liquid bag (8) acting on the throat of the patient with swallowing dysfunction, a supporting frame (7) arranged on the liquid bag (8), a vertical beam (1) arranged on the supporting frame (7), and a fluid pump (91) arranged between the vertical beam (1) and the liquid bag (8). The upper end face of the liquid bag (8) is supported, expansion medium liquid is injected into the liquid bag (8) through the fluid pump (91), and external interference activity acting force is generated on the throat of a patient with swallowing dysfunction through the liquid bag (8). According to the swallowing-dysfunction patient rehabilitation device, slow expansion force generated by viscous liquid acts on the throat of a swallowing-dysfunction patient in the rehabilitation process, the technical problem that the throat of the patient is lifted up through the hands of a doctor is solved, and therefore the rehabilitation treatment effect of the swallowing-dysfunction patient is improved.
Owner:RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Multipurpose airway device

An airway device facilitates the insertion of an ETT into a patient, the delivery of oxygenated air into a patient, an exchange of the pre-inserted ETT in an intubated patient, and an evaluation of the larynx and trachea in an intubated patient, The device comprises an overtube having a mask section attached to a distal portion of the overtube. An inflatable bladder affixed to the mask section includes a shape and surface configured to seamlessly contact the circumference of the elliptical construction of the laryngeal opening. Once the inflatable bladder is positioned adjacent the laryngeal opening enhanced sealing properties are created so that the axis of the airflow entering the device matches the axis of the trachea, allowing for the improved delivery of oxygenated air into the patient's lungs. The specific utilization of the bladder allows for the device to be constructed smaller than a typical airway device, which may more easily facilitate the insertion process. Additionally, the device may provide a seamless transition into endotracheal intubation when necessary.
Owner:KIM CHONG S

Throat specimen collection device with tongue depressor for positioning collection container

Throat specimen collection devices and methods of using the same are provided. In certain embodiments, a throat specimen collection device includes i) a tongue depressor configured to restrain a subject's tongue, and ii) a collection container including an elongate member and a collection member, where the elongate member is positioned to depress the subject's tongue when the tongue depressor is positioned to depress the subject's tongue and the collection container is in a collection position. The acquisition component touches a subject's throat and acquires a throat specimen from the subject. Also provided is a method of collecting a throat specimen, the method comprising applying the throat specimen collection device to a mouth of a subject and collecting the throat specimen.
Owner:ABBOTT DIAGNOSTICS SCARBOROUGH INC

Intelligent voice prosthesis

1. The name of the design product: intelligent auxiliary voice artificial larynx. 2. The use of the design product: auxiliary voice. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.
Owner:HENAN UNIVERSITY OF TECHNOLOGY

Linkage adjusting device for lower jaw position and airway pressure of snoring patient

The invention relates to the technical field of snoring patient treatment, and discloses a snoring patient lower jaw position and airway pressure linkage adjusting device which comprises a breathing machine body, a mask is connected to one end of an air delivery pipe, a tap is mounted on the outer wall of one end of the air delivery pipe, and an upper gear sleeve is connected to one end of a first air guide pipe; according to the breathing machine, the lower jaw airway linkage adjusting mechanism is arranged, oxygen on the breathing machine body can enter the first hose through the tap joint, and when a snore symptom patient wears a mask, the oxygen can enter the first hose through the tap joint, so that the breathing machine body is more comfortable to wear, and the breathing machine body is more comfortable to wear. An upper tooth sleeve and a lower tooth sleeve on one side of the mask are worn in the oral cavity of a patient, oxygen intermittently enters a second hose, air bags on the upper tooth sleeve and the lower tooth sleeve are intermittently expanded and contracted, then the throat of the lower jaw of the patient in sleep is intermittently expanded, gas between the lower jaw and an airway flows in a linkage mode, and therefore the patient can feel more comfortable. And the patient can breathe smoothly.
Owner:GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY

