5results about How to "Reduce nephrotoxicity" patented technology

The invention relates to a polymyxin inhalation liquid preparation and a preparation method thereof. The polymyxin inhalation liquid preparation comprises 0.1-5% (W / V) of polymyxin B sulfate, 0.05-1% (W / V) of a stabilizer, 0.1-0.9% (W / V) of an osmotic pressure regulator, a pH value regulator and a solvent, the pH (Potential of Hydrogen) of the liquid preparation is 3.0 to 6.0; the solvent is selected from purified water and water for injection; the polymyxin inhalation solution provided by the invention is simple in composition, the pH value of the polymyxin inhalation solution is 3.0-6.0, osmotic pressure and isotonic pressure are simultaneously realized, bronchus spasm and cough caused by the polymyxin inhalation solution can be reduced, safety evaluation verifies that the polymyxin inhalation solution has better safety, and a new choice is provided for clinical application.

The application relates to a preparation method of a Gan Tong Pian and a related preparation and belongs to the field of traditional Chinese medicine preparations. The preparation method comprises the following steps: 1) extracting volatile oil from honeysuckle by adding 10 times the amount of water; collecting the water solution after distillation; 2) taking isatis root, soaking the isatis root in a solvent at room temperature, filtering the isatis root after soaking, drying the isatis root after soaking, and crushing the isatis root into fine powder for standby; 3) combining the remaining isatis root with gardenia, licorice and indigowood, adding water to the combination to boil three times, filtering the combination, combining the filtrate with the above water solution, filtering the combination, adding ethanol to the filtrate until the ethanol content is 60%, filtering the combination, recovering ethanol from the filtrate, and concentrating the filtrate into thick paste; 4) mixing the thick paste with the above fine powder, drying the mixture, crushing the mixture into fine powder, mixing the fine powder with paracetamol, amantadine hydrochloride and appropriate accessories, uniformly mixing the mixture, preparing granules, spraying the volatile oil into the granules, uniformly mixing the granules, pressing the granules, coating the granules with film, and obtaining the Gan Tong Pian.

The invention provides targeted hollow mesoporous Prussian blue nanoparticles loaded with rapamycin as well as a preparation method and application thereof in treating acute kidney injury induced by ischemia reperfusion. The nano particles comprise hollow mesoporous Prussian blue nano particles, rapamycin is loaded in the hollow mesoporous Prussian blue nano particles, and aminated hyaluronic acid is modified on the surfaces of the hollow mesoporous Prussian blue nano particles. The nanoparticles are endowed with kidney targeting property through aminated hyaluronic acid modification; the hollow mesoporous Prussian blue nano particles and the rapamycin play a dual role in promoting mitochondrial autophagy and relieving oxidative stress reaction. Therefore, the nanoparticles can effectively recover renal functions, relieve pathological changes of tissues and inhibit oxidative stress and inflammatory response in treatment of acute kidney injury induced by ischemia-reperfusion, and finally protect kidney cells from apoptosis injury, and have great application potential clinically.

The present invention aims to provide a Actinium-225-labeled anti-MUC5AC humanized antibody that is superior in the specificity for mucin subtype 5AC (MUC5AC) and accumulation in tumor, and shows reduced renal toxicity. The present invention relates to a conjugate of a chelating agent chelated with Actinium-225 and an antibody, wherein the antibody is a humanized antibody that specifically binds to mucin subtype 5AC and has a heavy chain variable region consisting of the amino acid sequence shown in any of SEQ ID NOs: 1 to 4, and a light chain variable region consisting of the amino acid sequence shown in any of SEQ ID NOs: 5 to 8.

The invention discloses a synthetic method of curcumin modified polymyxin B. A synthesized medicine can be self-assembled into nano particles with the particle size of about 100 nm in water, the problem that curcumin is poor in water solubility is solved, the structure of the nano particles enables the polymyxin B to be more easily proportioned into an inhalation preparation, and the renal toxicity of the polymyxin B is reduced. The synthesis method comprises the following steps: (1) taking curcumin as an initial raw material, adding p-formylbenzoic acid, and carrying out esterification reaction to generate formyl-modified curcumin CF; (2) the obtained CF and polymyxin B are subjected to a Schiff base condensation reaction, and curcumin modified polymyxin B is synthesized; and (3) carrying out self-assembly on the product obtained in the step (2) to obtain the nanoparticles.