111results about How to "Prevent adverse side effects" patented technology

Compositions and methods for administering collagen to a human subject have been developed. The collagen-containing lipid vesicles of the invention provide a delivery system for human collagen which eliminates problems associated with chemical and physical instability of the collagen as well as immune responses to non-human collagen.

Described herein are systems, method and devices for modulating the cholinergic anti-inflammatory pathway. The systems described herein may include one or more implantable leads configured to be used to stimulate the inflammatory reflex. These leads typically include a flexible body region, a plurality of electrodes (or contacts) and may be used with a stylet or other inserter. The leads may also include one or more anchors. Exemplary leads may be intra-carotid sheath field-effect leads (“sheath FE” leads), carotid sheath cuff leads (“sheath cuff” leads), intracardiac leads, vagus nerve cuff leads (“vagus cuff” leads), and intravenous leads (“intravascular” leads). Leads (e.g., intravascular leads) may be chronic or acute.

The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject.

The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and / or the generation of one or more tissue constructs from cell and / or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and / or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated.

The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject.

Exemplary embodiments of apparatus and method for tissue cooling using a plurality of hollow needles to deliver a cooled fluid into the tissue can be provided. For example, a volume and / or temperature of the fluid can be controlled to cool the tissue to a particular temperature or to within a predetermined temperature range. A tissue surface overlying the tissue to be cooled can be pre-cooled using conventional cooling techniques to increase the efficacy of the exemplary procedure. The exemplary method and apparatus can be used, e.g., to disrupt or damage fatty tissue that may then be reabsorbed by the body.

The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and / or the generation of one or more tissue constructs from cell and / or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and / or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

The present invention relates to methods and compositions which may be used to immunize infant mammals against a target antigen, wherein an immunogeniclly effective amount of a nuclic acid encoding a relevant epitope of a desired target antigen is administered to the infant. It is based, at least in part, on the discovery that such genetic immunization of infant mammals could give rise to effective cellular and humoral immune responses against target antigens.

The present invention provides one kind of viscose fiber with antibacterial and antifouling tea component, and the viscose fiber contains antiseptic comprising at least one of natural tea pigment, tea polyphenol and catechin. The powder or solution of at least one of natural tea pigment, tea polyphenol and catechin in the amount of 1-10 wt% is added into viscose spinning fluid to result in lasting antibacterial and antifouling functions. The viscose fiber has also the fragrance of tea, dyeing effect and no side effect on human body, and is suitable for use in making underwear, other costumes and bedding.

The quality (e.g., resolution) of image data, video data, and sound data representing a scene or signal is enhanced by a quality enhancement function trained on high quality and low quality representations of a portion of the same scene or signal. The enhancement function is thus optimized to the most relevant input. A training algorithm uses low quality image of a scene or scene portion, along with a high quality image of the same scene or scene portion, to optimize the parameters of a quality enhancement function. The optimized enhancement function is then used to enhance other low quality images of the scene or scene portion. Sound data is enhanced by using a low resolution sample of a portion of a signal, and a high resolution sample of the same signal portion, to train a quality enhancement function which is then used to enhance the remainder of the signal.

The present invention is directed to methods of treating or protecting mucosal tissue from damage associated with radiation and / or chemotherapeutic treatment of cancers, by the topical application of amifostine and related compounds. These methods avoid the side effects of systemically applied radio / chemo protectants. The invention is also directed to treatment and prevention of infections associated with mucositis by topical application of amifostine and related compounds.

The persent invention relates to a sodium tanshinon IIA sulfonate glucose injection and its preparation method. Said injection contains (by wt%) 0.002-0.016% of sodium tanshinon IIA sulfonate, 5-25% of glucose, 0.05-0.2% of antioxidant and the rest is injection water. Said injection can obtain good therapeutic effect, and its preparation method is simple.

A wireless device includes a data structure that relates peak channel capacity to the quality of the wireless communication link. The wireless communication link quality forms an index to indicate the expected peak channel capacity for that particular quality value of the wireless communication link. The wireless device uses the data storage structure to determine an expected data transfer throughput based on the quality of the wireless communication link. A transfer rate lower than expected may indicate congestion in the core network or the RAN. In this case, the network may slow the data delivery from the data source or temporarily suspend delivery. Conversely, low data throughput may be the result of a poor quality wireless communication link. If the data structure indicates that the data throughput corresponds to the expected throughput for the quality value of the wireless communication link, the system need not take any steps to reduce congestion.

Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for treating or preventing a disease that is associated with Frizzled homologue 10 (FZD10) in a subject is provided.

In an apparatus and method for controlling blood circulation in a living body using a magnetic field to improve blood circulation, the apparatus includes a magnetic field generating unit for generating a magnetic field that is oriented in a direction of blood flow and an affixing unit for affixing the magnetic field generating unit to the living body.

The present invention provides infusion devices and methods for subcutaneous delivery of high viscosity fluids. The devices and methods described are innovative subcutaneous infusion systems that allow for the rapid delivery of viscous therapeutic fluids while avoiding adverse side effects and promoting patient comfort. The devices and methods described are also useful for rapid delivery of high volumes of therapeutic fluids.

The quality (e.g., resolution) of image data, video data, and sound data representing a scene or signal is enhanced by a quality enhancement function trained on high quality and low quality representations of a portion of the same scene or signal. The enhancement function is thus optimized to the most relevant input. A training algorithm uses low quality image of a scene or scene portion, along with a high quality image of the same scene or scene portion, to optimize the parameters of a quality enhancement function. The optimized enhancement function is then used to enhance other low quality images of the scene or scene portion. Sound data is enhanced by using a low resolution sample of a portion of a signal, and a high resolution sample of the same signal portion, to train a quality enhancement function which is then used to enhance the remainder of the signal.