Calcium or magnesium chloride salt-based composition

ActiveUS12419908B1Powder deliverySpray deliveryCough suppressionLarynx
Hydration of a larynx and / or vicinity with a composition comprising a salt formulation (e.g., CaCl2, MgCl2, KCl and / or NaCl) can achieve prophylactic and / or therapeutic effects (e.g., cough suppression, improving voice quality, increasing pulse oxygen saturation and / or increasing mucosal vaccination effectiveness). The composition is administered as dry particles (e.g., aerosol) or as a liquid (e.g., solution, aerosol). The liquid can have a pH of 7.0 up to around 10.0, or preferably around 7.5 up to around 9.5, or more preferably around 8.0 up to around 9.0, or even more preferably 8.0 to 8.5 or most preferably around 8.0. The droplets can have a mass median aerodynamic diameter from approximately 8 μm to approximately 15 μm or from approximately 15 μm to approximately 500 μm. A therapeutic dose (e.g., 0.5 mg to 4.0 mg mass of salt) is administered in response to an indication. Such can employ an osmolitically active composition.
Owner:SENSORY CLOUD LLC

Larynx-Tubus

The invention relates to a laryngeal tube (10) and proposes an improved design which has a positive effect on the use and manufacture of the laryngeal tube (10).
Owner:VBM MEDIZINTECHN

Electronic laryngoscope

ActiveCN309661543SVideo laryngoscopeLarynx
1. The name of the design product: electronic laryngoscope. 2. The use of the design product: for checking the lesions of pharynx and larynx. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.
Owner:吴秀荣

Larynx-Tubus

The invention relates to a laryngeal tube (10) and proposes an improved design which has a positive effect on the use and manufacture of the laryngeal tube (10).
Owner:VBM MEDIZINTECHN

A box type support laryngoscope operation simulation training device

The application discloses a box type supporting laryngoscope operation simulation training device, which comprises a box body and a larynx body simulation training module. An instrument operation port is formed on the front surface of the box body, and the angle between the instrument operation port and the larynx body simulation training module is an acute angle. The larynx body simulation training module comprises a perforable circular ring and a reversed V-shaped adhesive tape, and the adhesive tape is located at the back side of the circular ring. The box type supporting laryngoscope operation simulation training device is formed by combining the box body and the larynx body simulation training module, and the instrument operation port is formed on the box body. The surgical instrument is placed into the instrument operation port, reaches the operation area of the larynx body simulation training module in the box, and performs corresponding laryngoscope operation simulation operation, thereby forming a simplified simulation, making the simulation operation simpler, being suitable for primary skill training, and being capable of practicing by taking other simulation objects as carriers. The device can be used for training at any time by using the spare time, and is easy to popularize.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV

A bionic TENG sensor unit for artificial larynx and a preparation method thereof

The application discloses a kind of bionic TENG sensor unit for artificial throat and preparation method thereof, it is related to artificial throat field, the sensor unit includes gradient microdome friction layer, strain amplification layer, electrode layer and back cavity substrate layer.Gradient microdome array realizes progressive contact by the gradient change of height diameter;Strain amplification layer utilizes cantilever beam-sliding block structure to convert vertical vibration into horizontal strain;Back cavity array is selectively amplified to specific frequency vibration based on Helmholtz resonance principle.The application also provides a corresponding preparation method, including back cavity forming, electrode deposition, microstructure manufacturing and surface treatment and the like steps.The sensor has the advantages of high sensitivity, good frequency selectivity and strong durability, and is particularly suitable for detecting weak laryngeal vibration signals of laryngeal patients.
Owner:FUZHOU UNIV

Method for preparing laryngeal organoid and use thereof

PCT designated stageWO2026177454A1LarynxLaryngeal Epithelium
The present invention relates to a medium composition for forming a laryngeal organoid and a method for preparing a laryngeal organoid by using same. The method for preparing a laryngeal organoid in which laryngeal epithelial cells are three-dimensionally cultured using the medium composition for forming a laryngeal organoid according to the present invention enables stable long-term serial passaging for two or more generations, so that a large quantity of cells can be obtained from a small amount of tissue. In addition, the laryngeal organoid prepared by the method includes a stratified squamous epithelium structure or pseudostratified ciliated columnar epithelium structure that is histologically highly similar to the larynx, and thus may be used as a graft material for laryngeal tissue or as a model capable of replacing cell and animal experiments in disease modeling and drug screening.

