12results about How to "Reduce Toxicity Risk" patented technology

The invention relates to a manufacturing method of a biodegradable polylactic acid agricultural film with a pesticide slow-release function. Pesticide is packaged in situ through a porous organic framework material, a packaging body with a slow release function is formed, the packaging body and a polylactic acid raw material are blended, and then extrusion and film blowing are performed to form the pesticide-porous organic framework-polylactic acid composite film. The composite film can slowly release effective components such as pesticides into the environment, so that the effective period of the effective components is prolonged, and the pesticide application frequency is reduced. Meanwhile, the composite film prepared by taking a biodegradable material polylactic acid as a matrix can be degraded into pollution-free micromolecular substances within a certain time through direct composting or soil covering burying. Compared with the prior art, the method is wide in application range, high in pesticide utilization rate, low in toxicity risk and long in validity period, and has the characteristics of pesticide slow release and biodegradability.

The invention discloses a method for predicting toxicological properties of cosmetic raw materials. The invention discloses an organic compound toxicity prediction method and model based on molecular structure characteristics and a machine learning algorithm, and aims to predict four key toxicological properties of cosmetic raw materials, namely mutagenicity, carcinogenicity, eye irritation and skin sensitization. The method comprises the following steps: firstly, collecting structural data and four toxicological property data of a compound, and constructing a toxicity data set; then, dividing the data set into a training set and an external test set, calculating molecular feature fingerprints of the data set, and screening the molecular fingerprints of the training set by using a feature selection method; a toxicity classification prediction model is established by using a machine learning algorithm and training set data, and the prediction accuracy and reliability of the model are verified through external test set data. According to the method, the safety risk of cosmetic raw material research and development can be effectively reduced, the cost of toxicology testing is reduced, and meanwhile guiding significance and practical value are provided for safety risk assessment of cosmetic raw materials.

The invention discloses a carbon nanotube simultaneously doped with nitrogen and phosphorus and a preparation method and application thereof, the preparation method comprises the following steps: (1) preparing a reaction liquid: adding acetonitrile into absolute ethyl alcohol, uniformly mixing, then adding triphenyl phosphate, uniformly mixing, then adding a catalyst, and finally performing ultrasonic treatment to obtain the reaction liquid; (2) air replacement: argon is introduced into the quartz tube reactor for air replacement; (3) heating reaction: after the replacement is completed, heating and introducing carrier gas, pumping the obtained reaction liquid into the quartz tube reactor after the temperature is increased to the reaction temperature, and starting the reaction; and (4) after the reaction is completed, stopping pumping the reaction liquid, maintaining the reaction temperature, reacting for a period of time, finally cooling to room temperature, and taking out the reactant, thereby obtaining the carbon nanotube product. The carbon nanotube doped with nitrogen and phosphorus elements prepared on the basis of the floating catalytic chemical vapor deposition method has excellent electrochemical performance; and the preparation process is easy for large-scale production and has an excellent application prospect.

The invention belongs to the field of medicine application, and particularly relates to disordered protein cocktail extracted from Antarctic nematodes and application of the disordered protein cocktail in cell low-temperature protection. The disordered protein disclosed by the invention can effectively reduce low-temperature damage and improve the survival rate of cells under a low-temperature condition by preventing ice crystal formation and stabilizing a cell membrane structure. Compared with a traditional low-temperature protective agent, the low-temperature protective agent can play a protective role at low concentration, and the toxicity risk to cells is remarkably reduced. Meanwhile, the natural anti-oxidation characteristic is achieved, oxidative stress damage induced by low temperature can be relieved, and therefore cells are further protected. The method is wide in application range, can be applied to low-temperature preservation of various types of cells, tissues and organs, and is suitable for multiple fields of medicine, agriculture, scientific research and the like.

The invention discloses a preparation method of bio-friendly sphere-like nano manganous-manganic oxide and a product, and relates to the technical field of functional nano materials. The method comprises the following steps: mixing manganese salt with ultrapure water to obtain a manganese salt solution; the catalyst is selected from monoethanolamine, diethanolamine and triethanolamine, and the modifier is selected from polyethylene glycol, sodium alginate and derivatives thereof, chitosan and derivatives thereof, and water-soluble cellulose and derivatives thereof; dropwise adding an alkaline solution and an acidic solution to adjust the pH value of the manganese salt solution, adding ultrapure water, uniformly stirring, and pouring into a hydrothermal reaction kettle; putting the hydrothermal reaction kettle into a drying box, and heating and reacting completely to obtain manganous-manganic oxide slurry; filtering, rinsing and drying to obtain a manganous-manganic oxide powder product; the biotoxicity of the manganous-manganic oxide nano-particles is effectively reduced, strict biomedical application requirements are met, the preparation method is simple, process conditions are mild, expensive equipment is not needed, and cost control is facilitated.

This invention discloses a highly stable amphotericin B liposome and its preparation method, belonging to the field of pharmaceutical formulation technology. This invention utilizes a methanol-water-chloroform ternary mixed solvent system to achieve complete molecular-level dissolution of the raw materials, eliminating the conventional drying process and directly hydrating and homogenizing. It also provides optimal formulation ratios and process parameters. The preparation method includes steps such as oil phase preparation, aqueous phase preparation, homogenization, incubation, cooling, filtration, volumetric filling, and lyophilization. This invention creatively proposes optimal formulation composition and process conditions, resulting in a product with high encapsulation efficiency, uniform particle size, and strong stability. Furthermore, the preparation process is simple and easily industrialized, solving the problems of complex preparation processes and poor stability of existing injectable amphotericin B liposomes, and possesses good clinical application value.

