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Gelatin porous material prepared by using high inner phase emulsion as template and preparation method of gelatin porous material

A high-internal-phase emulsion and porous material technology, applied in the field of gelatin porous materials and its preparation, can solve problems such as the complexity of the preparation process, and achieve the effects of simple preparation methods, reduced toxicity risks, and short production cycles

Active Publication Date: 2014-06-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of this material is too complicated, and at the same time, small molecule surfactants, initiators, chemical cross-linking agents and other substances are used in the synthesis process, which makes the material have potential biological toxicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Dissolve 0.5g of gelatin and 5mg of genipin in 5mL of water to form a water phase, add 5mL of the water phase into 20mL of n-hexane, form a high internal phase emulsion under stirring at 9000rpm, react the obtained sample at room temperature for 24 hours, and then Extract with water and ethanol for 24 hours respectively, and finally freeze-dry the sample to obtain a gelatin porous material.

Embodiment 2

[0018] Example 2 Dissolve 0.25g of gelatin and 4mg of genipin in 5mL of water to form an aqueous phase, add 5mL of the aqueous phase to 20mL of toluene, and form a high internal phase emulsion under stirring at 13500rpm, react the obtained samples at room temperature for 36 hours, and then Extract with water and ethanol for 24 hours respectively, and finally freeze-dry the sample to obtain a gelatin porous material.

Embodiment 3

[0019] Example 3 Dissolve 0.5g of gelatin and 4mg of genipin in 5mL of water to form a water phase, add 5mL of the water phase into 45mL of p-xylene, form a high internal phase emulsion under stirring at 15000rpm, and react the resulting sample at room temperature for 40 hours. Subsequently, the samples were extracted with water and ethanol for 24 hours respectively, and finally the samples were freeze-dried to obtain gelatin porous materials.

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PUM

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Abstract

The invention discloses a gelatin porous material prepared by using a high inner phase emulsion as a template and a preparation method of the gelatin porous material. A gelatin solution and an organic solvent are stirred and mixed at a high speed to form an oil-in-water type (O / W) high inner phase emulsion, and a continuous phase is crosslinked by using genipin to form a three-dimensional network-state structure, and the three-dimensional network-state structure is frozen and dried to prepare the porous material with a pore diameter of 10-100 mu m and a porosity of more than 70 percent. The gelatin porous material prepared by adopting the preparation method is easily formed, is good in biocompatibility, and can be widely applied to a tissue engineering material.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a gelatin porous material prepared with a high internal phase emulsion as a template and a preparation method. Background technique [0002] Porous materials can provide three-dimensional space for cell attachment, growth and reproduction in tissue engineering applications. Porous materials with high porosity can provide more space for cell growth, and its connectivity can promote cell proliferation, migration and communication between cells. Therefore, the improvement of the structure and the optimization of the function of porous materials have aroused the interest of many researchers in recent years. [0003] A high internal phase emulsion is an emulsion with 74% or more internal phase, sometimes as high as 99%. By immobilizing the continuous phase of such emulsions by crosslinking and then removing the internal phase, porous materials with high porosity can be obtained. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J3/24C08L89/00C08K5/1545
Inventor 林炜谭欢魏涛穆畅道
Owner SICHUAN UNIV
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