The invention provides a viscose fiber with the anti-bacterial function, which comprises viscose fiber and an antimicrobial contained therein. The viscose fiber with the anti-bacterial function is characterized in that the antimicrobial is a natural plant antimicrobial containing sarcandra glabra extractives. A sarcandra glabra extractive solution is added to a viscose filature stock solution, and the addition of sarcandra glabra extractive powder contained in the sarcandra glabra extractive solution is 1-5 percent by mass of the viscose filature stock solution. In the invention, the sarcandra glabra extractives are adopted as the antimicrobial which is evenly distributed in the fiber so that the fiber has lasting anti-bacterial function and dying effect without side effects on human bodies. The viscose fiber with the anti-bacterial function of sarcandra glabra is suitable for making knitted underwear, other clothes and bedding fabrics, has wide range of applications and great economic and social benefits. The preparation method of the invention has reasonable and simple process and is suitable for the industrialized production.

The present invention relates to the use of T cell redirecting, bispecific, in particular trifunctional, antibodies for the treatment of a cancer disease, wherein said antibody is administered via the subcutaneous route. Thereby, the release of proinflammatory cytokines is reduced and, simultaneously, the release of inhibitory cytokines is substantially suppressed. That treatment by bispecific, in particular trifunctional, antibodies may be combined in a combination therapy with other anti-cancer drugs.

A polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. Embodiment one is a two-chamber structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of a fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. Embodiment two is a single chamber device consisting of a multifunctional nanocomposite with a ROS-scavenging nanoparticle constituent (nanoceria) and a multimodal reporting nanoparticle component (i.e. Dex-IO-DiR). The device and system are utilized in treatment of diseases with a pro-inflammatory component, including, but not limited to, Crohn's disease, ulcerative colitis, inflammatory bowel disease, cystic fibrosis, arthritis, and cancer chemotherapy.

Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated.

Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

A polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. Embodiment one is a two-chamber structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of a fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. Embodiment two is a single chamber device consisting of a multifunctional nanocomposite with a ROS-scavenging nanoparticle constituent (nanoceria) and a multimodal reporting nanoparticle component (i.e. Dex-IO-DiR). The device and system are utilized in treatment of diseases with a pro-inflammatory component, including, but not limited to, Crohn's disease, ulcerative colitis, inflammatory bowel disease, cystic fibrosis, arthritis, and cancer chemotherapy.

A pharmaceutical composition comprising a water insoluble sesquiterpene, one or more antioxidants and one or more solubilizers selected from the group consisting of an oil, PEG400, a derivative of castor oil and ethylene oxide, and polysorbate 80, and methods of use thereof.

Belonging to the fields of preparation technologies and immune application of herbal veterinary drugs, the invention relates to a glycyrrhetinic acid nano-liposome for improving the immune function of livestock and poultry and its preparation method. A film dispersion technique is employed to prepare the glycyrrhetinic acid nano-liposome. With the encapsulation rate as an index, a response surface technique is adopted to study the following 3 factors: a lipid-drug ratio, a film material ratio and a water bath temperature, and preferable selection is conducted to determine the optimal preparation conditions as: a lipid-drug ratio of 9.0:1, a film material ratio of 2.5:1, and a water bath temperature of 31DEG C. The obtained glycyrrhetinic acid nano-liposome has a high encapsulation rate and strong immunoenhancement activity. The glycyrrhetinic acid nano-liposome provided in the invention significantly enhances the immunoenhancement activity of glycyrrhetinic acid.

A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.

The invention provides the application of carubinose in preparing medicine that can treat lung acute inflammation diseases. The molecular formula of carubinose is C6H12O6, the structure is D-carubinose. Said medicine comprises medicine acceptable shaping agent or carrying agent. The produced dosage form mainly comprises liquid dosage form, granule, tablet, gas spraying form, drop or pill. The invention can reduce the lung tissue TNF-alpha level of mice ALT model induced by LPS, release neutral granulocyte wettability in lung tissue, inhibit capillary blood permeability, decrease protein exudation and lung water content, reduce MPO level in BALF supernatant and improve pathologic change for lung tissue inflammation. The invention discloses the functions of anti-inflammation, anti-oxidation and pneumochysis reduction of carubinose.

The invention discloses a synbiotic feed additive for growing and fattening of pigs. The synbiotic feed additive is prepared from composite probiotic agents, maltodextrin, isomaltooligosacharide, glucose, citric acid, composite vitamins, composite trace elements, charcoal, attapulgite, leguminosae, dioscorea opposita, poria cocos, atractylodes macrocephala rhizomes, dried unripe fruits of citrus aurantium, common vladimiria roots, Chinese thorowax, dried ripe fruits of crataegus pinnatifida, oblongleaf kadsura stems or roots and bidens pilosa. The invention further provides an application method of the additive. During the growth and fattening period of pigs, the synbiotic feed additive for growing and fattening of pigs is added to a feed according to the addition quantity of the synbioticfeed additive to the body weight of fattening pigs being 0.1-5% for feeding. Through adoption of the synbiotic feed additive for growing and fattening pigs and the application method disclosed by theinvention, the weight increment speed of the body weight of the pigs can be increased, the lean meat proportion is increased, the nutrients are comprehensive, the feed feeding quantity can be reduced, the utilization rate of the feed can be increased, the growth speed of the pigs is high, the meat quality is bright red, tender in nature and good in mouth feel, the economic benefits are increased,and the synbiotic feed additive has good application prospects.