The application discloses a kind of preparation methods and products of biological friendly spheroid-like trimanganese tetraoxide nanometer, it is related to functional nanometer material technical field;The application includes that manganese salt is mixed with ultrapure water and obtains manganese salt solution;Catalyst, modifier are added and stirred uniformly, catalyst is selected from monoethanolamine, diethanolamine, triethanolamine, modifier is selected from polyethylene glycol, sodium alginate and its derivative, chitosan and its derivative, water-soluble cellulose and its derivative;Basic solution and acidic solution are added dropwise to adjust the pH value of manganese salt solution, ultrapure water is added and stirred uniformly and poured into hydrothermal reaction kettle;Hydrothermal reaction kettle is placed in drying oven and heated to complete reaction to obtain trimanganese tetraoxide slurry;Filter, rinse and dry to obtain trimanganese tetraoxide powder product;The application effectively reduces the biological toxicity of trimanganese tetraoxide nanoparticle, meets the strict biomedical application requirement, preparation method is simple, process condition is mild, does not need expensive equipment, and cost is conducive to control.

This invention relates to the field of daily chemical technology, and in particular to a method for preparing kava extract based on enzymatic hydrolysis technology, its products, and applications. The preparation method comprises the following steps: S01 low-temperature treatment of kava rhizomes, followed by pulverization and sieving; S02 enzymatic hydrolysis of the kava rhizome powder; S03 fermentation treatment of the kava rhizome enzymatic hydrolysis extract obtained in S02; and S04 stabilization treatment of the fermented kava rhizome extract obtained in S03. This invention employs a combination of multi-enzyme synergistic pretreatment and probiotic co-fermentation, conducted entirely in an aqueous environment, eliminating the need for organic solvents such as ethanol and methanol. The operation is safe and environmentally friendly, aligning with the development trend of green raw materials in cosmetics.

The invention belongs to the field of hydrogel, and particularly relates to injectable composite hydrogel as well as a preparation method and a use method thereof. The injectable composite hydrogel provided by the invention comprises a component A and a component B, wherein the component A comprises a polyfunctional polymer, a thixotropic agent and an aqueous solvent, the polyfunctional polymer is one or more of gelatin, carboxymethyl chitosan and collagen, and the thixotropic agent is one or more of montmorillonite, bentonite, kaolinite, halloysite, magnesium aluminum silicate and magnesium lithium silicate; the component B comprises a multi-arm polyethylene glycol derivative and an aqueous solvent. The injectable composite hydrogel provided by the invention has good shear thinning performance and in-situ crosslinking performance, and has excellent injectability and embolism effect.

The invention provides a manioc waste liquid feed preparation process based on microbial fermentation, and belongs to the technical field of feed. According to the application, the nano calcium phosphate loaded high-valence ferric salt and the metal ion doped hydroxyapatite are introduced to solve the problems of excessive metal ions and anti-nutrient substance residues; the nano calcium phosphate loaded high-valence ferric salt efficiently oxidizes and removes cyanide ions and tannin in the fermentation liquor through ferrate loaded on the surface; oxidation products and part of ferric ions are fixed, so that inhibition on microorganisms is avoided; the metal ion-doped hydroxyapatite effectively captures excessive metal ions through ion exchange and complexation, reduces the free concentration of the metal ions, prevents adverse effects on microbial metabolism, can compete with anions in a fermentation liquid, inhibits the generation of toxic complexes, and reduces the toxicity to a fermentation system; the synergistic effect of removal of anti-nutrient substances and dynamic regulation and control of metal ions is achieved, and the nutritional value and safety of the final feed are improved.

The invention discloses a test solution for detecting the content of triptolide, a preparation method and a detection method, and relates to the technical field of compound content detection. The preparation method of the test solution comprises the following steps: precisely weighing an object to be detected, adding an extraction solvent for extraction, filtering, passing the filtrate through a neutral alumina column, eluting with methanol, collecting the eluate, and recovering the eluate to be dry to obtain residues; adding a first methanol solution into the residues, dissolving, fixing the volume, and uniformly shaking; the to-be-detected substance comprises the content of the artemisia selengensis wind-dispelling capsule. The preparation method disclosed by the invention is simple to operate, the same solvent is preferably selected for extraction and elution, the redundant operation of concentrating and redissolving when different solvents are used is avoided, and the toxicity risk of the solvents is greatly reduced. The test solution for detecting the content of triptolide, provided by the invention, is suitable for HPLC (High Performance Liquid Chromatography) analysis and has a good impurity removal effect; when the test solution provided by the invention is used for detecting the content of triptolide, and specific chromatographic conditions are matched, the method has the advantage of high accuracy.

The invention belongs to the technical field of biology, and particularly relates to a recombinant botulinum toxin A chimeric protein and application thereof. The recombinant A-type botulinum toxin chimeric protein is constructed by replacing only a C-terminal receptor binding domain or a whole receptor binding domain in a receptor structural domain on the basis of wild-type BoNT / A. The recombinant botulinum toxin A chimeric protein has substrate cleavage activity equivalent to that of wild toxin in vitro, can be effectively taken in Neuro-2a nerve cells and realize substrate cleavage, shows a significantly reduced toxicity level in animal bodies, and has a good application prospect. Wherein the AAAF chimeric protein has the characteristics of rapid effect taking and short action time, and is suitable for situations requiring short-term intervention of neural activity, such as short-term muscular tension regulation or local injection treatment; the AAFF chimeric protein has relatively long neuromuscular blocking duration and relatively high safety, and is suitable for long-term treatment of chronic nervous system diseases.