Collar artificial larynx

ActiveCN309870738SLarynxAcoustics
1. Name of the designed product: artificial larynx with collar. 2. Use of the designed product: as a tool for speaking with the aid of sound. 3. Design points of the designed product: in shape. 4. Picture or photo best showing the design points: perspective view.
Owner:BEIJING XINZHI RUISHENG TECHNOLOGY CO LTD

A hyolaryngeal complex kinematic assessment method and system based on wearable ultrasound

PendingCN122350766AAnatomical structuresHyoid bone
The application relates to the technical field of ultrasonic diagnosis, and provides a hyoid-larynx complex mobility evaluation method based on wearable ultrasound, which comprises the following steps: S1: collecting neck superficial tissue ultrasonic signals, continuously acquiring an ultrasonic image sequence containing hyoid and C2-C4 cervical vertebra anatomical structure images; S2: adopting a two-stage intelligent recognition and tracking strategy of initialization calibration+real-time tracking, automatically recognizing and continuously marking the position information of a point; S3: taking the line connecting the C2 cervical vertebra lower front edge point and the C4 cervical vertebra lower front edge point as a reference to establish a relative coordinate system; S4: based on the relative coordinate system, extracting real-time coordinates of a hyoid upper edge point in the whole process of a swallowing event, and calculating the position change amount of the marking point relative to the coordinate system; and S5: outputting the position change amount of the hyoid upper edge point as a core quantitative index of the hyoid movement amplitude. Relying on the scene advantages of ultrasonic noninvasive quantification and wearable devices, real-time, continuous and objective detection of hyoid displacement and related biomechanical parameters is realized.
Owner:LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE +1

Laryngoscope

PendingUS20260248375A1LarynxPharynx
The present invention relates to a laryngoscope that can be used to intubate a patient while simultaneously providing oxygenation and suction at the level of the distal pharynx / proximal larynx to improve both oxygen availability and visualization of the patient's airway access during the intubation procedure. The laryngoscope comprises two lumens coupled to the handle and blade of the device, the lumens configured to connect directly to external sources, such as suction or oxygen. The present device permits the user to complete the intubation procedure without having to remove the device from the patient's airway before the intubation procedure is complete or have a second person insert and operate additional devices to supply oxygen and / or suction during the intubation procedure. A cover for a laryngoscope with the same features is also described. The present laryngoscope and cover are believed to have application in an emergency medical setting.
Owner:SAFE SCOPE INC

Air pipe assembly with closed structure

The invention discloses an air pipe assembly with a closed structure, and belongs to the technical field of medical instruments, the air pipe assembly comprises a pipe body, an air bag and an inflation assembly are arranged on the pipe body, a steel wire sleeve is arranged in the pipe body in a sleeved mode, the air pipe assembly further comprises a plug, a patch and a transmission part, the plug is installed on a connector of the pipe body, and the transmission part is arranged in the pipe body in a penetrating mode and connected with the plug and the air bag; and the patch is arranged close to the plug and is used for plugging a gap between the tube body and the throat or mouth of the patient. According to the trachea assembly with the closed structure, the inner cavity of the tube body can be blocked through the plug, so that when medical staff assess the autonomous respiration function of a patient, the tube body does not need to be blocked with the help of cotton swabs, adhesive tape and the like, and the leakproofness of the blocked tube body is guaranteed; meanwhile, the air bag can be collected through the plug and the transmission piece, the situation that the air bag is loosened at will to affect autonomous respiration of the patient is avoided, the patient can cough out sputum easily, and the accuracy of medical staff for evaluating whether the autonomous respiration function of the patient is good or not is improved.
Owner:CHENGDU MILITARY GENERAL HOSPITAL OF PLA

Neck-worn artificial throat

The invention discloses a neck-worn artificial throat which comprises a neck-worn shell, a key shell, a display screen shell and a sensor, the key shell and the display screen shell are fixedly connected with the two ends of the neck-worn shell respectively, and containing spaces are formed in the neck-worn shell, the key shell and the display screen shell; a circuit board is fixedly arranged in the accommodating space of the key shell, a microphone, an audio coding chip, a CPU (Central Processing Unit), a communication module and a decoder are integrated on the circuit board, and a microphone port and keys are arranged on the key shell; a battery and a loudspeaker are fixedly arranged in the containing space of the display screen shell, a loudspeaker opening and a charging interface are formed in the display screen shell, and a display screen is fixedly arranged on the outer side of the display screen shell. The neck-worn artificial throat provided by the invention can be directly worn on the neck, and the sensor can be accurately positioned and adhered to the neck, so that the signal acquisition position is kept unchanged all the time, and the sensor can adaptively follow the dynamic change of the neck or the throat to prevent the signal from being interfered.
Owner:BEIJING XINZHI RUISHENG TECHNOLOGY CO LTD

