8 results about "Amifostine" patented technology

The invention belongs to the technical field of biological medicine, and provides an iron-based nanodot capable of guiding MRI and delivering medicine and a preparation method and application of the iron-based nanodot. The iron-based nanodot is used as a chemotherapeutic drug carrier, and is prepared from a cell protective agent amifostine (AT) and key nutritional metal iron ions (Fe < 3 + >) for inducing ferroptosis through a supramolecular self-assembly technology. The iron-based nanodot can efficiently load the chemotherapeutic drug, improves pharmacokinetic behaviors such as short in-vivo circulation period and fast metabolism of the chemotherapeutic drug, accurately delivers the chemotherapeutic drug to a tumor site, and improves the drug effect of the chemotherapeutic drug; in addition, the iron-based nanodots can realize efficient ferroptosis treatment under the guidance of MRI to induce immunogenic cell death and inhibit growth, metastasis and diffusion of tumor cells.

The application provides a kind of gamma delta T cell preparation and its preparation method and application, it is related to the field of biotechnology.The composition provided by the application includes: coenzyme Q10, vitamin C, human blood albumin, trehalose, sodium pyruvate and amifostine.Using the composition and related preparation provided by the application can effectively improve the killing ability of gamma delta T cells and maintain the function of gamma delta T cells, and can effectively inhibit tumor growth.

The present invention provides a composition comprising 5-aminolevulinic acid or a salt or ester thereof, comprising: (a) an active ingredient selected from 5-aminolevulinic acid or a salt or ester thereof; and (b) an aqueous carrier comprising an analgesic. The 5-aminolevulinic acid or the salt or ester thereof can be used for photodynamic therapy analgesia for more than 20 minutes, so that the clinical treatment cycle can be covered, the pain feeling after photodynamic therapy can be obviously relieved, the photodynamic therapy receiving time of a patient is prolonged, and the medication compliance of the patient is improved. Moreover, the composition provided by the invention can also improve the condition of tissue edema after photodynamic therapy, improve the skin smoothness after photodynamic therapy and shorten the pigmentation time, and meanwhile, compared with a marketed preparation, the composition has a better effect in the aspect of photodynamic therapy of inflammatory diseases (such as psoriasis or contact dermatitis) or acne and the like, and has a good application prospect. The acceptability of the patient to the photodynamic therapy is further improved; and the application scene of the photodynamic therapy is widened.

A colon-targeted delivery system, a preparation method and application thereof, comprising amifostine, pectin and chitosan; through a chemical amidation reaction, carboxyl in the pectin and amino in the amifostine are connected through an amide bond to form a nanoparticle core PEC-AMF, and the chitosan and the pectin form a nanoparticle coating layer through electrostatic interaction to synthesize CS / PEC-AMF nanoparticles; the colon-targeted delivery system in the application realizes precise and controlled drug release by means of the step-by-step change of pH values in the gastrointestinal tract environment and the catalysis of pectinase in the colon; experiments prove that the delivery system has excellent stability in the stomach and small intestine, and can rapidly release amifostine in the colon, thereby effectively protecting the intestinal epithelium and immune cells from damage caused by radiotherapy, while the pectin regulates the intestinal microecology, protects the normal tissues of the colorectum and does not affect the effect of radiotherapy on tumors.

The application discloses a preparation method of an oral radiation protection nano drug, and the preparation method is characterized in that 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (EDC / NHS) catalytic systems are used to graft amifostine to carboxymethyl chitosan under normal temperature conditions, and a pH-responsive radiation protection nano drug is synthesized by one-step method. The oral pH-responsive radiation protection nano drug can realize intestinal radiation protection, the nano drug has pH sensitivity and can realize targeted intestinal radiation protection, can effectively improve the bioavailability of a small-molecule drug amifostine in a gastrointestinal tract and reduce the biological toxicity of the small-molecule drug, and has important significance in the field of intestinal radiation protection.

The present invention relates to a process for the preparation of lyophilized 2-[(3-aminopropyl)amino]ethanethiol comprising the following steps: a) reacting an amifostine solution with a strong acid to obtain a 2-[(3-aminopropyl)amino]ethanethiol solution, and b) lyophilizing the 2-[(3-aminopropyl)amino]ethanethiol solution, with or without the addition of excipients.

The invention provides application of combination of amifostine and calycosin in preparation of a preparation for preventing and / or treating radiation-induced lung injury, and belongs to the technical field of medicines. According to the invention, the amifostine and the calycosin are combined for use, so that the medication side effect caused by independent use of the amifostine in the prior art is effectively solved, and the prevention effect and the treatment stability of the amifostine are improved. According to the pharmaceutical composition disclosed by the invention, the amifostine and the calycosin are combined for use, so that the pharmaceutical composition has a good prevention and treatment effect on radiation-induced lung injury caused by ionizing radiation, and adverse reactions such as hypotension and nausea generated when the amifostine is independently used cannot be generated. And when the administration dosage of the amifostine and the calycosin is low, the survival rate of a radiation-induced lung injury model mouse is remarkably improved, and no toxic or side effect exists.