2results about How to "Reduce nephrotoxicity" patented technology

The application relates to a preparation method of a Gan Tong Pian and a related preparation and belongs to the field of traditional Chinese medicine preparations. The preparation method comprises the following steps: 1) extracting volatile oil from honeysuckle by adding 10 times the amount of water; collecting the water solution after distillation; 2) taking isatis root, soaking the isatis root in a solvent at room temperature, filtering the isatis root after soaking, drying the isatis root after soaking, and crushing the isatis root into fine powder for standby; 3) combining the remaining isatis root with gardenia, licorice and indigowood, adding water to the combination to boil three times, filtering the combination, combining the filtrate with the above water solution, filtering the combination, adding ethanol to the filtrate until the ethanol content is 60%, filtering the combination, recovering ethanol from the filtrate, and concentrating the filtrate into thick paste; 4) mixing the thick paste with the above fine powder, drying the mixture, crushing the mixture into fine powder, mixing the fine powder with paracetamol, amantadine hydrochloride and appropriate accessories, uniformly mixing the mixture, preparing granules, spraying the volatile oil into the granules, uniformly mixing the granules, pressing the granules, coating the granules with film, and obtaining the Gan Tong Pian.

The present invention aims to provide a Actinium-225-labeled anti-MUC5AC humanized antibody that is superior in the specificity for mucin subtype 5AC (MUC5AC) and accumulation in tumor, and shows reduced renal toxicity. The present invention relates to a conjugate of a chelating agent chelated with Actinium-225 and an antibody, wherein the antibody is a humanized antibody that specifically binds to mucin subtype 5AC and has a heavy chain variable region consisting of the amino acid sequence shown in any of SEQ ID NOs: 1 to 4, and a light chain variable region consisting of the amino acid sequence shown in any of SEQ ID NOs: 5 to 8.