Laryngoscope blade with sputum suction function

The laryngoscope blade with the sputum suction function comprises a laryngoscope blade body, a tongue depressor, a hard tube, a hose and a three-way connector, the laryngoscope blade body comprises the tongue depressor, the hard tube is fixed on the tongue depressor, one end of the hard tube is connected with the hose, the hose is connected with the three-way connector, the three-way connector comprises three ports, and the three ports are communicated with the three-way connector. The three ports are a first connecting port, a second connecting port and a pressing port respectively, the first connecting port is used for being connected with a negative pressure aspirator, the second connecting port is connected with the hose, and the hose and the three-way connector are located at the end, away from the laryngoscope inlet, of the laryngoscope lens body. According to the laryngoscope, the hard tube is arranged on the tongue depressor, so that secretions such as sputum can be sucked away through the hard tube, the view field of the laryngoscope cannot be affected, and the laryngoscope is convenient to use.
Owner:HANGZHOU FUYANG DISTRICT FIRST PEOPLES HOSPITAL

Traditional Chinese medicine composition for clearing away lung-heat, dispersing nodules and clearing and nourishing throat and preparation method of traditional Chinese medicine composition

The invention provides a traditional Chinese medicine composition for clearing away lung-heat, dispersing nodules and clearing and nourishing throat and a preparation method thereof. The traditional Chinese medicine composition is prepared from 15-25 parts of American ginseng, 60-70 parts of bulbus fritillariae cirrhosae, 300-400 parts of loquat, 45-55 parts of platycodon grandiflorum, 25-30 parts of semen armeniacae amarae, 1-5 parts of menthol, 55-60 parts of caragana sinica rehd, 35-40 parts of adina rubella hance roots, 25-35 parts of rhizoma dioscoreae nipponicae, 15-20 parts of rhizoma picrorhizae, 20-30 parts of radix adenophorae, 20-30 parts of rhizoma polygonati and 10-15 parts of rhizoma bletillae. The embodiment of the invention has remarkable treatment advantages in the aspects of clearing away lung-heat, dispersing nodules and clearing and nourishing throat.
Owner:JIANGXI ANSHUNTANG BIOLOGICAL SCI & TECH CO LTD

Anaesthetic mask

The utility model discloses an anaesthetic mask. The anaesthetic mask comprises a mask body and an oropharynx assembly. The mask is crescent, a threaded opening is formed in the middle of the mask and provided with a fixing pipe, threads are arranged in the middle of the fixing pipe, and the side, close to the face, of the fixing pipe is movably connected with the oropharynx assembly. A traditional oval face mask is changed into the crescent face mask, so that the nasal cavity of a patient is exposed out of the crescent notch part, but the crescent notch part can be attached to the mouth, the wearing effect of the face mask is guaranteed, meanwhile, the fixing tube and the oropharyngeal trachea can be freely detached, the patient can be conveniently fixed through the face mask after oropharyngeal intubation is conducted, and the use is convenient. The oropharyngeal trachea is prevented from sliding out of the throat of the patient.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV

An in vitro magnetic target positioning and navigation method and system for the larynx

The present invention discloses an extracorporeal magnetic target positioning and navigation method and system for the larynx, belonging to the field of medical equipment technology. The method comprises: constructing a three-dimensional anatomical model based on laryngeal imaging data and marking the position of a reference magnet. The optimal path of the catheter from the entrance to the target point is planned, with a built-in guide magnet at the front end and extracorporeal magnet traction control. The magnetic sensor array tracks the position in real time, and closed-loop control corrects deviations. The distance to the tissue is monitored in real time, and a warning is issued and the path is replanned when it is less than a threshold. The method of the present invention improves the accuracy and safety of catheter positioning and navigation.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

System and method for evoking a reflex to monitor the nerves of the larynx

ActiveUS12419575B2Tracheal tubesElectrotherapyReflex responseLarynx
A system includes an endotracheal tube having a plurality of electrodes, wherein the electrodes include at least one stimulating electrode configured to stimulate tissue of a patient and at least one monitoring electrode configured to monitor at least one nerve of a patient. The system includes a nerve integrity monitor device configured to send a stimulation signal to the at least one stimulating electrode to evoke a reflex response, and configured to receive a monitoring signal from the at least one monitoring electrode.
Owner:MEDTRONIC XOMED INC